Results 41 to 50 of about 437,585 (266)

Genome-wide association studies and the genetics of entrepreneurship [PDF]

European Journal of Epidemiology, 2010
Entrepreneurship is a vital element of well-functioning economies. It is sometimes denoted as their ‘scarcest input factor’. Entrepreneurs introduce innovations into the economic system and may contribute towards higher productivity levels and hence economic growth [1, 2, 3].
van der Loos, M.J.H.M., Koellinger, Ph.D., Groenen, P.J.F., Thurik, A.R.   +3 more
openaire   +7 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]

Genomics & Informatics, 2014
Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj   +1 more source

Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana [PDF]

PeerJ, 2020
Salmonella enterica serovar Javiana is the fourth most reported serovar of laboratory-confirmed human Salmonella infections in the U.S. and in Tennessee (TN). Although Salmonella ser.
Lauren K. Hudson, Lisha Constantine-Renna, Linda Thomas, Christina Moore, Xiaorong Qian, Katie Garman, John R. Dunn, Thomas G. Denes   +7 more
doaj   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Genetic differences according to onset age and lung function in asthma: A cluster analysis

Clinical and Translational Allergy, 2023
Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Tae‐Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. Adcock, Kian Fan Chung, Tae‐Bum Kim, Bermseok Oh   +11 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A genome-wide association study of aging

Neurobiology of Aging, 2011
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.
Walter, Stefan, Atzmon, Gil, Völker, Uwe, Yu, Lei, Arnold, Alice, Benjamin, Emelia J, Biffar, Reiner, Buchman, Aron S, Boerwinkle, Eric, Couper, David, De Jager, Philip L, Evans, Denis A, Demerath, Ellen W, Harris, Tamara B, Hoffmann, Wolfgang, Hofman, Albert, Karasik, David, Kiel, Douglas P, Kocher, Thomas, Kuningas, Maris, Launer, Lenore J, Lohman, Kurt K, Lutsey, Pamela L, Garcia, Melissa E, Mackenbach, Johan, Marciante, Kristin, Psaty, Bruce M, Reiman, Eric M, Rotter, Jerome I, Seshadri, Sudha, Shardell, Michelle D, Smith, Albert V, van Duijn, Cornelia, Walston, Jeremy, Kaplan, Robert C, Zillikens, M Carola, Bandinelli, Stefania, Baumeister, Sebastian E, Bennett, David A, Ferrucci, Luigi, Gudnason, Vilmundur, Kivimaki, Mika, Liu, Yongmei, Murabito, Joanne M, Newman, Anne B, Kumari, Meena, Tiemeier, Henning, Franceschini, Nora, Lunetta, Kathryn L, Milaneschi, Yuri, Tanaka, Toshiko, Tranah, Gregory J   +51 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population

Clinical Epigenetics
Background While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA methylation, our understanding of ...
Ho-Sun Lee, Boram Kim, Taesung Park
doaj   +1 more source