Results 11 to 20 of about 434,983 (266)

Single-step genome-wide association study for susceptibility to Teratosphaeria nubilosa and precocity of vegetative phase change in Eucalyptus globulus

Frontiers in Plant Science, 2023
IntroductionMycosphaerella leaf disease (MLD) is one of the most prevalent foliar diseases of Eucalyptus globulus plantations around the world. Since resistance management strategies have not been effective in commercial plantations, breeding to develop ...
Marianella Quezada, Marianella Quezada, Facundo Matias Giorello, Cecilia Corina Da Silva, Ignacio Aguilar, Gustavo Balmelli   +5 more
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Genome-wide association studies in cancer [PDF]

Human Molecular Genetics, 2008
Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F, Easton, Rosalind A, Eeles
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Genome-wide Association Study for AKI

Kidney360, 2023
Key Points Two genetic variants in the DISP1-TLR5 gene locus were associated with risk of AKI.DISP1 and TLR5 were differentially regulated in kidney biopsy tissue from patients with AKI compared with no AKI. Background
Pavan K. Bhatraju, Ian B. Stanaway, Melody R. Palmer, Rajasree Menon, Jennifer A. Schaub, Steven Menez, Anand Srivastava, F. Perry Wilson, Krzysztof Kiryluk, Paul M. Palevsky, Abhijit S. Naik, Sana S. Sakr, Gail P. Jarvik, Chirag R. Parikh, Lorraine B. Ware, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Steve G. Coca, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Mark M. Wurfel   +24 more
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Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population [PDF]

Diabetes & Metabolism Journal, 2023
Background Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date ...
Heejin Jin, Soo Heon Kwak, Ji Won Yoon, Sanghun Lee, Kyong Soo Park, Sungho Won, Nam H. Cho   +6 more
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Dissecting the genetic heterogeneity of gastric cancerResearch in context

EBioMedicine, 2023
Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.
Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schüller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schröder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Ángeles Pérez-Aísa, Rafael Campo, Jesús Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopeña, Ángel Lanas, María Pellisé, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, René Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhüser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Małgorzta Ławniczak, Victor Moreno, Vicente Martín, Manolis Kogevinas, Marina Pollán, Justyna Dąbrowska, Antonio Salas, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hölscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sīviņš, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Nöthen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinón-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Höblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plaßmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubiński, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A. García-González, Marino Venerito, Johannes Schumacher   +133 more
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Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gut Pathogens, 2021
Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang   +12 more
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Genome-Wide Association Study of Motor Coordination [PDF]

Frontiers in Human Neuroscience, 2021
The ability to finely control our movement is key to achieving many of the educational milestones and life-skills we develop throughout our lives. Despite the centrality of coordination to early development, there is a vast gap in our understanding of the underlying biology.
Mountford, HS, Hill, A, Barnett, AL, Newbury, DF   +3 more
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Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
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Guidelines for Genome-Wide Association Studies

PLoS Genetics, 2012
Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Gregory S Barsh, Gregory P Copenhaver, Greg Gibson, Scott M Williams   +3 more
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Replication in Genome-Wide Association Studies

Statistical Science, 2009
Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data ...
Kraft, Peter, Zeggini, Eleftheria, Ioannidis, John P. A.   +2 more
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