Results 61 to 70 of about 40,713,960 (307)

Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]

Genomics & Informatics, 2014
Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj   +1 more source

Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana [PDF]

PeerJ, 2020
Salmonella enterica serovar Javiana is the fourth most reported serovar of laboratory-confirmed human Salmonella infections in the U.S. and in Tennessee (TN). Although Salmonella ser.
Lauren K. Hudson, Lisha Constantine-Renna, Linda Thomas, Christina Moore, Xiaorong Qian, Katie Garman, John R. Dunn, Thomas G. Denes   +7 more
doaj   +2 more sources

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
core  

Genetic differences according to onset age and lung function in asthma: A cluster analysis

Clinical and Translational Allergy, 2023
Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Tae‐Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. Adcock, Kian Fan Chung, Tae‐Bum Kim, Bermseok Oh   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D., Marjo-Riitta Jarvelin, Coin, Lachlan, Matthew A. Brown (131482), Ferreira, Manuel, O'Connor, George T, Guy B Marks, Dharmage, Shyamali C, Adaikalavan Ramasamy (4841), Anneli Pouta, Lehtimäki Terho, Tari Haahtela, Veikko Salomaa (62543), Shyamali C. Dharmage, Manuel A R Ferreira, Lehtimaki, Terho, Anneli Pouta (116626), Pekkanen Juha, Joel N Hirschhorn, Gajdos, Zofia K, Strachan David P., Palotie Aarno, Colin F. Robertson (131511), Philip J Thompson, Lehtimäki, T, Montgomery, Grant, Andrew C. Heath, Duffy David L., Strachan, David P, Elisabeth Widen (75580), Matthias Wjst (56613), Thompson, Philip, David L. Duffy (131489), Martin, Nicholas G., Laitinen, Tarja, Hirschhorn, Joel, Raitakari, Olli T, Alexessander Couto Alves, Tarja Laitinen, Lyon, Helen, Wareham, Nick, Laitinen Tarja, Palmer, CD, Raitakari Olli T., Peter Le Souef, Christer Janson, Vedantam, Sailaja, Janson Christer, Sailaja Vedantam (131467), George T. O'Connor (110263), Marks Guy B., Ramasamy, Adaikalavan, Ferreira, Manuel AR, Andrew C Heath, Peter Le Souef (131503), David P Strachan, Palotie, Aarno, Eriksson, Johan, Jing Hua Zhao (73808), Jorma Viikari, Tari Haahtela (131492), Nick Wareham, Grant W. Montgomery (131518), Heathe, Andrew C, Khaw, KT, Nicholas G. Martin (113568), Jarvelin, Marjo-Riitta, Robertson, CF, Mika Kähönen (131499), Michael J. Abramson, Matheson, M C, Kay-Tee Khaw, Pouta, Anneli, David P. Strachan, Abramson, Michael J, Manuel A. R. Ferreira, Aarno Palotie (41342), Juha Pekkanen (27303), Palotie, A, Mikko Kuokkanen, Ferreira, MA, Marks, Guy B., Helen N Lyon, Philip J. Thompson (131523), Cameron D Palmer, Deborah L. Jarvis (131514), Thompson, Philip J., Colin F. Robertson, Janson, Christer,, Heath, Andrew C, Madden, Pamela AF, Kuokkanen Mikko, Strachan, David P., Salomaa, Veikko, Jaana Laitinen (116629), Coin, L, Haahtela, T, Widen Elisabeth, Ramasamy, A, Martin, NG, Janson, C, Madden, PA, Eriksson, J, Laitinen Jaana, Thompson Philip J., Couto Alves, A, Matheson, Melanie C, Australian Asthma Genetics, Martin Nicholas G., ?, ?, Salomaa, V, Zhao, Jing Hua, Olli T Raitakari, Palmer, Cameron D, David L Duffy, Jarvis Deborah L., Palmer, Cameron, Widen, Elizabeth, Zofia K. Gajdos (131468), Matheson, Melanie C., Widen, Elisabeth, O'Connor George T., Martin, Nicholas, Raitakari, OT, O'Connor, George, Kähönen Mika, Colin F Robertson, O'Connor, GT, Kähönen, M, Gajdos, Zofia, Duffy, David L., Lachlan Coin (3863), Jarvelin Marjo-Riitta, Dharmage Shyamali C., Dharmage, Shyamali C., Raitakari, Olli T., Jousilahti, P, Hirschhorn Joel N., Pekka Jousilahti, Ferreira Manuel A. R., Lyon, Helen N., Guy B. Marks (116572), Martin, Nicholas G, Nicholas G Martin, Brown, MA, Marks, Guy, Michael J. Abramson (131480), Pekkanen, Juha, Lyon, HN, Matheson Melanie C., Pekkanen, J, Madden Pamela A. F., Duffy, DL, Heath, AC, Gajdos Zofia K., Olli T. Raitakari (115559), Lachlan Coin, Lyon, Helen N, Camerond Palmer, Nicholas G. Martin, Strachan, David, Jousilahti Pekka, Jousilahti, Pekka, Dharmage, Shyamali, Pamela A. F. Madden (127156), Veikko Salomaa, Madden, Pamela, Wjst Matthias, Zofia K. Gajdos, Marks, GB, Matthew A Brown, Manuel A. R. Ferreira (131476), Khaw, Kay-Tee, Jarvis, Deborah L., Kahonen, Mika, Montgomery, GW, Montgomery, Grant W, Eriksson Johan, Pouta, A, Viikari, J, Heath Andrew C., Johan Eriksson, Shyamali C. Dharmage (131486), Laitinen, T, Laitinen, J, Johan Eriksson (131534), Pekka Jousilahti (131538), David L. Duffy, Palmer, Cameron D., Palmer, Cameron Douglas, George T O'Connor, Duffy, David, Viikari, E, Jaana Laitinen, Kay-Tee Khaw (110271), Viikari Jorma, Matheson, MC, Mikko Kuokkanen (131465), Khaw Kay-Tee, Matthew A. Brown, Thompson, Philip J, Montgomery Grant W., Le Souef, P, Robertson, Colin, Jarvis, Debbie, Mika Kähönen, Pamela A F Madden, Melanie C Matheson, Pouta Anneli, Alexessander Couto Alves (131470), Andrew C. Heath (127152), Tarja Laitinen (131542), George T. O’connor, Viikari, Jorma, Aarno Palotie, O'Connor, George T., Melanie C. Matheson (131507), Lyon Helen N., Marks, Guy B, Joel N. Hirschhorn, Ramasamy Adaikalavan, Terho Lehtimäki (49739), Juha Pekkanen, Marjo-Riitta Jarvelin (110290), Heathe, Andrew, Abramson Michael J., Heath, Andrew C., Wareham Nick, Gajdos, ZK, Zhao, Jing, Brown, Matthew A, Deborah L. Jarvis, Matheson, M, Abramson, Michael, Michael J Abramson, Christer Janson (83414), Jarvelin, MR, Adaikalavan Ramasamy, Duffy, David L, Jing Hua Zhao, Zhao Jing Hua, Jorma Viikari (49741), Montgomery, Grant W., Brown, Matthew A., Vedantam Sailaja, Robertson Colin F., Wjst, Matthias, Cameron D. Palmer (131509), David P. Strachan (110302), Hirschhorn, Joel N., Ferreira, Manuel A. R., Er Couto Alves, Thompson, PJ, Raitakari, Olli, Brown, Matthew, Laitinen, Jaana, Haahtela Tari, Grant W Montgomery, Brown Matthew A., Alves, Alexessander Couto, Robertson, Colin F., Matthias Wjst, Olli T. Raitakari, Zhao, JH, Couto Alves, Alexessander, Shyamali C Dharmage, Melanie C. Matheson, Gajdos, Zofia K., Kuokkanen, M, Widen, E, Hirschhorn, Joel N, Salomaa Veikko, Deborah L Jarvis, Janson, Christer, Guyb. Marks, Le Souef, Peter, Le Souef Peter, Wareham, N, Haahtela, Tari, Kuokkanen, Mikko, Hirschhorn, JN, Vedantam, S, Dharmage, SC, Jarvis, DL, Jarvis, Deborah L, Couto Alves Alexessander, Strachan, DP, Nick Wareham (131528), Pamela A. F. Madden, Abramson, MJ, Coin Lachlan, Elisabeth Widen, Madden, Pamela A, Zofia K Gajdos, Wjst, M, Sailaja Vedantam, Grant W. Montgomery, Robertson, Colin F, Philip J. Thompson, Helen N. Lyon (131473), Australian Asthma Genetics Consortium Collaborators, Abramson, Michael J., Joel N. Hirschhorn (131545), Terho Lehtimäki, Helen N. Lyon, Madden, Pamela A. F., Strachan, D. P., Jousilahti, P., Raitakari, O. T., Thompson, P. J., Lehtimäki, T., Salomaa, V., Dharmage, S. C., Montgomery, G. W., Widen, E., Gajdos, Z. K., O'Connor, G. T., Couto Alves, A., Eriksson, J., Laitinen, T., Vedantam, S., Haahtela, T., Heath, A. C., et al,, et al., Pouta, A., Hirschhorn, J. N., Abramson, M. J., Palotie, A., Duffy, D. L., Viikari, J., Jarvelin, M. R., Kähönen, M., Brown, Matthew. A., Wjst, M., Kuokkanen, M., Coin, L., Lyon, H. N., Matheson, M. C., Palmer, C. D., Khaw, K. T., Ferreira, M. A. R., Le Souef, P., Martin, N. G., Robertson, C. F., Wareham, N., Janson, C., Pekkanen, J., Madden, P. A. F., Zhao, J. H., Jarvis, D. L., Laitinen, J., Marks, G. B., Ramasamy, A.   +353 more
core   +3 more sources

