Results 71 to 80 of about 39,899,172 (210)
Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer
Advanced Science, EarlyView.Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang +10 morewiley +1 more sourceUnraveling genotype–phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis
BMC GenomicsBackground Type I hereditary hemochromatosis (HH), caused by pathogenic HFE variants, is among the most common autosomal recessive disorders in Northern Europe.Miriam Nurm, Tarmo Annilo, Sebastian May-Wilson, Anu Reigo, Reedik Mägi, Urmo Võsa, Neeme Tõnisson, Estonian Biobank Research Team, Toomas Haller +8 moredoaj +1 more sourcePhenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women [PDF]
Neuropsychopharmacology, 2016 To identify novel traits associated with alleles known to predispose to alcohol and nicotine use, we conducted a phenome-wide association study (PheWAS) in a large multi-population cohort. We investigated 7688 African-Americans, 1133 Asian-Americans, 14 081 European-Americans, and 3492 Hispanic-Americans from the Women's Health Initiative, analyzing ...Renato, Polimanti, Henry R, Kranzler, Joel, Gelernter +2 moreopenaire +2 more sourcesRational design of a lipophilic β‐galactosidase‐responsive near‐infrared probe for in vivo imaging of cellular senescence
Smart Molecules, EarlyView.We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers Jiani Huang, Feiyi Chu, Bin Feng, Lin Chen, Peili Cen, Jing Wang, Ying Qu, Lu Hong, Fei Wu, Huanfeng Tian, Yanpeng Fang, Yuanjie Chen, Mei Tian, Wenbin Zeng, Hong Zhang, Yan Zhong +15 morewiley +1 more sourceA genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium [PDF]
, 2011 Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease.Marsit CJ, Carmen J. Marsit, Oszutowska, Dorota, McLaughlin, John, Hung, Rayjean J, Fish Sherianne, Romkes Marjorie, Key, Timothy, Trichopoulos D, Lacko, Martin, Panico, S, González, C.A., Riboli, E., Oszutowska D, Arzani, Dario, Foglio, Mario, Hayes, Richard B, Schwartz SM, Wilbert H. M. Peters, Hashibe Mia, Tumino R, Dario Arzani, Key Timothy, Szeszenia-Dabrowska, Neonila, Stephen M Schwartz, Vineis P, Zhang Zuo-Feng, McLaughlin J, Lathrop, Mark, Trubicka Joanna, Brennan P., Lorenzo Richiardi, Chabrier, Amelie, Krogh, Vittorio, Chuang, S-C, Boffetta Paolo, Peters, Wilbert HM, Manni, Johannes J, Jingchun Luo, Liloglou T, Heath, S, Shama Buch, Bencko, V, Trichopoulos Dimitrios, Domenico Palli, Khaw KT, Luo, J., Voodern, T., Funkhouser WK, Macfarlane, Tatiana V, Field, John K, Wei Q, Doody David R., McClean Michael D., Herrero, R, Peters, W.H.M., Arzani, D, Macfarlane, TV, Njolstad, I., Quirós JR, Trichopoulou, A., Välk, K., Luo, Jingchun, Zhang, Z.F., Marsit, Carmen J., Martıínez, Carmen, Gaborieau Valerie, Boccia Stefania, H Bas Bueno-de-Mesquita, Hallmans, Göran, Alexandru Bucur, Conway, D. I., Blanché, H., Amelie Chabrier, Menezes, Ana, Lagiou, Pagona, Castellsagué, X, Tumino, R., Menezes Ana, José Eluf Neto, Neto JE, Koifman Sergio, Lagiou, P., McKay JD, Peters, W.H., Luo, JC, Riboli, Elio, Garrote LF, Tumino, Rosario, Fabianova, Eleonora, Conway, David I., Chen C, Luo Jingchun, Manni, Johannes J., Wünsch Filho V, Sturgis EM, Andres Metspalu, Heather H. Nelson, Ardanaz, Eva, Kumle, Merethe, Gary