Results 81 to 90 of about 43,083,361 (310)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş +5 morewiley +1 more sourceGenome-wide association study of Tourette's syndrome [PDF]
Molecular Psychiatry, 2012 Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry ...Scharf, JM, Yu, D, Mathews, CA, Neale, BM, Stewart, SE, Fagerness, JA, Evans, P, Gamazon, E, Edlund, CK, Service, SK, Tikhomirov, A, Osiecki, L, Illmann, C, Pluzhnikov, A, Konkashbaev, A, Davis, LK, Han, B, Crane, J, Moorjani, P, Crenshaw, AT, Parkin, MA, Reus, VI, Lowe, TL, Rangel-Lugo, M, Chouinard, S, Dion, Y, Girard, S, Cath, DC, Smit, JH, King, RA, Fernandez, TV, Leckman, JF, Kidd, KK, Kidd, JR, Pakstis, AJ, State, MW, Herrera, LD, Romero, R, Fournier, E, Sandor, P, Barr, CL, Phan, N, Gross-Tsur, V, Benarroch, F, Pollak, Y, Budman, CL, Bruun, RD, Erenberg, G, Naarden, AL, Lee, PC, Weiss, N, Kremeyer, B, Berrío, GB, Campbell, DD, Cardona Silgado, JC, Ochoa, WC, Mesa Restrepo, SC, Muller, H, Valencia Duarte, AV, Lyon, GJ, Leppert, M, Morgan, J, Weiss, R, Grados, MA, Anderson, K, Davarya, S, Singer, H, Walkup, J, Jankovic, J, Tischfield, JA, Heiman, GA, Gilbert, DL, Hoekstra, PJ, Robertson, MM, Kurlan, R, Liu, C, Gibbs, JR, Singleton, A, North American Brain Expression Consortium, Hardy, J, UK Human Brain Expression Database, Strengman, E, Ophoff, RA, Wagner, M, Moessner, R, Mirel, DB, Posthuma, D, Sabatti, C, Eskin, E, Conti, DV, Knowles, JA, Ruiz-Linares, A, Rouleau, GA, Purcell, S, Heutink, P, Oostra, BA, McMahon, WM, Freimer, NB, Cox, NJ, Pauls, DL +99 moreopenaire +10 more sourcesGenome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]
, 2015 Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A +9 morecore Genetic differences according to onset age and lung function in asthma: A cluster analysis
Clinical and Translational Allergy, 2023 Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Tae‐Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. Adcock, Kian Fan Chung, Tae‐Bum Kim, Bermseok Oh +11 moredoaj +1 more sourceABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif +8 morewiley +1 more sourceA genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]
, 2014 Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.Palmer, C. N. A.; id_orcid, H.M. Colhoun, C.N.A. Palmer, Colhoun, H. M., L.A. Donnelly, Liu, Y., Zhou, K., Palmer, C. N A, van Zuydam, N. R., Smith, B. H.; id_orcid, H.A. Deshmukh, N.R. van Zuydam, K. Zhou, A.D. Morris, Donnelly, L. A., Deshmukh, H. A., Morris, A. D., Meng, W., Smith, B. H., Y. Liu, B.H. Smith, W. Meng +21 morecore +1 more sourceInvestigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post +3 morewiley +1 more sourceMultiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease [PDF]
