Results 111 to 120 of about 98,679 (202)

Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI‐predicted functional consequences

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Genomic SEM of five ASCVD traits in > 3.8 million individuals identified 347 risk variants, including 19 novel loci. Integrating fine‐mapping and TWAS prioritized causal genes and revealed endothelial cell enrichment in vascular tissues. AI modelling shows the DCLRE1B mutation destabilizes the protein, impairing DNA repair and transcription.
Liwan Fu, Xiaodi Han, Qin Liu, Yuquan Wang, Yue‐Qing Hu   +4 more
wiley   +1 more source

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N., Smith, J Gustav, Smith, J.G., Heckbert, S.R., Zonderman, Alan B., Sotoodehnia, N., Mehra, R., Susan R. Heckbert, Ellinor, Patrick T, Palmer Cameron, Elsayed Z. Soliman, Benjamin, E.J., Newman, A.B., Müller, Martina, Kerr, K.F., Pfeufer, Arne, Newman, Anne B., Soliman, Elsayed Z, Magnani, JW, Candidate-gene Association Resource (CARe) Consortium, Ellinor Patrick T., Martina Müller, Kathleen F Kerr, Kerr, Kathleen F., Liu, Yongmei, Evans, Daniel S, Zonderman, Alan B, Palmer, C., Schnabel, Renate B, J Gustav Smith, Musani, Solomon K, Michele K Evans, Alonso Alvaro, Musani, Solomon K., Alonso, A, Newman, Anne B, Renate B Schnabel, Smith, JG, Smith, Gustav,, Schnabel Renate B., Magnani, Jared W., Emelia J Benjamin, null null, Ervin R Fox, Zonderman, AB, Jared W. Magnani, Paltoo, Dina N, Ellinor, Patrick T., Schnabel, R.B., Evans, M.K., Lund University., Kerr Kathleen F., Liu, Y, Cameron Palmer, Paltoo Dina N., Meng Yan A., Fox, Ervin R, Mehra Reena, Alonso, A., Patrick T. Ellinor, Anne B Newman, Redline Susan, Nalls, MA, Ellinor, PT, Schnabel, Renate B., Redline, Susan, Ellinor, P.T., Sotoodehnia, Nona, Nalls, Michael A., Arne Pfeufer, Smith J. Gustav, Newton-Cheh, Christopher, Solomon K Musani, Redline, S, Fox, ER, Renate B. Schnabel, Evans, Michele K., Mehra, R, Heckbert, SR, Meng, Yan A, Heckbert, Susan R, Christopher Newton-Cheh, Meng, YA, Evans, DS, Ervin R. Fox, Soliman Elsayed Z., Heckbert, Susan R., Michael A Nalls, Yan A. Meng, Fox, E.R., Susan Redline, Newton-Cheh Christopher, Fox, Ervin R., Evans, Michele K, Kathleen F. Kerr, Liu Yongmei, Alvaro Alonso, Nalls Michael A., Deo, R, Musani Solomon K., Newton-Cheh, C., Alan B. Zonderman, Soliman, EZ, Lubitz, S.A., Soliman, Elsayed Z., Dina N. Paltoo, Steven A Lubitz, Lubitz, SA, Alan B Zonderman, Evans, MK, Magnani, J.W., Patrick T Ellinor, Deo Rajat, Lubitz, Steven A, Nalls, Michael A, Pfeufer, A., Meng, Y.A., Evans Michele K., Benjamin, Emelia J., Benjamin Emelia J., Pfeufer Arne, Paltoo, D.N., Smith, J. Gustav, Sotoodehnia Nona, Elsayed Z Soliman, Soliman, E.Z., Jared W Magnani, Meng, Yan A., Redline, S., Newton-Cheh, C, Benjamin, Emelia J, Zonderman Alan B., Daniel S. Evans, Müller, M, Kerr, Kathleen F, Alonso, Alvaro, Rajat Deo, Kerr, KF, Schnabel, RB, Pfeufer, A, Müller, M., Paltoo, DN, Palmer, Cameron, Nona Sotoodehnia, Solomon K. Musani, Newman Anne B., Lubitz Steven A., Yongmei Liu, Zonderman, A.B., Nalls, M.A., Musani, S.K., Deo, Rajat, Musani, SK, Evans Daniel S., Deo, R., Dina N Paltoo, Newman, AB, Michele K. Evans, Mehra, Reena, Fox Ervin R., Yan A Meng, Evans, D.S., Evans, Daniel S., Benjamin, EJ, Susan R Heckbert, Emelia J. Benjamin, J. Gustav Smith, Reena Mehra, Palmer, C, Liu, Y., Magnani, Jared W, Anne B. Newman, Smith, Gustav, Daniel S Evans, Lubitz, Steven A., Steven A. Lubitz, Michael A. Nalls, Heckbert Susan R., Magnani Jared W., Müller Martina, Sotoodehnia, N   +180 more
core   +1 more source

