Results 91 to 100 of about 40,713,960 (307)
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels [PDF]
, 2009 The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n =Stewart, A.F.R., Stewart, AFR, O'Rahilly, S. (Stephen), Epstein, S.E., Pastinen, Tomi, Samani, NJ, O'Rahilly, S., Abecasis, Gonçalo R., Witteman, JC, Langenberg Claudia, Hall, A.S. (Alistair), Beate Glaser, Kijoung Song, Hengstenberg, Christian, Stephen E Epstein, Ruth J. F. Loos, Evans, D, Daniel J Rader, Witteman, J., Wichmann, H.-E., Willenborg, C., Toshiko Tanaka, Mary-Susan Burnett, Stark, K, Hingorani Aroon, König, Inke R, Langenberg, C, Samani, N., Van Duijn, C.M., Stark, K. (Klaus), Peter Vollenweider, Stark Klaus, Willenborg, C. (Christina), Robert K. Semple, Evans, D., Davey Smith George, Van Duijn, CM, Richards, J.B., Erdmann Jeanette, Loos, Ruth J F, Grassl, M., Josephine M. Egan, Davey Smith, George, Perry, John R. B., Wichmann, H.E., Frayling, Timothy M., Sladek, R. (Rob), Wichmann, H.E. (Heinz Erich), Barter Phil, Stewart Alexandre F. R., Mooser, Vincent, Waeber Gerard, John R Thompson, Vollenweider Peter, Reinhard, W, Ricketts Sally L., Waterworth, D. (Dawn), Meigs, J., Stark, Klaus, Davey Smith, G., Wichmann, H-Erich, Willenborg, Christina, Melzer, D, Pastinen, T., Reilly Muredach P., Rocha, Nuno, Hivert, MF, Thompson, J., Sattar, N, Smith, GD, Barter, P., König, I.R. (Inke), Winogradow, J, Meigs, JB, Stewart, Alexandre F.R., Reinhard, W. (Wibke), Semple, Robert K.; id_orcid, Nicholas John Timpson, Hall, AS, Ferrucci, L. (Luigi), Hivert, M., Scott Grundy, Christina Willenborg, ?, ?, Naveed Sattar, Witteman, Jaquelin C. M, Hall, A., Duijn, Cornelia, Florez, Jose, Sladek, R, Van Duijn Cornelia M., Saxena, R, Reilly, Muredach P., Soranzo, N. (Nicole), Melzer, David, Mahley Robert, Glaser, B, Prokopenko, Inga, Christian Hengstenberg, Schunkert, H, Dupuis, Josee, Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Aulchenko, Y, Koenig, Inke R., George Davey Smith, Loos, Ruth J.F., Thompson, JR, Frayling Timothy M., Barter, Phil, Deloukas Panos, Aulchenko Yurii, Sladek, Robert, Hengstenberg, C. (Christian), Wareham, N.J., Schunkert, H., Marie-France Hivert, Glaser Beate, John R B Perry, Reilly, M.P. (Muredach), Nicholas J Wareham, Claudia Langenberg, Timothy M, Rader Daniel J., Thompson, John R, McPherson, R. (Ruth), Erdmann, Jeanette, Spector, T., Vincent Mooser, Thompson, John R., O'Rahilly, Stephen, Loos, Ruth J. F., Josée Dupuis, Rader, D.J. (Daniel), Burling, K.A. (Keith), Tim D Spector, Ferrucci, L, Erdmann, J., Jose C. Florez, Konig, IR, Loos, RJF, Reilly, M., Tomi Pastinen, Dupuis, J, Luigi Ferrucci, Burnett, M., McPherson, R, Reilly, MP, Alexandre F R Stewart, H-Erich Wichmann, Brent Richards, J., Deloukas, P., Inke R. König, Egan, JM, Hivert Marie-France, Ferrucci Luigi, Mooser, V. (Vincent), Erdmann, J, Keith Burling, Grundberg, E, Burling, K, Frayling, T.M. (Timothy), Muredach P. Reilly, Grundy, S.M. (Scott), Kesaniemi, Y Antero, Burnett, MS, Waterworth, Dawn, Wareham, NJ, Consortium, GIANT, Waterworth, D, Egan, J., Frayling, TM, Waterworth, D., Perry, J.R.B. (John), Janina Winogradow, Meigs, James B., Evans, David, Martina Grassl, Waeber, Gerard, Ruth J F Loos, Semple, Robert K., Witteman Jaquelin C. M., Wareham, N., Samani, N.J. (Nilesh), Winogradow, Janina, Grundy, S, Rader, D., Cornelia