Results 71 to 80 of about 35,658 (190)

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

Prevalence and associated factors of skin cancer in aged nursing home residents: A multicenter prevalence study [PDF]

, 2019
Non-melanoma-skin cancer is an emerging clinical problem in the elderly, fair skinned population which predominantly affects patients aged older than 70 years.
Akdeniz, Merve, Blume-Peytavi, Ulrike, Hahnel, Elisabeth, Kottner, Jan, Ulrich, Claas   +4 more
core   +1 more source

Unraveling genotype–phenotype relationships in hereditary hemochromatosis through integrated biobank data analysis

BMC Genomics
Background Type I hereditary hemochromatosis (HH), caused by pathogenic HFE variants, is among the most common autosomal recessive disorders in Northern Europe.
Miriam Nurm, Tarmo Annilo, Sebastian May-Wilson, Anu Reigo, Reedik Mägi, Urmo Võsa, Neeme Tõnisson, Estonian Biobank Research Team, Toomas Haller   +8 more
doaj   +1 more source

P710: Phenome-wide association study (PheWAS) for the Canadian HostSeq Biobank

Genetics in Medicine Open
Erika Frangione, Xu Xinyi, Vincent Chapdelaine, Selina Casalino, Navneet Aujla, Radhika Mahajan, Lochana Jayachandran, Gregory Morgan, Mackenzie Scott, Juliet Young, Brendan Dickson, Saranya Arnoldo, Erin Bearss, Alexandra Binnie, Bjug Borgundvaag, Howard Chertkow, Marc Clausen, Marc Dagher, Luke Devine, Steven Friedman, Anne-Claude Gingras, Lee Goneau, Deepanjali Kaushik, Zeeshan Khan, Elisa Lapadula, Georgia MacDonald, Tony Mazzulli, Allison McGeer, Shelley McLeod, Chloe Mighton, Trevor Pugh, David Richardson, Jared Simpson, Seth Stern, Lisa Strug, Ahmed Taher, Iris Wong, Natasha Zarei, Elena Greenfeld, Yvonne Bombard, Abdul Noor, Hanna Faghfoury, Jennifer Taher, Daniel Taliun, Jordan Lerner-Ellis   +44 more
doaj   +2 more sources

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research, EarlyView.
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the National Health and Nutrition Examination Survey (NHANES), UK
Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang   +11 more
wiley   +1 more source

Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study

Human Genomics
Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal.
Eunyoung Choi, Jaeseung Song, Yubin Lee, Yeonbin Jeong, Wonhee Jang   +4 more
doaj   +1 more source

Genetic variation in the HLA region is associated with susceptibility to herpes zoster. [PDF]

, 2015
Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in childhood, can remain asymptomatically latent in nerve tissues for many years and often re-emerges as
Armstrong, G, Baldwin, E, Borthwick, KM, Bottinger, E, Burt, A, Carlson, CS, Carrell, DS, Carroll, RJ, Comstock, BA, Crane, PK, Crawford, DC, Crosslin, DR, de Andrade, M, Denny, JC, Doheny, KF, Hanna, DS, Harley, JB, Hayes, MG, Jarvik, GP, Keating, B, Kho, A, Kim, DS, Kuivaniemi, H, Kullo, IJ, Larson, EB, Li, R, McCarty, CA, Mirel, DB, Mukherjee, S, Pacheco, J, Peissig, PL, Pugh, E, Ritchie, MD, Stallings, S, Tromp, G, Underwood, JG, Verma, SS   +36 more
core  

Between dirigism and laissez-faire: Effects of implementing the science policy priority for biotechnology in the Netherlands [PDF]

, 1986
A Program Committee Biotechnology was established in the Netherlands for the period 1981¿1985, to stimulate biotechnological research and its contribution to innovation.
Nederhof, Anton J., Rip, Arie
core   +3 more sources

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery [PDF]

Current Genetic Medicine Reports, 2015
With the large volume of clinical and epidemiological data being collected, increasingly linked to extensive genotypic data, coupled with expanding high-performance computational resources, there are considerable opportunities for comprehensively exploring the networks of connections that exist between the phenome and the genome.
S A, Pendergrass, M D, Ritchie
openaire   +2 more sources