Results 61 to 70 of about 835,710 (239)

Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders [PDF]

, 2017
Twin studies indicate that latent genetic factors overlap across comorbid psychiatric disorders. In this study, we used a novel approach to elucidate shared genetic factors across psychiatric outcomes by clustering single nucleotide polymorphisms based ...
Adkins, Amy E., Aliev, Fazil, Bucholz, Kathleen K., Cho, Seung Bin, Clark, Shaunna L., Dick, Danielle M., Edenberg, Howard J., Porjesz, Bernice   +7 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genetic susceptibility to feline infectious peritonitis in Birman cats. [PDF]

, 2013
Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal.
Golovko, Lyudmila, Liu, Hongwei, Lyons, Leslie A, Pedersen, Niels C, Sørensen, Anne, Wehnert, Suzanne   +5 more
core   +1 more source

Genome-Wide Association Studies of Asthma

Allergology International, 2011
Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted. Genome-wide association studies (GWAS), which comprehensively assess genes related to multifactorial diseases and drug ...
Mayumi Tamari, Kaori Tomita, Tomomitsu Hirota   +2 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A foundation for provitamin A biofortification of maize: genome-wide association and genomic prediction models of carotenoid levels. [PDF]

, 2014
Efforts are underway for development of crops with improved levels of provitamin A carotenoids to help combat dietary vitamin A deficiency. As a global staple crop with considerable variation in kernel carotenoid composition, maize (Zea mays L.) could ...
Buckler, Edward S, Buell, C Robin, Cepela, Jason, DellaPenna, Dean, Diepenbrock, Christine H, Gore, Michael A, Kandianis, Catherine B, Kim, Eunha, Lipka, Alexander E, Magallanes-Lundback, Maria, Mateos-Hernandez, Maria, Owens, Brenda F, Rocheford, Torbert, Tiede, Tyler   +13 more
core   +1 more source

Genome-wide Association Studies Meet Chemoprevention [PDF]

JNCI Journal of the National Cancer Institute, 2013
The T variant at rs6983267 on 8q24 is a weakly protective allele for colorectal cancer discovered in the conduct of GWASs (2–4). This locus resides in an apparent enhancer domain for MYC (5), and deletion of the region in mice has been associated with resistance to APCmin-induced intestinal tumorigenesis (6) by decreasing TCF7L2 interaction with CTNNB1
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Susceptibility to chronic mucus hypersecretion, a genome wide association study [PDF]

, 2014
Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population.
Alizadeh, B.Z. (Behrooz), Bakke, A.B. (Arnold B.), Beaty, T.H. (Terri), Benn, M. (Marianne), Berge, M. (Maarten) van den, Boer, R.A. (Rudolf) de, Boezen, H.M. (Marike), Bossé, Y. (Yohan), Brouwer, U. (Uilke), Bruinenberg, M. (M.), Brusselle, G.G. (Guy), Cho, M.H. (Michael), Crapo, R.O. (Robert), Dahl, M. (Morten), Dahlback, M. (Magnus), Diemen, C.C. (Cleo) van, Dijkstra, A.E. (Akkelies), Duijn, C.M. (Cornelia) van, Franke, L. (Lude), Groen, H.J.M. (Henk), Gulsvik, A. (Amund), Harst, P. (Pim) van der, Hiemstra, P.S. (Pieter), Hillege, H.L. (Hans), Hofman, A. (Albert), Kauczor, H.U. (Hans), Klauw, M.M. (Melanie) van der, Koning, H.J. (Harry) de, Koppelman, G.H. (Gerard), Lahousse, L. (Lies), Lammers, J.-W.J. (Jan-Willem), Lomas, D.J. (David John), Loth, D.W. (Daan), Luinge, M.A. (Marjan), Mejza, F. (Filip), Nastalek, P. (Pawel), Navis, G. (Gerjan), Nawijn, M.C. (Martijn), Nielsen, S.F. (Sune), Nizankowska-Mogilnicka, E. (Eva), Nordestgaard, B.G. (Børge), Obeidat, M. (Ma'en), Ormel, J. (Johan), Owsijewitsch, M. (Michael), Picavet, H.S.J. (Susan), Platteel, I. (Inge), Postma, D.S. (Dirkje), Rivadeneira Ramirez, F. (Fernando), Rosmalen, J.G.M. (Judith), Silverman, E.K. (Edwin), Slaets, J.P.J. (Joris), Smit, H.A. (Henriëtte), Smolonska, J. (Joanna), Snieder, H. (Harold), Spira, M.E. (Micha), Sterk, P.J. (Peter), Stolk, R.P. (Ronald), Stricker, B.H.Ch. (Bruno), Timens, W. (Wim), Tosh, K. (Kerrie), Uitterlinden, A.G. (André), Verschuren, W.M.M. (W. M. Monique), Vestbo, J. (Jorgen), Vonk, J.M. (Judith), Wijmenga, C. (Ciska), Wolffenbuttel, B. (Bhr), Zanen, P. (Pieter)   +66 more
core   +1 more source