Results 111 to 120 of about 35,658 (190)

Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis

Frontiers in Immunology
BackgroundAnkylosing Spondylitis (AS) is a chronic inflammatory disorder which can lead to considerable pain and disability. Mendelian randomization (MR) has been extensively applied for repurposing licensed drugs and uncovering new therapeutic targets ...
Wenlong Zhao, Wenlong Zhao, Peng Fang, Chengteng Lai, Xiaoyu Xu, Yang Wang, Hao Liu, Hui Jiang, Xiaozhou Liu, Jun Liu   +9 more
doaj   +1 more source

The MeSH-gram Neural Network Model: Extending Word Embedding Vectors with MeSH Concepts for UMLS Semantic Similarity and Relatedness in the Biomedical Domain

, 2018
Eliciting semantic similarity between concepts in the biomedical domain remains a challenging task. Recent approaches founded on embedding vectors have gained in popularity as they risen to efficiently capture semantic relationships The underlying idea ...
Abdeddaïm, Saïd, Soualmia, Lina Fatima, Vimard, Sylvestre   +2 more
core  

Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population

Biomarker Research
Background The human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical diseases and diverse in drug responses.
Wan-Hsuan Chou, Lu-Chun Chen, Henry Sung-Ching Wong, Ching-Hsuan Chao, Hou-Wei Chu, Wei-Chiao Chang   +5 more
doaj   +1 more source

Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6

HGG Advances
Summary: Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups
Blaine A. Bates, Kylee E. Bates, Spencer A. Boris, Colin Wessman, David Stone, Justin Bryan, Mary F. Davis, Matthew H. Bailey   +7 more
doaj   +1 more source

On the Nature of the Beast: Re-Charting Political Geographies of the European Union. Swedish Society for Antropology and Geography, 2006 [PDF]

, 2006
This review paper begins with the premise that since the European Union remains a process of construction with no agreed or pre-designated end-point, its power structure is open to a diverse range of interpretations. Moreover, the apparent novelty of the
Siddaway, James D.
core  

Polygenic risk associated with post-traumatic stress disorder onset and severity. [PDF]

, 2019
Post-traumatic stress disorder (PTSD) is a psychiatric illness with a highly polygenic architecture without large effect-size common single-nucleotide polymorphisms (SNPs).
Abu-Amara, Duna, Doyle, Francis J, Flory, Janine D, Guffanti, Guia, Jett, Marti, Lori, Adriana, Marmar, Charles R, Misganaw, Burook, Mueller, Susanne, Ressler, Kerry J, SBPBC, Yehuda, Rachel   +11 more
core  

Esp Research Trends in Asian Context [PDF]

, 2015
Due to the influence of global and regional economic changes, English for Specific Purposes (ESP) plays a more vital role in English language studies worldwide, including in Asian context.
Jantaravipark, A. (Arpawan), Sa-ngiamwibool, A. (Amporn)   +1 more
core  

Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records

Ophthalmology Science
Purpose: To examine whether genetic predisposition to age at the onset of myopia is associated with the development of future diseases. Design: Mendelian randomization phenome-wide association study (MR-PheWAS) from the UK Biobank.
Xiayin Zhang, PhD, Shan Wang, MD, Yu Huang, PhD, Yanjie Xie, PhD, Ishith Seth, MD, Gabriella Bulloch, MD, Chunran Lai, MD, Yijun Hu, PhD, Xianwen Shang, PhD, Mingguang He, PhD, Zhuoting Zhu, PhD, Honghua Yu, PhD   +11 more
doaj   +1 more source

PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses

Frontiers in Pharmacology
IntroductionBasal cell carcinoma (BCC) is the most common skin cancer, lacking reliable biomarkers or therapeutic targets for effective treatment. Genome-wide association studies (GWAS) can aid in identifying drug targets, repurposing existing drugs ...
Qiu-Ju Han, Yi-Pan Zhu, Jing Sun, Xin-Yu Ding, Xiuyu Wang, Qiang-Zhe Zhang   +5 more
doaj   +1 more source

Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases

Immunological Medicine
Disorders associated with the immune system burden multiple organs, although the shared biology exists across the diseases. Preceding family-based studies reveal that immune diseases are heritable to varying degrees, providing the basis for ...
Yuji Yamamoto, Yuya Shirai, Ryuya Edahiro, Atsushi Kumanogoh, Yukinori Okada   +4 more
doaj   +1 more source