Results 91 to 100 of about 39,899,172 (210)
Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]
, 2009 OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid +53 morecore +1 more sourcePhenome-wide association of APOE alleles in the All of Us Research ProgramResearch in context
EBioMedicineSummary: Background: Apolipoprotein E (APOE) variation is associated with altered lipid metabolism, as well as cardiovascular and neurodegenerative disease.Ehsan Khajouei, Valentina Ghisays, Ignazio S. Piras, Kiana L. Martinez, Anthony T. Vicenti, Marcus Naymik, Preston Ngo, Tam C. Tran, Joshua C. Denny, Travis J. Wheeler, Matthew J. Huentelman, Eric M. Reiman, Jason H. Karnes +12 moredoaj +1 more sourceGenome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 [PDF]
, 2011 Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that ...Juliane Winkelmann, Sona Nevsimalova, Dauvilliers, Yves, Bachmann, Cornelius G., Wichmann, H. -Erich, Knauf F, Wichmann HE, Gschliesser V, Kettunen Johannes, Fontaine, B., Vávrová J, Müller-Myhsok, B., Montplaisir Jacques, Ondo, William, G., Czamara, D., Le Wei-Dong, Bertram Müller-Myhsok, Schulte, E.C., Birgit Högl, Fietze Ingo, Stiasny-Kolster, Karin, Kettunen, Johannes, Kaffe M, Müller Myhsok B, Vodicka, P., H.-Erich Wichmann, Vilariño-Güell, Carles, Wichmann, H.-E., Gschliesser, V., Perola Markus, Xiong, L., Illig Thomas, Silander, K., Fontenille C, Berger K, Bertram Müller-Myhsok, Berger, K., Cournu Rebeix I, Kaffe, Maria, Sonka K, Faraco J, Mueller-Myhsok, Bertram, Maria Kaffe, Sonka, K., Müller-Myhsok Bertram, Earley CJ, Cournu-Rebeix Isabelle, Kemlink David, Stiasny Kolster K, Vilariño-Güell Carles, Poewe Werner, Kaffe Maria, Ondo William G., Lichtner, P., Zimprich A, Fietze, I., Fontaine Bertrand, Bachmann, C.G., Farrer, Matthew J., Olli Polo, Allen, R. P., Vavrova, J., Hoegl, Birgit, Cournu-Rebeix, I., Oertel Wolfgang, Högl Birgit, Kettunen J, Zimprich, A., Meitinger, T., Fontaine, Bertrand, Högl, B., Richard P. Allen, Faraco, J., William G. Ondo, Lin Siong-Chi, Oertel, Wolfgang, Allen, Richard P., Meitinger T., Fuhs, Andrea, Cornelius G. Bachmann, Wichmann, H-Erich, Wszolek Zbigniew, Perola M, Polo, Olli, Meitinger Thomas, Darina Czamara, Xiong L, Siong-Chi Lin, Allen, R., Knauf, F., Le, Wei-Dong, Gross Nadine, Bachmann, C., Gieger, C., Berger, Klaus, Cournu-Rebeix, Isabelle, Matthew J Farrer, Paulus Walter, Peppard P, Stiasny-Kolster, K., Winkelmann, Juliane, Fietze I, Francavilla Marcella, Schulte, Eva C., Carles Vilariño-Güell, Walter Paulus, Christopher J Earley, Dauvilliers Y, Gieger C, Werner Poewe, Gieger Christian, Frauscher Birgit, Bachmann CG, Wolfgang Oertel, Ondo, W.G., Schulte EC, Bachmann, C. G., Guy A Rouleau, Falkenstetter Tina, Klaus Berger, Trenkwalder C, Earley, Christopher J., Fontenille, Claire, Faraco, Juliette, Prokisch, Holger, Lin, S. C., Juliette Faraco, Paulus, Walter J., Farrer Matthew J., Bertrand Fontaine, Schulte, E., Paulus, W., Ondo, W., Montplaisir, Jacques, Paul Peppard, Trenkwalder Claudia, Illig T, Dauvilliers, Y., Schulte Eva