Results 81 to 90 of about 40,713,960 (307)

Not so benign

eLife, 2018
Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.
Barbara Rivera
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure [PDF]

, 2011
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans1, 2, 3. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N =
Döring, Angela, Klauw, M.M. van der, Wichmann HE, Preuss, M., Ridker, P.M., Trompet, S., Launer, L, Pfeufer, Arne, Boerwinkle, E., Anneli Pouta, Ongen, H. (Halit), Palmer, L.J., van der Klauw, MM (Melanie), Glazer, NL, Toshiko Tanaka, De Buyzere, Marc, Loos, Ruth J, John M Starr, Smith, AV, Toniolo, D. (Daniela), Lathrop, Mark, Alizadeh, Behrooz Z., Musk, A William, Preuss M, Navarro, Pau, Felix, J.F., A. William Musk, Trompet, S. (Stella), Corsi, A.M. (Anna Maria), Stefansson, K, Chambers, John C, Willemsen, G.A.H.M. (Gonneke), Najjar, SS, Gider, P., Smith AV, O'Donnell, CJ, Palmer, Lyle J., Nelson, C.P. (Christopher P.), Wichmann, H.E. (Heinz Erich), Xiaowen Lu, Kuehnel, Brigitte, Rose, Lynda M, Maris Laan, Igl, W., Harris, T.B. (Tamara), Toomas Haller, Cockcroft JR, Ongen, Halit, Voelker, Uwe, Faletra, F., Toniolo, D, Munroe, PB, de Geus, E.J., Maouche S, Attwood T, Rose, L.M. (Lynda), Rebecca J. Webster, Andrews JS, de Geus, Eco J C, Milaneschi, Y. (Yuri), Rivadeneira, F, Francesco U. S. Mattace Raso, Murray E, Assime TL, Strachan, David P., Johnson, T, Alizadeh, B.Z., Sinning C, Chen L, Shuldiner AR, Rudan, I. (Igor), CKDGen consortium, Orru, Marco, Ulivi, S, Starr, J.M. (John), AortaGen Consortium, the, Uitterlinden, Andre G, Lindeman, J.H. (Jan H.), et al., Peter Henneman, Lopez, L.M., Smith, A.V. (Albert Vernon), Quertermous T, Völker, U. (Uwe), Benjamin F. Voight, Tammesoo, M.L., Janssens, A.C., Rice, K.M., Zhang, W., Illig T, Levy, D. (Daniel), Taylor, K.D., Gyllensten, Ulf B, Najjar SS, V??lker, Uwe, Milaneschi, Y, Raitakari, Olli T., Vitart, Veronique, Völzke, H. (Henry), De Bacquer D, Emilsson, V., Hercberg, S., John C. Chambers, Musk, AW, Lucas, Gavin, Janssens, ACJW, Wright, A.F., Shin, SY, Hadley, D., Lloyd-Jones H, Burtt N, Jaakko Tuomilehto, O' Donnell CJ, Ulf B. Gyllensten, Shih Jen Hwang, Hung, J. (Judy), Wareham, N.J., Nelson, CP, Gary F. Mitchell, Scharnagl H, CardioGram, Wild, S.H. (Sarah), Heath, S., Zhang, F.F., Erdmann, Jeanette, Del Greco, Fabiola M., Li, XZ, Dehghan A, Gregory L. Burke, Xinzhong Li, Tim D Spector, Galan, P., Zhang, WH, Nolte, I.M. (Ilja), Ramachandran S Vasan, Jackson, A.U., Wilson, James F, Org, E, Ian J Deary, Völzke, H, Parker, AN, Schillert A, Hung, J, Hofman A, de Geus, EJC, Dobnig H, Erdmann, J, Wright, AF, Boban, M., Larson, Martin G., Najjar, Samer S., Hottenga, J.J., Herrington DM, Farrall, M. (Martin), Palmer, LJ, Hercberg, Serge, Kooner, J.S. (Jaspal), Albert V Smith, Cornelia M. van Duijn, Beckmann, Jacques S, Sijbrands, EJ, Susana Eyheramendy, Melander, O, Jacques S. Beckmann, Thorsteinsdottir, U, Polasek, Ozren, A Cecile J W Janssens, Ruth J F Loos, Medack A, Jarvelin, MR, Snieder, H. (Harold), Salomaa, V. (Veikko), van Duijn, Cornelia M., Behrooz Z. Alizadeh, Chen, Y-DI, Thorsteinsdottir, U. (Unnur), Groop, L. (Leif), Alanna C. Morrison, Trompet, Stella, Ehret, Georg B, Gavin Lucas, Renner W, Sõber, S. (Siim), Jackson, Anne U, Newton-Cheh, C, Snieder, Harold, Faletra, Flavio, Braund P, Barroso, Ines, Tim D. Spector, Collins, FS, Palmas, W, Thor Aspelund, Olli T. Raitakari, Rietzschel, Ernst, Zhao, JH, Hernandez, Dena, Nolte, IM, Ozren Polašek, Lu, X. (Xiaowen), Volzke, H., Barroso, In S., Vollenweider, P, Smith, A., Wilmar Igl, Pouta, A. (Anneli), Najjar, S.S. (Samer), Navarro, P. (Pau), Jaspal S. Kooner, Stolk, Ronald P, Esko, T. (Tõnu), Barroso, I.E. (Inês), Elliott, P., Li, X., Pirastu, N, Pistis, G, Fu, J.Y., Palmas, W., Tanaka, T, Cupples LA, Marjo-Riitta Jarvelin, Hwang, S-J, Richard N Bergman, Psaty, Bruce M., Beilby, John