, 2013 Background Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (Seedorf, Udo, Eaton, C.B., Hottenga, Jouke J, Dongen, J. Van, Samani, NJ, Trompet, S., Ridker, P.M., McArdle, W. L., Danesh, J, de Geus, E. J. C., Reiner, AP, O'Donnell, C. J., Eaton, Charles B., McKnight, Barbara, Sanna, Serena, Sudlow, Cathie L.M., Boerwinkle, E., Markus, Hugh S, Franco-Cereceda, A., Kathiresan, S., Fornage, Myriam, Folsom, AR, Oudot-Mellakh, T., Strawbridge, RJ, Becker, Diane M, Sanna, S, Tregouet, David, Rothwell, Peter M., Bandinelli, S, Rudnicka, AR, Peters, Annette, Sanna, S., Uitterlinden, Andre G., Rose, LM, Huffman, JE, Rudnicka, Alicja R., Raikkonen, K., Huffman, Jennifer E., Buckley, BM, Reiner, A.P., WTCCC2, Goel, A, Navarro, Pau, Yanek, LR, Harris, Sarah E, Franco Duran, OH, Eaton, Charles B, Thorgeirsson, Gudmundur, Wallaschofski, H, Rothwell, Peter M, Wallaschofski, H., Widen, E., Boerwinkle, Eric, Franco, O.H., Chambers, John C, O'Donnell, CJ, Navarro, P, Deary, Ian J, Tregouet, D., Boerwinkle, E, Mehra, R, Curb, J David, Becker, L. C., Rose, Lynda M, Wild, SH, Hofman, A., Bis, JC, Bandinelli, S., Gieger, C, Tarasov, KV, Boomsma, D. I., Jukema, JW, Goel, Anuj, Watkins, H., Wright, Alan F, Schlessinger, D., Lopez, Lorna M., Franzosi, Maria Grazia, C4D Consortium, de Geus, Eco J C, Sattar, N, Becker, D.M., Starr, John M., Williams, F. M. K., Palotie, A, Homuth, G, Danesh, J., Campbell, Harry; id_orcid, Strachan, David P., Johnson, A. D., Kolcic, I., Oudot-Mellakh, T, Kocher, T., Lumley, T., Liewald, D.C., Rumley, Ann, Ridker, P. M., Hopewell, J. C., Tracy, Russell P., Baumert, J., Eriksson, P, ?, ?, Saleheen, D, Andersen, Karl, Tracy, R. P., Bevan, S, Kocher, T, O’Donnell, Christopher J., McKnight, B., Dongen, Jacques, Witteman, Jacqueline C M, Uitterlinden, Andre G, et al., Liewald, D. C., Lopez, L.M., Steri, M., Mosley, Thomas H, Taylor, KD, Strawbridge, Rona J., Hopewell, Jemma C., Palotie, A., Morange, Pierre-Emmanuel, Taylor, K.D., Tracy, RP, Baumert, Jens, Reilly, Muredach P., Tofler, Geoffrey H, Green, D., Grant, P.J., Seshadri, S., STROKE Consortium, Franco, O. H., Guo, Xiuqing, Bandinelli, Stefania, Huffman, Jennifer E, Sudlow, Cathie L M, Ikram, M Arfan, Dichgans, M, van Dongen, J.; id_orcid, Wright, A.F., Shin, SY, Kooner, J.S., Schunkert, H, Harris, S. E., Strawbridge, R.J., Huang, J, Folsom, A.R., Cucca, F., Franco, Oscar H, Schunkert, H., Eaton, C. B., Nelson, CP, Kooner, Jaspal S, Liu, S.M., Silveira, Angela, Rotter, Jerome I, Chen, Ming-Huei, Chen, MH, Lowe, G. D., Franzosi, MG, Chasman, Daniel, Rumley, A., Goel, A., Erdmann, Jeanette, Tang, Weihong, Steri, M, Jacobs, D, Seedorf, U, Buckley, B.M., Samani, N. J., Curb, J. D., Reiner, Alex P, Lowe, G.D., Yanek, Lisa R, Illig, T., Curb, J.D., Rothwell, PM, Naitza, S, Erdmann, J., Ferrucci, L, Chambers, J. C., Lahti, J., McArdle, Wendy L., Wilson, James F, Jukema, J.W., Ridker, PM, Jenny, N.S., Koenig, W, Lowe, Gordon D, Folsom, Aaron R, Davies, Gail, Reilly, MP, Homuth, G., Witteman, J. C. M., Witteman, Jacqueline C.M., Dehghan, Abbas, Nelson, Christopher