C., Wichmann, H., Thomas Illig, Silander, Kaisa, Winkelmann, J., Paulus W, Johannes Kettunen, Spieler D, Jacques Montplaisir, Peppard Paul, Frauscher B, Earley, C., Zimprich, Alexander, Alexander Zimprich, Falkenstetter, T., Le WD, Fontenille Claire, Rouleau, G.A., Czamara, Darina, Schormair, Barbara, Vodicka P, Spieler, Derek, Karel Sonka, William G Ondo, Paulus, Walter, Peppard, P., Wichmann, H. E., Le, W. D., Guy A. Rouleau, Frauscher, B., Montplaisir, J., Trenkwalder, Claudia, Marcella Francavilla, Le, W.D., Vilarino-Guell, C., Lin, S., Vilariño Güell C, Poewe, W., Le, W., Prokisch Holger, Fuhs, A., Högl B, Lichtner Peter, Wszolek, Z., Sonka Karel, Wei-Dong Le, Illig, T., Earley, Christopher, J., Schulte, E. C., Fontaine B, Vodicka Pavel, Mignot Emmanuel, Kaffe, M., Faraco Juliette, Barbara Schormair, Christopher J. Earley, Francavilla, M., Kaisa Silander, Xiong, Lan, Schormair B, Ingo Fietze, Prokisch, H., Gschliesser, Viola, Viola Gschliesser, Yves Dauvilliers, Mignot, Emmanuel, Emmanuel Mignot, Kemlink, D., Peter Lichtner, Polo O, Lichtner, Peter, Rouleau, Guy, A., Allen Richard P., Czamara D, Schulte, Eva, C., Karin Stiasny-Kolster, Knauf, Franziska, H-Erich Wichmann, Mignot, E., Lin, Siong-Chi, Zbigniew Wszolek, Perola, Markus, Müller-Myhsok, Bertram, Tina Falkenstetter, Rouleau, Guy A., Gieger, Christian, Ondo, W. G., Fietze, Ingo, Nevsimalova Sona, Lan Xiong, David Kemlink, Derek Spieler, Carles Vilariño-Güell, Zimprich Alexander, Allen RP, Earley, C. J., Eva C Schulte, Nevsimalova, Sona, Earley, C.J., Farrer, Matthew, J., Czamara Darina, Lin, S.C., Richard P Allen, Allen, R.P., Wichmann, Heinz-Erich, Montplaisir J, Gross, N., Poewe W, Allen, Richard, P., Vávrová Jana, Prokisch H, Christian Gieger, Francavilla, Marcella, Vavrova, Jana, Franziska Knauf, Matthew J. Farrer, Dauvilliers Yves, Rouleau Guy A., Farrer, M. J., Ondo WG, Gross, Nadine, Rouleau GA, Wszolek Z, Schormair Barbara, Falkenstetter T, Eva C. Schulte, Kemlink, David, Ondo, William G., Bachmann, Cornelius, G., Sonka, Karel, Kemlink D, Nevsimalova, S., Andrea Fuhs, Cornelius G Bachmann, Trenkwalder, C., Oertel, W., Farrer MJ, Falkenstetter, Tina, Poewe, Werner, Högl, Birgit, Bachmann Cornelius G., Wichmann H.-Erich, Schormair, B., Claudia Trenkwalder, Xiong Lan, Polo, O., Oertel W, Markus Perola, Farrer, M., Perola, M., Silander Kaisa, Polo Olli, Stiasny-Kolster Karin, Isabelle Cournu-Rebeix, Winkelmann J, Mignot E, Gschliesser Viola, Fontenille, C., Frauscher, Birgit, Nadine Gross, Berger Klaus, Illig, Thomas, Jana Vávrová, Meitinger, Thomas, Rouleau, G. A., Fuhs A, Winkelmann Juliane, Rouleau, G., Fuhs Andrea, Farrer, M.J., Earley Christopher J., Peppard, Paul, Birgit Högl, Vodicka, Pavel, Thomas Meitinger, Gross N, Birgit Frauscher, Spieler Derek, Lichtner P, Lin SC, Kettunen, J., Vilarino-Gueell, Carles, Pavel Vodicka, Spieler, D., Silander K, Wszolek, Zbigniew, Nevsimalova S, Claire Fontenille, Holger Prokisch, Knauf Franziska, Jana