Results 101 to 110 of about 35,658 (190)

Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis

Eye and Vision
Objective To investigate the relationship between leukocyte telomere length (LTL), a biomarker of cellular aging, and both the incidence and severity of age-related cataract (ARC) across cohorts from the UK and China. Methods The multicenter, multiethnic
Xianqi Zheng, Ting Su, Chenxiao Shen, Guanrong Wu, Zijing Du, Xingchen Geng, Yuling Xu, Ningni Jiang, Qinyi Li, Jiahui Cao, Ying Fang, Yijun Hu, Mingguang He, Zhuoting Zhu, Xiayin Zhang, Honghua Yu   +15 more
doaj   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Phenome-wide association studies between SERINC2 and neuropsychiatric disorders

Frontiers in Psychiatry
ObjectivesSERINC2 has been associated with alcoholism, bipolar disorder and autism, but the comparability and specificity issues of the findings remain unaddressed. The present study aimed to comprehensively analyze various neuropsychiatric disorders pinpoint the most reliable conditions predisposed by SERINC2.MethodsA total of 2,187 imputed SNPs ...
Ping Liu, Xinqun Luo, Liping Cao, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Xinghua Pan, Ruilan Yang, Zewen Tan, Yunlong Tan, Chiang-shan Li, Xiaoyun Guo, Zhiren Wang, Xingguang Luo, Xingguang Luo   +15 more
openaire   +2 more sources

A MaERF110‐MaMYB308 Transcriptional Module Negatively Regulates Lignin‐Mediated Defence Against Fusarium Wilt in Banana

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2811-2825, May 2026.
ABSTRACT Fusarium wilt of banana (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc), threatens global banana production. Lignin reinforces cell walls against pathogens and lodging, yet its regulatory mechanisms in banana remain elusive. Through genome‐wide association study (GWAS) of lignin content across 184 banana accessions, we identified ...
Yuqi Li, Yulin Hu, Weijun Xiao, Liu Yan, Junting Feng, Miaomiao Cao, Yanlin Si, Jinhan Lyu, Yankun Zhao, Kai Li, Yongzan Wei, Huigang Hu, Wei Li, Peitao Lü, Wei Wang, Zhenhai Han, Jianghui Xie   +16 more
wiley   +1 more source

A Super‐Pangenome for Cultivated Citrus Reveals Evolutive Features During the Allopatric Phase of Their Reticulate Evolution

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3345-3367, May 2026.
Structure of the cultivated citrus super‐pangenome. ABSTRACT The main genetic diversity observed in cultivated citrus results from a reticulate evolution involving four ancestral taxa whose radiation occurred in allopatry. In such context, GWAS analysis, genome diversity and transcriptomic studies will be significantly enhanced through pangenome ...
Gaetan Droc, Delphine Giraud, Caroline Belser, Karine Labadie, Simone Duprat, Corinne Cruaud, Benjamin Istace, Fredson Dos Santos Menezes, Edson Mario de Andrade Silva, Franck Curk, Gilles Costantino, Alexandre Soriano, Pierre Mournet, Alexis Dereeper, Maëva Miranda, Elodie Marchi, Sylvain Santoni, Raner José Santana Silva, Stéphanie Sidibe‐Bocs, François Luro, Nathalie Choisne, Florian Maumus, Barbara Hufnagel, Fabienne Micheli, Patrick Wincker, Jean‐Marc Aury, Arnaud Lemainque, Patrick Ollitrault   +27 more
wiley   +1 more source

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

eLife, 2019
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p<5×10−05)
Tom G Richardson, Sean Harrison, Gibran Hemani, George Davey Smith   +3 more
doaj   +1 more source

Plant–Plant Competition Limits Arabidopsis Shoot Branching and Silique Production Independently of Soil Mineral Nutrients, Strigolactones and BRANCHED1

Plant, Cell &Environment, Volume 49, Issue 5, Page 2413-2429, May 2026.
ABSTRACT In natural environments, plants compete with neighbouring plants for resources such as light, water and nutrients. To detect neighbours, plants have evolved mechanisms that are poorly understood at the molecular‐genetic level. This study examined the impact of competition on the growth and reproductive success of Arabidopsis thaliana grown in ...
Jessica Thome, Laura Trimborn, Helena Waldmann, Caroline Reize, Lea Weiler‐Tersch, Christian Schenkel, Hannah Weeks, Franziska Fichtner, Anja Linstädter, Juliette de Meaux, Ute Hoecker   +10 more
wiley   +1 more source

Fungal Pathogen Activity and Stress‐Dependent Responses of Grapevine Wood to Esca and Drought

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Biotic and abiotic stresses alter the physiology of perennial plants, with consequences for fungal endophytes and disease expression. In grapevine, drought inhibits esca disease expression, but the underlying molecular interactions between the plant and fungi are unknown. We combined wood metatranscriptomics, metabolomics, and metabarcoding to
Marie Chambard, Dario Cantù, Giovanni Bortolami, Ninon Dell'Acqua, Nathalie Ferrer, Gregory A. Gambetta, Jadran F. Garcia, Pierre Gastou, Mélanie Massonnet, Samuele Moretti, Adam Rochepeau, Pierre Pétriacq, Marie Foulongne‐Oriol, Chloé E. L. Delmas   +13 more
wiley   +1 more source

Phenome‐wide association studies: a new method for functional genomics in humans [PDF]

The Journal of Physiology, 2017
AbstractIn experimental physiological research, a common study design for examining the functional role of a gene or a genetic variant is to introduce that genetic variant into a model organism (such as yeast or mouse) and then to search for phenotypic consequences.
openaire   +2 more sources

A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders

Canadian Journal of Gastroenterology and Hepatology
Conclusions: Our study revealed genetic association between PBC and hypothyroidism through a phenome-wide Mendelian randomization, and then, colocalization identified two potential drug targets for hypothyroidism.
Shuyi Shi, Minghui Liu, Haonan Gao, Fang Liu, Yuhu Song   +4 more
doaj   +1 more source