Results 51 to 60 of about 39,899,172 (210)

The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study. [PDF]

NPJ Sci Food
Evidence linking the dietary inflammatory index (DII) to health outcomes remains inconsistent and limited. This study assessed the associations between DII and 845 health outcomes (N = 78,390 to 207,832), identifying 133 outcomes significantly associated
Chen W, Liu K, Jing X, Qian Y, Liu B, Chen Y, Li J, Sun X, Mao Y, Ye D.   +9 more
europepmc   +2 more sources

Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes

Communications Biology, 2022
A phenome-wide association study and polygenic risk score analysis identifies several loci linked to metabolic disease and type 2 diabetes in the Taiwanese population.
Chia-Jung Lee, Ting-Huei Chen, Aylwin Ming Wee Lim, Chien-Ching Chang, Jia-Jyun Sie, Pei-Lung Chen, Su-Wei Chang, Shang-Jung Wu, Chia-Lin Hsu, Ai-Ru Hsieh, Wei-Shiung Yang, Cathy S. J. Fann   +11 more
doaj   +1 more source

Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study [PDF]

EBioMedicine
Daniel Rubin, Leon Lenchik, Robert D Boutin   +2 more
exaly   +2 more sources

An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

Genome Medicine, 2018
Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear.
Junfei Zhao, Feixiong Cheng, Peilin Jia, Nancy Cox, Joshua C. Denny, Zhongming Zhao   +5 more
doaj   +1 more source

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study

Frontiers in Immunology, 2021
BackgroundC-reactive protein (CRP) has been used as a biomarker of chronic low-grade inflammation in observational studies. We aimed to determine whether genetically determined CRP was associated with hundreds of human phenotypes to guide anti ...
Shucheng Si, Shucheng Si, Shucheng Si, Jiqing Li, Jiqing Li, Jiqing Li, Marlvin Anemey Tewara, Fuzhong Xue, Fuzhong Xue, Fuzhong Xue   +9 more
doaj   +1 more source

A Phenome-Wide Association Study of Drugs and Comorbidities Associated With Gastrointestinal Dysfunction in Systemic Sclerosis

The Journal of Rheumatology, 2023
ObjectiveTo explore the causes of and contributors to gastrointestinal (GI) dysfunction in systemic sclerosis (SSc) in a phenome-wide association study (PheWAS), using real-world clinical records data.MethodsTwelve thousand five hundred thirty-five documented clinical assessments of 2058 consenting individuals with SSc at the Royal Free Hospital (UK ...
Rory H. Maclean, Fiza Ahmed, Voon H. Ong, Charles D. Murray, Christopher P. Denton   +4 more
openaire   +3 more sources

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned [PDF]

, 2010
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)).
D I Boomsma, Maclean, A. W., Sullivan, P.F., Sullivan, P F, G Willemsen, de Geus, E.J.C., D J Statham, Willemsen, G.; id_orcid, Gordon, SD, Penninx, BWJH, Smit, J H, Medland, S E, Maclean, A.W., S E Medland, Penninx, B. W. J. H., van den Oord, E J C G, Montgomery, G W, Pergadia, M L, Byrne, E.M., Heath, A.C., Martin, N.G., MacIntyre, Donald; id_orcid, Hickie, I.B., Statham, D.J., C M Middeldorp, E M Byrne, B W J H Penninx, Nyholt, D.R., J J Hottenga, J H Smit, A K Henders, Blackwood, D.H., Liu, J. Z., N G Martin, A W Maclean, Lewis, C.M., Montgomery, G. W., McGuffin, P, S D Gordon, McEvoy, B.P., MacIntyre, D J, McGhee, K A, P A F Madden, MacIntyre, D J; id_orcid, Pergadia, M. L., van den Oord, E.J., McEvoy, B P, Gordon, S.D., Martin, N. G., D H R Blackwood, P F Sullivan, De Geus, E. J. C., Montgomery, G.W., Hottenga, J.J., Hickie, I. B., McGhee, K.A., Medland, S. E., C M Lewis, J Z Liu, Gordon, S D, Smit, J. H., Boomsma, D. I., Hottenga, J. J., Smit, J.H., Middeldorp, C.M., Ripke, S., M L Pergadia, Hickie, I B, de Geus, E.J., Wray, NR, Van Den Oord, E. J. C. G., Wray, N. R., Blackwood, DHR, de Geus, E J C, Penninx, B.W., B P McEvoy, McGhee, K. A., Middeldorp, C. M., Byrne, E. M., McEvoy, B. P., Macgregor, S, E J C G van den Oord, Statham, D J, Heath, A C, Lewis, C. M., van den Oord, E.J.C.G., I B Hickie, Willemsen, G., Pergadia, M.L., Medland, S.E., Sullivan, P. F., Penninx, B.W.J.H., Heath, A. C., Maclean, AW, Nyholt, D. R., N R Wray, S Macgregor, MacIntyre, DJ, Boomsma, D.I., G W Montgomery, Lewis, C M, Henders, A K, Madden, P. A. F., Madden, P.A.F., Henders, A.K., Hottenga, J J, McGuffin, P., Boomsma, D I, Madden, P.A., de Geus, E.J.C.; id_orcid, Oord, E.J.C.G. van den, Henders, A. K., Wray, N R, Madden, P A F, E J C de Geus, Pergadia, ML, D R Nyholt, Maclean, A W, Ripke, S, A C Heath, Ripke, Stephan, MacIntyre, D. J., Geus, E.J.C. de, Blackwood, D. H. R., Statham, D. J., Penninx, B W J H, Macgregor, S., Gordon, S. D., McGhee, KA, D J MacIntyre, Nyholt, D R, Wray, N.R., Middeldorp, C M, Liu, J Z, S Ripke, K A McGhee, P McGuffin, Nyholt, DR, Willemsen, G, Boomsma, D.I.; id_orcid, Lewis, C. M.; id_orcid, Martin, N G, Blackwood, D H R, Liu, J.Z., Byrne, E M, MacIntyre, D.J.   +145 more
core   +2 more sources

