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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci [PDF]
, 2010 We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...Taylor JA, Diver WR, Vermeulen, Sita H, Xifeng Wu, Allione A, Hildebrandt, MA, Hengstler JG, Besenbacher, S, Godfrey, A., Trichopoulos D, Tjonneland A, Teo MT, Nuria Malats, Koppova, Kvetoslava, Panico, S, Malcolm C Pike, Albanes, D, Prokunina-Olsson, L, Riboli, E., Baris, D, Yeager, M, Dietrich, H., Kiltie, Anne, Xu, Z, Kiemeney L, Benhamou, Simone, Allen, Naomi E, Vineis P, Fletcher T, Yuan J, Knowles, M.A., Silverman, DT, Taylor, JA, Alan Schned, Bishop, DT, Manolis Kogevinas, Mark T W Teo, Xu Z, Lloreta, J., Hutchinson A, Sanz-Velez JI, Colin P Dinney, Wheeler, William, Francisco X Real, Fletcher, T, Godfrey, Ashley, Valdivia G, Matullo, Giuseppe, Fraumeni, Joseph F, Klaus Golka, Cancel-Tassin, Geraldine, Czerniak, B., Stefansson, K, Peter Rudnai, Federico Canzian, Czerniak, Bogdan, Thun M, McGrath, Monica, Gago-Dominguez, M., Clavel-Chapelon, F, Sanchez, Manuel, Gago-Dominguez, M, Panico S, Sulem P, Chanock, Stephen J, McGrath M, Lloreta, Josep, 1958-, Mayordomo, Jose I, Dinney, Colin P, Vineis, Paolo, Ljungberg, Borje, Weinstein, SJ, Real, FX, Chatterjee N, Olivier Cussenot, H Bas Bueno-de-Mesquita, Kumar, Rajiv, Xu, Z., Tony Fletcher, Hushan Yang, Bueno-De-Mesquita, HB, Hildebrandt, M.A.T., Rothman N, Chen, Meng, Naomi E Allen, Jacobs EJ, Albanes, Demetrius, Karagas, MR, Margaret A Knowles, Mayordomo JI, Kiemeney LA, Dinney, CP, Gurzau, Eugen, Riboli, E, Riboli, Elio, Dinney CP, Chen M, Grubb R. 3rd, Baris, D., Consol Serra, Borje Ljungberg, Garcia-Closas, M., Hengstler, JG, Polidoro, S., Geraldine Cancel-Tassin, Cussenot, O, Caporaso, N., Pike, MC, Johnson, A, Real, F.X., Teo, MTW, McGrath, M., Sacerdote C, Kogevinas, M., Maria Teresa Landi, Landi, M.T., Canzian, F, Makkinje RR, Tardon, A., Johnson A, Caporaso, Neil, Stern, M.C., Cancel Tassin G, Jan G Hengstler, Caporaso N, Fulvio Ricceri, Vermeulen SH, Clavel-Chapelon, F., Lloreta J, Allen, NE, Koppova, K., Navarro, Carmen, Xu, ZL, Gapstur, SM, Schwenn, Molly, Karagas MR, Robert Grubb, Ljungberg, B, Allen NE, Sanz Velez JI, Serra, Consol, Godfrey, A, Polidoro, Silvia, Hunter, David J, María D García-Prats, Selinski, S., De Vivo, I., Prokunina Olsson L, Fu, YP, Virtamo, J., Schned, Alan, Alessandra Allione, José I Sanz-Velez, J Alfred Witjes, Garcia-Closas, R., Giuseppe Matullo, Teo, MT, Golka K, Adonina Tardón, Sanchez M, Chen, M., Van Den Berg, D, Chatterjee, N, Clavel Chapelon F, Bolick, S.C., Yang, H, Fu, Y., Mariana C Stern, Diver, W.R., Andriole, Gerald, Pike, Malcolm C, Rudnai, P, Yi-Ping Fu, Diver, W Ryan, Hunter, DJ, Grubb R 3rd, Margaret R Karagas, De Vivo, Immaculata, Kvetoslava Koppova, Besenbacher, S., Cortessis, Victoria K, Grubb R, Tjonneland, A., Stern, Mariana