Results 51 to 60 of about 61,679 (166)

Impact of detecting potentially serious incidental findings during multi-modal imaging [version 3; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging.  We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow   +14 more
doaj   +1 more source

Genetics of educational resilience after adverse childhood experiencesResearch in context

EBioMedicine
Summary: Background: Adverse childhood experiences (ACEs) are associated with poorer mental health and may hinder educational attainment. Yet, some ACEs survivors still achieve higher education, suggesting the presence of educational resilience, whilst ...
Huazhen Yang, Hilda Björk Daníelsdóttir, Yu Zeng, Can Hou, Hongxi Wang, Arna Hauksdottir, Edda Björk Thordardottir, Gunnar Tómasson, Jóhanna Jakobsdóttir, Thor Aspelund, Jie Song, Fang Fang, Unnur Anna Valdimarsdóttir, Huan Song   +13 more
doaj   +1 more source

Impact of detecting potentially serious incidental findings during multi-modal imaging [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging.  We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow   +14 more
doaj   +1 more source

Multimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction

npj Digital Medicine, 2023
Cardiovascular disease (CVD), the leading cause of death globally, is associated with complicated underlying risk factors. We develop an artificial intelligence model to identify CVD using multimodal data, including clinical risk factors and fundus ...
Yeong Chan Lee, Jiho Cha, Injeong Shim, Woong-Yang Park, Se Woong Kang, Dong Hui Lim, Hong-Hee Won   +6 more
doaj   +1 more source

Association of sugar intake from different sources with incident dementia in the prospective cohort of UK Biobank participants

Nutrition Journal, 2023
Background Dementia is a common disease with around 55 million cases worldwide. Therefore, dietary changes and lifestyle interventions are important approaches to delay the progress of a decline in cognitive function.
Sylva M. Schaefer, Anna Kaiser, Gerrit Eichner, Mathias Fasshauer   +3 more
doaj   +1 more source

Demographics of lipoprotein(a) and stroke: The UK biobank

American Journal of Preventive Cardiology
Lipoprotein(a) [Lp(a)] is associated with ischemic stroke, but the strength of association based on demographic differences remains unclear. We aimed to investigate the association between Lp(a)>125 nmol/L and stroke by age, sex, and racial/ethnic subgroups.Using data from the UK Biobank, we included 353,309 participants with an Lp(a) measurement ...
Andrew S. Kao, Jonathan Kermanshahchi, Shamim Khosrowjerdi, Alexander C. Razavi, Jacqueline Levene, Mikaila Reyes, Parveen Garg, W.T. Longstreth, Kristiina Rannikmae, Cathie Sudlow, Michael Tsai, Sotirios Tsimikas, Anum Saeed, Harpreet S. Bhatia   +13 more
openaire   +4 more sources

Phenome-wide Heritability Analysis of the UK Biobank

PLOS Genetics, 2016
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common ...
Tian Ge, Chia-Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, Jordan W. Smoller   +4 more
openaire   +7 more sources

A framework for research into continental ancestry groups of the UK Biobank

Human Genomics, 2022
Background The UK Biobank is a large prospective cohort, based in the UK, that has deep phenotypic and genomic data on roughly a half a million individuals.
Andrei-Emil Constantinescu, Ruth E. Mitchell, Jie Zheng, Caroline J. Bull, Nicholas J. Timpson, Borko Amulic, Emma E. Vincent, David A. Hughes   +7 more
doaj   +1 more source

Association between physical activity and all-cause mortality in rheumatoid arthritis: evidence from NHANES and UK Biobank cohort studies

Arthritis Research & Therapy
Importance Rheumatoid arthritis (RA), a chronic autoimmune disease linked to higher mortality, benefits from physical activity (PA), which has been shown to reduce disease activity and improve physical function.
Haodong Zheng, Yunfeng Dai, Jiaye Fang, Shaowei Lin, Fei Gao, Junping Wen, Zhihan Chen   +6 more
doaj   +1 more source

The Potential of Microbiota-Modulating Dietary Strategies in Gallstone Prevention: Evidence from 2 Large Population- Based Cohorts

The Turkish Journal of Gastroenterology
Background/Aims: Gut–microbiota dysbiosis has been implicated in gallstone formation through alterations in bile acid and cholesterol metabolism, but whether adherence to a microbiota-supportive diet is associated with gallstone disease at the population
Hongyan He, Luohong Li, Xiaoli Yang
doaj   +1 more source