Results 71 to 80 of about 40,713,960 (307)
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke [PDF]
, 2012 Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of ...Furie, K., Seedorf, Udo, Cathie L M Sudlow, Spencer, C.C.A., Woo, D., Müller-Myhsok, B., Jackson, C. A., Sawcer, SJ, Markus, Hugh S, Lindgren, Arne,, Segal, H, Viswanathan, Ananth C., Syme, P. D., Valerie Valant, Rautanen, A, Matthew Traylor, Gray, E, Sarah Edkins, Attia, J., Palmer, C., Rothwell, Peter M., Juan P Casas, Levi, Chris, Worrall, Bradford B, Levi, C., Jankowski, J., Peltonen, L, Palmer, Colin N. A., Sawcer, S., Edkins, Sarah, Delavaran, Hossein,, Kissela, Brett, Pankaj Sharma, WTCCC2, Sharma, P, Goel, A, Gray, E., Joanna Pera, Palmer, CN, Boonen, S., Worrall, BB, Dorota Wloch-Kopec, Cordelia Langford, Helgadottir, A, Steve Bevan, Su, Zhan, Rothwell, Peter M, Sudlow, Cathie LM, Wellcome Trust Case Control Consortium 2 (WTCCC2) (), Bradford B Worrall, Viswanathan, A.C., Hossein Delavaran, Valant, V., Nalls, Michael A., Stefansson, K, Donnelly, P, Palmer, Colin NA, Worrall, B., Wloch-Kopec, D., Martin Farrall, Elvira Bramon, Lindgren, Arne, Valant, V, Kittner, Steven J., Corvin, A., Syme, PD, Meisinger, Christa, Schanz, R., Delavaran, H, Goel, Anuj, Audrey Duncanson, Unnur Thorsteinsdottir, Syme, P.D., Bramon, E, Stephen J Sawcer, Pirinen, Matti, Burgess, A., Kissela, B., Cheng, Y., Helen Segal, Cheng, YC, Meschia, JF, Edkins, S., Levi, C, Parati, E. A., Rainer Malik, Meschia, J., Trembath, R., Cortellini, L., Burgess, AI, Trembath, RC, ?, ?, Langford, C, Boncoraglio, G. B., Bevan, S, Poole, D, International Store Genetics Consortium, Burgess, A.I., Spencer, Chris CA, Spencer, Chris, Nalls, M.A., Bellenguez, C., Matthew Walters, Traylor, M, Boncoraglio, G.B., Attia, John, Freeman, Colin, Jackson, Caroline; id_orcid, Lemmens, Robin, Spencer, Chris C. A., Sudlow, Cathie L M, Ross-Adams, H., Thijs, V, Gray, Emma, Hugh S Markus, Dichgans, M, Nicholas W Wood, Wellcome Trust Case Control Consortium 2 (WTCCC2), Brown, MA, Norrving, Bo,, Wood, N.W., Brown, M., Burgess, Annette I, International Stroke Genetics Consortium (Meisinger, C.), Emma Gray, Mitchell, BD, Colin Freeman, Giorgio B Boncoraglio, Norrving, B., Franzosi, MG, James, T., Slark, Julia, Mitchell, B., Murphy, Lee, Wood, N. W., Goel, A., Julia Slark, Seedorf, U, Boonen, S, Udo Seedorf, Boonen, Steven, Sharma, Pankaj, Deborah Poole, Rothwell, PM, Casas, J., Su, Z., Edkins, S, Cheng, Yu-Ching, Colin N A Palmer, Franzosi, M., Lund University., Lee Murphy, Elizabeth Holliday, Wood, Nicholas W, Rothwell, P., Viswanathan, Ananth C, Norrving, Bo, Anuj Goel, Tom James, Casas, J. P., Gretarsdottir, S., Sarah Hunt, Sudlow, C.L.M., Gschwendtner, A., Bevan, Steve, Deloukas, P., Müller-Myhsok, Bertram, Janusz Jankowski, Yu-Ching Cheng, Macleod, M.J., Dronov, S, Slowik, A, Walters, Matthew, Meschia, James F, Pera, J, Plomin, R, Spencer, CCA, Casas, JP, Brown, Matthew A, Mathew, Christopher G., Peltonen L, Holliday, E., Slowik, A., Bramon, Elvira, Plomin, Robert, Cheng, Y. C., Band, G., Thorsteinsdottir, U, Helen