M. Van Duijn, Deloukas, Panos, Rocha, N. (Nuno), Prokopenko Inga, Wareham, Nicholas J., Grundberg Elin, Van Duijn, C., Grundy, Scott, Barter, P. (Phil), Deanfield, J., Meigs, J.B., Tikka-Kleemola, P. (Päivi), Perry, J.R.B., Hengstenberg Christian, McPherson Ruth, Rader, DJ, Epstein Stephen E., Burnett, Mary-Susan, Smith, A.V. (Davey), Egan, J.M., Hivert, Marie-France, Burnett Mary-Susan, Witteman, Jaquelin C M, Willenborg, C, James B Meigs, Timpson Nicholas John, Alistair S Hall, Vollenweider, P, Stewart, Alexandre F. R., Hingorani, A, Soranzo Nicole, Dupuis, J. (Josée), Mahley, R, Spector, TD, Elin Grundberg, Semple, R.K., Grassl, M. (Martina), Tanaka, T, Aulchenko, Y.S. (Yurii), Grundberg, E. (Elin), Stewart, A.F.R. (Alexandre), GIANT Consortium, Burnett, M.-S., Panos Deloukas, Consortium, G., Dupuis Josée, Ferrucci, L., Robert Mahley, Waterworth Dawn, David Melzer, Richards, J Brent, Deanfield, John, Reinhard Wibke, Tanaka, T., Kesaniemi, YA, Deloukas, P, Winogradow, J., Florez Jose C., Reinhard, W., Devaney, J., Glaser, B., Song, K. (Kijoung), Ruth McPherson, Meigs, J.B. (James), Kesaniemi, Y., Tanaka Toshiko, Kesaniemi, Y. Antero, Reinhard, Wibke, Josephine M Egan, Hall, Alistair S., Samani, Nilesh J., Prokopenko, I. (Inga), Song, K, Langenberg, Claudia, Vollenweider, P., Winogradow, J. (Janina), Waeber, G. (Gérard), Sattar Naveed, Pastinen, T, Ferrucci, Luigi, Soranzo, N, Sladek Robert, Ricketts, S.L. (Sally), Wibke Reinhard, Sattar, Naveed, O'Rahilly Stephen, Spector, Tim D., Jeanette Erdmann, Richards, J.B. (Brent), Schunkert Heribert, Grundberg, Elin, Burnett, M.S., Rocha Nuno, Devaney Joseph, Florez, Jose C, Egan Josephine M., Hingorani, Aroon, Egan, Josephine M., Phil Barter, Hengstenberg, C, Inga Prokopenko, Stark, K., Hingorani, A., Erdmann, J. (Jeanette), Joseph Devaney, Timothy M Frayling, Frayling, T., Epstein, SE, J. Brent, Thompson, J.R., Perry, J., Samani, N.J., Rader, Daniel J., David Evans, Soranzo, N., Epstein, S., Waeber, G., Pastinen, T. (Tomi), Winogradow Janina, Glaser, Beate, Perry, JR, Wichmann, HE, Florez, J.C., Epstein, S.E. (Stephen), Wichmann, H., Semple Robert K., Sladek, R., Alistair S. Hall, Davey Smith, G, Y Antero Kesaniemi, Gerard Waeber, Thompson, J.R. (John), Perry, John R.B., Wichmann H-Erich, Egan, Josephine M, Richards, J. Brent, Semple, Robert K, Kesaniemi, Y.A. (Antero), Tanaka, T. (Toshiko), Saxena Richa, Egan, J.M. (Josephine), Saxena, Richa, Florez, J.C. (Jose), Burling Keith, Mooser Vincent, Timpson, Nicholas John, Van Duijn, Cornelia M., Timpson, NJ, Ricketts, SL, Epstein, Stephen E., Spector Tim D., Semple, R., Aulchenko, Yurii S., Nilesh J. Samani, Rocha, N, Devaney, Joseph, Prokopenko, I, Thompson John R., Florez, J., Richards J. Brent, Yurii Aulchenko, Aulchenko, Y., Saxena, R., Samani Nilesh J., Semple, RK, Mooser, V, Sattar, N. (Naveed), Ricketts, Sally L, Song, K., Grundberg, E., Langenberg, C., Ricketts, S., J. Brent Richards, Muredach P Reilly, Florez, JC, Smith, George Davey, Spector, T.D. (Timothy), Cornelia M Van Duijn, Kesaniemi, Y.A., Vollenweider, Peter, Saxena, R. (Richa), Perry, JRB, Wareham Nicholas J., John Deanfield, Prokopenko, I., Soranzo, Nicole, Burling, Keith, Witteman, JCM, Rader, D.J., Melzer David, Grassl, M, König, I.R., Perry John R. B., Stewart, A., Devaney, J. (Joseph), Song Kijoung, Sattar, N., Witteman, Jaquelin C.M., Mahley, R., Dawn Waterworth, John R. Thompson, Melzer, D. (David), Melzer, D., Evans, D.M. (David), Loos, R., Hingorani, A. (Aroon), Re F. R. Stewart, Mooser, V., Stephen E. Epstein, Pastinen Tomi, Richa Saxena, Mahley, R. (Robert), König, I., König, Inke R., Timpson, N., Nuno Rocha, Nicole Soranzo, Hengstenberg, C., Grundy Scott, Hivert, M.