J. Macfarlane, et al., Gut, Ivo G., Therese Truong, -, Philip Lazarus, Navarro Carmen, Chabrier, A, Ivo G. Gut, Vatten, Lars Johan, Liloglou, T, John K Field, Benhamou Simone, Chabrier A, Bueno de Mesquita, H. Bas, Krogh V, Hashibe, M., Chabrier, A., Szeszenia-Dabrowska Neonila, Marsit, CJ, Overvad, Kim, Johannes J. Manni, Peters, W. H. M., Hung, Rayjean J., Funkhouser William K., Doody, DR., Clavel-Chapelon, F., Palli, D., Navarro, Carmen, Gallagher Carla J., Marsit Carmen J., Muscat, JE, Trubicka J, Eleonora Fabianova, John K. Field, Bueno-de-Mesquita, HB, Antonia Trichopoulou, Njølstad, I, Ahrens Wolfgang, Neto, J.E., Pagona Lagiou, Wei Qingyi, Gary E. Goodman, Shen-Chih Chang, Heath, S., Herrero Rolando, Clavel Chapelon F, Peeters, Petra H M, Talamini, R, McClean MD, McLaughlin John, Kelsey, Karl T., Heath Simon, Galan, P., Vineis, P., Goodman, G.E., Chuang, S.-C., Kumle, M., Bucur Alexandru, Peeters, Petra H. M., Carmen Navarro, H. Bas Bueno-de-Mesquita, Ardanaz, E, Quirós, José Ramón, Peters, Wilbert H. M, Galan P, Hung, RJ, Gary E Goodman, Wünsch-Filho, V, Zhang, ZF, Muscat JE, Holcatova, Ivana, Tjønneland, Anne, Gallagher, Carla J., Francoise Clavel-Chapelon, Chang, SC, Byrnes G, Navarro, C., Galan Pilar, Doody, D.R., Goodman, Gary E, Gaborieau, V, Nukui, Tomoko, Lathrop Mark, Fabianova E, Olshan, Andrew F, Marjorie Romkes, David R. Doody, Tõnu Voodern, González, CA, Trichopoulou A, Bouchardy, C., Schwartz, Stephen M, Toner, ME, Wuensch-Filho, V, Gut IG, Dimitrios Trichopoulos, Kjaerheim, K., Bucur, A, Vooder T, Castellsagué X, Trichopoulos, D., Peeters, P.H., Simonato, Lorenzo, Nelson, HH, Olshan AF, Therese Truong,, Delepine, Marc, Wolfgang Ahrens, Chang, S-C, Franceschi, S., Brennan, P, Bocciai, Stefania, Curado, M. P., Hayes, Richard B., Joshua E Muscat, Peters WH, Ramon Quiros, J., Zhong Shilong, Hayes, RB, Schwartz, Stephen M., Schwartz, SM, Gallagher CJ, Heather H Nelson, Garrote, L.F., Macfarlane, Tatiana V., Quirós J. Ramón, Galan, P, William K. Funkhouser, Weissler, MC, Carlos A. González, Cadoni, G, Anne Boland, Chang SC, Palli, Domenico, Therese Truong, Curado MP, McClean, MD, McKay James D., Macfarlane TV, Välk Kristjan, Marsit, C.J., Antonio Agudo, Overvad, K., Wünsch-Filho, Victor, Talamini R, Linseisen, Jakob, Zaridze David, Lenka Foretova, Bueno-de-Mesquita, H.B., Peeters, P. H. M., Neto, José Eluf, Wünsch-Filho, V., Larrañaga N, Sturgis, E.M., Patricia A. McKinney, Carmen Martínez, Kelsey, KT, Michael D. McClean, Lubiński, J., Delepine, M, Bueno-de-Mesquita H. Bas, Karl T. Kelsey, Overvad K, Oszutowska, D, Claire M Healy, MacFarlane, Tatiana, Ariana Znaor, Neonila Szeszenia-Dabrowska, Castellsagué, Xavier, Tatiana V Macfarlane, Zhang ZF, Wei, Q, Khaw, KT, Quirós, J.R., Funkhouser, WK, Truong, T., Chuang, S. -C., Bueno de Mesquita HB, Simonato, L, Curado, Maria Paula, Weissler Mark C., Chuang, Shu-Chun, Lathrop, M, Doris Lechner, Valk, K, Heath, Simon C., Marsit, Carmen J, Romkes M, Linseisen Jakob, Martínez C, Hung, R.J., Gut, I.G., Wang LE, Lazarus P, Zelenika, D, Romkes, Marjorie, Trichopoulou, Antonia, Agudo Antonio, Linseisen, J., Musca, Joshua E., Hayes RB, Chang, S.C., Jakob Linseisen, William K Funkhouser, Chen