Results 31 to 40 of about 61,679 (166)

Comorbidities and ethnic health disparities in the UK biobank

JAMIA Open, 2022
AbstractObjectiveThe goal of this study was to investigate the relationship between comorbidities and ethnic health disparities in a diverse, cosmopolitan population.Materials and MethodsWe used the UK Biobank (UKB), a large progressive cohort study of the UK population.
Whitney L Teagle, Emily T Norris, Lavanya Rishishwar, Shashwat Deepali Nagar, I King Jordan, Leonardo Mariño-Ramírez   +5 more
openaire   +3 more sources

Prevalence of Hypertrophic Cardiomyopathy in the UK Biobank Population [PDF]

JAMA Cardiology, 2021
This cohort study examines the prevalence of hypertrophic cardiomyopathy in the UK Biobank population.
Lopes, LR, Aung, N, van Duijvenboden, S, Munroe, PB, Elliott, PM, Petersen, SE   +5 more
openaire   +3 more sources

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Nature Communications, 2018
The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank ...
David M. Howard, Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, 23andMe Research Team, Saskia P. Hagenaars, Cathryn M. Lewis, Joey Ward, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary, Andrew M. McIntosh   +21 more
doaj   +1 more source

Insulin‐like growth factor‐1 and site‐specific cancers: A Mendelian randomization study

Cancer Medicine, 2020
Insulin‐like growth factor‐1 (IGF‐1) is involved in several processes relevant to carcinogenesis. We used 416 single‐nucleotide polymorphisms robustly associated with serum IGF‐1 levels to assess the potential causal associations between this hormone and
Susanna C. Larsson, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M. Mason, Stephen Burgess   +5 more
doaj   +1 more source

Anxiety disorders and age-related changes in physiology

European Psychiatry, 2022
Introduction Anxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan, and associated with substantially increased morbidity and early mortality.
J. Mutz, T. Hoppen, C. Fabbri, C. Lewis
doaj   +1 more source

Familial Influences on Neuroticism and Education in the UK Biobank [PDF]

Behavior Genetics, 2019
Abstract Genome-wide studies often exclude family members, even though they are a valuable source of information. We identified parent–offspring pairs, siblings and couples in the UK Biobank and implemented a family-based DNA-derived heritability method to capture additional genetic effects and multiple sources of environmental ...
Cheesman, R., Coleman, J., Rayner, C., Purves, K.L., Morneau-Vaillancourt, G., Glanville, K., Choi, S.W., Breen, G., Eley, T.C.   +8 more
openaire   +4 more sources

Quantile Regression for biomarkers in the UK Biobank

, 2023
Abstract Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes can lead to clinically relevant discoveries. GWAS for quantitative traits are based on simplified regression models modeling the conditional mean of a phenotype as a linear function of genotype.
Wang, Chen, Wang, Tianying, Wei, Ying, Aschard, Hugues, Ionita-Laza, Iuliana   +4 more
openaire   +2 more sources

Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen

Frontiers in Oncology, 2022
BackgroundGenetic factors increase the individual risk of colorectal cancer (CRC); however, the extent to which a healthy lifestyle can offset increased genetic risk is unknown. This study investigated whether a healthy lifestyle is associated with lower
E. Wu, E. Wu, Jun-Tao Ni, Xin Chen, Zhao-Hui Zhu, Hong-Quan Xu, Hong-Quan Xu, Lin Tao, Lin Tao, Tian Xie, Tian Xie   +10 more
doaj   +1 more source

UK Biobank's cardiovascular magnetic resonance protocol [PDF]

Journal of Cardiovascular Magnetic Resonance, 2016
UK Biobank's ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds.We describe the CMR protocol applied in UK Biobank's pilot phase, which will be extended into the main phase with three centres using the same equipment and ...
Petersen, SE, Neubauer, S, Matthews, P, Francis, J, Robson, MD, Zemrak, F, Boubertakh, R, Young, A, Hudson, S, Weale, P, Garratt, S, Collins, R, Piechnik, S, Neubauer, S   +13 more
openaire   +3 more sources

Age and cognitive decline in the UK Biobank

PLOS ONE, 2019
Age-related cognitive decline is a well-known phenomenon after age 65 but little is known about earlier changes and prior studies are based on relatively small samples. We investigated the impact of age on cognitive decline in the largest population sample to date including young to old adults.Between 100,352 and 468,534 participants aged 38-73 years ...
Marilyn C. Cornelis, Yamin Wang, Thomas Holland, Puja Agarwal, Sandra Weintraub, Martha Clare Morris   +5 more
openaire   +4 more sources