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UK Biobank: from concept to reality
Pharmacogenomics, 2005The UK Biobank is a major UK collaborative research project to recruit and follow longitudinally the health of 500,000 volunteers aged between 40-69 years. It will provide important biological samples and environmental exposure data. As such, it will constitute a resource for many future investigations of the separate and combined effects of genetic ...
Tim Peakman
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Aspirin and Subarachnoid Haemorrhage in the UK Biobank
Translational Stroke Research, 2022Previous studies investigating the relationship between aspirin use and subarachnoid haemorrhage (SAH) have yielded conflicting results. In this study, we aimed to clarify the association between aspirin and SAH in the general population. The UK Biobank is a prospective population-based cohort study.
Ewbank, Frederick +5 more
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Analysis of genetic dominance in the UK Biobank
Science, 2023Classical statistical genetics theory defines dominance as any deviation from a purely additive, or dosage, effect of a genotype on a trait, which is known as the dominance deviation. Dominance is well documented in plant and animal breeding. Outside of rare monogenic traits, however, evidence in humans is limited.
Duncan S. Palmer +11 more
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Putting the Teeth into the UK Biobank
Primary Dental Care, 2011The author of this article has been involved in the development of the UK Biobank, and was instrumental in ensuring that dentistry has been included in the project. He describes what the UK Biobank is, what the project involves and aims to achieve, and how by July 2010 some 500,000 UK citizens aged from 40–69 years had been recruited.
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Understanding visual impairment in UK Biobank
Ophthalmic and Physiological Optics, 2014Dear Editor, In their recent article, Dawes et al. report prevalence estimates for visual impairment and dual sensory problems in middle age and associations between visual impairment and demographic factors, using data from UK Biobank. UK Biobank recruited half a million individuals with a subsample of 122 000 having an enhanced ophthalmic examination
Phillippa M, Cumberland +2 more
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Psychiatric Genetics In UK Biobank
European Neuropsychopharmacology, 2019Abstract The UK Biobank (UKB) is a unique resource for psychiatric genetics. This is a unique resource with very broad phenotyping across physical traits that is being expanded to include psychiatry (on >250K) with CIDI based mental health questionnaire and neuroimaging (on 100K). These are further complemented by ongoing medical record linkage.
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