Vávrová, Rouleau, Guy,, Bachmann, Cornelius,, Schulte, Eva,, Earley, Christopher,, Farrer, Matthew,, Ondo, William,, Allen, Richard,, Winkelmann, J;Czamara, D;Schormair, B;Knauf, F;Schulte, EC;Trenkwalder, C;Dauvilliers, Y;Polo, O;Högl, B;Berger, K;Fuhs, A;Gross, N;Stiasny-Kolster, K;Oertel, W;Bachmann, CG;Paulus, W;Xiong, L;Montplaisir, J;Rouleau, GA;Fietze, I;Vávrová, J;Kemlink, D;Sonka, K;Nevsimalova, S;Lin, SC;Wszolek, Z;Vilarino-Guell, C;Farrer, MJ;Gschliesser, V;Frauscher, B;Falkenstetter, T;Poewe, W;Allen, RP;Earley, CJ;Ondo, WG;Le, WD;Spieler, D;Kaffe, M;Zimprich, A;Kettunen, J;Perola, M;Silander, K;Cournu-Rebeix, I;Francavilla, M;Fontenille, C;Fontaine, B;Vodicka, P;Prokisch, H;Lichtner, P;Peppard, P;Faraco, J;Mignot, E;Gieger, C;Illig, T;Wichmann, HE;Müller-Myhsok, B;Meitinger, T +336 morecore +2 more sourcesRecent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk
Journal of Internal Medicine, EarlyView.Abstract
Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede +5 morewiley +1 more sourceGenome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke [PDF]
, 2012 Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of ...Furie, K., Seedorf, Udo, Cathie L M Sudlow, Spencer, C.C.A., Woo, D., Müller-Myhsok, B., Jackson, C. A., Sawcer, SJ, Markus, Hugh S, Lindgren, Arne,, Segal, H, Viswanathan, Ananth C., Syme, P. D., Valerie Valant, Rautanen, A, Matthew Traylor, Gray, E, Sarah Edkins, Attia, J., Palmer, C., Rothwell, Peter M., Juan P Casas, Levi, Chris, Worrall, Bradford B, Levi, C., Jankowski, J., Peltonen, L, Palmer, Colin N. A., Sawcer, S., Edkins, Sarah, Delavaran, Hossein,, Kissela, Brett, Pankaj Sharma, WTCCC2, Sharma, P, Goel, A, Gray, E., Joanna Pera, Palmer, CN, Boonen, S., Worrall, BB, Dorota Wloch-Kopec, Cordelia Langford, Helgadottir, A, Steve Bevan, Su, Zhan, Rothwell, Peter M, Sudlow, Cathie LM, Wellcome Trust Case Control Consortium 2 (WTCCC2) (), Bradford B Worrall, Viswanathan, A.C., Hossein Delavaran, Valant, V., Nalls, Michael A., Stefansson, K, Donnelly, P, Palmer, Colin NA, Worrall, B., Wloch-Kopec, D., Martin Farrall, Elvira Bramon, Lindgren, Arne, Valant, V, Kittner, Steven J., Corvin, A., Syme, PD, Meisinger, Christa, Schanz, R., Delavaran, H, Goel, Anuj, Audrey Duncanson, Unnur Thorsteinsdottir, Syme, P.D., Bramon, E, Stephen J Sawcer, Pirinen, Matti, Burgess, A., Kissela, B., Cheng, Y., Helen Segal, Cheng, YC, Meschia, JF, Edkins, S., Levi, C, Parati, E. A., Rainer Malik, Meschia, J., Trembath, R., Cortellini, L., Burgess, AI, Trembath, RC, ?, ?, Langford, C, Boncoraglio, G. B., Bevan, S, Poole, D, International Store Genetics Consortium, Burgess, A.I., Spencer, Chris CA, Spencer, Chris, Nalls, M.A., Bellenguez, C., Matthew Walters, Traylor, M, Boncoraglio, G.B., Attia, John, Freeman, Colin, Jackson, Caroline; id_orcid, Lemmens, Robin, Spencer, Chris C. A., Sudlow, Cathie L M, Ross-Adams, H., Thijs, V, Gray, Emma, Hugh S Markus, Dichgans, M, Nicholas W Wood, Wellcome Trust Case Control Consortium 2 (WTCCC2), Brown, MA, Norrving, Bo,, Wood, N.W., Brown, M., Burgess, Annette I, International Stroke Genetics Consortium (Meisinger, C.), Emma Gray, Mitchell, BD, Colin