Results 101 to 110 of about 7,704,969 (300)

The Potential of Microbiota-Modulating Dietary Strategies in Gallstone Prevention: Evidence from 2 Large Population- Based Cohorts

The Turkish Journal of Gastroenterology
Background/Aims: Gut–microbiota dysbiosis has been implicated in gallstone formation through alterations in bile acid and cholesterol metabolism, but whether adherence to a microbiota-supportive diet is associated with gallstone disease at the population
Hongyan He, Luohong Li, Xiaoli Yang
doaj   +1 more source

UK Biobank Acknowledgement

, 2019
UK Biobank ...
Fernando Racimo (655564), Arbel Harpak (3558590), Anja Moltke Joergensen (7059956), Harpak, Arbel, Field, Yair, Mostafavi, Hakhamanesh, Berg, Jeremy J., Hakhamanesh Mostafavi (4413052), Evan August Boyle (7059959), Boyle, Evan August, Nasa Sinnott-Armstrong (7059953), Jonathan K. Pritchard (8027465), Sinnott-Armstrong, Nasa, Yair Field (269497), Graham Coop (86820), Xinjun Zhang (621709), Pritchard, Jonathan K., Coop, Graham, Joergensen, Anja Moltke, Racimo, Fernando, Zhang, Xinjun, Jeremy J. Berg (8027462)   +21 more
core   +1 more source

Body Composition Profiling in the UK Biobank Imaging Study [PDF]

, 2018
Objective To investigate the value of imaging-based multivariable body composition profiling by describing its association with coronary heart disease (CHD), type 2 diabetes (T2D), and metabolic health on individual and population levels.
Linge, Jennifer, Borger Magnus, Olof Dahlqvist Leinhard, Dumitriu, Alexandra, Tuthill, Theresa, Magnus Borga, Tunón, P., Melissa R. Miller, Tunon, Patrik, Miller, Melissa R., Theresa Tuthill, Tuthill, T., Miller, M.R., Dahlqvist Leinhard, Olof, Alexandra Dumitriu, Thomas, E. Louise, Romu, Thobias, Janne West, Borga, Magnus, Thomas, E.L., Leinhard, O.D., Linge, J., Romu, T., Patrik Tunón, Bell, J.D., West, Janne, E. Louise Thomas, Thobias Romu, Bell, Jimmy D., Dumitriu, A., West, J., Jennifer Linge, Jimmy D. Bell   +32 more
core   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts

BMC Medicine
Background Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies.
Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani, the PERFORM research team   +25 more
doaj   +1 more source

Visual Imagery Module, UK Biobank

Evaluation of the distribution and possible genetic basis of visual imagery vividness differences across the UK ...
Jill Rodd, Fenella Starkey, David Francis Marks, UK Biobank   +3 more
core   +1 more source

Latent structure in UK Biobank (10-2018)

, 2018
This project includes geographical analysis of genetic data in UK Biobank in order to illustrate latent structure within the genetic data of UK Biobank.
Haworth, Simon, Mitchell, Ruth, Timpson, Nicholas   +2 more
core   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts

Epidemiology and Psychiatric Sciences
Aims Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among adults with ...
Xin Qi, Li Liu, Jin Yang, Chuyu Pan, Jingcan Hao, Wenming Wei, Shiqiang Cheng, Yifan Gou, Boyue Zhao, Yan Wen, Bolun Cheng, Feng Zhang   +11 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source