Results 51 to 60 of about 7,704,969 (300)

UK Biobank demographic information.

, 2022
UK Biobank demographic information.
Chris Zajner (14253213), Vaibhav Sharma (11085561), Judes Poirier (1779919), AmanPreet Badhwar (768519), Sylvia Villeneuve (418760), Karin Saltoun (14253207), Sarah A. Gagliano Taliun (6836708), Chloé Savignac (14253204), Sali Farhan (6594914), Danilo Bzdok (333738), Kimia Shafighi (14253210)   +10 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

COVID-19 and the UK Biobank—Opportunities and Challenges for Research and Collaboration With Other Large Population Studies

Frontiers in Cardiovascular Medicine, 2020
Large population studies such as the UK Biobank provide great opportunities for understanding the pathophysiology, health impact and prognostic factors associated with COVID-19, a condition that has had significant impact on almost everyone around the ...
Mohammed Y. Khanji, Mohammed Y. Khanji, Nay Aung, Nay Aung, C. Anwar A. Chahal, C. Anwar A. Chahal, C. Anwar A. Chahal, Steffen E. Petersen, Steffen E. Petersen   +8 more
doaj   +1 more source

Structural health determinants and comorbidity risk factors for COVID-19 outcomes among participants in the UK Biobank.

International Journal of Population Data Science, 2022
Objectives COVID-19 disproportionately affects older patients with pre-existing health conditions. However at the time of writing, June 2021, the relationship between COVID-19, ethnicity and deprivation is unclear.
Deborah Allen, Alejandra Vergara-Lope, Daniel Wilson   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Associations between the geriatric nutritional risk index and the risk of and mortality associated with chronic kidney disease in older individuals

BMC Public Health
Background Malnutrition is a complication of chronic kidney disease (CKD). Whether malnutrition, assessed via the geriatric nutritional risk index (GNRI), is associated with the incidence and risk of CKD in older individuals remains unclear. Methods Data
Peilin Zou, Yucong Zhang, Liangkai Chen, Man Liu, Hao Nie, Hongyu Gao, Cuntai Zhang, Jinhua Yan   +7 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Age and cognitive decline in the UK Biobank

PLOS ONE, 2019
Age-related cognitive decline is a well-known phenomenon after age 65 but little is known about earlier changes and prior studies are based on relatively small samples. We investigated the impact of age on cognitive decline in the largest population sample to date including young to old adults.Between 100,352 and 468,534 participants aged 38-73 years ...
Marilyn C. Cornelis, Yamin Wang, Thomas Holland, Puja Agarwal, Sandra Weintraub, Martha Clare Morris   +5 more
openaire   +4 more sources

Sex differences in genetic architecture in the UK Biobank

Nature Genetics, 2021
Males and females present differences in complex traits and in the risk of a wide array of diseases. Genotype by sex (GxS) interactions are thought to account for some of these differences. However, the extent and basis of GxS are poorly understood. In the present study, we provide insights into both the scope and the mechanism of GxS across the genome
Elena Bernabeu, Oriol Canela-Xandri, Konrad Rawlik, Andrea Talenti, James Prendergast, Albert Tenesa   +5 more
openaire   +3 more sources