C, Carmen Navarro, Burdett, L., Anne Tjonneland, Andriole, G, Jacobs KB, Canzian, Federico, Fu Y, Elio Riboli, Laurie Burdett, Hengstler, Jan G, Serra, C, Karagas, Margaret R, De Vivo, I, Gapstur SM, Tardón García, Adonina, Czerniak B, Black, A, Wu, X, Baris, Dalsu, Guarrera, S, Eric J Jacobs, Teo, Mark T W, D García-Prats M, Eugen Gurzau, Taylor, Jack A, Yuan JM, Gago Dominguez M, Knowles MA, Golka, Klaus, Valdivia, Gabriel, Francoise Clavel-Chapelon, Guarrera, Simonetta, Michael Thun, Black A, García Closas R, Kiltie, Anne E, Fraumeni, JF, Benhamou, S, Lloreta, J, Besenbacher, Soren, Bolick, Sophia C E, McGrath, M, Ashley Godfrey, D García-Prats, María, Bolick, SCE, Kiltie, A.E., Kiltie AE, MA Hildebrandt, Dimitrios Trichopoulos, Cussenot, O., Wu, XF, Cancel-Tassin G, Rothman, Nathaniel, Hildebrandt MA, Rafnar, T, Trichopoulos, D., Brennan P, Virtamo J, Robert N Hoover, Purdue, Mark P, Grubb, R, Polidoro, S, Ricceri, F, Thun, M, Allen, N.E., Chanock, SJ, Allione, A., Yeager, Meredith, Thun, Michael, Porru S, Sanz-Velez, JI, Wu, X., Xu, Zongli, Jack A Taylor, Manuela Gago-Dominguez, Garcia-Closas, Montserrat, Debra T Silverman, Chatterjee, N., Monica McGrath, Koppova, K, Alison Johnson, Meng Chen, Makkinje, Remco R, Purdue, MP, Caporaso, N, Fraumeni JF Jr, Paul Brennan, Patrick Sulem, Chen, M, Brennan, P, Real FX, Trichopoulos, Dimitrios, Virtamo, Jarmo, Jacobs, E.J., Koppova K, Hildebrandt, MAT, De Vivo I, Allione, Alessandra, Purdue, M., Andriole G. Jr, Godfrey A, Brennan, Paul, Tjonneland, A, Schwenn, M, Vineis, P, Montserrat Garcia-Closas, Kiemeney, LA, Silverman, Debra T, Pike, M.C., Rajiv Kumar, Kevin B Jacobs, Schned, A., Sulem, P., Kiemeney, L.A.L.M., Sacerdote, C., Garcia Closas M, Canzian, F., Polidoro S, Zongli Xu, Hengstler, J.G., Jacobs, K.B., Baris D, Jacobs, EJ, Yang, HS, Wang, Z., Sophia C E Bolick, Black, A., Makkinje, R.R., García Closas, Montserrat, Trichopoulos, D, Katja K Aben, Berg, D.P.G. van den, Albanes, D., Jacobs, Eric J, Landi MT, Gurzau E, Kogevinas, M, Sacerdote, Carlotta, Porru, Stefano, Guarrera, S., Wang, Zhaoming, Rudnai P, Ljungberg, Börje,, Panico, Salvatore, Yang, H., Josep Lloreta, Hunter, D.J., Matullo G, Wheeler, W, Virtamo, J, Burdett, Laurie, Figueroa JD, Garcia-Prats, MD, Silverman DT, Tardón A, Jonine D Figueroa, Rafnar T, David J Hunter, Aben, K.K.H., Hoover, RN, Wang, Z, Wang, ZW, W Ryan Diver, Lloreta, Josep, Knowles, Margaret A, Wheeler, W., Prokunina-Olsson, L., D García-Prats, M, Landi, Maria Teresa, Kari Stefansson, Stephen J Chanock, Valdivia, G, Hildebrandt, Michelle AT, Bishop, David T, Joseph F Fraumeni, Figueroa, J.D., Garcia-Closas M, Ricceri, F., Immaculata De Vivo, Remco R Makkinje, Bueno de Mesquita HB, Malats, Nuria, Silvia Polidoro, Sulem, P, Pike MC, Cortessis, VK, Mayordomo, JI, Chanock, Stephen J., Mark P Purdue, Weinstein, Stephanie