Ross-Adams, Sudlow, C., Strange, A, Band, Gavin, Markus, H.S., Wellcome Trust Control Consortium, Rautanen, A., Nalls, Michael A, Worrall, B. B., Blackwell, J. M., Casas, Juan P., Deloukas, Panos, Macleod, MJ, Thijs, Vincent, Spencer, C., Ananth C Viswanathan, Traylor, M., Duncanson, A., Poole, Deborah, Bramon, E., Wloch-Kopec, D, Spencer, CC, Holliday, E, Macleod, Mary Joan, Band, G, Palmer, CNA, Bevan, S., Viswanathan, AC, Poole, D., Schanz, R, Macleod, M., Palmer, C. N. A., Meisinger, C., Furie, Karen, Viswanathan, A., Woo, Daniel, Delavaran, H., Dronov, S., International Stroke Genetics Consortium (ISGC), Anna Helgadottir, Kissela, B, Corvin, Aiden, Sudlow, CL, Casas, J.P., Annette I Burgess, Markus, H. S., Helgadottir, Anna, Panos Deloukas, Jackson, C., Jackson, Caroline A., Mitchell, Braxton D., Walters, M., Bertram Müller-Myhsok, Franzosi, M-G, Bo, N, Donnelly, P., Burgess, A. I., Andreas Gschwendtner, Deloukas, P, Rosand, Jonathan, Gavin Band, Langford, C., Vincent Thijs, Sawcer, Stephen J, Cortellini, L, Delavaran, Hossein, Solveig Gretarsdottir, Peltonen, L., Burgess, Annette I., Wood, N., Lemmens, R, Mueller-Myhsok, Bertram, Parati, E.A., Franzosi, M. G., Farrall, M, Segal, H., Corvin, A, Kittner, Steven J, Mathew, Christopher G.; id_orcid, Sudlow, Catherine; id_orcid, Valant, Valerie, Hunt, S., Leena Peltonen, Palmer, C.N.A., Franzosi, Maria-Grazia, Mary Joan Macleod, Segal, Helen, Wood, Nicholas W., Arne Lindgren, Hunt, S, Bellenguez, Céline, Daniel Woo, Kari Stefansson, Rothwell, P.M., Furie, K, Matti Pirinen, Murphy, L, Céline Bellenguez, Dichgans, M., Boncoraglio, Giorgio B, Peter M Rothwell, Blackwell, Jenefer M., Christopher G Mathew, Duncanson, A, Jonathan Rosand, Trembath, Richard C, Sudlow, CLM, Chris C A Spencer, Pera, Joanna, Nalls, M. A., Meisinger, C, Rosand, J., James F Meschia, Palmer, Colin N A, Gudmar Thorleifsson, Wloch-Kopec, Dorota, Robin Lemmens, Agnieszka Slowik, Markus, H., Lemmens, R., Slark, J., Kittner, S. J., Boncoraglio, Giorgio B., Viswanathan, A. C., Cortellini, Lynelle, Peltonen, Leena, Sawcer, Stephen J., Seedorf, U., Parati, E., Peter Donnelly, Serge Dronov, Worrall, Bradford B., Mitchell, Braxton D, Malik, R., Boncoraglio, GB, Strange, Amy, Lindgren, A, Caroline A Jackson, Freeman, C., Thorsteinsdottir, Unnur, Brown, M. A., Jenefer M Blackwell, Bo, N., Wood, NW, Langford, Cordelia, Ross-Adams, Helen, Parati, Eugenio A, Hunt, Sarah, Stefansson, K., Blackwell, Jenefer M, Boncoraglio, G., Markus, HS, Rosand, J, Jackson, Caroline A, Norrving, B, Dronov, Serge, Anna Rautanen, Farrall, M., Jackson, CA, Sudlow, C. L. M., Thorleifsson, G, Malik, R, Slowik, Agnieszka, Lindgren, A., Amy Strange, Mathew, C., Renata Schanz, James, Tom, Ross-Adams, H, Matthew A Brown, Farrall, Martin, Syme, Paul D, Schanz, Renata, Mathew, CG, Helgadottir, A., Donnelly, Peter, Brett Kissela, Stefansson, Kari, Pirinen, M., Sharma, P., Mathew, Christopher G, Martin Dichgans, Nalls, M., Zhan Su, Parati, EA, Attia, J, Gretarsdottir, Solveig, Trembath, Richard C., Kittner, S., Pirinen, M, Nalls, MA, Cheng, Y-C, Müller-Myhsok, B, Strange, A., Blackwell, JM, Slark, J, Sudlow, Cathie