P, Smith, N.L., Klauw, M.M. (Melanie) van der, Tuomilehto, J., Fu, J, Galan, P, Haller, T, Serge Hercberg, Marjo Riitta Jarvelin, Morrison, Alanna C, Germaine C. Verwoert, Gyllensten, Ulf B.,, Niblett D, Ehret, G.B., Holm H, Bis, J.C. (Joshua), Chasman, D.I. (Daniel), Faletra, F. (Flavio), Campbell, Harry, Foad N, Francesco U S Mattace-Raso, Voight, Benjamin F, Scott, J., Janssens, A Cecile J. W., Davies, G, Shin, S.Y., Dorret I Boomsma, Bochud, M., Hlatky M, Bergmann, S, Plump, A., Jacqueline C. M. Witteman, Lindeman, Jan H, Behrooz Z Alizadeh, Kari Stefansson, Gray E, Scott, J. (James), Khaw, KT, Schnabel R, Grosshennig A, Rotter JI, Hernandez, D.G. (Dena), Erdmann, J. (Jeanette), Chasman, DI, Pistis, G. (Giorgio), Vilmundur Gudnason, Absher D, Doering, Angela, Rao, Dabeeru C., Stott, D., Mattace-Raso, Francesco U S, Lathrop, G.M. (Mark), Mitchell, GF, Bis, J.C., Wilson, J.F., David Siscovick, Meisinger C, Samani, N.J., DeStefano, Anita L, van Duijn CM, Samani NJ, Feng Zhang, Beilby, JP, Anna Maria Corsi, Lorna M Lopez, Olli T Raitakari, Soranzo, N., Schmidt, H., Waeber, G., De Buyzere ML, Pouta, A., Kahonen, M., Mladen Boban, Raitakari, OT, Wichmann, HE, Preuss, Michael, Breteler, M, Pichler, Irene, Boban, Mladen, Hwang, S.J., DeStefano, A.L., Corsi, Anna Maria, O'Reilly, P.F., Antonella Fabretto, Bergmann, S., Maurizio Facheris, Rettig, R. (Rainer), Joseph Hung, Fabretto, A, Farrall, M., Siim Sõber, Ehret, Georg B., Deary, I.J., Laan, M, Emilsson, Valur, Gang Shi, Peden, John F., Doring, A., Vasan, RS, Beckmann, J.S. (Jacques), de Geus, E.J.C., Larson MG, Willemsen, G.; id_orcid, Giorgio Pistis, Chambers, J.C., Khaw, Kay-Tee, Schmidt, R. (Reinhold), Navarro, P., Debette, St??phanie, Sijbrands, E.J.G. (Eric), Holm, H, Ganesh, Santhi K, Mitchell, Gary F., Samani, Nilesh J, d'Adamo, AP, Gasparini, Paolo, Tomaschitz A, Nelson CP, Boomsma, Dorret I., McArdle, W.L., Melander, O., Zitting, P. (Paavo), Newhouse SJ, Fischer M, Hayward, Caroline, Masciullo, Corrado, Hofman, A. (Albert), Erdmann J, Albert Hofman, Belz S, Voight, B.F., Kuhnel, B. (Brigitte), O'Leary K, Fornage, M, Igl, Wilmar, Segers P, Kühnel, Brigitte, Kroemer, H.K., Facheris, M.F. (Maurizio), Caulfield, MJ, Shin, So-Youn, Hoen, PAC', Lyle J. Palmer, Winkler K, Schmidt, R., Kooner, JS, Mitchell, Gary F, Rebecca J Webster, Aspelund, T, Nelson, C.P., Mattace-Raso, FU, Oostra, B.A., Emilsson, V, Watkins, Hugh, Christian Gieger, Barroso, In??s, Greco, M.F. del, Shi, G. (Gang), KidneyGen Consortium, the, Buckley, B, O'Reilly, P.F. (Paul), Michael Boehnke, Spector, T.D., Sijbrands, E.J., Loos, R.J.F., Taylor, K.D. (Kent), Rice, Kenneth M, Larson, Martin G, Wilson, JF, Waeber, G, CHARGE Consortium Heart Failure, the, Webster, RJ, Gyllensten, U.B., Jemma C. Hopewell, Pollard H, de Geus, Eco J. C., Holm, H., Aulchenko, Yurii, Rupprecht HJ, Arora, P., Cinzia Sala, Münzel T, Pirastu, Nicola, Johnson, T. (Toby), Aulchenko, Yuriy, Wilson, J.F. (James), Meitinger, T. (Thomas), Leif Groop, Wain, Louise V, Bickel C, Hopewell, J.C., CardioGram,, Goncalo R Abecasis, Barbalic M, Rice, K. (Kenneth), KidneyGen consortium, Uda, M., Rivadeneira Ramirez, F. (Fernando), Böhm BO, Harris, Tamara B, d'Adamo, Adamo Pio, Morrison, A.C. (Alanna), Buckley, B., Gillebert TC, Campbell, H. (Harry), Caulfield, M. (Mark), Groop, L, Boehnke, M, Ruth J. F. Loos, Kathiresan S, Shi, Gang, Mari Liis Tammesoo, Knowles J, Kenneth M. Rice, Jewell E, Sidney S, Webster, Rebecca J, Levy D, Melander, Olle,, Peden, J. (John), Mitchell, G.F. (Gary), Sala, C, Kuhnel, B., Bochud, Murielle, Aspelund T, Parker, A.N. (Alex), Gasparini, P., Martin Farrall, Navarro, P, van Dijk, KW, Burke, Gregory L, Taylor KD, Wagner AK, Mooser, Vincent, Uitterlinden, AG, Tamara B Harris, Orru, M., Gieger, C, Ronald P Stolk, Haller, T. (Toomas), Levy, Daniel, Tamara B. Harris, Khaw, K-T. (Kay-Tee), Wichmann, H-Erich, Goel, Anuj, Watkins, H., Aspelund, T. (Thor), Buckley, Brendan, Lopez, Lorna