Results 71 to 80 of about 121,766 (195)

Phenome-wide Heritability Analysis of the UK Biobank

PLOS Genetics, 2016
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common ...
Tian Ge, Chia-Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, Jordan W. Smoller   +4 more
openaire   +6 more sources

The UK National Health Service’s 'innovation agenda': lessons on commercialization and trust [PDF]

, 2014
The UK National Health Service (the 'NHS'), encouraged by the 2011 report Innovation Health and Wealth, Accelerating Adoption and Diffusion in the NHS, and empowered by the Health and Social Care Act 2012, is in the process of adopting a new agenda for ...
Cockbain, Julian, Sterckx, Sigrid
core   +2 more sources

Healthy living and cancer: evidence from UK Biobank

ecancermedicalscience, 2018
CONTEXT: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. OBJECTIVE: A healthy lifestyle has been described as 'better than any pill, and no side effects [5].
Elwood, P, Whitmarsh, A, Gallacher, J, Bayer, A, Adams, R, Heslop, L, Pickering, J, Morgan, G, Galante, J, Dolwani, S, Longley, M, Roberts, Z   +11 more
openaire   +5 more sources

Accurate Genomic Prediction Of Human Height [PDF]

, 2017
We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning).
Avery, Steven G., Campos, Gustavo de los, Hsu, Stephen D. H., Lello, Louis, Tellier, Laurent, Vazquez, Ana   +5 more
core   +1 more source

Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]

, 2019
Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Association between physical activity and all-cause mortality in rheumatoid arthritis: evidence from NHANES and UK Biobank cohort studies

Arthritis Research & Therapy
Importance Rheumatoid arthritis (RA), a chronic autoimmune disease linked to higher mortality, benefits from physical activity (PA), which has been shown to reduce disease activity and improve physical function.
Haodong Zheng, Yunfeng Dai, Jiaye Fang, Shaowei Lin, Fei Gao, Junping Wen, Zhihan Chen   +6 more
doaj   +1 more source

International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome [PDF]

, 2017
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of
Bateman, K., Chavada, Govindsinh, Cornblath, D. R., Cornblath, David R., Dardiotis, E., Faber, C. G., Feasby, T. E., Gorson, K. C., Gorson, Kenneth C., Harbo, T., Harbo, Thomas, Hartung, H. P., Hartung, H. P., Hartung, Hans Peter, Hughes, R. A.C., Hughes, Richard A.C., Illa, I., Islam, B., Islam, Z., Jacobs, B. C., Jacobs, B. C., Jacobs, B. C., Jacobs, Bart C., Kusunoki, S., Kusunoki, S., Kusunoki, Susumu, Lehmann, H. C., Mohammad, Q. D., Nobile-Orazio, E., Péréon, Y., Reddel, S. W., Reisin, R. C., Roodbol, J., Shahrizaila, N., van den Berg, B., van den Berg, B., van den Berg, Bianca, van den Bergh, P., van der Kooi, A. J., van Dijk, G. W., van Doorn, P. A., van Doorn, Pieter A., van Woerkom, M., Verboon, C., Verboon, C., Verboon, Christine, Visser, L. H., Wang, Y. Z., Willison, H. J., Willison, Hugh J.   +49 more
core   +3 more sources

Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts

BMC Medicine
Background Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies.
Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani, the PERFORM research team   +25 more
doaj   +1 more source

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts

Epidemiology and Psychiatric Sciences
Aims Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among adults with ...
Xin Qi, Li Liu, Jin Yang, Chuyu Pan, Jingcan Hao, Wenming Wei, Shiqiang Cheng, Yifan Gou, Boyue Zhao, Yan Wen, Bolun Cheng, Feng Zhang   +11 more
doaj   +1 more source

Will UK Biobank pay off?

BMJ, 2006
UK Biobank has been promised £61m funding to collect data about genetic and environmental factors that affect human health and disease.
openaire   +2 more sources