Results 71 to 80 of about 7,704,969 (300)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Impact of detecting potentially serious incidental findings during multi-modal imaging [version 3; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging.  We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow   +14 more
doaj   +1 more source

Large‑scale analysis of iliopsoas muscle volumes in the UK Biobank [PDF]

, 2020
Psoas muscle measurements are frequently used as markers of sarcopenia and predictors of health. Manually measured cross-sectional areas are most commonly used, but there is a lack of consistency regarding the position of the measurement and manual ...
Whitcher, B., Cule, M., Thomas, E.L., Liu, Y., Bell, J.D., Fitzpatrick, J., Basty, N.   +6 more
core   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Genetics of educational resilience after adverse childhood experiencesResearch in context

EBioMedicine
Summary: Background: Adverse childhood experiences (ACEs) are associated with poorer mental health and may hinder educational attainment. Yet, some ACEs survivors still achieve higher education, suggesting the presence of educational resilience, whilst ...
Huazhen Yang, Hilda Björk Daníelsdóttir, Yu Zeng, Can Hou, Hongxi Wang, Arna Hauksdottir, Edda Björk Thordardottir, Gunnar Tómasson, Jóhanna Jakobsdóttir, Thor Aspelund, Jie Song, Fang Fang, Unnur Anna Valdimarsdóttir, Huan Song   +13 more
doaj   +1 more source

Impact of detecting potentially serious incidental findings during multi-modal imaging [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging.  We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow   +14 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Multimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction

npj Digital Medicine, 2023
Cardiovascular disease (CVD), the leading cause of death globally, is associated with complicated underlying risk factors. We develop an artificial intelligence model to identify CVD using multimodal data, including clinical risk factors and fundus ...
Yeong Chan Lee, Jiho Cha, Injeong Shim, Woong-Yang Park, Se Woong Kang, Dong Hui Lim, Hong-Hee Won   +6 more
doaj   +1 more source

Factors associated with potentially serious incidental findings and with serious final diagnoses on multimodal imaging in the UK Biobank Imaging Study: a prospective cohort study

, 2019
SPSS code is provided in order for readers to see our analytical approach; due to the confidential nature of questionnaire responses and clinical information on participants with potentially serious incidental findings, it is not possible to publicly ...
Gibson, Lorna Mary, Nolan, John
core   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source