M., Roberts R, Andersen K, Mark J. Caulfield, Yuri Milaneschi, Louise V Wain, van Duijn, CM, Starr, John M., Zhang, W.H., Paul M. Ridker, Jan H Lindeman, Melanie M van der Klauw, Ferrucci, L. (Luigi), Chasman, Daniel I, Stolk, RP (Ronald), Sõber, S, Nolte, IM (Ilja), Singleton, Andrew, Johnson, T., Salomaa, V, Webster, R.J., Felix, Janine, Daniela Toniolo, Lumley T, Eric J G Sijbrands, Siscovick, David, Mark Lathrop, Jaspal S Kooner, Liu Y, Soranzo, N. (Nicole), Esko, T??nu, Uda, Manuela, John P. Beilby, Scholz M, Breteler, M., Parker, Alex N., Dena Hernandez, Harris T, Francis S Collins, Snieder, H, Bergmann, Sven, Bergmann, S.M. (Sven), Daniel I. Chasman, Loos, R.J.F. (Ruth), Debette, S, Wareham, N.J. (Nick), Del Greco, F. (Fabiola), Burke, G.L., König IR, Lorna M. Lopez, Parsa A, Alavere, H. (Helene), Pola?ek O.,, Esko, T, Henneman, Peter, Nicholas J Wareham, Stefansson, K. (Kari), Hengstenberg C, Goel, A., 't Hoen, Peter A. C., Marco Orru, Vincent Mooser, van Dijk, K.W., Krishnan U, Risch N, Alizadeh, Behrooz Z, Wilkinson IB, Erdmann, J., Arora, Pankaj, Laitinen, J, Del Greco M, Fabiola, Boban, M, Simon Heath, Paavo Zitting, Marisa Loitfelder, Fabretto, Antonella, Lindeman, JH, Jukema, J.W., Schmidt, Helena, Lucas, G. (Gavin), Luigi Ferrucci, Corsi, A.M., Goncalo R. Abecasis, Tobin, Martin D, Deloukas P, H-Erich Wichmann, Inke R. König, Faletra, F, Benjamin EJ, Del Greco M, F, Mooser, V. (Vincent), Loley C, Brenda W Penninx, CKDGen Consortium, the, Wain, L.V. (Louise), Musk, A.W. (Arthur), James Scott, Rankin A, Syvannen AC, Penninx, Brenda W., Beckmann, J.S., Janssens, A.C.J.W., Bruce M Psaty, Chambers, John C., Alizadeh, B.Z. (Behrooz), Penninx, B.W., Waeber, Gerard, John F Peden, Polasek, O., Dijk, K.W. van, Collins, Francis S., Schunkert H, Harris, TB, David Altshuler, Pilz S, Wareham, Nicholas J., Laitinen, Jaana, De Backer, Gui, Abecasis, GR, Oostra, B.A. (Ben), Wang, TJ, Tõnu Esko, Zhao, J.H., Eardman J, Vitart, V, Larson, M.G., Fortmann S, Hayward, C, Jennifer L. Bragg Gresham, Mattace-Raso, F.U., Chen IY, Post WS, Gyllensten, U. (Ulf), Strachan, DP, Vasan, R.S., Tanguy Corre, Glazer, N.L., Helena Schmidt, Van Bortel, Lucas, Spector, TD, Li, X.Z., Najjar, Samer S, Georg B. Ehret, Igor Rudan, Wain, L., Milaneschi, Y., Rietzschel ER, Debette, Stephanie, Benjamin F Voight, Siscovick, D.S. (David), Ferrucci, L., Van Bortel L, Jouke-Jan Hottenga, Uwe Völker, Bruce M. Psaty, Anita L DeStefano, Chen, Y.D.I. (Yii-Der Ida), Peden, JF, Uda, M. (Manuela), Lehtimäki, T, Strachan, David P, null null, Tammesoo, ML, Ilja M. Nolte, Pierre Meneton, Shi, G., Tiret L, Felix, Janine F, Heimerl S, Abecasis, G.R. (Gonçalo), Lakatta EG, Samani, Nilesh J., Flavio Faletra, Stéphanie Debette, Campbell, H, Pichler, I. (Irene), Fabretto, A., Marciante K, Hofman, Bert, Lindeman, Jan H., Hercberg, S. (Serge), Toniolo, D., De Bacquer, Dirk, Gillebert, Thierry, Watkins, H, Jukema, J Wouter, Eiriksdottir G, Ehret, Georg Benedikt, Mitchell, G.F., Hall A, Ferrucci, Luigi, Kenneth M Rice, Siscovick, D, Gary F Mitchell, Spector, Tim D., Sijbrands, Eric J G, Jorma Viikari, Witteman JC, Snieder, H., Ulivi, Sheila, Nicaud V, Kleber M, Kay-Tee Khaw, Fu, Jingyuan; id_orcid, Heyo K Kroemer, Uitterlinden, André, Pouta, Anneli, Khaw, K-T, Meneton, Pierre, Sanna S, Gieger, C., Terho Lehtimäki, Pihur, Vasyl, Verwoert, G.C. (Germaine), Walter Palmas, Davies, G., Stolk, Ronald P., Ridker, Paul M, Mika Kähönen, Nicola Pirastu, Elliott, P. (Paul), Sven Bergmann, Gudmar Thorleifsson, Lenore Launer, O'Donnell, Christopher J., Richard N. Bergman, Lehtim??ki, Terho, Jarvelin, M-R, Pola??ek, Ozren, Stella Trompet, Loitfelder, Marisa, Altshuler, D, Corre, T. (Tanguy), John P Beilby, Clarke, Robert, Patricia B Munroe, Chambers, JC, Mangino, Massimo, de Geus, E.J.C.; id_orcid, Irene Pichler, Lyle J