J, Thun, M., Hutchinson, A., Panico, S., Simone Benhamou, Chanock SJ, Bolick, SC, Bolick SC, Amanda Black, Tardon, A, Andriole G Jr, Dalsu Baris, Brennan, P., Allione, A, Hoover, Robert N, Fraumeni JF, Jian-Min Yuan, Meredith Yeager, Yeager, M., Karagas, M.R., Jose I Mayordomo, Landi, MT, Clavel-Chapelon F, Hunter DJ, Real, Francisco X, Matullo, G, Weinstein SJ, Soren Besenbacher, Hoover RN, Selinski, S, Hutchinson, A, Besenbacher S, Navarro C, Makkinje, RR, Cortessis, V.K., Rothman, N, Porru, S, Ludmila Prokunina-Olsson, Burdett, L, Andriole, G.L., Andriole G, Sacerdote, C, Malats, N., Figueroa, Jonine D, Sulem, Patrick, Prokunina-Olsson L, Anne E Kiltie, Ricceri F, Cussenot, Olivier, Stern, MC, Michelle A T Hildebrandt, Matullo, G., Johnson, A., Nilanjan Chatterjee, Kumar, R, CAPORASO, NICOLA, Tjonneland, Anne, Taylor, J.A., Kiltie, AE, Sita H Vermeulen, Demetrius Albanes, Real, Francisco X., William Wheeler, Gapstur, Susan M, Cortessis VK, Vilneis, P., Dietrich, Holger, Schwenn M, Jarmo Virtamo, Rafnar, Thorunn, Figueroa, JD, Vermeulen, SH, Bueno-de-Mesquita, H Bas, Guarrera S, Jacobs, Kevin B, Dietrich H, Cancel-Tassin, G, Dinney, C.P., Stefansson, Kari, Ricceri, Fulvio, Prokunina-Olsson, Ludmila, Serra, C., Chatterjee, Nilanjan, Grubb, R., Molly Schwenn, Vermeulen, S., Canzian F, García Prats MD, Cussenot O, Carlotta Sacerdote, Bolick, Sophia CE, Zhaoming Wang, Weinstein, S.J., Manuel Sanchez, Schwenn, M., Van Den Berg D, Hildebrandt, Michelle A T, Stern MC, Wheeler W, Clavel-Chapelon, Francoise, Rudnai, Peter, Malats N, Dietrich, H, Grubb, Robert, Bueno-De-Mesquita, H.B., Riboli E, Wu, Xifeng, Cancel-Tassin, G., Kogevinas M, Witjes, JA, Stefano Porru, Garcia-Closas, M, Gago-Dominguez M, Witjes, J Alfred, Purdue MP, Nathaniel Rothman, Simonetta Guarrera, Rafnar, T., Bishop, D.T., Garcia-Closas, R, Diver, WR, Albanes D, Fletcher, Tony, Gabriel Valdivia, Kiemeney, Lambertus A, Stefansson K, Susan M Gapstur, Aben, Katja K, Bishop DT, Yuan, JM, Victoria K Cortessis, Kogevinas, Manolis, Kumar R, Amy Hutchinson, Lambertus A Kiemeney, Bueno-de-Mesquita HB, Benhamou S, Yeager M, Witjes JA, Carrato, Alfredo, Gago-Dominguez, Manuela, Teo, M.T., Neil Caporaso, Wang Z, Ljungberg B, Wu X, Yang H, Gurzau, E, Yuan, Jian-Min, Schned, A, Serra C, Navarro, C, Reina García-Closas, Holger Dietrich, Golka, K., David T Bishop, Burdett L, Salvatore Panico, Aben, KK, Sanchez, M, Witjes, J.A., Yang, Hushan, D. García Prats M, Gapstur, S.M., Czerniak, B, Selinski, Silvia, Schned A, Silvia Selinski, Yuan, J.M., Stephanie J Weinstein, Sanz-Velez, José I, Carrato, A., Malats, N, Fu, Yi-Ping, Den Berg DV, Hutchinson, Amy, García-Closas R, Vivo ID, Knowles, MA, Thorunn Rafnar, Alfredo Carrato, Carrato, A, Johnson, Alison, Bogdan Czerniak, Gerald Andriole, Teo, Mark TW, Aben KK, Carrato A, Jacobs, KB, Mayordomo, J.I., Fletcher, T., Rudnai, P., Fu