Results 71 to 80 of about 98,679 (202)

A comprehensive analysis of the health effects associated with smoking in the largest population using UK Biobank genotypic and phenotypic data

Heliyon
Background: Smoking is a widespread behavior, while the relationship between smoking and various diseases remains a topic of debate. Objective: We conducted analysis to further examine the identified associations and assess potential causal relationships.
Zixun Lin, Jiayi Xiong, Jiaqi Yang, Yuanfeng Huang, Jinchen Li, Guihu Zhao, Bin Li   +6 more
doaj   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris, Kumari, Meena, Hardy, R, Berry, Diane J, Cooper, Jackie, Ulf de Faire, Angelakopoulou, A, Jutta Palmen, de Faire, Ulf, Tzoulaki, I, Fowkes, F. Gerry R., Marmot, Michael, Samani, Nilesh, Price, Jackie; id_orcid, Andrew Wong, Wong, A, Munroe, Patricia B, Kumari, M, Shah, T, Jefferis, BJ, Deanfield, John, Simpson, Iain A., Simpson, Iain A, Shah, S, Juan P. Casas, Thomson, Andy, Jefferis, Barbara J., Samani, N, Whittaker, John C, Bruna Gigante, Philippa J. Talmud, Lathrop, Mark, Munroe, Patricia B., John C. Whittaker, Drenos, F, Motterle, Anna, John Deanfield, F. Gerry R. Fowkes, Helen Ireland, Shu Ye, Price, J, Whincup, PH, Steve E. Humphries, Verzilli, C, Kivimaki, Mika, Power, C, Leander, Karin, Sofat, R, Jackie Price, Hypponen, Elina, Caulfield, Mark, Humphries, Steve E, Tina Shah, Anna Motterle, Kuh, Diana, Jefferis, Barbara J, Gigante, B, Maniatis, Nikolas, Whincup, Peter H, Casas, Juan P, Palmen, J, Diana Kuh, Shah, Sonia, Liam Smeeth, Gigante, Bruna, Ireland, Helen, Price, Jackie, Thomson, A, Elina Hypponen, Verzilli, Claudio, Nikolas Maniatis, Smeeth, Liam, Casas, JP, Angelakopoulou, Aspasia, Marmot, M, Ross C. Laxton, Munroe, PB, Barbara J. Jefferis, Cooper, J, Wallace, C, Simpson, IA, Caulfield, M, Talmud, PJ, Andy Thomson, Laxton, Ross C., Drenos, Fotios, Morris, Richard W, Iain A. Simpson, Chris Wallace, Mika Kivimaki, Lathrop, M, Humphries, SE, Motterle, A, Hingorani, AD, de Faire, U, Whittaker, JC, Meena Kumari, Jackie Cooper, Laxton, Ross C, Ioanna Tzoulaki, Claudio Verzilli, Ye, S, Wallace, Chris, Sonia Shah, Hardy, Rebecca, Shah, Tina, Aspasia Angelakopoulou, Berry, DJ, Hingorani, Aroon D, Laxton, RC, Nilesh Samani, Hypponen, E, Fowkes, F Gerry R, Morris, RW, Diane J. Berry, Rebecca Hardy, Maniatis, N, Mark Lathrop, Fowkes, FG, Reecha Sofat, Tzoulaki, Ioanna, Chris Power, Michael Marmot, Leander, K, Power, Chris, Smeeth, L, Mark Caulfield, Ye, Shu, Sofat, Reecha, Ireland, H, Fotios Drenos, Talmud, Philippa J, Kuh, D, Deanfield, J, Kivimaki, M, Wong, Andrew, Peter H. Whincup, Patricia B. Munroe, Berry, Diane J., Karin Leander, Palmen, Jutta, Aroon D. Hingorani   +141 more
core   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research
Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory ...
Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang   +11 more
doaj   +1 more source

High Endothelial Venules in Small Cell Lung Cancer: Prognostic Subtypes and Therapeutic Implications for Immunoradiotherapy

International Journal of Cancer, EarlyView.
ABSTRACT Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with an immunosuppressive tumor microenvironment, and current immunotherapy provides limited benefit. This highlights the need to identify microenvironmental features enabling effective immune responses.
Jiatian Fang, Zilian Wang, Hui Wang, Jianxin Xue, Kai Kang   +4 more
wiley   +1 more source

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis [PDF]

