Results 61 to 70 of about 35,658 (190)

Phenome-wide association study of population-differentiating genetic variants around gene <i>ACSL1</i>. [PDF]

Evol Med Public Health
Abstract Background and objectives Demographic dynamics and natural selection during human evolution shaped the present-day patterns of genetic variations, and geographically varying genetic factors contribute to different disease prevalences across human populations.
Yang S, Cai H, Ye K.
europepmc   +3 more sources

HLA Class I or Class II and Disease Association: Catch the Difference if You Can [PDF]

, 2017
The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes
Fiorillo, Mt, Paladini, F, Sorrentino, R., Tedeschi, V   +3 more
core   +2 more sources

A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank [PDF]

, 2019
Background Mendelian randomisation allows for the testing of causal effects in situations where clinical trials are challenging to do. In this hypothesis-free, data-driven phenome-wide association study (PheWAS), we sought to assess possible ...
Biener, Bowden, Burgess, Burgess, Burgess, Bycroft, Chaker, Chiolero, Cronin, Davies, Denny, Dixon, Gkatzionis, Hartwig, Hemani, Kulkarni, Lau, Locke, Michailidou, Millard, Nyberg, Panoutsopoulou, Ruhl, Schoemaker, Sudlow, Sun, Todd, Tyrrell, Verbanck, Verma, Wills, Xu   +31 more
core   +1 more source

Efficient Replication of Over 180 Genetic Associations with Self-Reported Medical Data [PDF]

, 2011
While the cost and speed of generating genomic data have come down dramatically in recent years, the slow pace of collecting medical data for large cohorts continues to hamper genetic research. Here we evaluate a novel online framework for amassing large
Joyce Y. Tung, Chuong B. Do, David A. Hinds, Amy K. Kiefer, J. Michael Macpherson, Arnab B. Chowdry, Uta Francke, Brian T. Naughton, Joanna L. Mountain, Anne Wojcicki, Nicholas Eriksson   +10 more
core   +7 more sources

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration [PDF]

, 2015
Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls.
A Apt, A Götz, A Zumla, AJ Wolf, AJ Wolf, Ali Alisaac, B Howie, B Howie, BN Howie, Changxin Wu, Christian G Meyer, D Lin, DA Murphy, Delphine Cuchet-Lourenço, Emma Stebbings, ER Chimusa, F Zhang, FR Zhang, Francis Drobniewski, Helen L Zenner, Ingelore Baessmann, J Marchini, James Curtis, JB Maller, JD Ernst, Jeffrey C Barrett, Jimmy Z Liu, JM Korn, JP Ehlers, JS Szeszko, Kitty Lo, L Jostins, LB Barreiro, Liliya Kopanitsa, LL Roberts, M Möller, Mailis Maes, Olga Ignatyeva, PA Randazzo, Peter Nürnberg, PL Lin, Rolf D Horstmann, S Bharti, Sergey Nejentsev, T Müller, T Thye, T Thye, Thorsten Thye, Vincent Plagnol, Vladyslav Nikolayevskyy, Y Onodera, Yang Luo, Yanina Balabanova, Z Nie   +53 more
core   +3 more sources

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

MR-PheWAS:Hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization [PDF]

, 2015
Observational cohort studies can provide rich datasets with a diverse range of phenotypic variables. However, hypothesis-driven epidemiological analyses by definition only test particular hypotheses chosen by researchers.
Davey Smith, George, Davies, Neil M, Flach, Peter A, Millard, Louise A C, Tilling, Kate M, Timpson, Nicholas John   +5 more
core   +2 more sources

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

A comprehensive analysis of the health effects associated with smoking in the largest population using UK Biobank genotypic and phenotypic data

Heliyon
Background: Smoking is a widespread behavior, while the relationship between smoking and various diseases remains a topic of debate. Objective: We conducted analysis to further examine the identified associations and assess potential causal relationships.
Zixun Lin, Jiayi Xiong, Jiaqi Yang, Yuanfeng Huang, Jinchen Li, Guihu Zhao, Bin Li   +6 more
doaj   +1 more source