Palmer, Verwoert, Germaine, Hadley, D, Lucas, G, Fu, JY, Elin Org, Wild, S.H., Clarke, R., Palmas, W. (Walter), Gonneke Willemsen, Abecasis, Goncalo R., Hamsten, A. (Anders), James F Wilson, Stefansson, K., Johnson, AD, Alan F Wright, Siscovick, D., Facheris, M., Massimo Mangino, Jingyuan Fu, Johnson, A., Halit Ongen, Willemsen, G, Caroline Hayward, Harris, Tamara B., Boomsma, D.I.; id_orcid, Ramachandran S. Vasan, 't Hoen, PAC, Fu, J., Gérard Waeber, Harry Campbell, Rice K, Strachan, D.P., Chen, Y.D.I., Inês Barroso, Jan H. Lindeman, Schmidt, R, Chen, YDI, Uitterlinden, André; id_orcid, Lieb W, Farrall, Martin, Uitterlinden A, Schmidt, H, Kahonen, Mika, Henry Völzke, Ben A Oostra, Veronique Vitart, Rivadeneira, F., Mooser, V, Viikari, J, Rudan, Igor, Christopher J. O'Donnell, Beckmann, Jacques S., Gulde S, Zitting, P., Zeginigg, M. (Marion), Launer, L., Ko Willems van Dijk, Crisp-Hihn A, Lathrop, M., Lopez, LM, Johnson, Toby, Anita L. DeStefano, Facheris, M, O'Donnell, Christopher J, A William Musk, Meitinger, T, Pirastu, N. (Nicola), Rettig, R., Tang H, Witteman, Jacqueline CM, Debette, S., Thorsteinsdottir, U., Grammer TB, Keis, A, Boomsma, DI, Hung, Joseph, Rainer Rettig, Mattace-Raso FU, Spector, Tim D, Chakravarti, A., Uitterlinden, A.G., Sarah H Wild, Sigurdsson S, Lu, X, Bekaert S, Ridker, P.M. (Paul), Abecasis GR, Järvelin, M.R., Psaty, BM, Ferrucci L, Holm, H. (Hilma), Org, Elin, Oostra BA, Willemsen, G., Melander, Olle, Plump, A.S. (Andrew), Glazer, Nicole L, Smith, NL, James F. Wilson, Boomsma, D.I., Psaty, B.M., Raitakari, O. (Olli), Hofman, A, van der Klauw, Melanie M, Galan, P. (Pilar), Rudan, I, Hopewell, JC, Doering A, LifeLines Cohort Study, the, Andrew D Johnson, Vitart, V., Beilby, John P., Stott, D, Döring, A, Isaacs A, Hopewell, J., Jouke Jan Hottenga, Witteman, J.C.M. (Jacqueline), Pilar Galan, Uda M, Jian'an Luan, Vollenweider, P. (Peter), Henneman, P., Wendy L McArdle, Nilesh J Samani, Luan, J.A., Hamsten, Anders, Henneman, P, Haller, T., Loos, Ruth JF, Burke, Gregory L., Boehnke, M., Vasan, Ramachandran S, Singleton, A, Parker, A.N., Snieder, Harold; id_orcid, Kundu, S, Fornage, Myriam, Corre, T, Amin, N. (Najaf), Fu, Jingyuan, Mangino, M., Bandinelli, S, Milaneschi, Yuri, Fu, J. (Jingyuan), Ongen, H, Nicole L Glazer, Rose, LM, Uitterlinden, Andre G., Rettig, Rainer, Reinhold Schmidt, Keis, Aime, Hung, J., Thorsteinsdottir U, Heath, S, Blankenberg S, Groop, L., Lu, X., Loos, Ruth J F, CHARGE Consortium Heart Failure, Hugh Watkins, Gasparini, P, Deary, Ian J, Altshuler, D., Goodall AH, Hofman, A., Sober, Siim, Smith, Albert V, Schmidt, Reinhold, Lindeman, J.H., Heyo K. Kroemer, Jarvelin, Marjo-Riitta, D??rr, Marcus, Wichmann, H-E, Voight, Benjamin F., Sijbrands, E.J.G.; id_orcid, König, I.R. (Inke), Gider, Pierre, David Stott, Ulivi, S. (Shelia), Bergman, R.N., Martin G Larson, K??hnel, Brigitte, Salomaa, Veikko, Bergman, Richard N., Collins, Francis S, König, Inke R., Kundu, S. (Suman), Lu, XW, Sala, Cinzia, Andres Metspalu, Debette, S. (Stéphanie), Guiducci C, EchoGen consortium, Deary, I.J. (Ian), Segers, Patrick, Andrew D. Johnson, de Geus, EJ, Valur Emilsson, Santhi K Ganesh, Laan, M., Lord, Graham, Kähönen, M, Hopewell, Jemma C., Nolte, Ilja M, Aravinda Chakravarti, Rice, Kenneth M., Chasman, Daniel I., Mark J Caulfield, Caulfield, M.J., Kooner, J.S., Fernando Rivadeneira, Gieger, C. (Christian), Launer LJ, Sijbrands, Eric JG, Sijbrands, EJG, Shih-Jen Hwang, Mangino, M, Schmitz G, Kooner, Jaspal S, Daniel I Chasman, Pihur, V., Beilby, J.P. (John), Newman AB, Nicholas J. Wareham, Germaine C Verwoert, Loos, Ruth J. F., Paul F O'Reilly, Sie MP, Heath, S.C. (Simon), Corrado Masciullo, Gwilliams R, Duijn, C.M. van, Angela Döring, Loos, RJF, Munroe, Patricia B., Harris TB, Cupples L, Nolte, Ilja M.; id_orcid, Proust C, Collins, F.S., Scott, J, CHARGE Consortium Heart Failure Working Group, Palmer, Lyle