P., Uitterlinden, A. G., Gross, M, Buckley, Brendan M., Sudlow, C.L.M., Williams, Frances M.K., Bevan, Steve, Wallaschofski, Henri, de Geus, EJC, Hottenga, JJ (Jouke Jan), de Geus, Eco J.C., Erdmann, J, Wright, AF, Dehghan, A., Hottenga, J.J., Koenig, Wolfgang, Teumer, A., Haritunians, Talin, Sennblad, B, Tracy, R.P., Wright, Alan F., Rose, Lynda M., Stott, D.J., Reiner, Alex P., Chambers, John C., Teumer, A, Huang, J., Polasek, Ozren, Polasek, O., Eriksson, Per, Mosley, Thomas H., Eriksson, J.G., Markus, H.S., Rotter, J.I., Huffman, J. E., Psaty, B. M., Trompet, Stella, Homuth, Georg, Mosley, T.H., Sudlow, C.L., Franco-Cereceda, Anders, Wild, Sarah H, Chasman, D, Gross, M., Rose, L. M., Jacobs, David, Ikram, Arfan, Sabater-Lleal, M., Rudan, I., Saleheen, D., Jukema, J. W., Starr, JM, Harris, SE, Tarasov, Kirill V., Lopez, Lorna M, Guo, XQ, Wilson, James F., Lumley, Thomas, Smith, Nicholas L., Cucca, Francesco, Hofman, Albert, Grotevendt, Anne, Deary, Ian J., Becker, Diane M., Bevan, S., Chen, M.H., Schlessinger, David, Illig, Thomas, Wilson, James F.; id_orcid, Kooner, J. S., Volzke, H., Basu, S, Hayward, C, Mehra, Reena, Tarasov, Kirill V, Geus, E.J.C. de, Hamsten, A, Tarasov, K.V., Chen, M.-H., Sabater-Lleal, Maria, Strachan, DP, Starr, J. M., Green, David, Spector, TD, Witteman, J.C., Rumley, A, Wallace, Robert, Buckley, Brendan M, Folsom, A. R., Johnson, Andrew D., Rotter, JI, Johnson, Andrew D, Markus, H. S., Tanaka, T, Spector, Timothy D, Eriksson, Johan G, Nelson, Christopher P, Becker, DM, Psaty, Bruce M., Tofler, Geoffrey H., Ferrucci, L., Smith, N.L., Bis, J. C., Strachan, D. P., Basu, Saonli, Teichert, Martina, Tanaka, T., Swords Jenny, Nancy, Bis, Joshua C, Curb, J. David, Tofler, GH, Swords Jenny, N., Yanek, L. R., Strachan, David P, Grotevendt, A., Hayward, C., Spector, T. D., Williams, FMK, Stott, David J, Samani, Nilesh J., Becker, D. M., Tarasov, K. V., Campbell, Harry, Franzosi, M. G., Campbell, H, Rudnicka, A.R., Strawbridge, Rona J, Deary, I. J., Hofman, Bert, Jenny, NS, Wright, A. F., Folsom, Aaron R., Jukema, J. Wouter, Naitza, Silvia, Song, J, Wallace, R, Wild, Sarah H.; id_orcid, Johnson, A.D., Jukema, J Wouter, Watkins, H, Eriksson, P., Kolcic, I, Oudot-Mellakh, Tiphaine, Koenig, W., Tracy, Russell P, Guo, X., Shin, S.Y., Davies, G, Eriksson, Johan G., van Dongen, J., Basu, Sreya, Redline, S, Ferrucci, Luigi, Soranzo, N, Psaty, Bruce M, Morange, PE, Dehghan, A, Sattar, Naveed, Palotie, Aarno, Stott, David J., Rothwell, P.M., CD4 Consortium, Lumley, T, Silveira, A., Franco, Oscar H., Dichgans, M., Starr, J.M., Hamsten, A., Folkersen, Lasse, Smith, N. L., Gieger, C., Eriksson, JG, Sudlow, CLM, Guo, X.Q., Davies, G., Chasman, D., Buckley, B. M., McKnight, B, Ridker, Paul M, Pulanic, D., Nelson, C. P., Shin, S.