L. M., Thorsteinsdottir, U., Kittner, S.J., Mathew, C. G., Su, Z, Plomin, R., Kittner, SJ, Spencer, Chris C A, Jackson, C.A., Worrall, B.B., Casas, Juan P, Gschwendtner, Andreas, Dichgans, Martin, Blackwell, J., Thorleifsson, G., Michael A Nalls, Gschwendtner, A, Macleod, M. J., Aiden Corvin, Eugenio A Parati, Murphy, L., Rautanen, Anna, Thorleifsson, Gudmar, Jankowski, Janusz, Freeman, C, Syme, P., Sawcer, S.J., Meschia, J. F., Steven J Kittner, John Attia, Brown, Matthew A., Rothwell, P. M., Syme, Paul D., ISGC, Parati, Eugenio A., Markus HS, Robert Plomin, James, T, Walters, M, Mitchell, B. D., Bo Norrving, Trembath, R. C., Meschia, J.F., Pera, J., Duncanson, Audrey, Mitchell, B.D., Woo, D, Spencer, C. C. A., Markus, Hugh S., Jankowski, J, Blackwell, J.M., Chris Levi, Thijs, V., Gretarsdottir, S, Christa Meisinger, Richard C Trembath, Holliday, Elizabeth, Steven Boonen, Mathew, C.G., Murphy, Lee; id_orcid, Bellenguez, C, Meschia, James F., Malik, Rainer, Braxton D Mitchell, Sawcer, S. J., Traylor, Matthew, Karen Furie, Trembath, R.C., Lynelle Cortellini, Maria-Grazia Franzosi, Paul D Syme, Palmer, Colin N. A.; id_orcid +455 morecore +2 more sourcesA genome-wide association study identifies protein quantitative trait loci (pQTLs) [PDF]
, 2008 There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and ...Marjo-Riitta Jarvelin, Simon-Sanchez, J, Hana Lango, Henley W, Greg Tranah, HURST A., Singleton, A, Murray, A, WEEDON M., McCarthy, Mark I, Rafferty I, Lango H, David Melzer, Rafferty, Ian, Singleton A, Bandinelli, S, Bennett, A, BRITTON A., Hurst, A, Newman, Anne B, van de Leemput J, Colin Dayan, GIBBS J., Paolisso, G, Lango, H, Dayan, Colin; id_orcid, Hurst A, Anne B Newman, Murray, Anna, FRAYLING T., Tranah, G, Panicker, V, Perry, John R. B., SHOLZ S., Frayling, Timothy M., Ferrucci, Luigi, Scholz, Sonja, Corsi AM, RICE N., Simon-Sanchez J, J Raphael Gibbs, Tranah G, Harris, Tamara, Jarvelin, Marjo-Riitta, Ruokonen A, Jarvelin, Marjo Riitta, Melzer, D, Paolisso G, Javier Simon-Sanchez, AREPALLI S., Amanda Bennett, Timothy M Frayling, Murray A, Scholz, S, Henley, William E., Hernandez D, Fulvio Lauretani, Hurst, Alison, Singleton, Andrew, RAFIQ S., Jarvelin MR, Rafiq S, McCarthy, MI, Perry, JR, Rafiq, S, Arepalli, S, van de Leemput, Joyce, PANICKER V., TRANAH G., Guralnik, J, Stevens K, Dayan, Colin M., Melzer, David, Rongling Li, Giuseppe Paolisso, Gibbs, J. Raphael, STEVENS K., Sajjad Rafiq, Corsi, Anna Maria, Perry JRB, Bennett A, Harris, T, Perry, John R.B., Bandinelli, Stefania, Nicole Washecka, Lauretani, Fulvio, Lango, Hana, Dena Hernandez, Harris T, Scholz S, McCarthy, Mark I., Frayling, Timothy M, William Henley, HARRIS T., Guralnik J, Stevens, K, Panicker, Vijay, Jack Guralnik, Li, R, DAYAN C., McCarthy MI, Rice N, Weedon, Michael N., Sampath Arepalli, Dayan C, Guralnik, Jack, Lauretani, F, John R B Perry, Melzer D, Dayan, C, Newman, Anne B., Lauretani F, RAFFERTY I., Britton A, Newman AB, Sonja Scholz, Angela Britton, HERNANDEZ D., Frayling TM, Corsi, Anna-Maria, Britton, A, Washecka, Nicole, Andrew Singleton, Ferrucci, L, Tamara