J, O'Donnell, C.J. (Christopher), van der Klauw, MM, Yasmin, Schroeder L, Kong A, Stott, D.J. (David. J.), Verwoert, Germaine C, Holm, Hilma, Rao, D.C. (Dabeeru C.), Hottenga, JJ (Jouke Jan), Pfeufer, A. (Arne), Alex N. Parker, Breteler, M.M.B. (Monique), Toby Johnson, Ganesh, Santhi K., Van Duijn, Volker, U., De Meyer T, Stott, D.J., Bergman, RN, Vasan, Ramachandran S., Johnson AD, Musunuru K, Bragg-Gresham, JL, Louise V. Wain, Eco J C de Geus, Wright, A.F. (Alan), Jing Hua Zhao, McArdle, W.L. (Wendy), Hadley, D. (David), Melander, O. (Olle), Vitart, V. (Veronique), Luan, J., Janine F. Felix, Psaty, B.M. (Bruce), Wild, Sarah H, Fabiola Del Greco M, 't Hoen, Peter AC, Stott, David, Zeginigg, M, Ulivi, S., Rudan, I., Thomas J. Wang   +999 more
core   +2 more sources

Meta-Analysis in Genome-Wide Association Studies [PDF]

Pharmacogenomics, 2009
The advent of genome-wide association studies has allowed considerable progress in the identification and robust replication of common gene variants that confer susceptibility to common diseases and other phenotypes of interest. These genetic effect sizes are almost invariably moderate to small in magnitude and single studies, even if large, are ...
Zeggini, E., Ioannidis, J. P.
openaire   +3 more sources

A Genome-Wide Association Study Identifies Genomic Regions for Virulence in the Non-Model Organism Heterobasidion annosum ss [PDF]

, 2013
The dense single nucleotide polymorphisms (SNP) panels needed for genome wide association (GWA) studies have hitherto been expensive to establish and use on non-model organisms.
Brandström Durling, Mikael, Mikael Brandström-Durling, Stenlid, Jan,, Olson, Åke,, Sveriges lantbruksuniversitet., Jan Stenlid (102750), Kerstin Dalman (102738), Himmelstrand, Kajsa,, Himmelstrand, Kajsa, Mårten Lind (102744), Kerstin Dalman, Mårten Lind, Olson, Åke, Lind, Mårten,, Kajsa Himmelstrand (102739), Jan Stenlid, Åke Olson (102741), Stenlid, Jan, Lind, Mårten, Mikael Brandström-Durling (102747), Dalman, Kerstin,, Brandström Durling, Mikael,, Åke Olson, Kajsa Himmelstrand, Dalman, Kerstin   +24 more
core   +3 more sources

A genome-wide interaction study of thyroid-stimulating hormone levels and particulate matter exposure among Koreans

Genes and Environment
Background Although the associations between air pollution exposure and thyroid function have been reported, the interactive effects of the genes involved remain unknown. Therefore, we aimed to identify candidate genetic loci involved in thyroid function
Young Jun Park, Hyun-Jin Kim, Ho-Young Son, Juhyun Kim, Jae Moon Yun, Hyuktae Kwon, Belong Cho, Jin-Ho Park, Jong-Il Kim   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A genome-wide association search for type 2 diabetes genes in African Americans [PDF]

, 2011
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Bostrom, Meredith A, Ingelsson, E., Shields, B.M., Fischer-Rosinsky, A., Sanna, Serena, Roh, BH, Boerwinkle, E., Anneli Pouta, Qi, L., Hicks, Andrew A, Fedson, A.C., Palmer, L.J., Laura J McCulloch, Fedson, AC, Cao, A, Lajunen, T., Glazer, NL, Toshiko Tanaka, Peter Shrader, Kao, Wen H L, Tiinamaija Tuomi, Couper, DJ, Christine Cavalcanti-Proença, Steven A McCarroll, Kaprio, Jaakko, Navarro, Pau, Hammond, Naomi, Roh, B., Antti Jula, Qi, Lu, Soumya Raychaudhuri, Palmer, CN, Uitterlinden, André G, Perry, J.R., Thomas A Buchanan, Syvänen, A.C., Barroso, Inês, Divers Jasmin, Boehm, Bernhard O, Qi Sun, Stefansson, K, Johnson, Paul RV, Benediktsson, R., Dedoussis, GV, de Geus, E.J., Ardlie, Kristin, Nigel W Rayner, Kong, A., Eric Brunner, Qi, L, Michael A Province, de Geus, Eco J C, Denis Rybin, Smith, GD, Hallmans, Göran, Rivadeneira, F, Meigs, JB, Meredith A Bostrom, Ganser, M, Raychaudhuri, Soumya, Antonio Cao, Visvikis-Siest, S., Zethelius, Björn, Johnson, T, Alisa K Manning, Steve A McCarroll, Jula A, Patrik K E Magnusson, Penninx, B.W.J.H., Syddall, H, Jarvelin MR, Freedman, BI, Platou, Carl Geoffrey Parrinder, Jessica M. 