Chu, Brennan, P., Field, John K., Palli D, Gallagher, C. J., Macfarlane, GJ, Vatten L, Erich M Sturgis, Larrañaga Nerea, Kristina Kjaerheim, Carla J Gallagher, Shangina, O., Manni, JJ, Conway, D.I., Stefania Boccia, Zhong, S., Navarro C, Quirós, J. R., Krogh, V, Bouchardy C, Overvad, K, Key T, Simonato Lorenzo, Lechner D, Chabrier Amelie, Oxana Shangina, McClean, Michael D., Foglio, M., Boffetta, Paolo, Luo J, Zhong, SL, Sturgis, EM, Larrañaga, N., Fernandez Garrote, L, Key, T, Weissler, Mark C., Key, T., Zhong, Shilong, Lechner, D., Hallmans Göran, Kelsey, K. T., Palli, D, Agudo, Antonio, Healy Claire M., Khaw, Kay-Tee, Linseisen J, McKay, JD, Bueno-de-Mesquita, H Bas, Janout, V, Voodern Tõnu, Bouchardy Christine, Doody, David R., Christine Bouchardy, Weissler, M. C., Macfarlane, Gary J., Olshan, A.F., Lorenzo Simonato, Manni, J. J., Richard B. Hayes, Vatten, L, Vladimir Bencko, Vatten, L., Horwitz, Marshall S., Shangina Oxana, Doody, DR, Kristjan Välk, Fish, S, Joshua E. Muscat, Bueno-de-Mesquita, Bas, Ardanaz, E., Kumle M, Kumle Merethe, Bencko, V., Zelenika, Diana, Chang Shen-Chih, Peeters, Petra HM, Castellsagué, X., Clavel-Chapelon Francoise, Manni Johannes J., Clavel-Chapelon, Francoise, Koifman S, Tjønneland, A., Eva Ardanaz, Wang, Li-E., Rudnai, Peter, Nerea Larrañaga, Fernandez Garrote, Leticia, Overvad Kim, Goodman, G. E., Simonato L, Blanche´, Hélène, Zhang, Z. -F., INHANCE Consortium, Ahrens, Wolfgang, Cadoni, Gabriella, Göran Hallmans, Talamini Renato, McLaughin, John, Szeszenia-Dabrowska, N., Curado, M.P., Menezes, A, Carlos A González, Holcatova, I., Merethe Kumle, Schwartz, S.M., Znaor, Ariana, Olshan, Andrew F., Lubiński, J, David I. Conway, Martínez, C, McLaughlin, John R., Macfarlane, G.J., Hayes, R. B., Benhamou S, Doody DR, Hallmans G, Truong Therese, Cadoni Gabriella, Neto, J. E., Lener, M., Boffetta, P., Field, J.K., Hayes, R.B., Merletti, F, Krogh Vittorio, Canova, Cristina, McKay, James D., Salvatore Panico, Healy, C. M., McKinney, PA, Weissler, Mark C, Zaridze, D., Byrnes, G, Conway, David I, Szeszenia Dabrowska N, Larrañaga, N, Brennan Paul, Foretova L, Ramon Quiros, J, McKinney, P.A., Sturgis, E. M., Tatiana V. Macfarlane, Muscat, Joshua E., Chuang Shu-Chun, Luo, J, J. Ramón Quirós, McKinney PA, Lacko Martin, Richard B Hayes, Canova, C., Zaridze, David, James D McKay, Rayjean J. Hung, Macfarlane, T. V., Boeing, H., Rudnai, P., Claire M. Healy, Paolo Vineis, Trubicka, J, Kjaerheim Kristina, Zhang, Zuo-Feng, Weissler, M.C., Trubicka, Joanna, Välk, Kristjan, Victor Wünsch-Filho, Foretova, L., Wang, L-E, McLaughlin, J., Lagiou, P, Martínez, C., Peters, Wilbert H. M., Wei, QY, Znaor Ariana, Gaborieau, V., Graham Byrnes, Benhamou, Simone, Heath S, Boccia S, Wang, Li-E, David Zaridze, Cadoni G, Hallmans, G, Janout V, Barzan L, Macfarlane, G. J., Njølstad, Inger, Timothy Key, McClean, M.D., Silvia Franceschi, Boland A, David I Conway, Lars Vatten, Peter Rudnai, Nelson HH, Wei, Q., Qingyi Wei, Zaridze, D, Znaor A, McClean, M. D., Clavel-Chapelon, F, J Ramón Quirós, Nukui, T, Franceschi, S, McKinney Patricia A., Blanche, H, Tõnu Vooder, Garrote, L. F., Panico Salvatore, Bucur, A., Trubicka, J., Boland, A., Shangina O, Nelson, Heather H., Garrote, LF, Menezes, Ana