Results 121 to 130 of about 8,179,520 (254)
PLoS ONE, 2016 PurposeTo describe an approach to the use of optical coherence tomography (OCT) imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness.MethodsIn UK ...
Pearse A Keane +9 more
doaj +1 more source
Human evolution and the obstetrical dilemma: The pelvic floor hypothesis
The Anatomical Record, EarlyView.Abstract Human childbirth is mechanically difficult because a large‐headed, broad‐shouldered fetus must pass through a comparatively narrow, twisted bony birth canal. Traditional explanations of this “obstetrical dilemma” emphasize the role of bipedal locomotion in inhibiting the evolution of a wider, more spacious pelvis.
Barbara Fischer, Ekaterina Stansfield
wiley +1 more source
Clinical Epidemiology, 2023 Julian Matthewman,1 Kathryn E Mansfield,1 Joseph F Hayes,2 Elizabeth I Adesanya,1 Catherine H Smith,3 Amanda Roberts,1 Sinéad M Langan,1 Alasdair D Henderson1 1Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical ...
Matthewman J +7 more
doaj
Human digital Meissner's corpuscles are not doubly innervated
The Anatomical Record, EarlyView.Abstract Recent studies have shown that murine and avian Meissner‐like corpuscles are innervated by two distinct mechanoreceptor afferents with different functional properties. In addition, there is evidence that one subpopulation of Meissner corpuscles of monkeys is doubly innervated by mechanoreceptors and nociceptors.
Patricia Cuendias +8 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen +10 more
wiley +1 more source
UK biobank data distribution based on menopausal status.
, 2018 UK biobank data distribution based on menopausal status.
Kenneth R. Muir (146404) +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton +8 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Improvement in medication adherence is often proposed as a potential advantage of pharmacogenetic‐guided prescribing over a traditional one‐size‐fits‐all approach. This paper provides a review of the published literature and presents the findings of studies that measure adherence to medication as an outcome of pharmacogenetic‐informed care, or that ...
Lucy Galloway +2 more
wiley +1 more source
Biobanks, bioethics and concepts of donated blood in the UK [PDF]
Sociology of Health & Illness, 2006 AbstractIn recent years international bioethics bodies have made prominent declarations about the uses of donated tissue and related information in genetic research1. Following the ‘legislative’ mode of bioethics2, these organisations have put forward a number of general principles with a view to promoting the fair and equitable use of donated tissue ...
openaire +3 more sources
Clinical Anatomy, EarlyView.ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová +11 more
wiley +1 more source