-F., Loos, RJ, O'Rahilly, S, Sally L Ricketts, Loos Ruth J. F., Barter, P, Stewart, AF, Wichmann, Heinz-Erich, Robert K Semple, Devaney, J, Mahley, Robert, Ricketts, Sally L., Heribert Schunkert, Klaus Stark, John R. B. Perry, Deanfield John, Schunkert, H. (Heribert), McPherson, Ruth, Tanaka, Toshiko, Dupuis, J., J Brent Richards, Aroon Hingorani, Inke R König, Daniel J. Rader, Song, Kijoung, Hivert, M.-F. (Marie-France), Jaquelin C M Witteman, Grassl, Martina, Schunkert, Heribert, Spector, T.D., Loos, R.J.F., Hall, Alistair S, Grassl Martina, Waeber, G, Semple, R.K. (Robert), Hall, A.S., Grundy, S., Florez, Jose C., Witteman, Jaquelin C. M., Perry, John R B, Frayling, T.M., Y. Antero Kesaniemi, Jose C Florez, Sally L. Ricketts, Evans David, Rocha, N., Willenborg Christina, Robert Sladek, Aulchenko, Yurii, Stephen O'Rahilly, Citation Richards, Meigs, James, Kesaniemi Y. Antero, Witteman, J.C.M. (Jacqueline), Richards, J., Timpson, N.J. (Nicholas), Deanfield, J. (John), Meigs James B., Aulchenko, Yuriy, Witteman, J.C.M., Glaser, B. (Beate), Richards, JB, König Inke R., Vollenweider, P. (Peter), Burling, K., Deanfield, J, McPherson, R., Deloukas, P. (Panagiotis), Nilesh J Samani, Timpson, N.J., Langenberg, C. (Claudia), Hall Alistair S., Reilly, M.P., Jaquelin C. M. Witteman, Ricketts, S.L., Smit George, Davey, Kesaniemi Y. Antero,, Van Duijn Cornelia, M, Richards J. Brent,, Ricketts Sally, L, Thompson John, R, Stewart Alexandre F. R,, Samani Nilesh, J., Epstein Stephen, E, Reilly Muredach, P, Koenig Inke, R, Hall Alistair, S, Rader Daniel, J, Meigs James, B., Timpson Nicholas, John, Wareham Nicholas, J., Spector Tim, D., Frayling Timothy, M., Semple Robert, K, Egan Josephine, M., Witteman Jaquelin, C. M., Grundberg, Elin, Perry John R. B,, Loos Ruth J. F,, Florez Jose, C. +505 morecore +2 more sourcesGenome-Wide Association Study of Vascular Dementia [PDF]
Stroke, 2012 Background and Purpose— Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods— We performed a genome-Schrijvers, Elisabeth M.C., Schürmann, Britta, Koudstaal, Peter J., Van Den Bussche, Hendrik, Van Duijn, Cornelia M., Hentschel, Frank, Heun, Reinhard, Hofman, Albert, Jessen, Frank, Kölsch, Heike, Kornhuber, Johannes, Peters, Oliver, Rivadeneira, Fernando, Rüther, Eckart, Uitterlinden, André G., Riedel-Heller, Steffi, Dichgans, Martin, Wiltfang, Jens, Maier, Wolfgang, Breteler, Monique M.B., Ikram, M. Arfan +20 moreopenaire +5 more sourcesInvestigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post +3 morewiley +1 more sourceMeta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]
