Results 21 to 30 of about 40,713,960 (307)

Genome-Wide Association Studies in Glioma [PDF]

open access: yesCancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review, we describe a chronological history of glioma GWAS, culminating in the most recent study comprising 12,496 cases and 18,190 controls. We additionally
Kinnersley, B, Houlston, RS, Bondy, ML
openaire   +3 more sources

Genome-Wide Association Study of Motor Coordination [PDF]

open access: yesFrontiers in Human Neuroscience, 2021
The ability to finely control our movement is key to achieving many of the educational milestones and life-skills we develop throughout our lives. Despite the centrality of coordination to early development, there is a vast gap in our understanding of the underlying biology.
Mountford, HS   +3 more
openaire   +7 more sources

First genome-wide association study on anxiety-related behaviours in childhood [PDF]

open access: yes, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B.   +66 more
core   +1 more source

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. [PDF]

open access: yes, 2011
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA.
Keating, BJ   +999 more
core   +2 more sources

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 [PDF]

open access: yes, 2011
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that ...
Juliane Winkelmann   +336 more
core   +2 more sources

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

open access: yes, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ   +53 more
core   +1 more source

Guidelines for Genome-Wide Association Studies

open access: yesPLoS Genetics, 2012
Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Gregory S Barsh   +3 more
openaire   +4 more sources

Genome-Wide Association Studies of Cancer [PDF]

open access: yesJournal of Clinical Oncology, 2010
Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Zsofia K, Stadler   +9 more
openaire   +2 more sources

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium [PDF]

open access: yes, 2011
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease.
Marsit CJ   +934 more
core   +2 more sources

Replication in Genome-Wide Association Studies

open access: yesStatistical Science, 2009
Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data ...
Kraft, Peter   +2 more
openaire   +6 more sources

Home - About - Disclaimer - Privacy