Results 61 to 70 of about 8,179,520 (254)
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
PLoS ONE, 2015 ObjectiveWe performed a systematic review of the accuracy of patient self-report of stroke to inform approaches to ascertaining and confirming stroke cases in large prospective studies.MethodsWe sought studies comparing patient self-report against a ...
Rebecca Woodfield +3 more
doaj +1 more source
Latent structure in UK Biobank (10-2018)
, 2018 This project includes geographical analysis of genetic data in UK Biobank in order to illustrate latent structure within the genetic data of UK Biobank.
Haworth, Simon +2 more
core +1 more source
Baseline characteristics of study participants in the UK Biobank.
, 2022 Baseline characteristics of study participants in the UK Biobank.
Katie Harris (7912034) +3 more
core +1 more source
Age and cognitive decline in the UK Biobank
PLOS ONE, 2019 Age-related cognitive decline is a well-known phenomenon after age 65 but little is known about earlier changes and prior studies are based on relatively small samples. We investigated the impact of age on cognitive decline in the largest population sample to date including young to old adults.Between 100,352 and 468,534 participants aged 38-73 years ...
Marilyn C. Cornelis +5 more
openaire +4 more sources
Sex differences in genetic architecture in the UK Biobank
Nature Genetics, 2021 Males and females present differences in complex traits and in the risk of a wide array of diseases. Genotype by sex (GxS) interactions are thought to account for some of these differences. However, the extent and basis of GxS are poorly understood. In the present study, we provide insights into both the scope and the mechanism of GxS across the genome
Elena Bernabeu +5 more
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Summary of female reproductive disorders in UK Biobank.
, 2022 Summary of female reproductive disorders in UK Biobank.
Teresa Ferreira (418982) +9 more
core +1 more source
Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria
Genetics in Medicine, 2021 Erythropoietic protoporphyria (EPP), characterized by painful cutaneous photosensitivity, results from pathogenic variants in ferrochelatase (FECH). For 96% of patients, EPP results from coinheriting a rare pathogenic variant in trans of a common hypomorphic variant c.315-48T>C (minor allele frequency 0.05). The estimated prevalence of EPP derived from
Amy K. Dickey +17 more
openaire +5 more sources