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Y., Posthuma, D.; id_orcid, Illig, T, Jerome I Rotter, McDonough, Catrin W, Cristen J Willer, de Geus, E.J.C., Willemsen, G.; id_orcid, Prokopenko, I, Payne, Felicity, Ganser, Martha, Navarro, P., Day, I.N., Kristian Hveem, Hattersley, Andrew T, Florez, JC, Kaisa Silander, Kovacs, Peter, Reedik Mägi, Michael N Weedon, Grarup, N., Hayward, Caroline, Schwarz, Peter, van Vliet-Ostaptchouk, Jana V, Albert Hofman, Kaakinen, M., Amanda J Bennett, Voight, B.F., Lingyi Lu, Rotimi, C.N., Olov Rolandsson, Göran Hallmans, Hottenga, Jouke Jan, Hicks, AA, Megan E Rudock, Kuusisto, Johanna, An, Ping, Adeyemo, A., McDonough CW, Weedon, MN, Barter, Philip, Oostra, B.A., Rayner, NW, Elliott, Amanda, Watkins, Hugh, Christian Gieger, Buchanan, Thomas A, Daniel Shriner (137188), Amanda L Elliott, Christine Proença, Divers, J, Morken, Mario A, Lathrop, G.M., Samy Hadjadj, Kristin Ardlie, Song, Kijoung, Michael Boehnke, Spector, T.D., Sijbrands, E.J., Elliott, Amanda L, Taina Lajunen, Scott, LJ, Hicks, P.J., Jessica N Cooke, McDonough, C., Wilson, JF, Forouhi, NG, Dina, Christian, Bumpstead, S.J., Waeber, G, Shields, B., Aulchenko, Yurii S, Perry, John RB, Jose C Florez, Province, Michael A, Peter Nilsson, Carl D Langefeld, Raychaudhuri, S, Carl Platou, Williams, G.H., Robert Sladek, Crisponi, L., Gloyn, AL, Petersen, Ann-Kristin, McDonough, CW, Shields, BM, Paolisso, Giuseppe, Zillikens, MC, Leif Groop, Hadjadj, Samy, Couper, D.J., Goncalo R Abecasis, Bumpstead, S, McPherson, R., Erdos, Michael R, Braxton D Mitchell, Froguel, P., Peter Kovacs, Timpson, N.J., Matthew J Neville, Froguel, P, Fox, Caroline S, Sutapa Mukherjee, Rocheleau, Ghislain, Johnson, PR, Uda, M., Pedersen, Oluf, Mark Walker, Wheeler, E., Groop, L, Boehnke, M, Sanna, S, Isomaa, B., Hillman, DR, Wing, Maria, Hitman, G.A., Assiamira Ferrara, Peltonen, L, Kaakinen M, Owen, Katharine R, Hu, F.B., Sharp, SJ, Cooper, Matthew N, Langenberg, C, Owen, K.R., Strassburger, Klaus, Tuomi T, McCulloch, Laura J, Bostrom, Meredith, Swift, A.J., Simon C Potter, Joshua P. Lewis (190257), Cao, A., Waeber, Gérard, Sijbrands, Eric, Bochud, Murielle, Jana V van Vliet-Ostaptchouk, Lind, Lars, Palmer, Colin NA, Ebrahim, S., Hveem, K., Navarro, P, Le Bacquer, Olivier, van Dijk, KW, Kong, Augustine, Kesaniemi YA, Wagner, P.J., Mooser, Vincent, Uitterlinden, AG, Sovio, U, Joshua Randall, Gieger, C, Pakyz, Ruth, Mandy van Hoek, van Vliet-Ostaptchouk, JV, Gérard Waeber, Wichmann, H-Erich, Marmot, M, Welch, R.P., Matthew E. Talbert (190255), Goel, Anuj, Watkins, H., Pfeiffer, Andreas FH, Timothy D Spector, Schlessinger, D., Isomaa, B, Narisu, N., Seppo Koskinen, Ziegler Julie T., Chines, P.S., van Duijn, CM, Graessler, J., Pramstaller, Peter Paul, Sparsø, T, MAGIC Consortium,, Langefeld, CD, Campbell, Harry; id_orcid, Jarvelin, M.R., Blagieva, Roza, Scott Grundy, Singleton, Andrew, Johnson, T., Salomaa, V, Sethupathy, Praveen, Steinthorsdottir, V, Todd Green, Serrano-Ríos, Manuel, Province, MA, Eric J G Sijbrands, Shuldiner, A.R., Rudock, M.E., Lieverse, A, Elliott, Katherine S, Magnusson, PK, Uda, Manuela, Isomaa, Bo, Prokopenko, Inga, Francis S Collins, Bergmann, Sven, Amy J Swift, Hofmann, Oliver M, Eleftheria Zeggini, Neville, MJ, Jacqueline Witteman, Paolisso, G., Kanoni, S., Scuteri, A., Hunter, David J, Sparsø, Thomas, Ariyurek, Y., Mukherjee, Sutapa, Crisponi, Laura, Chines, Peter S, Maria R Wing, Hitman, Graham A, Henneman, Peter, Rotter, Jerome I, Nicholas J Wareham, Claudia Langenberg, Joe Hung, Bong H. Roh (190243), Bostrom, MA, Visvikis-Siest, Sophie, Goel, A., Bowden, Donald W., Hicks, PJ, Udo Seedorf, Vincent Mooser, Uitterlinden, A, van Dijk, K.W., Julie T. Ziegler (190269), Lyssenko, V, Naitza, S, Bonnefond, A., Bostrom, M.A., Sale, Michele M, Bravenboer, B., Forouhi, Nita