Results 81 to 90 of about 8,179,520 (254)

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among US Veterans

Arthritis Care &Research, EarlyView.
Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Summary statistics for the eligible UK biobank cohort.

, 2021
Summary statistics for the eligible UK biobank cohort.
Erika Spaeth Tuff (5814950), Aviv Gafni (3517400), Richard Allman (5814947), Gillian S. Dite (4711506), John L. Hopper (8115797)   +4 more
core   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

Genetics of educational resilience after adverse childhood experiencesResearch in context

EBioMedicine
Summary: Background: Adverse childhood experiences (ACEs) are associated with poorer mental health and may hinder educational attainment. Yet, some ACEs survivors still achieve higher education, suggesting the presence of educational resilience, whilst ...
Huazhen Yang, Hilda Björk Daníelsdóttir, Yu Zeng, Can Hou, Hongxi Wang, Arna Hauksdottir, Edda Björk Thordardottir, Gunnar Tómasson, Jóhanna Jakobsdóttir, Thor Aspelund, Jie Song, Fang Fang, Unnur Anna Valdimarsdóttir, Huan Song   +13 more
doaj   +1 more source

Autonomous Reconfigurable Modular Conductive Hydrogels for Adaptive and Degradable Bioelectronic Interfaces

Advanced Materials Technologies, EarlyView.
Bridging rigid electrodes with soft, irregular tissues demands more than conductivity alone. Modular conductive hydrogels autonomously reconfigure into conformal electrode‐tissue interfaces, coupling mixed ionic‐electronic conduction with tissue‐like mechanics, self‐healing, and degradability.
Matthew K. Burgess, Zofia B. Wolny, Zekun Liu, Karolina Cysewska, Malavika Nair   +4 more
wiley   +1 more source

Multimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction

npj Digital Medicine, 2023
Cardiovascular disease (CVD), the leading cause of death globally, is associated with complicated underlying risk factors. We develop an artificial intelligence model to identify CVD using multimodal data, including clinical risk factors and fundus ...
Yeong Chan Lee, Jiho Cha, Injeong Shim, Woong-Yang Park, Se Woong Kang, Dong Hui Lim, Hong-Hee Won   +6 more
doaj   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank [PDF]

, 2016
Genome-wide association studies have detected many loci underlying susceptibility to disease, but most of the genetic factors that contribute to disease susceptibility remain unknown.
Canela-Xandri, Oriol, Ricardo Pong-Wong, Rawlik, Konrad; id_orcid, Konrad Rawlik, Tenesa, Albert, Chris S Haley, Munoz, Maria, Pong-Wong, Ricardo; id_orcid, Albert Tenesa, Oriol Canela-Xandri, María Muñoz, Haley, Christopher, Haley, Chris S., Pong-Wong, Ricardo, Rawlik, Konrad   +14 more
core   +1 more source

Summary of characteristics of UK Biobank participants by analysis dataset.

, 2021
Summary of characteristics of UK Biobank participants by analysis dataset.
Daniela Zanetti (560934), Erik Ingelsson (232651), Joanna Lankester (488041), Themistocles L. Assimes (7658045)   +3 more
core   +1 more source