Results 131 to 140 of about 39,899,172 (210)

The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank

Human Genomics
Background Disease comorbidities and longer-term complications, arising from biologically related associations across phenotypes, can lead to increased risk of severe health outcomes.
Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim   +3 more
doaj   +1 more source

PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses

Frontiers in Pharmacology
IntroductionBasal cell carcinoma (BCC) is the most common skin cancer, lacking reliable biomarkers or therapeutic targets for effective treatment. Genome-wide association studies (GWAS) can aid in identifying drug targets, repurposing existing drugs ...
Qiu-Ju Han, Yi-Pan Zhu, Jing Sun, Xin-Yu Ding, Xiuyu Wang, Qiang-Zhe Zhang   +5 more
doaj   +1 more source

A Guide for Exploring Pleiotropic Associations in Genome‐Wide Association Studies Using Summary Statistics

Statistics in Medicine, Volume 45, Issue 20-22, September 2026.
ABSTRACT Genome‐wide association studies (GWAS) have shown that pleiotropy, whereby a single genetic variant or gene influences multiple traits, is common in complex human diseases. Detecting cross‐phenotype associations from GWAS summary statistics remains challenging because of small effect sizes, extensive multiple testing, heterogeneous effects ...
Christina Y. Feng, Pierre‐Emmanuel Sugier, Nan Zou, Benoit Liquet   +3 more
wiley   +1 more source

Clinical and genetic associations for night eating syndrome in a patient biobank

Journal of Eating Disorders
Objective Night eating syndrome (NES) is an eating disorder characterized by evening hyperphagia. Despite having a prevalence comparable to some other eating disorders, NES remains sparsely investigated and poorly characterized.
Hannah Wilcox, Richa Saxena, John W. Winkelman, Hassan S. Dashti   +3 more
doaj   +1 more source

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source

Neuropathy in Val122Ile Hereditary Transthyretin (ATTR) Amyloidosis: A Multicenter Retrospective Cohort Study

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims The Val122Ile ATTR Amyloidosis has traditionally been linked to cardiac manifestations. Recent studies suggest that neuropathy may be relevant. In this study, we characterized its peripheral nerve manifestations in depth. Methods This was a national, multicenter, observational, retrospective study.
Anna Paula Paranhos, Marcela Câmara Machado Costa, Carolina Lavigne Moreira, Diogo Fernandes dos Santos, Marcondes Cavalcante França, Renan Flavio de França Nunes, Osvaldo José Moreira do Nascimento, Jemima Araujo da Silva Batista, Eduardo Boiteux Uchôa Cavalcanti, Cleonisio Leite Rodrigues, Ândrea Virgínia Ferreira Chaves, Marcelo Soares Kerstenetzky, Lara Albuquerque de Brito, Carlo Domênico Marrone, Marcus Vinicius Magno Gonçalves, Pedro José Tomaselli, Wilson Marques   +16 more
wiley   +1 more source

Risk of Cardiovascular Disease Mortality in Patients With Diagnosed Cancer and Associated Genetic and Proteomic Mechanisms: A UK Biobank‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have identified a link between cancer and cardiovascular disease; however, the underlying genetic and proteomic mechanisms remain unclear. Therefore, this study aimed to investigate the association between cancer diagnosis and
Yuan Du, Sen Han, Jiaxi Cheng, Zhangyu Lin, Yanjun Song, Shanshan Shi, Zixiang Ye, Yingyi Xie, Wenbo Ding, Yuanlin Guo, Shuang Wang, Kefei Dou   +11 more
doaj   +1 more source

Unveiling the Immune Mechanisms of Hypertension With Single‐Cell Transcriptome‐Wide Mendelian Randomization

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
This study integrates expression quantitative trait loci data across 14 immune cell subsets with Mendelian randomization and colocalization to uncover 17 eGenes causally associated with hypertension in a cell type‐specific manner, prioritizes three eGenes (DDX5, VIM, and CTSW) with cell type‐specific differential expression levels between hypertensive ...
Yukang Mao, Peng Li, Chen Cheng, Xiangqing Kong, Wei Sun, Tingting Wu   +5 more
wiley   +1 more source

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

Frontiers in Immunology
BackgroundRecurrent spontaneous abortion (RSA) significantly impacts women’s health, yet the underlying biological mechanisms remain poorly defined.
Weixu Ma, Weixu Ma, Zhongjia Gu, Qiwang Lin, Mingzhu Cao, Junmin Zhong, Xin Li, Hongyan Li, Yue Lin, Han Lin, Mengchang Xu, Jianqiao Liu, Lili Du, Ge Song   +13 more
doaj   +1 more source

N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis

N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three Lac-AA: N-Lactoyl phenylalanine
Alshafai, Mashael, Razzaq, Aleem, Elrayess, Mohamed A., Naja, Khaled, Elashi, Asma A, Diboun, Ilhame, Albagha, Omar, Anwardeen, Najeha, Elrayess, Mohamed A, Elashi, Asma A.   +9 more
core   +1 more source