Results 101 to 110 of about 39,899,172 (210)

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris, Kumari, Meena, Hardy, R, Berry, Diane J, Cooper, Jackie, Ulf de Faire, Angelakopoulou, A, Jutta Palmen, de Faire, Ulf, Tzoulaki, I, Fowkes, F. Gerry R., Marmot, Michael, Samani, Nilesh, Price, Jackie; id_orcid, Andrew Wong, Wong, A, Munroe, Patricia B, Kumari, M, Shah, T, Jefferis, BJ, Deanfield, John, Simpson, Iain A., Simpson, Iain A, Shah, S, Juan P. Casas, Thomson, Andy, Jefferis, Barbara J., Samani, N, Whittaker, John C, Bruna Gigante, Philippa J. Talmud, Lathrop, Mark, Munroe, Patricia B., John C. Whittaker, Drenos, F, Motterle, Anna, John Deanfield, F. Gerry R. Fowkes, Helen Ireland, Shu Ye, Price, J, Whincup, PH, Steve E. Humphries, Verzilli, C, Kivimaki, Mika, Power, C, Leander, Karin, Sofat, R, Jackie Price, Hypponen, Elina, Caulfield, Mark, Humphries, Steve E, Tina Shah, Anna Motterle, Kuh, Diana, Jefferis, Barbara J, Gigante, B, Maniatis, Nikolas, Whincup, Peter H, Casas, Juan P, Palmen, J, Diana Kuh, Shah, Sonia, Liam Smeeth, Gigante, Bruna, Ireland, Helen, Price, Jackie, Thomson, A, Elina Hypponen, Verzilli, Claudio, Nikolas Maniatis, Smeeth, Liam, Casas, JP, Angelakopoulou, Aspasia, Marmot, M, Ross C. Laxton, Munroe, PB, Barbara J. Jefferis, Cooper, J, Wallace, C, Simpson, IA, Caulfield, M, Talmud, PJ, Andy Thomson, Laxton, Ross C., Drenos, Fotios, Morris, Richard W, Iain A. Simpson, Chris Wallace, Mika Kivimaki, Lathrop, M, Humphries, SE, Motterle, A, Hingorani, AD, de Faire, U, Whittaker, JC, Meena Kumari, Jackie Cooper, Laxton, Ross C, Ioanna Tzoulaki, Claudio Verzilli, Ye, S, Wallace, Chris, Sonia Shah, Hardy, Rebecca, Shah, Tina, Aspasia Angelakopoulou, Berry, DJ, Hingorani, Aroon D, Laxton, RC, Nilesh Samani, Hypponen, E, Fowkes, F Gerry R, Morris, RW, Diane J. Berry, Rebecca Hardy, Maniatis, N, Mark Lathrop, Fowkes, FG, Reecha Sofat, Tzoulaki, Ioanna, Chris Power, Michael Marmot, Leander, K, Power, Chris, Smeeth, L, Mark Caulfield, Ye, Shu, Sofat, Reecha, Ireland, H, Fotios Drenos, Talmud, Philippa J, Kuh, D, Deanfield, J, Kivimaki, M, Wong, Andrew, Peter H. Whincup, Patricia B. Munroe, Berry, Diane J., Karin Leander, Palmen, Jutta, Aroon D. Hingorani, Hingorani, A.D., Angelakopoulou, A., Hypponen, E., Sofat, R., Shah, S., Shah, T.   +147 more
core   +1 more source

Comparative Genome‐Wide Association Studies of Metabolites and Grain‐Related Traits in Common Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT The metabolome is highly diverse and the closest layer to phenotype; therefore, it is commonly regarded as a bridge between the genome and phenome in plants. Here, we performed large‐scale metabolome analysis using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and 33 grain‐related traits in a diverse panel of natural accessions and
Guoguo Lv, Yanyan Liu, Bingyang Zhang, Ranran Shen, Maosong Yu, Yongyang Wu, Wanting Du, Xinru Yuan, Congwei Sun, Yan Yan, Wei Chen, Feng Chen   +11 more
wiley   +1 more source

Impacts of leukocyte telomere length on incidence and severity of age-related cataract: a cross-cohort analysis

Eye and Vision
Objective To investigate the relationship between leukocyte telomere length (LTL), a biomarker of cellular aging, and both the incidence and severity of age-related cataract (ARC) across cohorts from the UK and China. Methods The multicenter, multiethnic
Xianqi Zheng, Ting Su, Chenxiao Shen, Guanrong Wu, Zijing Du, Xingchen Geng, Yuling Xu, Ningni Jiang, Qinyi Li, Jiahui Cao, Ying Fang, Yijun Hu, Mingguang He, Zhuoting Zhu, Xiayin Zhang, Honghua Yu   +15 more
doaj   +1 more source

Root trait dynamics of historical canola varieties under low and high nitrogen supply

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley   +1 more source

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

eLife, 2019
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p<5×10−05)
Tom G Richardson, Sean Harrison, Gibran Hemani, George Davey Smith   +3 more
doaj   +1 more source

Affordable Phenomics special topic—Foreword for The Plant Phenome Journal

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract The Affordable Phenomics special topic in The Plant Phenome Journal showcased recent advances that expand the accessibility, cost‐effectiveness, and scalability of plant phenotyping technologies. This collection of 15 articles presented innovative approaches, ranging from low‐cost sensors and open‐source analytical pipelines to artificial ...
Valerio Hoyos‐Villegas, Michael A. Gore   +1 more
wiley   +1 more source

Philosophy of phenomic prediction and its incompatibility with causal inference

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Breeding programs need to make decisions frequently to improve populations and develop varieties efficiently. These needs led to the development of genomic prediction in the early 2000s and phenomic prediction in the mid‐2010s. In practice, phenomic prediction techniques rely on the same statistical tools and computational frameworks as other ...
Mitchell J. Feldmann, Fangyi Wang, Daniel E. Runcie   +2 more
wiley   +1 more source

High Endothelial Venules in Small Cell Lung Cancer: Prognostic Subtypes and Therapeutic Implications for Immunoradiotherapy

International Journal of Cancer, Volume 159, Issue 9, Page 2314-2327, 1 November 2026.
ABSTRACT Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with an immunosuppressive tumor microenvironment, and current immunotherapy provides limited benefit. This highlights the need to identify microenvironmental features enabling effective immune responses.
Jiatian Fang, Zilian Wang, Hui Wang, Jianxin Xue, Kai Kang   +4 more
wiley   +1 more source

A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders

Canadian Journal of Gastroenterology and Hepatology
Conclusions: Our study revealed genetic association between PBC and hypothyroidism through a phenome-wide Mendelian randomization, and then, colocalization identified two potential drug targets for hypothyroidism.
Shuyi Shi, Minghui Liu, Haonan Gao, Fang Liu, Yuhu Song   +4 more
doaj   +1 more source

Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis

Frontiers in Immunology
BackgroundAnkylosing Spondylitis (AS) is a chronic inflammatory disorder which can lead to considerable pain and disability. Mendelian randomization (MR) has been extensively applied for repurposing licensed drugs and uncovering new therapeutic targets ...
Wenlong Zhao, Wenlong Zhao, Peng Fang, Chengteng Lai, Xiaoyu Xu, Yang Wang, Hao Liu, Hui Jiang, Xiaozhou Liu, Jun Liu   +9 more
doaj   +1 more source