, 2014 Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...Rasmussen-Torvik, Laura J., Ayo Doumatey, Jennifer A. Pacheco (496628), MEDIA Consortium (), Daniel S. Evans (230365), Dhananjay Vaidya, Liu, YM, Loren L Armstrong, McKnight, Barbara, Lynne Wagenknecht (610797), Boerwinkle, E., Zhao, W, Fornage, Myriam, M Geoffrey Hayes, Beverly M. Snively (156128), Palmer, N.D., Becker, Diane M, Langefeld, Carl D, Goodarzi, Mark O., Sudha K. Iyengar (129292), James G. Wilson (113688), Mathias, Rasika A, Peyser, Patricia A., Chen, B.H., Myriam Fornage (45591), Kao, W.H.L., Jensen Richard A., Rice Kenneth, Liu Simin, Borecki, IB, Kraja, A, Borecki, Ingrid B., Yanek, LR, Yang Lingyao, Palmer Nicholette D., Rasmussen-Torvik, Laura J, Kabagambe, E.K., Lowe, W.L., Adeyemo Adebowale, Leslie J Raffel, Laura J. Rasmussen-Torvik (174672), Iyengar, S.K., Palmer, Nicholette D, Doumatey, A, Boerwinkle, Eric, Bowden, Donald W, Nalls, Michael A., Doumatey, Ayo, Xiuqing Guo (73591), Armstrong, Loren L., Zhao, Wei, Evans, Michele K., Chen, Y.-D. Ida, Boerwinkle, E, Bowden, D.W., Y-D Ida Chen (610799), Dana C. Crawford (102216), Pacheco, J.A., Taylor, HA, Chen, Brian H, Guanjie Chen, Evans, DS, Raffel, LJ, William L Lowe, Rich, Stephen S., Alan B. Zonderman (178692), Sedor, J.R., Hsueh, Wen-Chi, Chen, Guanjie, Jensen, Richard A., Wen-Chi Hsueh, Ping An (24129), Couper, David J., Michael A Province, Mudgal, P., Becker, D.M., Dana C Crawford, Andrew B. Singleton (178128), Guo Xiuqing, Crawford, DC, Barry I. Freedman (120811), Lu, YC, Langefeld, CD, Vaidya, Dhananjay, Cummings, Steven R, Taylor, H.A.J., Goodarzi Mark O., Rasmussen-Torvik, LJ, Bielak Lawrence F., Lu, Y., Jirong Long, Simin Liu, Erwin P. Bottinger (3212694), Zonderman Alan B., ?, ?, Sale Michèle M., Wei Zhao, Freedman, BI, Blot, William J., Steven R Cummings, Aldi Kraja, McKnight, B., Pankow James S., Cummings, Steven R., Lu, Yingchang, Province, MA, Peyser, PA, Borecki, Ingrid B, Ping An, Kao, WH Linda, Raffel Leslie J., Rotimi, Charles N, Nalls, M.A., Nicholette D. Palmer (190239), Shu, X.O., Jennifer A Pacheco, McKnight Barbara, Robert P. Igo Jr. (5660086), Aldi Kraja (73605), Vaidya, D, James S Pankow, Chen, Y-D Ida, Sedor, John R., Sedor, John R, Guo, Xiuqing, MuTHER Consortium (), Leslie J. Raffel (610798), Rice, Kenneth, Sun, Y.V., Keene Keith L., Wei Zheng, Lawrence F Bielak, Mark O. Goodarzi (123440), Wagenknecht Lynne, Crawford, D.C., FIND Consortium (), Li, Jiang, Herman A. Taylor Jr. (5660083), Adebowale Adeyemo, Xiao-Ou Shu, Bielinski, S.J., Mathias, Rasika A., Armstrong, LL, Rotimi, CN, Hayes, M Geoffrey, David S. Siscovick (174822), Chen Wei-Min, Sale, Michèle M., Rotter, Jerome I, Maggie C. Y. Ng (190281), An, P., Rice, K., Mudgal Poorva, Bowden, Donald W., Long, Jirong, Hayes, MG, David S Siscovick, Lowe, WL, Singleton, Andrew B., Adolfo Correa, Igo Robert P., Yanek Lisa R., Loos, Ruth J. F., Yanek, Lisa R, DIAGRAM Consortium, Barbara McKnight, Ng, MCY, Loos, RJF, Bowden Donald W., Raffel, L.J., Yingchang Lu, Nicholette D Palmer, Diane M Becker, Sims, M, Armstrong, L.L., Evans, M.K., Wilson, James G, Adeyemo, Adebowale, Omri Gottesman, Palmer, Nicholette D., Sun, Yan V, Jensen, R.A., Chen Brian H., Couper David, Langefeld Carl D., Shu, X., Lawrence F. Bielak (446522), Josyf C. Mychaleckyj (171602), Nayak Uma, Sun, Yan V., Long Jirong, Sims Mario, Kraja Aldi, Ng Maggie C. Y., Laura J Rasmussen-Torvik, Chen, Y.I., Goodarzi, Mark O, Chen, Brian H., Province Michael A., Rasika A Mathias, Grundberg, E, Comeau, Mary E, Mychaleckyj, JC, Keene, K.L., James S. Pankow (174656), Igo, R.P., Wagenknecht, Lynne, Rich Stephen S., Mychaleckyj, Josyf C., Bruce M Psaty, Snively Beverly M., Hayes