Freeman, Giorgio B Boncoraglio, Norrving, B., Franzosi, MG, James, T., Slark, Julia, Mitchell, B., Murphy, Lee, Wood, N. W., Goel, A., Julia Slark, Seedorf, U, Boonen, S, Udo Seedorf, Boonen, Steven, Sharma, Pankaj, Deborah Poole, Rothwell, PM, Casas, J., Su, Z., Edkins, S, Cheng, Yu-Ching, Colin N A Palmer, Franzosi, M., Lund University., Lee Murphy, Elizabeth Holliday, Wood, Nicholas W, Rothwell, P., Viswanathan, Ananth C, Norrving, Bo, Anuj Goel, Tom James, Casas, J. P., Gretarsdottir, S., Sarah Hunt, Sudlow, C.L.M., Gschwendtner, A., Bevan, Steve, Deloukas, P., Müller-Myhsok, Bertram, Janusz Jankowski, Yu-Ching Cheng, Macleod, M.J., Dronov, S, Slowik, A, Walters, Matthew, Meschia, James F, Pera, J, Plomin, R, Spencer, CCA, Casas, JP, Brown, Matthew A, Mathew, Christopher G., Peltonen L, Holliday, E., Slowik, A., Bramon, Elvira, Plomin, Robert, Cheng, Y. C., Band, G., Thorsteinsdottir, U, Helen Ross-Adams, Sudlow, C., Strange, A, Band, Gavin, Markus, H.S., Wellcome Trust Control Consortium, Rautanen, A., Nalls, Michael A, Worrall, B. B., Blackwell, J. M., Casas, Juan P., Deloukas, Panos, Macleod, MJ, Thijs, Vincent, Spencer, C., Ananth C Viswanathan, Traylor, M., Duncanson, A., Poole, Deborah, Bramon, E., Wloch-Kopec, D, Spencer, CC, Holliday, E, Macleod, Mary Joan, Band, G, Palmer, CNA, Bevan, S., Viswanathan, AC, Poole, D., Schanz, R, Macleod, M., Palmer, C. N. A., Meisinger, C., Furie, Karen, Viswanathan, A., Woo, Daniel, Delavaran, H., Dronov, S., International Stroke Genetics Consortium (ISGC), Anna Helgadottir, Kissela, B, Corvin, Aiden, Sudlow, CL, Casas, J.P., Annette I Burgess, Markus, H. S., Helgadottir, Anna, Panos Deloukas, Jackson, C., Jackson, Caroline A., Mitchell, Braxton D., Walters, M., Bertram Müller-Myhsok, Franzosi, M-G, Bo, N, Donnelly, P., Burgess, A. I., Andreas Gschwendtner, Deloukas, P, Rosand, Jonathan, Gavin Band, Langford, C., Vincent Thijs, Sawcer, Stephen J, Cortellini, L, Delavaran, Hossein, Solveig Gretarsdottir, Peltonen, L., Burgess, Annette I., Wood, N., Lemmens, R, Mueller-Myhsok, Bertram, Parati, E.A., Franzosi, M. G., Farrall, M, Segal, H., Corvin, A, Kittner, Steven J, Mathew, Christopher G.; id_orcid, Sudlow, Catherine; id_orcid, Valant, Valerie, Hunt, S., Leena Peltonen, Palmer, C.N.A., Franzosi, Maria-Grazia, Mary Joan Macleod, Segal, Helen, Wood, Nicholas W., Arne Lindgren, Hunt, S, Bellenguez, Céline, Daniel Woo, Kari Stefansson, Rothwell, P.M., Furie, K, Matti Pirinen, Murphy, L, Céline Bellenguez, Dichgans, M., Boncoraglio, Giorgio B, Peter M Rothwell, Blackwell, Jenefer M., Christopher G Mathew, Duncanson, A, Jonathan Rosand, Trembath, Richard C, Sudlow, CLM, Chris C A Spencer, Pera, Joanna, Nalls, M. A., Meisinger, C, Rosand, J., James F Meschia, Palmer, Colin N A, Gudmar Thorleifsson, Wloch-Kopec, Dorota, Robin Lemmens, Agnieszka Slowik, Markus, H., Lemmens, R., Slark, J., Kittner, S. J., Boncoraglio, Giorgio B., Viswanathan, A. C., Cortellini, Lynelle, Peltonen, Leena, Sawcer, Stephen J., Seedorf, U., Parati, E., Peter Donnelly, Serge