Results 121 to 130 of about 35,658 (190)

The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank

Human Genomics
Background Disease comorbidities and longer-term complications, arising from biologically related associations across phenotypes, can lead to increased risk of severe health outcomes.
Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim   +3 more
doaj   +1 more source

Clinical and genetic associations for night eating syndrome in a patient biobank

Journal of Eating Disorders
Objective Night eating syndrome (NES) is an eating disorder characterized by evening hyperphagia. Despite having a prevalence comparable to some other eating disorders, NES remains sparsely investigated and poorly characterized.
Hannah Wilcox, Richa Saxena, John W. Winkelman, Hassan S. Dashti   +3 more
doaj   +1 more source

Risk of Cardiovascular Disease Mortality in Patients With Diagnosed Cancer and Associated Genetic and Proteomic Mechanisms: A UK Biobank‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have identified a link between cancer and cardiovascular disease; however, the underlying genetic and proteomic mechanisms remain unclear. Therefore, this study aimed to investigate the association between cancer diagnosis and
Yuan Du, Sen Han, Jiaxi Cheng, Zhangyu Lin, Yanjun Song, Shanshan Shi, Zixiang Ye, Yingyi Xie, Wenbo Ding, Yuanlin Guo, Shuang Wang, Kefei Dou   +11 more
doaj   +1 more source

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

Frontiers in Immunology
BackgroundRecurrent spontaneous abortion (RSA) significantly impacts women’s health, yet the underlying biological mechanisms remain poorly defined.
Weixu Ma, Weixu Ma, Zhongjia Gu, Qiwang Lin, Mingzhu Cao, Junmin Zhong, Xin Li, Hongyan Li, Yue Lin, Han Lin, Mengchang Xu, Jianqiao Liu, Lili Du, Ge Song   +13 more
doaj   +1 more source

Health Implications Associated with Fat-Free Mass: A Phenome-Wide Mendelian Randomization Study

Cardiorenal Medicine
Introduction: Fat-free mass (FFM) is a critical component of the human body, with implications for various diseases. Methods: We conducted a comprehensive analysis integrating a phenome-wide association study (PheWAS), a two-sample Mendelian randomization (MR) analysis, and a systematic review to investigate the associations between FFM and health ...
Yuchen Ying, Chunxia Zhang, Shanshan Wu, Shudan Wang, Jiangfang Lian, Yupin Lin, Haiwang Guan, Dihui Cai   +7 more
openaire   +3 more sources

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

Unveiling therapeutic targets for spinal stenosis from genetic insights: a Mendelian randomization analysis

Scientific Reports
Spinal stenosis is a commonly chronic spinal degenerative disease, which is a major cause of pain and dysfunction in the elderly. Mendelian randomization (MR) has been widely applied to repurpose licensed drugs and identify novel therapeutic targets ...
Zhaopeng Fan, Bohong Chen, Le Ding, Hua Guo   +3 more
doaj   +1 more source

Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era. [PDF]

Acta Pharmacol Sin, 2023
Cao Q, Du X, Jiang XY, Tian Y, Gao CH, Liu ZY, Xu T, Tao XX, Lei M, Wang XQ, Ye LL, Duan DD.   +11 more
europepmc   +1 more source

Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response. [PDF]

Front Genet
Namjou B, Lape M, Weirauch MT, Kaufman KM, Kottyan LC.   +4 more
europepmc   +1 more source

Comorbidities, biomarkers and cause specific mortality in patients with irritable bowel syndrome: A phenome-wide association study. [PDF]

United European Gastroenterol J, 2023
Seeling KS, Hehl L, Vell MS, Rendel MD, Creasy KT, Trautwein C, Mehler DMA, Keszthelyi D, Schneider KM, Schneider CV.   +9 more
europepmc   +1 more source