M. Geoffrey, Freedman, B.I., Ruth J F Loos, Armstrong Loren L., Vaidya Dhananjay, Shriner, D, Yingchang Lu (149264), DIAGRAM Consortium (Gieger, C. ; Grallert, H. ; Illig, T. ; Klopp, N. ; Müller-Nurasyid, M. ; Peters, A.), Gottesman, O., Rotter Jerome I., Lingyao Yang (215359), M. Geoffrey Hayes (327753), Kao, WHL, Rotter, J.I., An Ping, William J. Blot (191278), Yang, LY, Nalls, Michael A, Couper, David, Bottinger, Erwin P, Loren L. Armstrong (529937), Crawford, Dana C, Grundberg Elin, Carl D. Langefeld (120828), Kraja, A., Pacheco, Jennifer A., John R. Sedor (306528), Patel, S.R., Michèle M Sale, Correa, A, Chen, GJ, Bottinger, Erwin P., Guo, XQ, Wilson, James G., Pankow, James S., Suzette J Bielinski, W H Linda Kao, Jerome I. Rotter (103729), Singleton, A.B., Yongmei Liu, Myriam Fornage, Bottinger Erwin P., Eric Boerwinkle, Becker, Diane M., Patel, Sanjay R., Yang, L., Evans Daniel S., Rotimi, Charles N., Langefeld, Carl D., Sale, M.M., Keith L Keene, Sale, MM, Peyser Patricia A., Chen, G., Zheng, W, Blot, W.J., Patel, Sanjay R, Diane M. Becker (113669), Sudha K Iyengar, Doumatey Ayo, Keene, KL, Iyengar Sudha K., Lynne Wagenknecht, Ayo Doumatey (255558), W. H. Linda Kao (160779), Chen, Y.-D.I., Hsueh Wen-Chi, Armstrong, Loren L, Pacheco Jennifer A., Gottesman, O, Sims, Mario, Brian H. Chen (610796), Daniel S Evans, Gottesman, Omri, Goodarzi, MO, Michael A. Province (53600), Elin Grundberg, Mychaleckyj, Josyf C, Robert P Igo, Rotter, JI, David Couper (215307), Zonderman, Alan B., Becker, DM, Psaty, Bruce M., Daniel Shriner, Y-D Ida Chen, Charles N. Rotimi (137216), Bielak, L.F., Lowe, William L., Long, J., Bielak, Lawrence F, Liu, J., Taylor, Herman A, Kenneth Rice, Jiankang Liu, Evans, Daniel S, Zonderman, Alan B, Mathias, RA, Raffel, Leslie J., Beverly M Snively, Zheng Wei, Kraja, Aldi, Liu, JK, Michele K Evans, Zheng, W., An, P, Wei Zhao (14321), Jirong Long (181371), Kao W. H. Linda, Borecki Ingrid B., Wilson James G., Cummings, S.R., Patricia A Peyser, Guanjie Chen (28943), Zonderman, AB, Cummings, SR, Richard A. Jensen (103656), Jiankang Liu (48049), Taylor, H.A., Fornage Myriam, Uma Nayak (446511), Ruth J. F. Loos (110224), Sims, M., Bielinski Suzette J., Poorva Mudgal (522965), Mario Sims, Kabagambe, Edmond K., Guo, X., Chen, BH, Patel, SR, Josyf C Mychaleckyj, Rasika A. Mathias (134405), Ng, Maggie CY, Donald W Bowden, Mudgal, P, Psaty, Bruce M, Doumatey, A., William L. Lowe (610802), Mathias Rasika A., Igo, Robert P., Shriner Daniel, Nayak, U, Simin Liu (11987), Charles N Rotimi, Grundberg, Elin, Michael A. Nalls (113680), Correa Adolfo, Long, JR, Bottinger, EP, Qiuyin Cai (25449), Bielinski, SJ, Liu, Jiankang, Mary E. Comeau (192855), Igo, R.P.J., Wilson, J.G., Edmond K Kabagambe, Jiang Li, Adeyemo, A, Mark O Goodarzi, Mario Sims (412259), Siscovick, DS, Uma Nayak, Bielak, LF, Evans, MK, Elin Grundberg (116416), Mudgal, Poorva, McKnight, B, Freedman Barry I., Cai Qiuyin, Province, M.A., Hayes, M.G., Blot, WJ, Correa, A., Rich, SS, Lisa R Yanek, MEta-analysis of type 2 DIabetes in African Americans Consortium, Singleton Andrew B., Langefeld, C.D., Mychaleckyj, J.C., Shu, XO, Freedman, Barry I, Sanjay R. Patel (120915), Becker Diane M., Lingyao Yang, Edmond K. Kabagambe (127046), Palmer, ND, Jiang Li (272926), Siscovick David S., Igo, RP, Wen-Chi Hsueh (264276), Michèle M. Sale (113676), Chen Guanjie, Comeau, ME, Li, J, Cummings Steven R., Keene, Keith L, Iyengar, Sudha K., Xiao-Ou Shu (25450), Ingrid B. Borecki (113678), Fornage, M., Singleton, Andrew B, Zheng, Wei, Bruce M. Psaty (103721), Shriner, Daniel, Bielak, Lawrence F., Kabagambe Edmond K., Evans, Daniel S., Eric Boerwinkle (36288), Chen, Wei-Min, Rasmussen-Torvik Laura J., Wei-Min Chen (110472), Comeau, M.E., Rasmussen-Torvik, L.J., Sedor John R., Liu, SM (Simin), William J Blot, Patricia A. Peyser (446515), Wei Zheng (25452), Ng, Maggie C. Y., Pacheco, JA, Jensen, Richard A, Hayes, M. Geoffrey, Jerome I Rotter, Siscovick, David S., Kabagambe, Edmond K, Liu, Simin, Kabagambe, EK, Nayak, Uma, Michele K. Evans (27920), Maggie C Y Ng, Yanek, L.R., Rich, S.S., Gottesman Omri, Chen, YDI, Keene, Keith L., Bowden, DW, Couper, D, Mychaleckyj Josyf C., Crawford, Dana C., Raffel, Leslie J, Liu, Yongmei, Sun Yan V., Yanek, Lisa R., Grundberg, E., Liu, S., Rice, K, Ingrid B Borecki, Hsueh, W.C., Snively, Beverly M, Province, Michael A., Peyser, P.A., Crawford Dana C., Rotimi Charles N., Li, J., Comeau Mary E., Boerwinkle Eric, Cai, Q., Freedman, Barry I., Vaidya, D., Barry I Freedman, David Couper, Poorva Mudgal, Nalls, MA, Pacheco, Jennifer A, Hsueh, WC, Fornage, M, Bottinger, E.P., Zhao, W., Cai, Qiuyin, John R Sedor, Snively, B.M., Igo, Robert P, Adolfo Correa (610800), Shu Xiao-Ou, Qiuyin Cai, Siscovick, D.S., Pankow, JS, Comeau, Mary E., Siscovick, David S, FIND Consortium, Rotimi, C.N., Sale, Michèle M, Erwin P Bottinger, Iyengar, Sudha K, Cai, QY, Taylor Herman A., Taylor, Herman A., Sedor, JR, Mathias, R.A., Michael A Nalls, Zhao Wei, Loos Ruth J. F., Yan V Sun, Evans, Michele K, Liu Yongmei, Suzette J. Bielinski (262597), Omri Gottesman (133442), Nalls Michael A., Donald W. Bowden (120806), Shriner, D., Yang, Lingyao, Rich, Stephen S, An, Ping, Adeyemo, A., Blot, William J, Goodarzi, M.O., Sanjay R Patel, Alan B Zonderman, Pankow, James S, Lowe, William L, Daniel Shriner (137188), Xiuqing Guo, Bielinski, Suzette J., Wagenknecht, L, Lisa R. Yanek (113564), Chen Y-D Ida, Psaty, BM, Snively, Beverly M., Adebowale Adeyemo (28944), Wagenknecht, L., Evans Michele K., Steven R. Cummings (361400), Bielinski, Suzette J, Herman A Taylor, Andrew B Singleton, Loos, R.J.F., Psaty, B.M., MuTHER Consortium, Wilson, JG, Barbara McKnight (103714), Brian H Chen, Iyengar, SK, Stephen S. Rich (110262), Ng, M.C.Y., Hsueh, W., Lu Yingchang, Province, Michael A, Singleton, AB, Pankow, J.S., Carl D Langefeld, Zonderman, A.B., Jensen, RA, Chen, WM, Psaty Bruce M., Couper, D., Stephen S Rich, Sun, YV, Correa, Adolfo, Yan V. Sun (446508), Shu, Xiao-Ou, Blot William J., Borecki, I.B., James G Wilson, Kao, W. H. Linda, Evans, D.S., Nayak, U., Peyser, Patricia A, Snively, BM, Mary E Comeau, Liu, Y., Richard A Jensen, Chen, W., Rotter, Jerome I., Wei-Min Chen, Lowe William L., Dhananjay Vaidya (149887), eMERGE Consortium, Liu Jiankang, Kenneth Rice (211836), Yongmei Liu (104713), Patel Sanjay R., eMERGE Consortium (), Keith L. Keene (540212), Li Jiang, Loos, Ruth JF +585 morecore +2 more sourcesA Genome-Wide Association Study of Myasthenia Gravis [PDF]
