Results 31 to 40 of about 121,766 (195)

Algorithms for the Capture and Adjudication of Prevalent and Incident Diabetes in UK Biobank.

PLoS ONE, 2016
ObjectivesUK Biobank is a UK-wide cohort of 502,655 people aged 40-69, recruited from National Health Service registrants between 2006-10, with healthcare data linkage. Type 2 diabetes is a key exposure and outcome.
Sophie V Eastwood, Rohini Mathur, Mark Atkinson, Sinead Brophy, Cathie Sudlow, Robin Flaig, Simon de Lusignan, Naomi Allen, Nishi Chaturvedi   +8 more
doaj   +1 more source

Biosamples as gifts? How participants in biobanking projects talk about donation. [PDF]

, 2015
Funded by National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust University of Oxford Oxford Biomedical Research Centre FellowshipPeer reviewedPublisher ...
Andrews, Barr, Cragg Ross Dawson, Dixon-Woods, Dixon-Woods, Gaskell, Haddow, Haimes, Hoeyer, Hoeyer, Kanellopoulou, Kaye, Laurie, Lenk, Lipworth, Locock, Manson, Mauss, Medical Research Council, Nuffield Council on Bioethics, OECD, People Science and Policy Ltd, Primary Care Reports, Scheper-Hughes, Seale, Solbakk, Titmuss, Tutton, Tutton, Waldby, Walsh, Widdows, Widdows   +32 more
core   +1 more source

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

Nature Communications, 2020
Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imaging ...
Thomas J. Littlejohns, Jo Holliday, Lorna M. Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy D. Bell, Chris Boultwood, Rory Collins, Megan C. Conroy, Nicola Crabtree, Nicola Doherty, Alejandro F. Frangi, Nicholas C. Harvey, Paul Leeson, Karla L. Miller, Stefan Neubauer, Steffen E. Petersen, Jonathan Sellors, Simon Sheard, Stephen M. Smith, Cathie L. M. Sudlow, Paul M. Matthews, Naomi E. Allen   +23 more
doaj   +1 more source

Overestimated prediction using polygenic prediction derived from summary statistics

BMC Genomic Data, 2023
Background When polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We compared two types of PRS studies derived from raw genetic data (denoted as rPRS) and the summary ...
David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim   +8 more
doaj   +1 more source

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants [PDF]

, 2017
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index ...
Anderson, Jana, Bailey, Mark E.S., Celis-Morales, Carlos, Gill, Jason M.R., Gray, Stuart, Guo, Yibing, Iliodromiti, Stamatina, Lyall, Donald M., Mackay, Daniel F., Pell, Jill, Petermann, Fanny, Sattar, Naveed, Steell, Lewis, Welsh, Paul   +13 more
core   +1 more source

Confound modelling in UK Biobank brain imaging

NeuroImage, 2020
AbstractDealing with confounds is an essential step in large cohort studies to address problems such as unexplained variance and spurious correlations. UK Biobank is a powerful resource for studying associations between imaging and nonimaging measures such as lifestyle factors and health outcomes, in part because of the large subject numbers.
Alfaro-Almagro, Fidel, McCarthy, Paul, Afyouni, Soroosh, Anderson, Jesper L.R., Bastiani, Matteo, Miller, Karla L., Nichols, Thomas E., Smith, Stephen M.   +7 more
openaire   +5 more sources

Identification and validation of myocardial infarction and stroke outcomes at scale in UK Biobank

International Journal of Population Data Science, 2017
Aims We aimed (i) to create algorithms for identifying stroke and acute myocardial infarction (MI) cases in a large prospective population-based study (UK Biobank), using linked data from national hospital admissions data and death registers, combined ...
Christian Schnier, Spiros Denaxas, Rosalind Eggo, Riyaz Patel, Qiuli Zhang, Rebecca Woodfield, Robin Flaig, Harry Hemingway, Cathie Sudlow   +8 more
doaj   +1 more source

Insulin‐like growth factor‐1 and site‐specific cancers: A Mendelian randomization study

Cancer Medicine, 2020
Insulin‐like growth factor‐1 (IGF‐1) is involved in several processes relevant to carcinogenesis. We used 416 single‐nucleotide polymorphisms robustly associated with serum IGF‐1 levels to assess the potential causal associations between this hormone and
Susanna C. Larsson, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M. Mason, Stephen Burgess   +5 more
doaj   +1 more source

Anxiety disorders and age-related changes in physiology

European Psychiatry, 2022
Introduction Anxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan, and associated with substantially increased morbidity and early mortality.
J. Mutz, T. Hoppen, C. Fabbri, C. Lewis
doaj   +1 more source

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Nature Communications, 2018
The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank ...
David M. Howard, Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, 23andMe Research Team, Saskia P. Hagenaars, Cathryn M. Lewis, Joey Ward, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary, Andrew M. McIntosh   +21 more
doaj   +1 more source