Results 111 to 120 of about 43,083,361 (310)

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

open access: yes, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J.   +999 more
core   +2 more sources

Genome-Wide Association Study Implicates Immunogenetic Variation in Chemokine Signaling Pathways in Pediatric Tuberculosis Susceptibility

open access: yesJournal of Human Immunity
IntroductionAlthough immune responses to Bacillus Calmette–Guérin (BCG) vaccination and susceptibility to mycobacterial infection vary across individuals, the underlying cellular mechanisms regulating this heterogeneity are poorly understood.
Christine Anterasian   +12 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

open access: yes, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo   +999 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Evaluation of association of HNF1B variants with diverse cancers : collaborative analysis of data from 19 genome-wide association studies [PDF]

open access: yes, 2010
Background Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk.
Mann, GJ   +273 more
core   +1 more source

Genome-wide association studies for transpiration efficiency and physiological traits in Ethiopian Sorghum genotypes

open access: yesScientific Reports
Sorghum (Sorghum bicolor L. Moench) is a drought-tolerant crop, with its resilience essentially attributed to high transpiration efficiency (TE), and simply defined as the biomass produced per unit of water transpired.
Yirgalem Tsehaye   +7 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]

open access: yes, 2011
Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...
Donovan, Jenny   +57 more
core   +1 more source

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

open access: yesPharmacogenomics and Personalized Medicine, 2021
Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...
Zhou Z   +6 more
doaj  

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