-Y., Rivadeneira, Fernando, Lahti, Jari, Becker, Lewis C., Willemsen, Gonneke, Bis, J.C., Wilson, J.F., Harris, S.E., Samani, N.J., Kathiresan, S, Clarke, Robert, Teichert, M., Soranzo, N., Chambers, JC, Deary, IJ, Seedorf, U., Davies, G.E., de Geus, E.J.C.; id_orcid, Widen, Elisabeth, Rudnicka, A. R., Rotter, J. I., Völzke, Henry, Jacobs, D., Jenny, N. Swords, Campbell, H., Eaton, CB, Peters, A., VTE Consortium, Harris, Sarah E., Wild, S.H., Clarke, R., Fornage, M., Mosley, TH, Liewald, David C., Grant, Peter J, Markus, HS, Spector, Timothy D., Malarstig, Anders, Johnson, AD, Bis, Joshua C., Liu, SM (Simin), Huang, Jie, Ikram, M.A., Liewald, David C, Seshadri, S, Teumer, Alexander, Willemsen, G, Boomsma, D.I.; id_orcid, Becker, L.C., Tregouet, D.A., Navarro, Pau; id_orcid, Sudlow, C. L. M., Deary, I.J., Illig, T, Boomsma, Dorret I, Tofler, G.H., Mehra, R., Song, J., Liu, Simin, van Dongen, Jenny, Strachan, D.P., Wellcome Trust Case Control Consortium 2 (WTCCC2)(including Jankowski J), Lahti, J, Smith, Nicholas L, de Geus, E.J.C., Becker, LC, Willemsen, G.; id_orcid, Yanek, L.R., Uitterlinden, André; id_orcid, Grant, Peter J., Chambers, J.C., Zemunik, Tatijana, Navarro, P., Rivadeneira, F., Yanek, Lisa R., Rudan, Igor, Baumert, J, Huffman, J.E., Samani, Nilesh J, Morange, P.-E., Franco-Cereceda, A, Ikram, M. Arfan, Liu, S., Rose, L.M., Boomsma, Dorret I., McArdle, W.L., Zemunik, T., Clarke, R, Williams, Frances M K, Wilson, J. F., Strawbridge, R. J., Morange, P.E., O'Donnell, C.J., Basu, S., Grant, P. J., Pulanic, D, Soranzo, Nicole, Folkersen, L, Hayward, Caroline, Witteman, JCM, Malarstig, A., Eriksson, J. G., Lopez, LM, Redline, Susan, O'Donnell, Christopher J, Sattar, N., Fornage, M, Taylor, Kent D., Wild, S. H., Williams, Frances M K; id_orcid, Wallace, R., Danesh, John, Song, Jaejoon, Gieger, Christian, Grotevendt, A, Reiner, A. P., CARDIoGRAM Consortium, Yao, Jie, Reilly, M. P., Taylor, K. D., Boomsma, DI, Pulanic, Drazen, Hottenga, Jouke J., Shin, So-Youn, Haritunians, T., McArdle, Wendy L, Dichgans, Martin, Mosley, T. H., Kooner, Jaspal S., Cucca, F, Hottenga, J. J., Kocher, Thomas, Uitterlinden, A.G., Kooner, JS, Stott, DJ, Silveira, A, Nelson, C.P., Naitza, S., Jankowski, Janusz, Sennblad, B., Peters, A, Watkins, Hugh, Folkersen, L., McArdle, WL, Tofler, G. H., Williams, F.M., Gross, Myron, Starr, John M, Psaty, BM, Sennblad, Bengt, Green, D, Becker, Lewis C, Rothwell, P. M., Willemsen, G., Yao, J., Reilly, Muredach P, Tanaka, Toshiko, Kolcic, Ivana, Tang, W., Redline, S., Schlessinger, D, Saleheen, Danish, Schunkert, Heribert, Spector, T.D., Smith, NL, Franzosi, M.G., Boomsma, D.I., Psaty, B.M., Haritunians, T, Kathiresan, Sekar, Wilson, JF, Hopewell, Jemma C, Yao, JJ, Ikram, M. A., Tang, W.H., Markus, Hugh S., Rudan, I, Trompet, S, Grant, PJ, Hopewell, JC, Stott, D. J., Wild, Sarah H., Tregouet, D, Widen, E, Sabater-Lleal, M, Liewald, DC, Chasman, D.I., Curb, JD, Williams, F.M.K., Zemunik, T, Tang, WH, Witteman, J.C.M., Lopez, L. M., Lowe, GD, Hayward, Caroline; id_orcid, Rudnicka, Alicja