Results 81 to 90 of about 39,899,172 (210)

Supplemental material for Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus

, 2018
Supplemental Material for Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus by A. Barnado, R.J. Carroll, C. Casey, L. Wheless, J.C. Denny and L.J.
J.C. Denny (6012626), L.J. Crofford (6012629), R.J. Carroll (6012617), L. Wheless (6012623), A. Barnado (6012614), C. Casey (6012620)   +5 more
core   +1 more source

First genome-wide association study on anxiety-related behaviours in childhood [PDF]

, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B., Oliver S. P. Davis, Plomin, Robert, Maciej Trzaskowski (185577), Hanscombe, Ken B, Doherty, Sophia J, Thomas Price, Haworth, C., Haworth, Claire M. A., Ken B Hanscombe, Robert Plomin (27675), Davis, OS, Haworth, Claire M A, Thalia C Eley, Sophia J. Doherty, Eley, Thalia C, Price, T.S, Hanscombe, KB, Eley Thalia C., Doherty, Sophia J., Eley, Thalia C., Oliver S P Davis, Claire M. A. Haworth (185578), Price, T, Oliver S. P. Davis (185580), Robert Plomin, Doherty, SJ, Maciej Trzaskowski, Claire M A Haworth, Haworth, CM, Thalia C. Eley (397316), Price Thomas, Davis, O.S.P., Haworth Claire M. A., Trzaskowski, Maciej, Claire M. A. Haworth, Davis, Oliver S P, Price, Thomas, Meaburn, Emma L, Thomas Price (397319), Thalia C. Eley, Eley, T.C., Davis Oliver S. P., Trzaskowski, M., Hanscombe Ken B., Docherty, Sophia J., Meaburn Emma L., Meaburn, EL, Davis, Oliver S. P., Emma L. Meaburn, Ken B. Hanscombe (185575), Plomin, R., Sophia J. Doherty (397317), Meaburn, Emma L., Price, Tom S., Plomin Robert, Sophia J Doherty, Doherty, S.J., Trzaskowski, M, Hanscombe, Ken B., Ken B. Hanscombe, Plomin, R, Emma L. Meaburn (397318), Eley, TC, Trzaskowski Maciej, Emma L Meaburn, Doherty Sophia J.   +66 more
core   +1 more source

Phylogenomic analysis of ultraconserved elements clarifies relationships and morphological evolution in Cryptoplacoidea (Mollusca: Polyplacophora)

Cladistics, EarlyView.
Abstract Targeted enrichment of ultraconserved elements (UCEs) is a powerful tool for resolving phylogeny in groups with limited morphological or molecular data. Here, we use UCEs to reconstruct the first comprehensive phylogeny of the chiton superfamily Cryptoplacoidea, including museum material up to 133 years old.
Katarzyna Vončina, Zeyuan Chen, Enrico Schwabe, Anna K. Hundsdoerfer, Julia D. Sigwart   +4 more
wiley   +1 more source

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy A Phenome-Wide Association Study

, 2018
This phenome-wide association study assesses clinical associations between interleukin 6 receptor ( IL6R ) single-nucleotide polyporphisms and known IL6R drug effects and whether large biobanks and genetics can be used to assess potential beneficial and ...
Huang, Jie, Sun, Jiehuan, Honerlaw, Jacqueline, Damrauer, Scott, Cai, Tianrun A, O’Donnell, Christopher J, Ho, Yuk-Lam, Hong, Chuan, Gagnon, David, Tsao, Philip, Link, Nicholas, Cho, Kelly, Schubert, Petra, Zhang, Yichi, Cai, Tianxi, Ahuja, Yuri, Sun, Yan V, Costa, Lauren, Wilson, Peter, Gaziano, J. Michael, Liao, Katherine P   +20 more
core   +1 more source

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
Palmer, C. N. A.; id_orcid, H.M. Colhoun, C.N.A. Palmer, Colhoun, H. M., L.A. Donnelly, Liu, Y., Zhou, K., Palmer, C. N A, van Zuydam, N. R., Smith, B. H.; id_orcid, H.A. Deshmukh, N.R. van Zuydam, K. Zhou, A.D. Morris, Donnelly, L. A., Deshmukh, H. A., Morris, A. D., Meng, W., Smith, B. H., Y. Liu, B.H. Smith, W. Meng   +21 more
core   +1 more source

Genome‐wide association study and polygenic risk scores of eosinophilia in Taiwan

Clinical & Translational Immunology
Objectives Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examining polygenic risk scores (PRS ...
Hsing‐Fang Lu, Su Boon‐Yong, Chi‐Ya Yang, Jiu‐Yao Wang, Yen‐Ting Chang, Fuu‐Jen Tsai   +5 more
doaj   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR [PDF]

npj Genomic Medicine, 2019
AbstractWe conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genesPCSK9,APOB, andLDLR. Using high-density genotype data, we tested the associations of variants in the three genes with 1232 EHR-derived binary phecodes in 51,700 European ...
Maya S. Safarova, Benjamin A. Satterfield, Xiao Fan, Erin E. Austin, Zhan Ye, Lisa Bastarache, Neil Zheng, Marylyn D. Ritchie, Kenneth M. Borthwick, Marc S. Williams, Eric B. Larson, Aaron Scrol, Gail P. Jarvik, David R. Crosslin, Kathleen Leppig, Laura J. Rasmussen-Torvik, Sarah A. Pendergrass, Amy C. Sturm, Bahram Namjou, Amy Sanghavi Shah, Robert J. Carroll, Wendy K. Chung, Wei-Qi Wei, QiPing Feng, C. Michael Stein, Dan M. Roden, Teri A. Manolio, Daniel J. Schaid, Joshua C. Denny, Scott J. Hebbring, Mariza de Andrade, Iftikhar J. Kullo   +31 more
openaire   +2 more sources

Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans [PDF]

, 2023
Background: The variation in the rate at which humans age may be rooted in early events acting through the genomic regions that are influenced by such events and subsequently are related to health phenotypes in later life.
Y Zeng (7803473), MJ Adams (14212811), C Hayward (7641530), C Amador (21952982), A Campbell (7713596), CS Haley (21282596), Y Liu (4702669), DJ Porteous (7713812), KL Evans (11048373), M Li (3216264), X Bai (7490021), C Gao (81541), RM Walker (15900053), RA Madden (21952985), X Shen (7801967), P Navarro (21826118), AM McIntosh (14449110)   +16 more
core   +1 more source

Phenome-wide profiling identifies genotype-phenotype associations in Phelan-McDermid syndrome using family-sourced data from an international registry

Molecular Autism
Background Phelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused by 22q13 deletions that include the SHANK3 gene or pathogenic sequence variants in SHANK3.
Rui Yin, Maxime Wack, Claire Hassen-Khodja, Michael T. McDuffie, Geraldine Bliss, Elizabeth J. Horn, Cartik Kothari, Brittany McLarney, Rebecca Davis, Kristen Hanson, Megan O’Boyle, Catalina Betancur, Paul Avillach   +12 more
doaj   +1 more source