Results 91 to 100 of about 8,179,520 (254)

Demographics of lipoprotein(a) and stroke: The UK biobank

American Journal of Preventive Cardiology
Lipoprotein(a) [Lp(a)] is associated with ischemic stroke, but the strength of association based on demographic differences remains unclear. We aimed to investigate the association between Lp(a)>125 nmol/L and stroke by age, sex, and racial/ethnic subgroups.Using data from the UK Biobank, we included 353,309 participants with an Lp(a) measurement ...
Andrew S. Kao, Jonathan Kermanshahchi, Shamim Khosrowjerdi, Alexander C. Razavi, Jacqueline Levene, Mikaila Reyes, Parveen Garg, W.T. Longstreth, Kristiina Rannikmae, Cathie Sudlow, Michael Tsai, Sotirios Tsimikas, Anum Saeed, Harpreet S. Bhatia   +13 more
openaire   +4 more sources

Phenome-wide Heritability Analysis of the UK Biobank

PLOS Genetics, 2016
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common ...
Tian Ge, Chia-Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, Jordan W. Smoller   +4 more
openaire   +7 more sources

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Association of sugar intake from different sources with incident dementia in the prospective cohort of UK Biobank participants

Nutrition Journal, 2023
Background Dementia is a common disease with around 55 million cases worldwide. Therefore, dietary changes and lifestyle interventions are important approaches to delay the progress of a decline in cognitive function.
Sylva M. Schaefer, Anna Kaiser, Gerrit Eichner, Mathias Fasshauer   +3 more
doaj   +1 more source

UK Biobank Chronic Obstructive Pulmonary Disease Phenotype

, 2019
UK Biobank Chronic Obstructive Pulmonary Disease ...
Kenan Direk (4588036)
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Demographic characteristics of the UK Biobank cohort.

, 2018
Demographic characteristics of the UK Biobank cohort.
Stuart K. Kim (112150)
core   +1 more source

Performance of Axiom UK Biobank array on the BRCA module.

, 2022
Performance of Axiom UK Biobank array on the BRCA module.
Adrian Bivol (4666309), Anuradha Mittal (838746), Jeanette P. Schmidt (14135198), Jeremy Gollub (5548), Teresa A. Webster (14135186), Orna Mizrahi-Man (42539), Marcos H. Woehrmann (14135183), Sara M. Keeble (5782319), Katherine H. Aull (14135189), Brant A. Wong (14135195), Alan H. Roter (14135192)   +10 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

UK Biobank End Stage Renal Disease Phenotype

, 2019
UK Biobank End Stage Renal Disease ...
Kenan Direk (4588036)
core   +1 more source