Results 121 to 130 of about 41,823,825 (180)

Spatial Transcriptomic and Proteomic Analysis Identifies Novel Immune‐Associated Biomarkers of Anti‐PD1 Response in Metastatic Melanoma

Scandinavian Journal of Immunology, Volume 104, Issue 4, October 2026.
Integrated anti‐PD1 transcriptomic datasets identified poor survival predictor biomarkers associated with therapy resistance in metastatic melanoma. Spatial transcriptomic and proteomic profiling revealed FAM57A, GSTA4, and KCTD1 as immune‐associated biomarkers linked to altered immune transcriptomic signatures, increased PI3K‐AKT‐mTORC1/MAPK proteomic
S. A. Koskela, R. E. Kallionpää, I. Mäkelä, E.‐M. Birkman, M. Sundvall, C. R. Figueiredo   +5 more
wiley   +1 more source

NLP6/7‐mediated nitrate signaling facilitates high‐affinity potassium uptake and enhances tolerance to low potassium environments in Arabidopsis

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Balancing the acquisition of the macronutrients nitrogen (N) and potassium (K) is critical for plant growth, yet the mechanisms that balance N and K acquisition remain poorly understood. Here, we show that the NIN‐LIKE PROTEIN7 (NLP7) transcription factor, which mediates nitrate signaling, plays a crucial role in promoting K acquisition in ...
Kosuke Usuda, Mailun Yang, Namie Ohtsuki, Nana Sugimura, Daiki Teshima, Yasuhito Sakuraba, Shuichi Yanagisawa   +6 more
wiley   +1 more source

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

Advancing clinical precision medicine via peripheral blood immune single‐cell omics

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Liyang Li, Jialu Hu, Wanxin Duan, Yan‐Ming Xu, Jiaqiang Zhang, Xiangdong Wang   +5 more
wiley   +1 more source

Additional file 1 of Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization

Additional file 1: Table S1. Phenome-wide association estimates per standard deviation unit increase in standardized plasma caffeine level genetic risk score. Table S2.
Loukas Zagkos (14309460), Stephen Burgess (3368630), Christos S. Mantzoros (8357052), Héléne T. Cronjé (14564843), Roxane de La Harpe (17630759), Paul Elliott (27295), Ioanna Tzoulaki (257920), Benjamin Woolf (3994577), Susanna C. Larsson (6105620), Shuai Yuan (305841), Dipender Gill (13716483)   +10 more
core   +1 more source

N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis

N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three Lac-AA: N-Lactoyl phenylalanine
Alshafai, Mashael, Razzaq, Aleem, Elrayess, Mohamed A., Naja, Khaled, Elashi, Asma A, Diboun, Ilhame, Albagha, Omar, Anwardeen, Najeha, Elrayess, Mohamed A, Elashi, Asma A.   +9 more
core   +1 more source

A phenome-wide association study of rurality in the <i>All of Us</i> Research Program. [PDF]

JAMIA Open
Awan AH, Chaillet KS, Williams-Rogers CY, Channa Y, Shittu DA, Waxse BJ, Schlueter DJ, Ferrara TM, Denny JC, Mo H.   +9 more
europepmc   +1 more source

A phenome-wide association study of CNVs genotyped from genome sequencing read depth in the UK Biobank. [PDF]

Am J Hum Genet
Garg P, Jadhav B, Shadrina M, Martin-Trujillo A, Sharp AJ.   +4 more
europepmc   +1 more source

Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response. [PDF]

Front Genet
Namjou B, Lape M, Weirauch MT, Kaufman KM, Kottyan LC.   +4 more
europepmc   +1 more source

The potential effect and pathway of valsartan: genome-wide and phenome-wide association study from UK Biobank data. [PDF]

Pharmacogenet Genomics
Zeng S, Li Y, Zhang Y, Lu Y, Ruan L, Zhang C, Zhang J, Chen B, Li T.   +8 more
europepmc   +1 more source