R, Seshadri, Sudha, Rotter, Jerome I., Lowe, Gordon D., Hopewell, J.C., Polasek, O, Steri, Maristella, Taylor, Kent D, Hamsten, Anders, Reilly, M.P., Uitterlinden AG, Baumert J, Zemunik T, Kathiresan S, Tarasov KV, McKnight B, McArdle WL, Huffman JE, Liewald DC, Taylor KD, Ridker PM, Raikkonen K, Rivadeneira F, Chen MH, Rose LM, Wilson JF, Gieger C, Tregouet D, Eriksson JG, Haritunians T, Eriksson P, Lumley T, Franzosi MG, Illig T, Basu S, Sennblad B, Silveira A, Homuth G, O'Donnell CJ, Volzke H, Harris SE, Tracy RP, Dehghan A, Eaton CB, Teichert M, Yanek LR, Hofman A, Reiner AP, Rumley A, Becker DM, Curb JD, Johnson AD, Clarke R, Guo XQ, Schunkert H, Yao J, Witteman JCM, Morange PE, Wild SH, de Geus EJC, Franco Cereceda A, Rudan I, Gross M, Sudlow CLM, Koenig W, Folkersen L, Chambers JC, Williams FMK, Psaty BM, Jukema JW, Franco OH, Mosley TH, Pulanic D, Rudnicka AR, Lopez LM, Watkins H, Jenny NS, Becker LC, Widen E, Grant PJ, Green D, Bis JC, Bevan S, Peters A, Rotter JI, Reilly MP, Folsom AR, Sanna S, Stott DJ, Lahti J, Willemsen G, Dichgans M, Liu SM, Buckley BM, Samani NJ, Fornage M, Sabater-Lleal, Maria;Huang, Jie;Chasman, Daniel;Naitza, Silvia;Dehghan, Abbas;Johnson, Andrew D;Teumer, Alexander;Reiner, Alex P;Folkersen, Lasse;Basu, Saonli;Rudnicka, Alicja R;Trompet, Stella;Malarstig, Anders;Baumert, Jens;Bis, Joshua C;Guo, Xiuqing;Hottenga, Jouke J;Shin, So-Youn;Lopez, Lorna M;Lahti, Jari;Tanaka, Toshiko;Yanek, Lisa R;Oudot-Mellakh, Tiphaine;Wilson, James F;Navarro, Pau;Huffman, Jennifer E;Zemunik, Tatijana;Redline, Susan;Mehra, Reena;Pulanic, Drazen;Rudan, Igor;Wright, Alan F;Kolcic, Ivana;Polasek, Ozren;Wild, Sarah H;Campbell, Harry;Curb, J David;Wallace, Robert;Liu, Simin;Eaton, Charles B;Becker, Diane M;Becker, Lewis C;Bandinelli, Stefania;Räikkönen, Katri;Widen, Elisabeth;Palotie, Aarno;Fornage, Myriam;Green, David;Gross, Myron;Davies, Gail;Harris, Sarah E;Liewald, David C;Starr, John M;Williams, Frances M K;Grant, Peter J;Spector, Timothy D;Strawbridge, Rona J;Silveira, Angela;Sennblad, Bengt;Rivadeneira, Fernando;Uitterlinden, Andre G;Franco, Oscar H;Hofman, Albert;van Dongen, Jen, Rothwell PM, Wallace R, Sabater Lleal M, Smith NL, Danesh J, Hottenga JJ, Kooner JS, Navarro P, Chasman D, Steri M, Saleheen D, Trompet S, Palotie A, Deary IJ, Ikram MA, Hayward C, Nelson CP, Redline S, Jacobs D, Davies G, Erdmann J, Sattar N, van Dongen J, Tanaka T, Goel A, Tang WH, Boomsma DI, Malarstig A, Starr JM, Naitza S, Grotevendt A, Teumer A, Huang J, Kolcic I, Boerwinkle E, Spector TD, Ferrucci L, Strawbridge RJ, Hopewell JC, Wright AF, Markus HS, Kocher T, Williams, Frances MK, Wallaschofski H, Seedorf U, Hamsten A, Polasek O, Lowe GD, Tofler GH, Bandinelli S, Schlessinger D, Mehra R, Soranzo N, Oudot Mellakh T, Strachan DP, Song J, Seshadri S, Campbell H, Shin SY, Räikkönen, Katri, Raikkonen, K, Volzke, H, Malarstig, A +731 morecore +2 more sources
