Results 131 to 140 of about 98,679 (202)

Genome-wide association study of anterior uveitis [PDF]

Background/aims: The purpose of this study is to define genetic factors associated with anterior uveitis through genome-wide association study (GWAS).
Leinonen, Sanna, Elnahas, Abdelrahman, Saviauk, Krista-Roberta, Estonian Biobank Research Team Consortium, FinnGen Consortium, Ahokas, Oona, Kajanne, Risto, Karjalainen, Minna K, Esko, Tõnu, Palta, Priit, Liinamaa, Johanna, Saarela, Ville, Koskimäki, Fredrika, Kettunen, Johannes, Reis, Kadri, Reigo, Anu   +15 more
core   +1 more source

The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank

Human Genomics
Background Disease comorbidities and longer-term complications, arising from biologically related associations across phenotypes, can lead to increased risk of severe health outcomes.
Vivek Sriram, Jakob Woerner, Yong-Yeol Ahn, Dokyoon Kim   +3 more
doaj   +1 more source

Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT study. [PDF]

Disease networks offer a potential road map of connections between diseases. Several studies have created disease networks where diseases are connected either based on shared genes or Single Nucleotide Polymorphism (SNP) associations.
Martina Hall, Marit K Skinderhaug, Hall, Martina, Skinderhaug, Marit K., Almaas, Eivind, Eivind Almaas   +5 more
core   +1 more source

Clinical and genetic associations for night eating syndrome in a patient biobank

Journal of Eating Disorders
Objective Night eating syndrome (NES) is an eating disorder characterized by evening hyperphagia. Despite having a prevalence comparable to some other eating disorders, NES remains sparsely investigated and poorly characterized.
Hannah Wilcox, Richa Saxena, John W. Winkelman, Hassan S. Dashti   +3 more
doaj   +1 more source

Risk of Cardiovascular Disease Mortality in Patients With Diagnosed Cancer and Associated Genetic and Proteomic Mechanisms: A UK Biobank‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies have identified a link between cancer and cardiovascular disease; however, the underlying genetic and proteomic mechanisms remain unclear. Therefore, this study aimed to investigate the association between cancer diagnosis and
Yuan Du, Sen Han, Jiaxi Cheng, Zhangyu Lin, Yanjun Song, Shanshan Shi, Zixiang Ye, Yingyi Xie, Wenbo Ding, Yuanlin Guo, Shuang Wang, Kefei Dou   +11 more
doaj   +1 more source

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

Frontiers in Immunology
BackgroundRecurrent spontaneous abortion (RSA) significantly impacts women’s health, yet the underlying biological mechanisms remain poorly defined.
Weixu Ma, Weixu Ma, Zhongjia Gu, Qiwang Lin, Mingzhu Cao, Junmin Zhong, Xin Li, Hongyan Li, Yue Lin, Han Lin, Mengchang Xu, Jianqiao Liu, Lili Du, Ge Song   +13 more
doaj   +1 more source

A genome-wide association between foveal thickness and arrhythmia

Communications Medicine
Background The fovea is one of the most crucial parts of the visual system and has a special structure. We aimed to identify susceptibility single nucleotide polymorphisms (SNPs) for foveal thickness in a large Japanese cohort.
Shin-ya Nakao, Masahiro Miyake, Kohta Fujiwara, Eri Nakano, Yuki Mori, Kazuya Morino, Yoshikatsu Hosoda, Nagahama Study Group, Yasuharu Tabara, Masato Akiyama, Kenji Yamashiro, Hiroshi Tamura, Jun Hata, Toshiharu Ninomiya, Fumihiko Matsuda, Koh-Hei Sonoda, Akitaka Tsujikawa   +16 more
doaj   +1 more source

Phenome-wide association studies go large [PDF]

Nature Reviews Genetics, 2013
openaire   +1 more source

A phenome-wide association study of CNVs genotyped from genome sequencing read depth in the UK Biobank. [PDF]

Am J Hum Genet
Garg P, Jadhav B, Shadrina M, Martin-Trujillo A, Sharp AJ.   +4 more
europepmc   +1 more source

Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response. [PDF]

Front Genet
Namjou B, Lape M, Weirauch MT, Kaufman KM, Kottyan LC.   +4 more
europepmc   +1 more source