, 2009
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration.
Sendtner, M., Ding, J., Guralnik, J., Sabatelli, M., Dunkley, T., Marinou, K., F. Valentino, Singleton, A, LA BELLA V, Shiao-Lin Lai, Zachary Simmons, D. J. Hunter, LA BELLA, Vincenzo, MANCARDI GL, Hardy, J., Bandinelli, S, Fisher, E.M., Wichmann, H.-E., Beck, M, SCHMIDT S, Carlesi, C, ORRELL RW, Lupoli ,S, CAPONNETTO C, Federica Lombardo, Kwee, L. C., SICILIANO, GABRIELE, Bandinelli ,S, Mancardi, GL, D. Hernandez, Arepalli ,S, Connor ,J, I. Rafferty, Kwee ,LC, Schymick, JC, Chanock ,SJ, Siciliano, G., Conte, Amelia, Bandinelli, S., F. Torri, Gieger, C, MANCARDI, GIOVANNI LUIGI, SCHYMICK J, J. Ding, Singleton ,A, Sabatelli ,M, Dunkley ,T, KASPERAVICIUTE D, Hunter ,DJ, Simmons ,Z, Lupoli, S., Schmidt ,S, Beck ,M, Giannini, F., Rothstein ,J, Carlesi, C., Pioro, EP, CHANOCK SJ, PIORO E, Oddone, E.Z., Macciardi, F., S. Arepalli, VALENTINO F, Lai, S.-L., B. J. Traynor, Sara Lupoli, Mandrioli, J, Stefania Battistini, Schymick, J. C., STEPHAN D, FUNG H, Kasperaviciute, D., Gibbs, J.R., Mancardi ,GL, CARLESI, CECILIA, M. Sendtner, H. Fung, Arepalli, S, Guralnik, J, Mandrioli ,J, Battistini ,S, Lupoli, S, MORA G, KWEE L, Mario Sabatelli, KWEE LC, Ilaria Bartolomei, Schymick,JC, Hardy ,J, Sendtner, M, Adriano Chiò, Sola, P, Dena Hernandez, LAI S, Kwee, LC, Ding, J.H., Battistini, S., Wichmann, H. E., Crews ,C, MUTANI R, Salvi, F, Simmons, Z, J. Mandrioli, Carlesi ,C, Calvo, A., SABATELLI M, Sampath Arepalli, BATTISTINI S, Rothstein, J, NALLS M, A. Calvo, Salvi ,F, Scholz, S. W., Jabonka ,S, ODDONE E, FISHER E, TRAYNOR BJ, CHIO' A, Sola ,P, Chanock, S.J., K. Marinou, Valentino, F, Britton, A, Travis Dunkley, Andrew Singleton, Fisher, E. M., Ferrucci, L, Hunter, DJ, C. Crews, Gibbs, JR, F. Salvi, CONTE A, HARDY J, Mancardi, G.L., Dunkley, T, FUNG HC, L. Ferrucci, Dalia Kasperaviciute, Luigi Ferrucci, Lucie Bruijn, BERGER S, Beck, M., Scholz,SW, Fisher, EM, Sola, P., TORRI F, Lombardo, F, BARTOLOMEI I, Nalls, M, Restagno,G, Sonja W. Scholz, Amelia Conte, S. Bandinelli, Salvi, F., Restagno, G, Thomas ,G, Conte, A., Sendtner ,M, Z. Simmons, SENDTNER M, Mora, G, Macciardi, F, C. Caponnetto, Michael Nalls, Tedeschi ,G, G. Restagno, TRAYNOR B., LOMBARDO F, Scholz, S.W., Crews, C, L. Bruijn, Lai ,SL, Ding ,J, James Connor, Mutani, R., Caponnetto, C., Wichmann ,HE, E. P. Pioro, Hernandez ,D, H. E. Wichmann, Ferrucci ,L, Monsurro, M.R., Britton ,A, SICILIANO G, A. Conte, Jabonka, S, Tedeschi, G, Stephan, D.A., John Hardy, Rafferty, I., DING J, Gabriele Mora, CHIÒ A, P. Sola, Erik P. Pioro, Chanock, SJ, Kalliopi Marinou, Stephen J. Chanock, Mora ,G, Stephan, D. A., TEDESCHI G, Chio, A., Connor, J, Sibylle Jabonka, Traynor, B.J., Nalls ,M, David J. Hunter, Gibbs ,JR, BECK M, MONSURRO', Maria Rosaria, Bruijn, L., S. Berger, Pioro, E.P., H. C. Fung, FERRUCCI L, RESTAGNO G, LAI SL, Hernandez, D, F. Lombardo, J. Hardy, Jeffrey Rothstein, Ding, J, J. C. Schymick, Restagno, G., Valentino, F., Stefania Bandinelli, Gieger ,C, Lai, SL, Giovanni Luigi Mancardi, Rafferty, I, R. Mutani, C. Gieger, HUNTER D, Eugene Z. Oddone, Oddone, E. Z., Maria Rosaria Monsurrò, Ferrucci, L., D. Kasperaviciute, Vincenzo La Bella, ORRELL R, S. Battistini, G. Tedeschi, Fung, HC, Pioro, E. P., ROTHSTEIN J, CHANOCK S, Connor, J., Thomas, G., Arepalli, S., A. Chiò, Oddone, EZ, TEDESCHI, Gioacchino, Bryan J. Traynor, S. Lai, Kwee, L.C., Mutani, R, La Bella, V., TALBOT K, A. Britton, Hunter, D.J., Orrell, R.W., Sabatelli, Mario, J. Guralnik, Bartolomei ,I, M. R. Monsurrò, Gioacchino Tedeschi, Gibbs, J. R., D. A. Stephan, Stephen Berger, SIMMONS Z, Torri, F, Singleton, A., Claudia