A., Muscat, Joshua E, Li-E Wang, Vineis, Paolo, Sherianne Fish, Mark C. Weissler, Valerie Gaborieau, Zhong, S, Vaelk, Kristjan, Bueno-de-Mesquita, H. B., Peters Wilbert H. M., Riboli, E, Mary E Toner, Wang, LE, Gut Ivo G., Chuang, SC, Macfarlane Tatiana V., Andrew F. Olshan, Muscat Joshua E., Goodman, GE, Chuang SC, Toner, Mary E., González, C. A., Välk K, Mark Lathrop, Nukui T, Jan Lubiński, Macfarlane, TV., Franceschi, Silvia, Boffetta, P, Lazarus, P., Hélène Blanché, Toner, Mary E, Metspalu Andres, Zelenika Diana, Vatten Lars, Peeters Petra H. M., Toner Mary E., Funkhouser, William K, Lechner, D, Barzan Luigi, James D. McKay, Curado Maria Paula, Mario Foglio, Blanché, Hélène, McKinney, Patricia A., Ahrens, W, Petra H M Peeters, Romkes, M, Lathrop M, Wei, Qingyi, Conway David I., Goodman, Gary E., Chen, Chu, Fish, Sherianne, Hashibe, M, Key, Timothy J., Heiner Boeing, Njølstad Inger, Kelsey, K.T., Richiardi Lorenzo, Rudnai, P, Nelson Heather H., Delepine Marc, Fish, S., Foglio M, Shangina, O, Quirós, JR, Zuo-Feng Zhang, Healy, C.M., Simon Heath, Byrnes, Graham, McKinney, Patricia A, Hashibe M, Khaw Kay-Tee, Elio Riboli, Carla J. Gallagher, Boeing, H, Franceschi S, Lazarus, Philip, Manni, J.J., Njolstad, Inger, Liloglou, T., Bucur A, Kelsey, Karl T, Lissowska, J, Lowry R, Arzani, D., Koifman, Sergio, Trichopoulou, A, Benhamou, S, Fabianova, E., Buch S, Vooder, T., Arzani Dario, Lacko M, Boland Anne, Martin Lacko, Menezes, Ana M., Oszutowska, D., Andrew F Olshan, Peeters PH, Ahrens W, Castellsagué Xavier, Macfarlane GJ, Merletti F, Healy, Claire M, Byrnes Graham, Lissowska Jolanta, Boland, Anne, Healy, Claire M., Lagiou P, McKinney, P. A., Doody, D. R., Kim Overvad, Menezes, A., Martínez Carmen, Gallagher, C.J., Herrero, R., Carmen J Marsit, Barzan, L., Wang, L. -E., Barzan, L, Toner, M. E., Kjaerheim, K, Wünsch-Filho Victor, Gallagher, Carla J, Vooder, Tõnu, Boccia, S., González CA, Rolando Herrero, González Carlos A., Fabianova Eleonora, Paul Brennan, Foretova, L, Bencko V, McKay, J.D., Vineis Paolo, Trichopoulos, Dimitrios, Boccia, Stefania, Liloglou, Triantafillos; id_orcid, Chen, C, Quirós, J Ramón, Lacko, M, Fish S, Macfarlane, G, Lowry Ray, Sturgis, Erich M, Holcatova Ivana, Doody, David R, Riboli Elio, Brennan, Paul, Peeters, PHM, Tjonneland, A, Voodern, T, Tumino, R, Vineis, P, Liloglou Triantafillos, Trichopoulou Antonia, Macfarlane, T.V., Heath, Simon, Toner, M.E., Weissler MC, Ahrens, W., Hayes Richard B., Peeters, P.H.M., Tjønneland Anne, Hayes, RB., Tumino Rosario, Paolo Boffetta, Foretova Lenka, Merletti Franco, Koifman, S., Marc Delepine, Lubiński Jan, Njolstad, I, Franco Merletti, Stephen M. Schwartz, Menezes A, Muscat, J.E., Funkhouser, William K., Bencko Vladimir, Conway, DI, Trichopoulos, D, Bueno-de-Mesquita, H. Bas, Richiardi, L, Gallagher, CJ, Field, J. K., Lacko, M., Vittorio Krogh, Buch Shama, Fabianova, E, Zaridze D, Arzani D, Agudo, A., Rudnai P, Lazarus, P, Panico, Salvatore, Field JK, Kjaerheim, Kristina, Gut, IG, Erich M. Sturgis, Merletti, F., Karl T Kelsey, David R Doody, Mia Hashibe, Boeing Heiner, Zhang, Z-F, McKay, James D, Funkhouser, W.K., Hung RJ, Rudnai Peter, Janout, V., Canova, C, Linseisen, J, Kelsey Karl T., Macfarlane, Gary