Results 151 to 160 of about 8,179,520 (254)

Characteristics of the 240,477 UK Biobank participants included in analyses.

, 2018
Characteristics of the 240,477 UK Biobank participants included in analyses.
Luigi Ferrucci (150038), George A. Kuchel (4476775), Luke C. Pilling (705055), David Melzer (202058), Janice L. Atkins (4476778)   +4 more
core   +1 more source

RDW associations with incident conditions in 240,477 UK Biobank participants.

, 2018
RDW associations with incident conditions in 240,477 UK Biobank participants.
Luigi Ferrucci (150038), George A. Kuchel (4476775), Luke C. Pilling (705055), David Melzer (202058), Janice L. Atkins (4476778)   +4 more
core   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Comparing townsend deprivation index between UK Biobank participants and households in the 2001 UK Census.

, 2019
Comparing townsend deprivation index between UK Biobank participants and households in the 2001 UK Census.
Stephen F. Weng (3903466), Luis Vaz (6519641), Joe Kai (508035), Nadeem Qureshi (508036)   +3 more
core   +1 more source

Clinical Relevance of BACH1 Expression in Non–Small Cell Lung Cancer

International Journal of Cancer, EarlyView.
ABSTRACT BTB and CNC homolog 1 (BACH1) is a redox‐sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance in non–small cell lung cancer (NSCLC) remain unclear.
Jing Liu, Marc A. Schneider, Julia Held, Sabine Wrenger, Wenzhang Si, Michael Allgaeuer, Florian Eichhorn, Sabina Janciauskiene   +7 more
wiley   +1 more source

Discrepancies between general and central obesity in arterial stiffness: observational studies and Mendelian randomization study

BMC Medicine
Background Obesity has been linked to arterial stiffness, while no consensus was reached on the association. We aimed to clarify the association of general and central obesity with arterial stiffness by combining observational studies and Mendelian ...
Wuqing Huang, Zhaojing Gan, Ziting Gao, Qiaofen Lin, Xiaojiang Li, Wenhui Xie, Zesen Gao, Zhixian Zhou, Ziyi Qiu, Weihong Qiu, Shanshan Du, Liangwan Chen, Huashan Hong, Weimin Ye   +13 more
doaj   +1 more source

Gene Expression Biomarkers for Breast Ductal Carcinoma in Situ Recurrence Prediction

International Journal of Cancer, EarlyView.
ABSTRACT Breast ductal carcinoma in situ (DCIS) is often overtreated due to a lack of robust prognostic and predictive tools. This study aimed to evaluate gene expression in a well‐characterised DCIS cohort to determine their clinical utility as biomarkers for ipsilateral recurrence. RNA was extracted from microdissected tissues from primary DCIS.
Alexandria Un, Sakshi Mahale, David Byrne, Dorothea Lesche, Carlos Martinez‐Perez, Jia‐Min Pang, Maree Pechlivanis, Hugo Saunders, Madawa W. Jayawardana, Tongtong Luo, Sureshni I. Jayasinghe, Tanjina Kader, Lisa Devereux, Puay Hoon Tan, Andrew R. Green, Emad A. Rakha, Arran K. Turnbull, Stephen B. Fox, G. Bruce Mann, Kylie L. Gorringe   +19 more
wiley   +1 more source

Association between frailty and main work during the LIFE: A cross-sectional analysis of the UK Biobank

Experimental Gerontology
Background: The role of main work during the life course in predicting frailty, a typical geriatric syndrome, is still largely unknown. Therefore, with this research, we aimed to investigate the potential association between the main work done during the
Nicola Veronese, Laura Maniscalco, Domenica Matranga, Ligia J. Dominguez, Mario Barbagallo   +4 more
doaj   +1 more source

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source

UK Biobank: consequences for commons and innovation

, 2012
Biobanks as collections of population level genetic and health data will be central to the innovation of new drugs and drug targets. The UK Biobank, funded by massive public and charitable investment, was created to store and manage the genetic and ...
Papaioannou, Theo, Huzair, Farah
core   +1 more source