Results 11 to 20 of about 835,710 (239)
Genome-wide association studies [PDF]
Nature Reviews Methods Primers, 2021 Genome- wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology has generated a myriad of robust associations for a range of traits and diseases, and the number of associated variants is expected to grow steadily as GWAS ...
Emil Uffelmann +8 more
exaly +5 more sources
Genome-Wide Association Studies in Atherosclerosis [PDF]
Current Atherosclerosis Reports, 2011 Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.
Sivapalaratnam, S. +7 more
openaire +4 more sources
Genome-wide association study of male sexual orientation [PDF]
, 2017 Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men ...
Cloninger, C. Robert +2 more
core +5 more sources
Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. [PDF]
, 2009 OBJECTIVE: A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. METHODS: Here we apply the genome scan meta-analysis
Babron MC +9 more
core +1 more source
The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. [PDF]
, 2020 In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response.
Haldar, Tanushree +8 more
core +2 more sources
Genome-wide Association Studies
, 2013 Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 10,000 loci for common human diseases and traits have been identified by GWAS; and it is hard to think of a methodological breakthrough in recent times that has ...
Duncan, Emma, Brown, Matthew
openaire +4 more sources
Common variants in FOXP1 are associated with generalized vitiligo [PDF]
, 2010 In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent,
A Alkhateeb +34 more
core +2 more sources
A Pooled Genome-Wide Association Study of Asperger Syndrome. [PDF]
, 2015 Asperger Syndrome (AS) is a neurodevelopmental condition characterized by impairments in social interaction and communication, alongside the presence of unusually repetitive, restricted interests and stereotyped behaviour.
Allison, Carrie +12 more
core +15 more sources
Genome-wide association study of Tourette Syndrome [PDF]
, 2014 Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we
Anderson, Kelley +97 more
core +1 more source
Guidelines for Genome-Wide Association Studies
PLoS Genetics, 2012 Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Gregory S Barsh +3 more
openaire +4 more sources