Results 101 to 110 of about 98,679 (202)

Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative [PDF]

, 2017
Health systems are stewards of patient electronic health record (EHR) data with extraordinarily rich depth and breadth, reflecting thousands of diagnoses and exposures.
Gonçalo R. Abecasis, Bhramar Mukherjee, Stephen B. Gruber, Lars G. Fritsche, Chad M. Brummett, Matthew Zawistowski, Stephanie E. Moser, Zhenke Wu, Sachin Kheterpal, Ellen M. Schmidt, Victoria M. Blanc   +10 more
core   +1 more source

Genome–phenome association prediction using weighted deep matrix factorization with a multisource graph attention network

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Genome–phenome association (GPA) prediction can broaden the understanding of biological mechanisms underlying complex phenotypic traits (e.g., diseases and agronomic traits). Traditional deep matrix factorization (DMF)‐based GPA methods can integrate multiple data types and uncover nonlinear associations but often rely on low‐dimensional ...
Ran Duan, Wei Cao, Maozu Guo, Le Tian, Lingling Zhao   +4 more
wiley   +1 more source

Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. [PDF]

Int J Mol Sci
Latent autoimmune diabetes in adults (LADA) is characterized by the presence of glutamate decarboxylase autoantibodies (GADA). LADA has intermediate features between type 1 diabetes and type 2 diabetes. In addition, genetic risk factors for both types of
Nolasco-Rosales GA, Martínez-Magaña JJ, Juárez-Rojop IE, Rodríguez-Sánchez E, Ruiz-Ramos D, Villatoro-Velázquez JA, Bustos-Gamiño M, Medina-Mora ME, Tovilla-Zárate CA, Cruz-Castillo JD, Nicolini H, Genis-Mendoza AD.   +11 more
europepmc   +2 more sources

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source

Body Mass Index and Risks of More Than 40 Cause‐Specific Mortality in Chinese Women: A Prospective Cohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The health consequences of being underweight are less well‐studied than obesity. We aimed to examine the association between body mass index (BMI) and mortality from a wide range of diseases across the full BMI spectrum, with particular focus on how low BMI may affect premature and nonpremature death.
Jingcen Hu, Yalei Ke, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Xiaoyu Chang, Maxim Barnard, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, China Kadoorie Biobank Collaborative Group   +15 more
wiley   +1 more source

Symptom Flares in Endometriosis: Burden, Self‐Management and Barriers to Care in a Cross‐Sectional Survey

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 9, Page 1731-1741, August 2026.
ABSTRACT Objective To explore the characteristics of symptom flares, individual experiences and behaviours during flares in people with endometriosis. Design Online questionnaire shared on patient support sites. Setting People with a confirmed or working diagnosis of endometriosis (a working diagnosis is given by clinicians based on symptoms/history ...
Lydia Coxon, Emma Evans, Francine Toye, Emma Cox, Katy Vincent   +4 more
wiley   +1 more source

Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis

Eye and Vision
Objective To investigate the relationship between leukocyte telomere length (LTL), a biomarker of cellular aging, and both the incidence and severity of age-related cataract (ARC) across cohorts from the UK and China. Methods The multicenter, multiethnic
Xianqi Zheng, Ting Su, Chenxiao Shen, Guanrong Wu, Zijing Du, Xingchen Geng, Yuling Xu, Ningni Jiang, Qinyi Li, Jiahui Cao, Ying Fang, Yijun Hu, Mingguang He, Zhuoting Zhu, Xiayin Zhang, Honghua Yu   +15 more
doaj   +1 more source

Multiancestry and Multitrait GWAS Meta‐Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
This study integrated GWAS data for schizophrenia from European (PGC, FinnGen, iPSYCH) and East Asian cohorts with GWAS of chronic pulmonary diseases (COPD, asthma, ILD, pneumonia) and lung function traits, alongside transcriptomic and proteomic datasets (GEO, GTEx, CommonMind, pQTL).
Abudusalamu Ayoufu, Ayinigeer Abulimiti, Wusimanjiang Aierken, ZhouBin Wei, XueCheng Wang, HaiFeng Wang, Liang Zhao   +6 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals the Tumor‐Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer

BioFactors, Volume 52, Issue 4, July/August 2026.
This study identifies SEMA5B as a tumor suppressor in prostate cancer that suppresses the malignant phenotype, affects mitochondrial oxidative metabolism, induces cell cycle arrest and apoptosis, and is associated with the immune‐inflammatory tumor microenvironment, highlighting its potential as a biomarker and target for immunotherapy. ABSTRACT SEMA5B
Zhiguo Fan, Yihaoyun Lou, Xuan Zhou, Guang Liu, Xiaomin Zhang, Yuanjie Tang, Zhen Zhu, Shancheng Ren, Yifan Chang   +8 more
wiley   +1 more source

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

eLife, 2019
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p<5×10−05)
Tom G Richardson, Sean Harrison, Gibran Hemani, George Davey Smith   +3 more
doaj   +1 more source