G, Marmot, M., Laakso M, Hicks, P., Adeyemo, Adebowale, Palmer, Nicholette D., Grarup, Niels, Luigi Ferrucci, Crawford, Gabe, Morris, A.D., H-Erich Wichmann, Hester, J., Caitrin W. McDonough (190241), Hicks PJ, Rocheleau, G, van Dam, R.M., Kesaniemi, Y Antero, Yvonne Böttcher, Hester, JM, Anna L Gloyn, Bruce M Psaty, Jula, A, Freedman, B.I., Nita G Forouhi, Sampson, Michael J, McCarthy, M.I., Penninx, B.W., John F Peden, Raychaudhuri, S., Polasek, O., Charpentier, Guillaume, Koskinen, S., Uitterlinden, A., Posthuma, Danielle, Tichet, J., Jean Tichet, Stein, L.D., David Altshuler, Syvänen, AC, Deloukas, Panos, Lind, L, Ardlie, K., Megan E. Rudock (190251), Abecasis, GR, Petersen, AK, Karpe, Fredrik, Elliott, K.S., Angela Silveira, Zhao, J.H., Bouatia-Naji, N, Vitart, V, Ziegler, J.T., Hayward, C, Jasmin Divers (171577), Coin, Lachlan J M, Kanoni, Stavroula, Koskinen S, Glazer, N.L., Bostrom, M., Annelli Sandbaek, Bravenboer, B, Burtt, Noël P, Spector, TD, Delplanque, J., Goodarzi, MO, Igor Rudan, Lewis, Joshua P., Nicole Vogelzangs, Roh, B.H., Benjamin F Voight, Paul Scheet, Talbert Matthew E., Robert Mahley, Ferrucci, L., Hartikainen, A.L., Ardlie, K, Talbert, ME, David Melzer, Jørgensen, Torben, Hveem, Kristian, Spranger, Joachim, Kesaniemi, YA, Manning, AK, Sophie Visvikis-Siest, Buchanan, T.A., Tönjes, A, Hester Jessica M., Peden, JF, Witteman, Jacqueline, S Sandy An, Magnusson, P.K., Kaakinen, M, Benediktsson, R, Bumpstead, Suzannah, Ruth McPherson, Pierre Meneton, Hassanali, N., Sigurdsson, Gunnar, Elliott, A., Cornelis, Marilyn, Cisca Wijmenga, Campbell, H, Bouatia-Naji, Nabila, Hartikainen AL, Langenberg, Claudia, Watkins, H, Lincoln D Stein, Elliott, AL, Ferrucci, Luigi, Paul W Franks, Matthew N Cooper, Eric Sijbrands, Cooper, C., Sijbrands, Eric J G, Michael Stumvoll, Ward, Kim L, Matthew E Talbert, Franklin, CS, Niels Grarup, Talbert, M., Day, IN, Sandbaek, A., Roden, Michael, Kraft, P, Pouta, Anneli, Lieverse, A., Kao, W H Linda, Pouta A, Meneton, Pierre, Anke Tönjes, Shrader, Peter, Gieger, C., Siscovick, DS, Zeggini, Eleftheria, Jürgen Graessler, Green, Todd, Province, M.A., David Meyre, Shah Ebrahim, Sven Bergmann, Lathrop, GM, Gudmar Thorleifsson, Grallert, Harald, Cyrus Cooper, Zabena, Carina, Daly, Mark J, Sparsø, T., Altshuler, D, Lawlor, DA, John P Beilby, Clarke, Robert, Sun, Qi, Waterworth, D.M., Mangino, Massimo, de Geus, E.J.C.; id_orcid, Irene Pichler, Lyle J Palmer, Lu, L., Wild, S.H., Wing Maria R., Clarke, R., Gonneke Willemsen, Christopher J Groves, Rudock, Megan E., Rybin, D., Hassanali, Neelam, Tichet, J, Ferreira, T, Zhai, Guangju, James F Wilson, van Herpt, T, Chines, Peter, Midthjell, K., Stefansson, K., Forouhi, N.G., Hallmans, G., Rayner, N William, Meyre, David, Alan F Wright, Ward, K.L., Visvikis-Siest, S, Scheet, P, Johanna Kuusisto, Massimo Mangino, Saxena, Richa, Rosa Maria Roccasecca, Nathan, David M, Sun, Q., Willemsen, G, Caroline Hayward, Boomsma, D.I.; id_orcid, Mukherjee, S., Navarro, Pau; id_orcid, Proença, C, Harry Campbell, Andrew Walley, Sethupathy, P., Bert Bravenboer, John W G Yarnell, Cavalcanti-Proença, C., Scuteri, A, Bowden, DW, Cooper, MN, Ben A Oostra, Veronique Vitart, Proença, Christine, Saxena, R., Rivadeneira, F., Meredith A. Bostrom (190249), Angelo Scuteri, Mooser, V, Rudan, Igor, Sigurdsson, G., Song, K., Jarred B McAteer, Griffin, S, Smith, George Davey, O'Connell, J, Syddall, H., An, S Sandy, Nancy L Pedersen, Rice, K, Inês Barroso, Ingrid B Borecki, Ko Willems van Dijk, Rotimi Charles N., Lu, L.Y., Ben-Shlomo, Yoav, Huth, Cornelia, Andrew D Morris, Potter, SC, Wijmenga, Cisca, Weedon, Michael N, Sovio, U., Freedman, Barry I., Johnson, Toby, Ghislain Rocheleau, Salomaa V, Divers, J., Simpson, L., Spranger, J., Lawlor, Debbie A, Meitinger, T, André G Uitterlinden, Ferrara, , Assiamira, Han, X., Syddall, Holly, Pankow, JS, Day, Ian