Results 41 to 50 of about 434,983 (266)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Genome-wide association studies and the genetics of entrepreneurship [PDF]

European Journal of Epidemiology, 2010
Entrepreneurship is a vital element of well-functioning economies. It is sometimes denoted as their ‘scarcest input factor’. Entrepreneurs introduce innovations into the economic system and may contribute towards higher productivity levels and hence economic growth [1, 2, 3].
van der Loos, M.J.H.M., Koellinger, Ph.D., Groenen, P.J.F., Thurik, A.R.   +3 more
openaire   +7 more sources

Genome-Wide Association Study of Hepatitis in Korean Populations [PDF]

Genomics & Informatics, 2014
Hepatitis is a common and serious disease for the Korean population. It is caused by a virus, the A and B types of which are plentiful in Koreans. In this study, we tried to find genetic factors for hepatitis through genome-wide association studies.
Youngbok Hong, Sejong Oh
doaj   +1 more source

Genomic characterization and phylogenetic analysis of Salmonella enterica serovar Javiana [PDF]

PeerJ, 2020
Salmonella enterica serovar Javiana is the fourth most reported serovar of laboratory-confirmed human Salmonella infections in the U.S. and in Tennessee (TN). Although Salmonella ser.
Lauren K. Hudson, Lisha Constantine-Renna, Linda Thomas, Christina Moore, Xiaorong Qian, Katie Garman, John R. Dunn, Thomas G. Denes   +7 more
doaj   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genetic differences according to onset age and lung function in asthma: A cluster analysis

Clinical and Translational Allergy, 2023
Background The extent of differences between genetic risks associated with various asthma subtypes is still unknown. To better understand the heterogeneity of asthma, we employed an unsupervised method to identify genetic variants specifically associated
Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Tae‐Woong Ha, Hae Un Jung, Won Jun Lee, Dong Jun Kim, Eun Ju Baek, Ian M. Adcock, Kian Fan Chung, Tae‐Bum Kim, Bermseok Oh   +11 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A genome-wide association study of aging

Neurobiology of Aging, 2011
Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death.
Walter, Stefan, Atzmon, Gil, Völker, Uwe, Yu, Lei, Arnold, Alice, Benjamin, Emelia J, Biffar, Reiner, Buchman, Aron S, Boerwinkle, Eric, Couper, David, De Jager, Philip L, Evans, Denis A, Demerath, Ellen W, Harris, Tamara B, Hoffmann, Wolfgang, Hofman, Albert, Karasik, David, Kiel, Douglas P, Kocher, Thomas, Kuningas, Maris, Launer, Lenore J, Lohman, Kurt K, Lutsey, Pamela L, Garcia, Melissa E, Mackenbach, Johan, Marciante, Kristin, Psaty, Bruce M, Reiman, Eric M, Rotter, Jerome I, Seshadri, Sudha, Shardell, Michelle D, Smith, Albert V, van Duijn, Cornelia, Walston, Jeremy, Kaplan, Robert C, Zillikens, M Carola, Bandinelli, Stefania, Baumeister, Sebastian E, Bennett, David A, Ferrucci, Luigi, Gudnason, Vilmundur, Kivimaki, Mika, Liu, Yongmei, Murabito, Joanne M, Newman, Anne B, Kumari, Meena, Tiemeier, Henning, Franceschini, Nora, Lunetta, Kathryn L, Milaneschi, Yuri, Tanaka, Toshiko, Tranah, Gregory J   +51 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source