Harris, LANGO H., Gibbs, JR, BENNET A., Perry, JRB, Dayan, Colin Mark, Michael N Weedon, Weedon, Michael N, Luigi Ferrucci, Bennett, Amanda, Neil Rice, Rice, N, Anna-Maria Corsi, BANDINELLI S., Washecka, N, Henley, William, Ruokonen, Aimo, Henley, W, Gibbs JR, SIMON SANCHEZ J., Kara Stevens, Arepalli, Sampath, Stevens, Kara, Joyce van de Leemput, MELZER D., Weedon MN, Frayling, TM, Panicker V, SINGLETON A., Weedon, MN, Dayan, Colin, Jarvelin, MR, Anna Murray, Arepalli S, Ferrucci L, FERRUCCI L., Rice, Neil, Li, Rongling, Tranah, Greg, Washecka N, HENLEY W., MCCARTHY M., Perry, John RB, Ruokonen, A, JARVELIN M., Li RL, VAN DE LEEMPUT J., Rafiq, Sajjad, PERRY J., Hernandez, Dena, WASHECKA N., Mark I McCarthy, Vijay Panicker, Ian Rafferty, MURRAY A., LI R., Newman, AB, Bandinelli S, NEWMAN A., Gibbs, J Raphael, Paolisso, Giuseppe, GURALNIK J., Hernandez, D, CORSI A., Van De Leemput, J, Simon-Sanchez, Javier, Stefania Bandinelli, Alison Hurst, RUOKONEN A., Corsi, AM, Britton, Angela, Rafferty, I, Aimo Ruokonen, et al, +197 morecore +1 more sourceGenome-wide association studies with metabolomics [PDF]
Genome Medicine, 2012 Genome-wide association studies (GWAS) analyze the genetic component of a phenotype or the etiology of a disease. Despite the success of many GWAS, little progress has been made in uncovering the underlying mechanisms for many diseases. The use of metabolomics as a readout of molecular phenotypes has enabled the discovery of previously undetected ...openaire +2 more sourcesFrom mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato +2 morewiley +1 more sourceCommon genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis [PDF]
, 2011 Objectives: To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being ...Donovan, Jenny, Rosalind A. Eeles, Eyre, S, Kote-Jarai, Zsofia, Goh, Chee L., Neal, David E., Freddie C. Hamdy, Giles, GG, Kote-Jarai, Z, Giles, Graham, Eyre, S; id_orcid, Ali Amin Al Olama, Govindasami, K, Muir, K R; id_orcid, Al Olama, AA, Guy, M, Easton, Douglas F., Giles, G G, Govindasami, Koveela, Hamdy, Freddie C., Donovan, J L, Benlloch, Sara, Chee L. Goh, Guy, Michelle, Goh, CL, Zsofia Kote‐Jarai, Muir, KR, Al Olama, Ali Amin, Al Olama, A A, Eeles, R A, Neal, D E, Hamdy, FC, Benlloch-Garcia, S, Donovan, JL, Eyre, Steve, Muir, Kenneth, Neal, DE, Sara Benlloch‐Garcia, Severi, G, Eeles, RA, David E. Neal, Steve Eyre, Orozco, Gisela, Hamdy, F C, Michelle Guy, Hamdy, Freddie, Goh, C L, Severi, Gianluca, Koveela Govindasami, Jenny L. Donovan, Kenneth R. Muir, Graham G. Giles, Easton, DF, Gianluca Severi, Orozco, G, Douglas F. Easton, Easton, D F, Gisela Orozco, Eeles, Rosalind A. +58 morecore +1 more sourceGenome-Wide Association Studies and Beyond [PDF]
Annual Review of Public Health, 2010 Genome-wide association studies (GWAS) provide an important avenue for undertaking an agnostic evaluation of the association between common genetic variants and risk of disease. Recent advances in our understanding of human genetic variation and the technology to measure such variation have made GWAS feasible.openaire +2 more sources