JAMA Neurology, 2015 Myasthenia gravis is a chronic, autoimmune, neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups. Although genetic factors are known to play a role in this neuroimmunological condition, the genetic etiology underlying myasthenia gravis is not well understood.To identify genetic variants that alter susceptibility to ...Renton, Ae, Pliner, Ha, Provenzano, Carlo, Evoli, Amelia, Ricciardi, R, Nalls, Ma, Marangi, Giuseppe, Abramzon, Y, Arepalli, S, Chong, S, Hernandez, Dg, Johnson, Jo, Bartoccioni, Emanuela, Scuderi, Flavia, Maestri, M, Gibbs, Jr, Errichiello, E, Chiò, A, Restagno, G, Sabatelli, Mario, Macek, M, Scholz, Sw, Corse, A, Chaudhry, V, Benatar, M, Barohn, Rj, Mcvey, A, Pasnoor, M, Dimachkie, Mm, Rowin, J, Kissel, J, Freimer, M, Kaminski, Hj, Sanders, Db, Lipscomb, B, Massey, Jm, Chopra, M, Howard, Jf, Koopman, Wj, Nicolle, Mw, Pascuzzi, Rm, Pestronk, A, Wulf, C, Florence, J, Blackmore, D, Soloway, A, Siddiqi, Z, Muppidi, S, Wolfe, G, Richman, D, Mezei, Mm, Jiwa, T, Oger, J, Drachman, Db, Traynor, Bj +54 moreopenaire +4 more sourcesGenome-Wide Association Study Implicates Immunogenetic Variation in Chemokine Signaling Pathways in Pediatric Tuberculosis Susceptibility
Journal of Human ImmunityIntroductionAlthough immune responses to Bacillus Calmette–Guérin (BCG) vaccination and susceptibility to mycobacterial infection vary across individuals, the underlying cellular mechanisms regulating this heterogeneity are poorly understood.Christine Anterasian, Kim Dill-McFarland, Josh Ivie, Humphrey Mulenga, Justin Shenje, Simon C. Mendelsohn, Munyaradzi Musvosvi, Elisa Nemes, Javeed A. Shah, Thomas J. Scriba, Mark Hatherill, Tom Hawn, CORTIS Kids Study Team +12 moredoaj +1 more sourceAn epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz +14 morewiley +1 more sourceEvaluation of association of HNF1B variants with diverse cancers : collaborative analysis of data from 19 genome-wide association studies [PDF]
, 2010 Background
Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk.Tomlinson, IP, Mann, GJ, Hwang, Shih-Jen, Hopper, John L., Hwang, SJ, Amos, CI, Barkardottir, Rosa B., McCarthy, Mark I, Carvajal-Carmona Luis, Albanes, D, Xu, J, Armstrong, Bruce K., Kenneth Muir, Stefansson Kari, Jacobs, EJ, Amos Christopher I., Zanke, B, Barkardottir, Rosa B, Jenab, M, Michaud, DS, Xu Jianfeng, Mendelsohn, JB, Muir, K, Hamdy, Freddie C., Stolzenberg-Solomon, RZ, Aitken, JF, Mathieu Lemire, Aitken, Joanne F., John P. A. Ioannidis, null null, Hunter, David, Hallmans, G, Donovan, Jenny L, Murabito Joanne M., Risch, HA, Hamdy, FC, Rafnar Thorunn, Giles, Graham G., Donovan, JL, Tomlinson, Ian P. M., Hunter David J., Margaret R Spitz, Macgregor, Stuart, Tomlinson Ian P. M., Spitz, Margaret R., Hopper, JL, David E. Neal, Duell, EJ, Stefansson, K, Simon N Stacey, Gudbjartsson, Daniel F, Julius Gudmundsson, David J Hunter, Armstrong, BK, Neal David E., Easton Douglas F., Amundadottir, L, Kari Stefansson, Stephen J Chanock, Hayward Nicholas K., Zeggini, E, Neal, David E, Isaacs, William B, Easton, DF, Chanock, Stephen J, Patel, AV, Douglas F. Easton, Brown Kevin M., Petersen, GM, Thorlacius, Steinunn, Isaacs, William B., William B Isaacs, Gallinger, S, Klein, AP, Gaborieau Valerie, Donovan, Jenny, Kraft, P, Kevin M Brown, Giovannucci, EL, Holly, EA, Lemire, Mathieu, Rosa B. Barkardottir, Sulem, P, Barkardottir, RB, Neal, David E., Zeggini, Eleftheria, Valerie Gaborieau, Chanock, Stephen J., Kevin M. Brown, Zeggini