Results 21 to 30 of about 437,585 (266)

Replication in Genome-Wide Association Studies

Statistical Science, 2009
Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data ...
Kraft, Peter, Zeggini, Eleftheria, Ioannidis, John P. A.   +2 more
openaire   +6 more sources

Data mining and machine learning approaches for the integration of genome-wide association and methylation data: methodology and main conclusions from GAW20

BMC Genetics, 2018
Background Multiple layers of genetic and epigenetic variability are being simultaneously explored in an increasing number of health studies. We summarize here different approaches applied in the Data Mining and Machine Learning group at the GAW20 to ...
Burcu Darst, Corinne D. Engelman, Ye Tian, Justo Lorenzo Bermejo   +3 more
doaj   +1 more source

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Human Genomics, 2019
Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper, Brian A. Walker, Walter M. Gregory, Per Hoffmann, Graham H. Jackson, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Markus Hansson, Martin Kaiser, Pieter Sonneveld, Hartmut Goldschmidt, Kari Stefansson, Kari Hemminki, Björn Nilsson, Gareth J. Morgan, Richard S. Houlston   +28 more
doaj   +1 more source

Genome-Wide Association Studies in Glioma [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review, we describe a chronological history of glioma GWAS, culminating in the most recent study comprising 12,496 cases and 18,190 controls. We additionally
Kinnersley, B, Houlston, RS, Bondy, ML
openaire   +3 more sources

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Selecting Closely-Linked SNPs Based on Local Epistatic Effects for Haplotype Construction Improves Power of Association Mapping

G3: Genes, Genomes, Genetics, 2019
Genome-wide association studies (GWAS) have gained central importance for the identification of candidate loci underlying complex traits. Single nucleotide polymorphism (SNP) markers are mostly used as genetic variants for the analysis of genotype ...
Fang Liu, Renate H. Schmidt, Jochen C. Reif, Yong Jiang   +3 more
doaj   +1 more source

Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

Rice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei, Ryokei Tanaka, Taiji Kawakatsu, Shota Teramoto, Nobuhiro Tanaka, Matthew Shenton, Yusaku Uga, Shiori Yabe   +7 more
doaj   +1 more source

Genome-wide Association Studies

, 2013
Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 2000 loci for common human diseases have been identified by GWAS.
Duncan, Emma, Brown, Matthew
openaire   +5 more sources

Developing Novel Therapeutic Strategies Against Ring Finger Protein 213 Vasculopathy: Is It an Achievable Goal?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
See Article Choi et ...
Minghua Liu, Jose Gutierrez
doaj   +1 more source

Genome-Wide Association Study of Opioid Cessation [PDF]

Journal of Clinical Medicine, 2020
The United States is experiencing an epidemic of opioid use disorder (OUD) and overdose-related deaths. However, the genetic basis for the ability to discontinue opioid use has not been investigated. We performed a genome-wide association study (GWAS) of opioid cessation (defined as abstinence from illicit opioids for >1 year or <6 months before ...
Jiayi W. Cox, Richard M. Sherva, Kathryn L. Lunetta, Emma C. Johnson, Nicholas G. Martin, Louisa Degenhardt, Arpana Agrawal, Elliot C. Nelson, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer   +10 more
openaire   +5 more sources