NM, Thorsteinsdottir, U., Boomsma, DI, Zelenika, D., Cécile Lecoeur, Lu, L, Mohlke, KL, Palmer ND, Rocheleau, G., Martínez-Larrad, M.T., Cavalcanti-Proença, C, Cooper, C, Uitterlinden, A.G., Antje Fischer-Rosinsky, Sarah H Wild, Penninx, Brenda W J H, Hicks, Pamela, Philippe Froguel, Shriner, D., Goodarzi, M.O., Pankow, James S, Serrano-Ríos, M, Wing, Maria R., Psaty, BM, Zeggini, E., Walker, M., Willemsen, G., McPherson, Ruth, Tuomi, T, Cao, Antonio, Lajunen, T, Dupuis, J., Lindgren, C.M., Bennett, AJ, Glazer, Nicole L, Rybin, Denis, Smith, NL, Jaakko Kaprio, Boomsma, D.I., Psaty, B.M., Ulla Sovio, Hansen, Torben, Hofman, A, Dina, C, Sovio, Ulla, Proença, C., Franklin, C.S., Perry, John R B, van Hoek, Mandy, Frayling, T.M., Pramstaller, Peter P, Rudan, I, Wu, G., Narisu, N, Blagieva, R, Vitart, V., Boström, KB, Pedersen, O, Kyvik, K.O., Cooper, Cyrus, Lachlan J M Coin, Jouke Jan Hottenga, Wing, M.R., Sayer, Avan Aihie, Pilar Galan, Katharine R Owen, Michele M. Sale (3944525), Hayward, Caroline; id_orcid, Jian'an Luan, Henneman, P., Diana Zelenika, Polasek, O, Sun, Q, Samuli Ripatti, Hamsten, Anders, Henneman, P, Loos, Ruth JF, Zethelius, B, Seedorf, Udo, Sladek, Rob, Boehnke, M., McDonough Caitrin W., Wu, Guanming, Silander, K, Jasmin Divers, Singleton, A, McCarthy, Mark I, van Herpt, T., Karpe, F, Kivimäki M, Palmer, N.D., Michael J Sampson, Ng, M.C., Mangino, M., Ruokonen, A., Griffin, S., Franks, P.W., Kuusisto, J, Zabena, C, Bonnycastle, LL, Sanna, S., Nicole L Glazer, Silander, K., Rybin, D, Cavalcanti-Proença, Christine, Lyssenko, V., Hung, J., Jorgensen, T, Groop, L., Eco J C de Geus, Torben Jørgensen, Walker, M, Kyvik, Kirsten Ohm, Loos, Ruth J F, Hugh Watkins, Roccasecca, RM, Rob M van Dam, Pearson, D, Simpson, L, Kim L Ward, Zethelius, B., Carina Zabena, Stephane Cauchi, Altshuler, D., Borch-Johnsen, K., Timpson, Nicholas J, Hofman, A., Lu Qi, Marika Kaakinen, Manjinder Sandhu, Watanabe, R.M., Meisinger, Christa, Beverley M Shields, Valgerdur Steinthorsdottir, Jarvelin, Marjo-Riitta, Cecilia M Lindgren, Melzer, D, Perola M, Franzosi, Maria Grazia, Böttcher, Y., Markku Laakso, Barter, P., Praveen Sethupathy, Bergman, R.N., Roden, M, Martínez-Larrad, MT, Cauchi, Stephane, Salomaa, Veikko, Collins, Francis S, Laakso, M, Hillman, David R, Ingelsson, Erik, Eleanor Wheeler, Fischer-Rosinsky, Antje, Lauritzen, T, Avan Aihie Sayer, Abbas Dehghan, Rudock Megan E., de Geus, EJ, McCarthy, MI, Kao, WH Linda, Ping An, Manuel Serrano-Ríos, Gyllensten, U., Shields, B, Doney, Alex S F, Jessica N. Cooke (190248), Saxena, R, Shields, Beverley, Melzer, David, Thomas Illig, Giuseppe Paolisso, Michael Marmot, Crawford, G., Roza Blagieva, Hide, W.A., DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Gieger, C. ; Klopp, N. ; Meitinger, T. ; Petersen, A.-K. ; Wichmann, H.-E. ; Illig, T.), Scuteri, Angelo, Andrew A Hicks, Cornelis, M, Sandy An, S, Huth, C., Michael Roden, Fernando Rivadeneira, Debbie A Lawlor, George Davey Smith, Norman Klopp, Sijbrands, Eric JG, Varma, D, Spranger, J, Sladek, Robert, Uitterlinden, Andre, Martínez-Larrad, María Teresa, Mangino, M, An, P., Robertson, NR, Silvia Naitza, Kovacs, P., Herder, C., Thorand, Barbara, Kyvik, Kirsten Ohm; id_orcid, Hunter, DJ, Simon Griffin, DIAGRAM Consortium, Wagner, PJ   +999 more
core   +5 more sources

A genomic‐based vision on the genetic diversity and key performance traits in selectively bred Arctic charr (Salvelinus alpinus)

Evolutionary Applications, 2022
Routine implementation of genomic information for guiding selection decisions is not yet common in the majority of aquaculture species. Reduced representation sequencing approaches offer a cost‐effective solution for obtaining genome‐wide information in ...
Christos Palaiokostas, Anam Anjum, Henrik Jeuthe, Khrystyna Kurta, Fernando Lopes Pinto, Dirk Jan deKoning   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source