Eleftheria, Barkardottir, Rosa, HASH(0x55a67fc6f008), Riboli, E, Hayward, NK, Shu, XO, Howard, B, David E Neal, Stacey, Simon N., Gronberg, H, PanScan, C, Parikh, H, Gudmundsson Julius, Hassan, M, Ian P. M. Tomlinson, Tomlinson, IPM, Ioannidis, JPA, Gudmundsson, Julius, Carvajal-Carmona, Luis, McCarthy, MI, Kefford, Richard F., Clipp, S, McCarthy Mark I., Donovan Jenny L., Brent Zanke, Muir, Kenneth, Neal, DE, Ioannidis, John P., Li, D, Amundadottir Laufey, Canzian, F, Eeles, RA, Rodriguez, L, Gudmundsson, J, Mark I. McCarthy, Xu, Jianfeng, Elliott, Katherine S, Hutchinson, A, Krogh, V, Mann, Graham J., Thomas, G, Ioannidis, John PA, Eeles Rosalind A., Brown, Kevin M., Stacey, SN, Ioannidis, John, Kefford, RF, Sulem, Patrick, Katherine S Elliott, Gudbjartsson Daniel F., Murabito, JM, Stacey Simon N., McCarthy, Mark I., Gudbjartsson, DF, Hamdy Freddie C., Jenny L. Donovan, Eleftheria Zeggini, Hunter, David J., Luis Carvajal-Carmona, Chanock, Stephen, Hayward, Nicholas K., Michael Gaziano, J, Hunter, David J, Shih-Jen Hwang, Jianfeng Xu, The PanScan Consortium, Buring, JE, Amos, Christopher I, Henrik Grönberg, PanScan Consortium, Giles, GG, Rafnar, Thorunn, Easton, Douglas F, Nicholas K. Hayward, Brown, KM, Chanock Stephen J., Jenny L Donovan, Rosalind A Eeles, Arslan, AA, Seminara, D, Goggins, M, Stefansson, Kari, Murabito, Joanne M., Hunter, DJ, McCarthy, Mark, Tomlinson, Ian PM, Donovan, Jenny L., Rajkovic, A, Zanke Brent, Hamdy, Freddie C, Nicholas K Hayward, Thorlacius Steinunn, Hayward, Nicholas K, Joanne M. Murabito, Lynch, SM, Isaacs William B., Daniel F. Gudbjartsson, Elliott, Katherine S., Ioannidis, John P. A., Fuchs, CS, de Andrade, M, Hankinson, SE, Grönberg Henrik, Lemire Mathieu, Christopher I. Amos, Gross, M, Mandelson, MT, Spitz, Margaret R, Ioannidis, John P.A., Helzlsouer, K, Laufey Amundadottir, Bracci, PM, Tomlinson, Ian, Kooperberg, C, Kurtz, RC, Grönberg, H, John P A Ioannidis, Sulem Patrick, Eeles, Rosalind A, McWilliams, RR, Gaborieau, V, Elliott Katherine S., Ioannidis, JP, Christopher I Amos, Tjønneland, A, Stuart Macgregor, Rosalind A. Eeles, Berg, CD, Rosa B Barkardottir, Joanne M Murabito, Isaacs, WB, Elliott, KS, Bamlet, WR, Freddie C. Hamdy, Macgregor, S, Freddie C Hamdy, Grönberg, Henrik, Carvajal-Carmona, L, Gaborieau, Valerie, Easton, Douglas F., Lemire, M, Rafnar, T, Simon N. Stacey, Olson, SH, Amundadottir, Laufey, Chanock, SJ, Cotterchio, M, Muir Kenneth, Stephen J. Chanock, Australian Melanoma Family Study Investigators, Ioannidis John P. A., Margaret R. Spitz, Thorlacius, S, Stacey, Simon N, Tomlinson, Ian P M, Spitz Margaret R., Ioannidis, John P A, Brennan Paul, Steinunn Thorlacius, Mark I McCarthy, Lacroix, A, Paul Brennan, David J. Hunter, Patrick Sulem, William B. Isaacs, Brennan, P, Hwang Shih-Jen, Brown, Kevin M, Douglas F Easton, Daniel F Gudbjartsson, Zheng, W, Katherine S. Elliott, Gudbjartsson, Daniel Fannar, Thorunn Rafnar, Bas Bueno-De-Mesquita, H, Hamdy, Freddie, Boutron-Ruault, MC, Gudbjartsson, Daniel F., Tomlinson, Ian P.M., Zanke, Brent, Macgregor Stuart, Barkardottir Rosa B., Amos, Christopher I., Murabito, Joanne M, Jacobs, KB, Australian, MFSI, Brennan, Paul, Peeters, PHM, Spitz, MR, Kaaks, R, Eeles, Rosalind A., Ian P M Tomlinson +280 morecore +1 more sourceStructure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.Alex J. Vecchiowiley +1 more source