J, Peters, Wilbert H.M., Lissowska, J., Chen, C., Schwartz Stephen M., Lubiński J, Muscat, J. E., Martínez, Carmen, Buch, Shama, Curado, MP, Njølstad I, Funkhouser, W. K., Kjærheim, Kristina, Truong, Therese, Blanché Hélène, Bucur, Alexandru, Canova C, Chu Chen, Peters, Wilbert H. M., Lener, Marcin, Kay-Tee Khaw, Krogh, V., Khaw, K-T, Herrero, Rolando, Hung Rayjean J., Delepine M, Xavier Castellsagué, Petra H. M. Peeters, Joanna Trubicka, Peters, WHM, Holcatova I, Delepine, M., González, Carlos A, Talamini, R., Healy, CM, Richiardi, Lorenzo, Quirós, J. Ramón, Panico, S., Macfarlane Gary J., Kjaerheim K, Simone Benhamou, Jolanta Lissowska, Healy CM, Byrnes, G., Goodman GE, Peters, Wilbert H M, Foglio Mario, Oszutowska Dorota, Kumle, M, Lowry, R., Gabriella Cadoni, Benhamou, S., Zhong S, Field John K., Cadoni, G., Richiardi, L., John McLaughlin, Chang, Shen-Chih, Buch, S., Boeing H, Lener Marcin, Metspalu, A., Blanché H, Conway, DI., Neto, JE, McLaughlin, J, Maria Paula Curado, Lowry, Ray, Hallmans, G., Wuensch-Filho, Victor, Neto José Eluf, Buch, S, Merletti, Franco, Metspalu A, Metspalu, A, Ray Lowry, Ardanaz E, Znaor, A, Garrote Leticia Fernández, Lechner, Doris, Sergio Koifman, Lissowska J, Boeing, Heiner, Herrero R, Tjonneland, Anne, Shu-Chun Chuang, Marcin Lener, Macfarlane, GJ., McKay, J. D., Romkes, M., Therese, T, Gary J Macfarlane, Gut, I. G., Liloglou, Triantafillos, Mary E. Toner, Rayjean J Hung, Conway DI, Vatten, Lars, Manni JJ, Khaw, K.T., Palli Domenico, Dorota Oszutowska, Shangina, Oxana, Lowry, R, Olshan, AF, Truong T, Lathrop, M., Vladimir Janout, Chuang, S.C., Nukui, T., Field, JK, Luigi Barzan, Rosario Tumino, Gaborieau V, Ivo G Gut, McClean, Michael D, Lechner Doris, Goodman Gary E., Szeszenia-Dabrowska, N, Riboli E, Hallmans, Göran,, Boland, A, Znaor, A., Njølstad, I., Nelson, H.H., Franceschi Silvia, Schwartz, S. M., Zelenika, D., Olshan Andrew F., Janout Vladimir, Zelenika D, Inger Njølstad, Olshan, A. F., Shilong Zhong, Khaw, K. -T., Koifman, S, Renato Talamini, Anne Tjønneland, Agudo, A, Kelsey KT, Wang, L.E., Agudo A, Lazarus Philip, Lagiou Pagona, Lener, M, Nelson, Heather H, Cristina Canova, Chang, S. -C., Janout, Vladimir, Gut, Ivo G, Horwitz, M.S., Johannes J Manni, Gaborieau, Valerie, Bouchardy, Christine, Nukui Tomoko, Leticia Fernández Garrote, Bouchardy, C, Navarro, C, Simonato, L., Ivana Holcatova, Triantafillos Liloglou, Toner ME, Boffetta P, Tjønneland A, Talamini, Renato, Mark C Weissler, Holcatova, I, Tomoko Nukui, Barzan, Luigi, Bencko, Vladimir, Hashibe, Mia, Michael D McClean, Truong, T, Lissowska, Jolanta, Canova Cristina, Wang Li-E, Pilar Galan, Marsit, C. J., Vaelk, K, Patricia A McKinney, Garrote, Leticia Fernández, Wilbert H M Peters, Ardanaz Eva, Foglio, M, Ana Menezes, Hung, R. J., Sturgis Erich M., Galan, Pilar, Diana Zelenika, Nelson, H. H., Boccia, S, Foretova, Lenka, Richiardi L, Sturgis, Erich M., Metspalu, Andres, Lener M, Lubinski, Jan, Eluf Neto, José, Voodern, Tônu, Larranaga, Nerea, González, Carlos A. +934 morecore +2 more sourcesPTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients
Brain Pathology, EarlyView.In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper +15 morewiley +1 more source