A genome-wide association study of aging

Neurobiology of Aging, 2011
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.
Walter, Stefan, Atzmon, Gil, Völker, Uwe, Yu, Lei, Arnold, Alice, Benjamin, Emelia J, Biffar, Reiner, Buchman, Aron S, Boerwinkle, Eric, Couper, David, De Jager, Philip L, Evans, Denis A, Demerath, Ellen W, Harris, Tamara B, Hoffmann, Wolfgang, Hofman, Albert, Karasik, David, Kiel, Douglas P, Kocher, Thomas, Kuningas, Maris, Launer, Lenore J, Lohman, Kurt K, Lutsey, Pamela L, Garcia, Melissa E, Mackenbach, Johan, Marciante, Kristin, Psaty, Bruce M, Reiman, Eric M, Rotter, Jerome I, Seshadri, Sudha, Shardell, Michelle D, Smith, Albert V, van Duijn, Cornelia, Walston, Jeremy, Kaplan, Robert C, Zillikens, M Carola, Bandinelli, Stefania, Baumeister, Sebastian E, Bennett, David A, Ferrucci, Luigi, Gudnason, Vilmundur, Kivimaki, Mika, Liu, Yongmei, Murabito, Joanne M, Newman, Anne B, Kumari, Meena, Tiemeier, Henning, Franceschini, Nora, Lunetta, Kathryn L, Milaneschi, Yuri, Tanaka, Toshiko, Tranah, Gregory J   +51 more
openaire   +3 more sources

Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population

Clinical Epigenetics
Background While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA methylation, our understanding of ...
Ho-Sun Lee, Boram Kim, Taesung Park
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source