Results 61 to 70 of about 43,083,361 (310)

A genome-wide association search for type 2 diabetes genes in African Americans [PDF]

open access: yes, 2011
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Bostrom, Meredith A   +999 more
core   +2 more sources

Genome-wide association studies and the genetics of entrepreneurship [PDF]

open access: yesEuropean Journal of Epidemiology, 2010
Entrepreneurship is a vital element of well-functioning economies. It is sometimes denoted as their ‘scarcest input factor’. Entrepreneurs introduce innovations into the economic system and may contribute towards higher productivity levels and hence economic growth [1, 2, 3].
van der Loos, M.J.H.M.   +3 more
openaire   +7 more sources

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

open access: yes, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris   +147 more
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Machine learning in genome‐wide association studies [PDF]

open access: yesGenetic Epidemiology, 2009
AbstractRecently, genome‐wide association studies have substantially expanded our knowledge about genetic variants that influence the susceptibility to complex diseases. Although standard statistical tests for each single‐nucleotide polymorphism (SNP) separately are able to capture main genetic effects, different approaches are necessary to identify ...
Silke Szymczak   +6 more
openaire   +3 more sources

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits [PDF]

open access: yes, 2011
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ...
Palmer Cameron D.   +799 more
core   +3 more sources

Genome-wide Association Study of Chicken Plumage Pigmentation [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2013
To increase plumage color uniformity and understand the genetic background of Korean chickens, we performed a genome-wide association study of different plumage color in Korean native chickens. We analyzed 60K SNP chips on 279 chickens with GEMMA methods
Mi Na Park   +8 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

A Genome-Wide Association Study of Myasthenia Gravis [PDF]

open access: yesJAMA Neurology, 2015
Myasthenia gravis is a chronic, autoimmune, neuromuscular disease characterized by fluctuating weakness of voluntary muscle groups. Although genetic factors are known to play a role in this neuroimmunological condition, the genetic etiology underlying myasthenia gravis is not well understood.To identify genetic variants that alter susceptibility to ...
Renton, Ae   +54 more
openaire   +4 more sources

Genome-wide associate study identifies five new schizophrenia loci [PDF]

open access: yes, 2011
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent ...
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
core   +1 more source

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