Results 51 to 60 of about 8,179,520 (254)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

COVID-19 and the UK Biobank—Opportunities and Challenges for Research and Collaboration With Other Large Population Studies

Frontiers in Cardiovascular Medicine, 2020
Large population studies such as the UK Biobank provide great opportunities for understanding the pathophysiology, health impact and prognostic factors associated with COVID-19, a condition that has had significant impact on almost everyone around the ...
Mohammed Y. Khanji, Mohammed Y. Khanji, Nay Aung, Nay Aung, C. Anwar A. Chahal, C. Anwar A. Chahal, C. Anwar A. Chahal, Steffen E. Petersen, Steffen E. Petersen   +8 more
doaj   +1 more source

Structural health determinants and comorbidity risk factors for COVID-19 outcomes among participants in the UK Biobank.

International Journal of Population Data Science, 2022
Objectives COVID-19 disproportionately affects older patients with pre-existing health conditions. However at the time of writing, June 2021, the relationship between COVID-19, ethnicity and deprivation is unclear.
Deborah Allen, Alejandra Vergara-Lope, Daniel Wilson   +2 more
doaj   +1 more source

UK Biobank Asthma Phenotype

, 2019
UK Biobank Asthma ...
Kenan Direk (4588036)
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

UK Biobank Acknowledgement

, 2019
UK Biobank ...
Fernando Racimo (655564), Arbel Harpak (3558590), Anja Moltke Joergensen (7059956), Harpak, Arbel, Field, Yair, Mostafavi, Hakhamanesh, Berg, Jeremy J., Hakhamanesh Mostafavi (4413052), Evan August Boyle (7059959), Boyle, Evan August, Nasa Sinnott-Armstrong (7059953), Jonathan K. Pritchard (8027465), Sinnott-Armstrong, Nasa, Yair Field (269497), Graham Coop (86820), Xinjun Zhang (621709), Pritchard, Jonathan K., Coop, Graham, Joergensen, Anja Moltke, Racimo, Fernando, Zhang, Xinjun, Jeremy J. Berg (8027462)   +21 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Associations between the geriatric nutritional risk index and the risk of and mortality associated with chronic kidney disease in older individuals

BMC Public Health
Background Malnutrition is a complication of chronic kidney disease (CKD). Whether malnutrition, assessed via the geriatric nutritional risk index (GNRI), is associated with the incidence and risk of CKD in older individuals remains unclear. Methods Data
Peilin Zou, Yucong Zhang, Liangkai Chen, Man Liu, Hao Nie, Hongyu Gao, Cuntai Zhang, Jinhua Yan   +7 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source