Results 31 to 40 of about 8,179,520 (254)

Identification and validation of myocardial infarction and stroke outcomes at scale in UK Biobank

International Journal of Population Data Science, 2017
Aims We aimed (i) to create algorithms for identifying stroke and acute myocardial infarction (MI) cases in a large prospective population-based study (UK Biobank), using linked data from national hospital admissions data and death registers, combined ...
Christian Schnier, Spiros Denaxas, Rosalind Eggo, Riyaz Patel, Qiuli Zhang, Rebecca Woodfield, Robin Flaig, Harry Hemingway, Cathie Sudlow   +8 more
doaj   +1 more source

Nonalcoholic fatty liver disease and type 2 diabetes: an observational and Mendelian randomization study

Frontiers in Endocrinology, 2023
IntroductionNonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are both chronic multisystem diseases that cause tremendous health burdens worldwide.
Yuetian Yu, Yuefeng Yu, Yuying Wang, Yi Chen, Ningjian Wang, Bin Wang, Yingli Lu   +6 more
doaj   +1 more source

Epidemiology of Cholesteatoma in the UK Biobank [PDF]

Clinical Otolaryngology
Level of Evidence: 3 Objective(s) To identify the risk factors for Cholesteatoma in a large UK cohort. Although some risk factors are well established (male sex, history of chronic otitis media), others require further evidence (deprivation, smoking). Design and Setting
Emma Wilson, Barbara Anne Jennings, Mizanur Khondoker, Carl M. Philpott, Peter Prinsley, Daniel S. Brewer   +5 more
openaire   +3 more sources

Comorbidities and ethnic health disparities in the UK biobank

JAMIA Open, 2022
AbstractObjectiveThe goal of this study was to investigate the relationship between comorbidities and ethnic health disparities in a diverse, cosmopolitan population.Materials and MethodsWe used the UK Biobank (UKB), a large progressive cohort study of the UK population.
Whitney L Teagle, Emily T Norris, Lavanya Rishishwar, Shashwat Deepali Nagar, I King Jordan, Leonardo Mariño-Ramírez   +5 more
openaire   +3 more sources

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

Nature Communications, 2020
Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imaging ...
Thomas J. Littlejohns, Jo Holliday, Lorna M. Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy D. Bell, Chris Boultwood, Rory Collins, Megan C. Conroy, Nicola Crabtree, Nicola Doherty, Alejandro F. Frangi, Nicholas C. Harvey, Paul Leeson, Karla L. Miller, Stefan Neubauer, Steffen E. Petersen, Jonathan Sellors, Simon Sheard, Stephen M. Smith, Cathie L. M. Sudlow, Paul M. Matthews, Naomi E. Allen   +23 more
doaj   +1 more source

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Nature Communications, 2018
The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank ...
David M. Howard, Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, 23andMe Research Team, Saskia P. Hagenaars, Cathryn M. Lewis, Joey Ward, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary, Andrew M. McIntosh   +21 more
doaj   +1 more source

Gout, Rheumatoid Arthritis, and the Risk of Death Related to Coronavirus Disease 2019: An Analysis of the UK Biobank

ACR Open Rheumatology, 2021
Objectives The objectives for this study were to assess whether gout and/or rheumatoid arthritis (RA) are risk factors for coronavirus disease 2019 (COVID‐19) diagnosis and to assess whether gout and/or RA are risk factors for death from COVID‐19 ...
Ruth K. Topless, Amanda Phipps‐Green, Megan Leask, Nicola Dalbeth, Lisa K. Stamp, Philip C. Robinson, Tony R. Merriman   +6 more
doaj   +1 more source

Overestimated prediction using polygenic prediction derived from summary statistics

BMC Genomic Data, 2023
Background When polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We compared two types of PRS studies derived from raw genetic data (denoted as rPRS) and the summary ...
David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim   +8 more
doaj   +1 more source

Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen

Frontiers in Oncology, 2022
BackgroundGenetic factors increase the individual risk of colorectal cancer (CRC); however, the extent to which a healthy lifestyle can offset increased genetic risk is unknown. This study investigated whether a healthy lifestyle is associated with lower
E. Wu, E. Wu, Jun-Tao Ni, Xin Chen, Zhao-Hui Zhu, Hong-Quan Xu, Hong-Quan Xu, Lin Tao, Lin Tao, Tian Xie, Tian Xie   +10 more
doaj   +1 more source

UK Biobank Motor Neurone Disease (MND) phenotype

, 2019
UK Biobank Motor Neurone Disease (MND ...
UK Biobank Outcome Adjudication Group (7239638), John Nolan (3432041), Kathryn Bush (7239637), Cathie Sudlow (259959)   +3 more
core   +1 more source