Dronov, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Strange, Amy, Lindgren, A, Caroline A Jackson, Freeman, C., Thorsteinsdottir, Unnur, Brown, M. A., Jenefer M Blackwell, Bo, N., Wood, NW, Langford, Cordelia, Ross-Adams, Helen, Parati, Eugenio A, Hunt, Sarah, Stefansson, K., Blackwell, Jenefer M, Boncoraglio, G., Markus, HS, Rosand, J, Jackson, Caroline A, Norrving, B, Dronov, Serge, Anna Rautanen, Farrall, M., Jackson, CA, Sudlow, C. L. M., Thorleifsson, G, Malik, R, Slowik, Agnieszka, Lindgren, A., Amy Strange, Mathew, C., Renata Schanz, James, Tom, Ross-Adams, H, Matthew A Brown, Farrall, Martin, Syme, Paul D, Schanz, Renata, Mathew, CG, Helgadottir, A., Donnelly, Peter, Brett Kissela, Stefansson, Kari, Pirinen, M., Sharma, P., Mathew, Christopher G, Martin Dichgans, Nalls, M., Zhan Su, Parati, EA, Attia, J, Gretarsdottir, Solveig, Trembath, Richard C., Kittner, S., Pirinen, M, Nalls, MA, Cheng, Y-C, Müller-Myhsok, B, Strange, A., Blackwell, JM, Slark, J, Sudlow, Cathie L. M., Thorsteinsdottir, U., Kittner, S.J., Mathew, C. G., Su, Z, Plomin, R., Kittner, SJ, Spencer, Chris C A, Jackson, C.A., Worrall, B.B., Casas, Juan P, Gschwendtner, Andreas, Dichgans, Martin, Blackwell, J., Thorleifsson, G., Michael A Nalls, Gschwendtner, A, Macleod, M. J., Aiden Corvin, Eugenio A Parati, Murphy, L., Rautanen, Anna, Thorleifsson, Gudmar, Jankowski, Janusz, Freeman, C, Syme, P., Sawcer, S.J., Meschia, J. F., Steven J Kittner, John Attia, Brown, Matthew A., Rothwell, P. M., Syme, Paul D., ISGC, Parati, Eugenio A., Markus HS, Robert Plomin, James, T, Walters, M, Mitchell, B. D., Bo Norrving, Trembath, R. C., Meschia, J.F., Pera, J., Duncanson, Audrey, Mitchell, B.D., Woo, D, Spencer, C. C. A., Markus, Hugh S., Jankowski, J, Blackwell, J.M., Chris Levi, Thijs, V., Gretarsdottir, S, Christa Meisinger, Richard C Trembath, Holliday, Elizabeth, Steven Boonen, Mathew, C.G., Murphy, Lee; id_orcid, Bellenguez, C, Meschia, James F., Malik, Rainer, Braxton D Mitchell, Sawcer, S. J., Traylor, Matthew, Karen Furie, Trembath, R.C., Lynelle Cortellini, Maria-Grazia Franzosi, Paul D Syme, Palmer, Colin N. A.; id_orcid +455 morecore +2 more sourcesCell‐based crop phenotyping for future climates
New Phytologist, EarlyView.Flow‐chart diagram illustrating the proposed pathway for improving the throughput of fluorescence imaging‐based phenotyping by using robotics and machine learning (ML) approaches. Summary
Abiotic stress tolerance has been significantly weakened in modern crops during the domestication process.Sergey Shabala, Ping Yun, Zhong‐Hua Chen, Meixue Zhou, Min Yu, Nadia Bazihizina +5 morewiley +1 more sourceHigh‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum
New Phytologist, EarlyView.Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung‐Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi, Aram Hwangbo, Hun Kim, Gyung Ja Choi, Yin‐Won Lee, Dae‐Geun Song, Hokyoung Son +15 morewiley +1 more sourceGenome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]
, 2015 Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A +9 morecore