A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders

Canadian Journal of Gastroenterology and Hepatology
Conclusions: Our study revealed genetic association between PBC and hypothyroidism through a phenome-wide Mendelian randomization, and then, colocalization identified two potential drug targets for hypothyroidism.
Shuyi Shi, Minghui Liu, Haonan Gao, Fang Liu, Yuhu Song   +4 more
doaj   +1 more source

Gene burden meta‐analysis of 748 879 individuals identifies LGI1‐ADAM23 protein complex association with epilepsy

Epilepsia, Volume 67, Issue 7, Page e118-e125, July 2026.
Abstract Epilepsy affects more than 50 million individuals globally and has a substantial genetic component that remains to be completely understood. Traditional studies have focused on severe, early onset cases enrolled through clinical or research settings.
Jessica Castrillon Lal, Costin Leu, Christian M. Boßelmann, Alina Ivaniuk, Eduardo Pérez‐Palma, Dennis Lal   +5 more
wiley   +1 more source

A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort [PDF]

, 2014
Glaucoma is a major cause of blindness in the world. To date, common genetic variants associated with glaucoma only explain a small proportion of its heritability. We performed a genome-wide association study of intra-ocular pressure (IOP), an underlying
Aung, T., van Koolwijk, L.M., Tanja, Z., Khor, C.-C., Venturini, C., Mackey, D.A., Jonas, J.B., Hammond, C., Vitart, V., Viswanathan, A.C., Hewitt, A.W., Gibson, J., Klaver, C.C., Nag, A., WTCCC, None, Xu, L., Lemij, H.G., Liao, J., Wang, J.J., Mitchell, P., Young, T. L., Macgregor, S., Ramdas, W.D., Vithana, E., Hofman, A., Lu, Y., Small, K.S., Wojciechowski, R., van Duijn, C.M., Hysi, P.G., Springelkamp, H., Yonova-Doing, E., Fleck, B.W., Williams, K.M., Wong, T.-Y., Uitterlinden, A.G., Lotery, A.J., Cheng, C.-Y., Tai, E.-S., Hohn, R., Teo, Y.-Y., Vingerling, J.R.   +41 more
core   +1 more source

Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis

Frontiers in Immunology
BackgroundAnkylosing Spondylitis (AS) is a chronic inflammatory disorder which can lead to considerable pain and disability. Mendelian randomization (MR) has been extensively applied for repurposing licensed drugs and uncovering new therapeutic targets ...
Wenlong Zhao, Wenlong Zhao, Peng Fang, Chengteng Lai, Xiaoyu Xu, Yang Wang, Hao Liu, Hui Jiang, Xiaozhou Liu, Jun Liu   +9 more
doaj   +1 more source

DRIVE v3: Command Line Application for Identity‐by‐Descent Haplotype Clustering in Large Biobank Scale Data

Genetic Epidemiology, Volume 50, Issue 5, July 2026.
ABSTRACT There is a need for genetic analytical methods that integrate multi‐individual identity‐by‐descent (IBD) tools with phenotypic enrichment testing to discover novel shared haplotypes contributing to disease traits. Existing tools are designed to identify IBD sharing and leave interpretation and phenotype association tests to further analyses ...
James T. Baker, Hung‐Hsin Chen, Grahame F. Evans, Alyssa C. Scartozzi, Ryan J. Bohlender, Chad D. Huff, Quinn S. Wells, David C. Samuels, Jennifer E. Below   +8 more
wiley   +1 more source

The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review

Journal of the Experimental Analysis of Behavior, Volume 126, Issue 1, July 2026.
Abstract Dr. Warren Bickel tirelessly investigated delay discounting (DD), a behavioral economic index of impulsive decision making, as a determinant of numerous health outcomes. Among the factors that contribute to a person's level of DD, a burgeoning body of research has illuminated its genetic foundations and the extent to which it may be a ...
Wei Q. Deng, Kyla L. Belisario, Amanda Doggett, Mahmoud Elsayed, Alysha Cooper, James MacKillop   +5 more
wiley   +1 more source

Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population

Biomarker Research
Background The human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical diseases and diverse in drug responses.
Wan-Hsuan Chou, Lu-Chun Chen, Henry Sung-Ching Wong, Ching-Hsuan Chao, Hou-Wei Chu, Wei-Chiao Chang   +5 more
doaj   +1 more source

Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6

HGG Advances
Summary: Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups
Blaine A. Bates, Kylee E. Bates, Spencer A. Boris, Colin Wessman, David Stone, Justin Bryan, Mary F. Davis, Matthew H. Bailey   +7 more
doaj   +1 more source