Caponnetto, Rafferty ,I, GuralMnik ,J, GIBBS JR, CAPONETTO C, Cecilia Carlesi, RAFFERTY I, Schymick, J.C., E. Z. Oddone, Roberto Mutani, N. Washecka, Traynor, B. J., Traynor,BJ, Tedeschi, G., J. R. Gibbs, Marinou, K, Chiò, A, Fabio Giannini, Kasperaviciute ,D, GIEGER C, MARINOU K, Michael Sendtner, BRITTON A, DUNKLEY T, Dietrich A. Stephan, Gieger, C., Mancardi, G. L., S. L. Lai, Rothstein, J., CREWS C, Talbot, K., Simmons, Z., M. Sabatelli, JABONKA S, I. Bartolomei, Cynthia Crews, Hernandez, D., Berger ,S, BANDINELI S, Mora, G., Crews, C., G. L. Mancardi, Washecka ,N, WICHMANN H, Gabriella Restagno, Stephan, DA, La Bella, V, PIORO EP, FISHER EM, Wichmann, HE, H. Erich Wichmann, Lombardo ,F, Macciardi ,F, Lai, S.L., CALVO A, V. La Bella, V. L. Bella, Fung ,HC, Jinhui Ding, Kasperaviciute, D, Fisher ,EM, SCHYMICK JC, SOLA P, Bartolomei, I., Lydia Coulter Kwee, J. Raphael Gibbs, GURALNIK J, Thomas, G, Nicole Washecka, Fung, H.-C., Jessica Mandrioli, BATTISTINI, STEFANIA, M. Beck, Orrell, R. W., T. Dunkley, Hon-Chung Fung, D. Hunter, CONNOR J, Jack Guralnik, Mandrioli, J., J. Connor, Jennifer C. Schymick, R. W. Orrell, SINGLETON A, Schmidt, S., Schmidt, S, Conte, A, S. Jabonka, Elizabeth M. Fisher, Hardy, J, Angela Britton, Lombardo, F., Talbot, K, Kevin Talbot, Bruijn ,L, Giannini ,F, A. Singleton, Chanock, S. J., Stephan ,DA, Calvo, A, Pioro ,EP, SALVI F, Battistini, S, Berger, S, WICHMANN HE, MANDRIOLI J, Nalls, M., Scholz, SW, Federica Torri, SCHOLZ SW, Sabatelli, M, Traynor, BJ, Fabrizio Salvi, Jabonka, S., Berger, S., G. Siciliano, MANCARDI G, Calvo ,A, Bruijn, L, Orrell ,RW, Marcus Beck, MACCIARDI F, K. Talbot, HUNTER DJ, Siciliano, G, Washecka, N, G. Mora, Mutani ,R, Fabio Macciardi, S. J. Chanock, C. Carlesi, SCHOLZ S, Conte ,A, S. W. Scholz, Christian Gieger, Caponnetto, C, VALENTINO, Francesca, Siciliano ,G, Bartolomei, I, Talbot ,K, HERNANDEZ D, E. M. Fisher, GIANNINI, FABIO, WASHECKA N, STEPHAN DA, S. Lupoli, BRUIJN L, F. Giannini, Gabriele Siciliano, Monsurrò ,MR, Fung, H.C., Richard W. Orrell, Silke Schmidt, Oddone ,EZ, Orrell, RW, AREPALLI S, L. C. Kwee, Gilles Thomas, Torri, F., M. Nalls, Ian Rafferty, ODDONE EZ, CARLESI C, Francesca Valentino, Marinou ,K, Giannini, F, Hunter, D. J., GIANNINI F, J. Rothstein, THOMAS J, G. Thomas, THOMAS G, BANDINELLI S, Andrea Calvo, Patrizia Sola, LUPOLI S, Washecka, N., Chiò,A, Caponnetto ,C, GIBBS J, Torri ,F, Britton, A., F. Macciardi, S. Schmidt, Monsurrò, MR, Monsurro, M. R., MONSURRÒ MR   +458 more
core   +1 more source

Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study

Human Genomics
Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal.
Eunyoung Choi, Jaeseung Song, Yubin Lee, Yeonbin Jeong, Wonhee Jang   +4 more
doaj   +1 more source

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

iMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson, Liam Scott, Irene Leung, Ferenc Sallo, Catherine Egan, Tunde Peto, The MacTel Consortium, Melanie Bahlo, Martin Friedlander, Simone Tzaridis, Lea Scheppke, Roberto Bonelli   +11 more
wiley   +1 more source

Genome-wide associate study identifies five new schizophrenia loci [PDF]

, 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent ...
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
core   +2 more sources

Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization

BMC Medicine
Background Caffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism.
Loukas Zagkos, Héléne T. Cronjé, Benjamin Woolf, Roxane de La Harpe, Stephen Burgess, Christos S. Mantzoros, Paul Elliott, Shuai Yuan, Susanna C. Larsson, Ioanna Tzoulaki, Dipender Gill   +10 more
doaj   +1 more source