Results 121 to 130 of about 39,899,172 (210)

Fairfax County-Wide Black Citizens Association (BCA)

, 1970
By-laws of the Fairfax County-Wide Black Citizens ...
Fairfax County-Wide Black Citizens Association
core   +1 more source

The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases

Genetic Epidemiology, Volume 50, Issue 6, September 2026.
ABSTRACT Mendelian randomization (MR) is a human genetics method for inferring causal relationships between risk factors and diseases. A common focus of MR studies has been on the causal inference of a single risk factor on a single disease. This has led to the successful discovery of numerous causal risk factors for disease.
Carla Márquez‐Luna, Martin Tournaire, Ghislain Rocheleau, Ron Do, Marie Verbanck   +4 more
wiley   +1 more source

Mendelianization: Concentrating Polygenic Signal Into a Single Causal Locus

Genetic Epidemiology, Volume 50, Issue 6, September 2026.
ABSTRACT Complex disorders such as depression and alcohol use involve numerous genetic variants, and implicated loci continue to grow with sample size. This proliferation hampers interpretability, as the mechanisms by which so many variants jointly contribute to pathophysiology remain unclear.
Eric V. Strobl
wiley   +1 more source

Clonotypic characterization defines B‐cell drivers of clonal expansion and intratumor heterogeneity in IgM monoclonal gammopathies

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) share the same cell of origin but differ in clonal size. Compared with other B‐cell neoplasms, the lymphoplasmacytic clone in WM can be rather small, limiting our understanding of clonal expansion.
David F. Moreno, Ferran Nadeu, Marta Casado‐Peláez, Caterina Mata, Ian Márquez‐López, Marco A. Fernández, Sergi Vaqué, Elena Medina, Helena Llobregat, Marta Garrote, Joan Mañé, Oriol Cardús, Luis Gerardo Rodríguez‐Lobato, Anna de Daniel, María Teresa Cibeira, Theo Gremen Oliveira, Elizaveta Kulaeva, Ester Lozano, Dolors Colomer, Laura Rosiñol, Ruben van Boxtel, Manel Esteller, Carlos Fernández de Larrea   +22 more
wiley   +1 more source

Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records

Ophthalmology Science
Purpose: To examine whether genetic predisposition to age at the onset of myopia is associated with the development of future diseases. Design: Mendelian randomization phenome-wide association study (MR-PheWAS) from the UK Biobank.
Xiayin Zhang, PhD, Shan Wang, MD, Yu Huang, PhD, Yanjie Xie, PhD, Ishith Seth, MD, Gabriella Bulloch, MD, Chunran Lai, MD, Yijun Hu, PhD, Xianwen Shang, PhD, Mingguang He, PhD, Zhuoting Zhu, PhD, Honghua Yu, PhD   +11 more
doaj   +1 more source

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer

The Journal of Pathology, Volume 270, Issue 1, Page 55-68, September 2026.
Abstract Recently, we suggested the combination of chemotherapy and P2RX4 inhibition as a promising novel therapeutic approach for P2RX4‐expressing epithelial tumors to prevent paracrine resistance. Here, we aimed to assess whether determining P2RX4 expression status in colorectal and pancreatic cancer patients would allow stratification of potentially
Christoph Steup, Julian Dosch, Christopher Dietz‐Fricke, Sara Khosraviseftejani, Esther Engel, Adalbert F de Valk, Dominic Menger, Patrick Welker, Peter J Wild, Kilian B Kennel, Maja Kantlehner, Paul K Ziegler, Florian R Greten   +12 more
wiley   +1 more source

Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases

Immunological Medicine
Disorders associated with the immune system burden multiple organs, although the shared biology exists across the diseases. Preceding family-based studies reveal that immune diseases are heritable to varying degrees, providing the basis for ...
Yuji Yamamoto, Yuya Shirai, Ryuya Edahiro, Atsushi Kumanogoh, Yukinori Okada   +4 more
doaj   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, Volume 270, Issue 1, Page 83-97, September 2026.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

SAIGE-GPU: accelerating genome- and phenome-wide association studies using GPUs

Bioinformatics
Abstract Motivation Genome-wide association studies (GWAS) at biobank scale are computationally intensive, especially for admixed populations requiring robust statistical models. SAIGE is a widely used method for generalized linear mixed-model GWAS but is limited by its CPU-based implementation,
Alex Rodriguez, Youngdae Kim, Tarak Nath Nandi, Karl Keat, Rachit Kumar, Mitchell Conery, Rohan Bhukar, Molei Liu, John Hessington, Ketan Maheshwari, Sumitra Muralidhar, Jennifer Moser, Jennifer E Deen, Philip S Tsao, Sumitra Muralidhar, J Michael Gaziano, Elizabeth Hauser, Amy Kilbourne, Michael Matheny, Dave Oslin, J Michael Gaziano, Jessica V Brewer, Mary T Brophy, Kelly Cho, Lori Churby, Scott L DuVall, Saiju Pyarajan, Luis E Selva, Shahpoor (Alex) Shayan, Stacey B Whitbourne, J Michael Gaziano, Brady Stephens, Todd Connor, Themistocles L Assimes, Adriana Hung, Henry Kranzler, Samuel Aguayo, Sunil Ahuja, Kathrina Alexander, Xiao M Androulakis, Prakash Balasubramanian, Zuhair Ballas, Elizabeth S Bast, Jean Beckham, Sujata Bhushan, Edward Boyko, David Cohen, Louis Dellitalia, Gerald Wayne Dryden, L Christine Faulk, Joseph Fayad, Daryl Fujii, Saib Gappy, Frank Gesek, Michael Godschalk, Jennifer Greco, Todd W Gress, Samir Gupta, Salvador Gutierrez, Mark Hamner, John Harley, Daniel J Hogan, Adriana Hung, Robin Hurley, Pran Iruvanti, Frank Jacono, Darshana Jhala, Seema Joshi, Scott Kinlay, Michael Landry, Peter Liang, Suthat Liangpunsakul, Jack Lichy, Tze Shien Lo, C Scott Mahan, Ronnie Marrache, Stephen Mastorides, Kristin Mattocks, Paul Meyer, Jonathan Moorman, Providencia Morales, Timothy Morgan, Maureen Murdoch, Eknath Naik, James Norton, Olaoluwa Okusaga, Michael K Ong, Kris Ann Oursler, Ismene Petrakis, Samuel Poon, Amneet S Rai, Michael Rauchman, Richard Servatius, Satish Sharma, River Smith, Peruvemba Sriram, Patrick Strollo, Neeraj Tandon, Philip Tsao, Gerardo Villareal, Jessica Walsh, John Wells, Jeffrey Whittle, Mary Whooley, Peter Wilson, Junzhe Xu, Shing Shing Yeh, Andrew W Yen, Edmon Begoli, Georgia Tourassi, Sumitra Muralidhar, Pradeep Natarajan, Benjamin F Voight, Kelly Cho, John Michael Gaziano, Scott M Damrauer, Katherine P Liao, Wei Zhou, Jennifer E Huffman, Anurag Verma, Ravi K Madduri   +120 more
openaire   +2 more sources

Genome–phenome association prediction using weighted deep matrix factorization with a multisource graph attention network

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Genome–phenome association (GPA) prediction can broaden the understanding of biological mechanisms underlying complex phenotypic traits (e.g., diseases and agronomic traits). Traditional deep matrix factorization (DMF)‐based GPA methods can integrate multiple data types and uncover nonlinear associations but often rely on low‐dimensional ...
Ran Duan, Wei Cao, Maozu Guo, Le Tian, Lingling Zhao   +4 more
wiley   +1 more source