Results 11 to 20 of about 437,585 (266)

Genome-Wide Association Studies of Asthma

Allergology International, 2011
Bronchial asthma is a common inflammatory disease caused by a combination of genetic and environmental factors. To discover the genes and cellular pathways underlying asthma, a large number of genetic studies have been conducted.
Mayumi Tamari, Kaori Tomita, Tomomitsu Hirota   +2 more
doaj   +3 more sources

A genome-wide association study on medulloblastoma [PDF]

Journal of Neuro-Oncology, 2020
Abstract Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.
Dahlin, Anna M., Wibom, Carl, Andersson, Ulrika, Bybjerg-Grauholm, Jonas, Deltour, Isabelle, Hougaard, David M., Scheurer, Michael E., Lau, Ching C., McKean-Cowdin, Roberta, Kennedy, Rebekah J., Hung, Long T., Yee, Janis, Margol, Ashley S., Barrington-Trimis, Jessica, Gauderman, W. James, Feychting, Maria, Schüz, Joachim, Röösli, Martin, Kjaerheim, Kristina, Prochazka, Michaela, Adel Fahmideh, Maral, Lannering, Birgitta, Schmidt, Lisbeth S., Johansen, Christoffer, Sehested, Astrid, Kuehni, Claudia, Grotzer, Michael, Tynes, Tore, Eggen, Tone, Klaeboe, Lars, Januszkiewicz-Lewandowska, Danuta, Fichna, Marta, Nowak, Jerzy, Searles Nielsen, Susan, Asgharzadeh, Shahab, Mirabello, Lisa, Hjalmars, Ulf, Melin, Beatrice S.   +37 more
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Genome-Wide Association Studies in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2011
Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role.
Sivapalaratnam, S., Motazacker, M.M., Maiwald, S., Hovingh, G.K., Kastelein, J.J.P., Levi, M., Trip, M.D., Dallinga-Thie, G.M.   +7 more
openaire   +4 more sources

Genome-wide association studies in Plasmodiumspecies [PDF]

BMC Biology, 2010
Abstract Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity.
Penman, Bridget, Buckee, Caroline, Gupta, Sunetra, Nee, Sean   +3 more
openaire   +5 more sources

Genome-wide association studies in ADHD [PDF]

Human Genetics, 2009
Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable neuropsychiatric disorder that is seen in children and adults. Although heritability is estimated at around 76%, it has been hard to find genes underlying the disorder. ADHD is a multifactorial disorder, in which many genes, all with a small effect, are thought to cause ...
Franke, Barbara, Faraone, Stephen V., Neale, Benjamin   +2 more
openaire   +5 more sources

Genome-wide Association Study for AKI

Kidney360, 2023
Key Points Two genetic variants in the DISP1-TLR5 gene locus were associated with risk of AKI.DISP1 and TLR5 were differentially regulated in kidney biopsy tissue from patients with AKI compared with no AKI. Background
Pavan K. Bhatraju, Ian B. Stanaway, Melody R. Palmer, Rajasree Menon, Jennifer A. Schaub, Steven Menez, Anand Srivastava, F. Perry Wilson, Krzysztof Kiryluk, Paul M. Palevsky, Abhijit S. Naik, Sana S. Sakr, Gail P. Jarvik, Chirag R. Parikh, Lorraine B. Ware, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Steve G. Coca, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Mark M. Wurfel   +24 more
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Genome-wide association studies in cancer [PDF]

Human Molecular Genetics, 2008
Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F, Easton, Rosalind A, Eeles
openaire   +2 more sources

Genome-Wide Association Study of Motor Coordination [PDF]

Frontiers in Human Neuroscience, 2021
The ability to finely control our movement is key to achieving many of the educational milestones and life-skills we develop throughout our lives. Despite the centrality of coordination to early development, there is a vast gap in our understanding of the underlying biology.
Mountford, HS, Hill, A, Barnett, AL, Newbury, DF   +3 more
openaire   +7 more sources

Guidelines for Genome-Wide Association Studies

PLoS Genetics, 2012
Genome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our understanding of the genetic architecture of complex traits.
Gregory S Barsh, Gregory P Copenhaver, Greg Gibson, Scott M Williams   +3 more
openaire   +4 more sources

Genome-Wide Association Studies of Cancer [PDF]

Journal of Clinical Oncology, 2010
Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies.
Zsofia K, Stadler, Peter, Thom, Mark E, Robson, Jeffrey N, Weitzel, Noah D, Kauff, Karen E, Hurley, Vincent, Devlin, Bert, Gold, Robert J, Klein, Kenneth, Offit   +9 more
openaire   +2 more sources