YP, Kumar, R., Paolo Vineis, Selinski S, Golka, K, David Van Den Berg, Black, Amanda, Jacobs, Eric J., Vermeulen, Sita H., Lloreta Trull, Josep, 1958-, Karagas, Margaret R., Mayordomo, Jose I., Kiltie, Anne E., Cortessis, Victoria K., Bishop, David T., Kiemeney, Lambertus A., Garcia-Closas, Reina, Stern, Mariana C., Hengstler, Jan G., Aben, Katja K., Makkinje, Remco R., Diver, W. Ryan, Witjes, J. Alfred, Silverman, Debra T., Figueroa, Jonine D., Bueno-de-Mesquita, H. Bas, Gapstur, Susan M., Sanz-Velez, Jose I., Bolick, Sophia C. E., Jacobs, Kevin B., Purdue, Mark P., Garcia-Prats, Maria D., Hunter, David J., Teo, Mark T. W., Weinstein, Stephanie J., Andriole, Gerald, Jr., Hildebrandt, Michelle A. T., Van den Berg, David, Allen, Naomi E., Taylor, Jack A., Dinney, Colin P., Fraumeni, Joseph F., Jr., Tardon, Adonina, Hoover, Robert N., Knowles, Margaret A., Grubb, Robert, III, Pike, Malcolm C. +611 morecore +2 more sourcesAssociation between human blood metabolome and the risk of delirium: a Mendelian Randomization study
Frontiers in EndocrinologyBackgroundDelirium significantly contributes to both mortality and morbidity among hospitalized older adults. Furthermore, delirium leads to escalated healthcare expenditures, extended hospital stays, and enduring cognitive deterioration, all of which ...Chubing Long, Chubing Long, Dong Lin, Dong Lin, Lieliang Zhang, Lieliang Zhang, Yue Lin, Yue Lin, Qing Yao, Qing Yao, Guangyong Zhang, Guangyong Zhang, Longshan Li, Longshan Li, Hailin Liu, Hailin Liu, Jun Ying, Jun Ying, Xifeng Wang, Xifeng Wang, Fuzhou Hua, Fuzhou Hua +21 moredoaj +1 more sourceDiscerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.Kati Fischermanns, Johannes Broichhagenwiley +1 more sourceGenetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors
Pharmacogenomics and Personalized Medicine, 2021 Zixiu Zhou, Sizhen Li, Qingsong Yang, Xiaodong Yang, Kuanxiao Hao, Yating Liu, Shanshan Xu Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, 211102, People’s Republic of ChinaCorrespondence: Sizhen LiNanjing Tongren ...Zhou Z, Li S, Yang Q, Yang X, Hao K, Liu Y, Xu S +6 moredoaj Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini +8 morewiley +1 more sourceImproved heritability estimation from genome-wide SNPs [PDF]
, 2012 Narrow-sense heritability (h(2)) is an important genetic parameter that quantifies the proportion of phenotypic variance in a trait attributable to the additive genetic variation generated by all causal variants.Johnson, Michael R., Balding, DJ, Hemani, G, Hemani, Gibran, Balding, David J., Speed, D, Johnson, MR, Speed, Doug +7 morecore +1 more sourceLiver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses Anna M. Dowbaj, Meritxell Huchwiley +1 more sourceEpigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan +4 morewiley +1 more source
