Results 111 to 120 of about 39,899,172 (210)

Commentary on: Genetic predictors of GLP1 receptor agonist weight loss and side effects (Nature volume 653, pages 770–775 (2026))

Journal of Diabetes Investigation, EarlyView.
Gotaro Toda, Toshimasa Yamauchi
wiley   +1 more source

Integrated Genome‐Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Wattles are finger‐like appendages on the ventral neck of goats, serving as a distinctive morphological marker for breed identification that serves potential implications for production performance. However, their genetic basis remains incompletely characterized.
Siyi Hu, Chen Wei, Da Feng, Shangquan Gan   +3 more
wiley   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, Volume 13, Issue 49, 3 September 2026.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population

Biomarker Research
Background The human leukocyte antigen (HLA) genes, exhibiting significant genetic diversity, are associated with susceptibility to various clinical diseases and diverse in drug responses.
Wan-Hsuan Chou, Lu-Chun Chen, Henry Sung-Ching Wong, Ching-Hsuan Chao, Hou-Wei Chu, Wei-Chiao Chang   +5 more
doaj   +1 more source

Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6

HGG Advances
Summary: Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups
Blaine A. Bates, Kylee E. Bates, Spencer A. Boris, Colin Wessman, David Stone, Justin Bryan, Mary F. Davis, Matthew H. Bailey   +7 more
doaj   +1 more source

Age‐friendly environments and incident motoric cognitive risk syndrome in older adults: A prospective cohort study

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Motoric cognitive risk syndrome (MCR) is a predementia condition that predicts multiple adverse health outcomes. Age‐friendly environments (AFE) represent a key strategy for promoting healthy aging and may reduce MCR risk. However, little is known about the association between AFE status and MCR risk.
Hui Zhang, Zixin Hu, Chongyu Ding, Yaqian Xu, Shuai Jiang, Yi Li, Jiucun Wang, Xiaofeng Wang, Meng Hao, Xiangwei Li   +9 more
wiley   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1907-1919, September 2026.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Rapid normal fibroblast‐tumor crosstalk promotes cancer‐associated fibroblast‐like activation and attenuates mitomycin C cytotoxicity in bladder cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Normal bladder fibroblasts rapidly engage in bidirectional crosstalk with bladder cancer cells, acquiring cancer‐associated fibroblast‐like activation features while promoting wound closure, epithelial‐mesenchymal transition‐like cadherin remodeling, and reduced mitomycin C‐induced cytotoxicity.
Jinhui Gao, Cindy Xinyu Ji, Ci Ren, John Hines, Eleanor Stride, Richard T. Bryan, Jennifer L. Rohn   +6 more
wiley   +1 more source

Disrupted Functional Network Organization in Crohn's Disease: Interoceptive Alterations Linked to Anxiety

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Crohn's disease shows widespread disruption and reorganization of functional brain networks, with altered activity in core interoceptive regions involved in sensory and emotional processing. Emotional disturbances modulate brain network dynamics, providing insight into neural mechanisms linking disease activity and affective symptoms.
Shuai Xu, Chunhui Bao, Xinyi Zhu, Qianfeng Wang, Boyu Zhang, Luyi Wu, Hongwei Li, Xuchen Yu, Zhou Hao, Zhensen Chen, He Wang, Huangan Wu   +11 more
wiley   +1 more source