Application of clinical text data for phenome-wide association studies (PheWASs) [PDF]

Bioinformatics, 2015
Abstract Motivation: Genome-wide association studies (GWASs) are effective for describing genetic complexities of common diseases. Phenome-wide association studies (PheWASs) offer an alternative and complementary approach to GWAS using data embedded in the electronic health record (EHR) to define the phenome. International Classification
Scott J. Hebbring, Majid Rastegar-Mojarad, Zhan Ye, John Mayer, Crystal Jacobson, Simon M. Lin   +5 more
openaire   +3 more sources

Genome-wide association study of receptive language ability of 12 year olds [PDF]

, 2013
Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...
Hanscombe, K.B., Meaburn, Emma L, Dale, Philip S, Plomin, Robert, Hayiou-Thomas, Marianna E, Jankowski, Janusz, Haworth, Claire M.A., Trzaskowski, M., Haworth, C., Haworth, Claire M. A., Hayiou-Thomas, Marianna E., Wellcome Trust Case Control Consortium (including Jankowski J), Harlaar, N., Haworth, Claire M A, Dale, Philip S., Dale, P., Harlaar, Nicole, Price, T.S, Price, Thomas S, Docherty, Sophia, Hayiou-Thomas, M.E., Davis, Oliver S. P., Plomin, R., Meaburn, Emma L., Price, Tom S., HASH(0x55a67fe4f3e8), Hanscombe, Ken B., ?, ?, Davis, O.S.P., Docherty, S.J., Price, Thomas S., Trzaskowski, Maciej, Davis, Oliver S P   +32 more
core   +1 more source

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. [PDF]

, 2016
We performed a Phenome-Wide Association Study (PheWAS) to identify interrelationships between the immune system genetic architecture and a wide array of phenotypes from two de-identified electronic health record (EHR) biorepositories.
Gerhard, Glenn S., Yuki Bradford (496693), Marylyn D. Ritchie (201209), James E. Crowe Jr (151303), Verma, Anurag, James E Crowe, Anna O Basile, Marylyn D Ritchie, Bradford, Yuki, Pendergrass, Sarah A., Crowe, James E., Glenn S Gerhard, David Carey (2936301), Yuki Bradford, Carey, David, Glenn S. Gerhard (259020), Anurag Verma, Sarah A. Pendergrass (87900), Tromp, Gerard, Helena Kuivaniemi (496630), Basile, Anna O., Kuivaniemi, Helena, Ritchie, Marylyn D., Helena Kuivaniemi, Anna O. Basile (2936304), Gerard Tromp, Anurag Verma (669308), Sarah A Pendergrass, David Carey, Gerard Tromp (63007)   +29 more
core   +2 more sources