Results 31 to 40 of about 40,713,960 (307)

Data mining and machine learning approaches for the integration of genome-wide association and methylation data: methodology and main conclusions from GAW20

BMC Genetics, 2018
Background Multiple layers of genetic and epigenetic variability are being simultaneously explored in an increasing number of health studies. We summarize here different approaches applied in the Data Mining and Machine Learning group at the GAW20 to ...
Burcu Darst, Corinne D. Engelman, Ye Tian, Justo Lorenzo Bermejo   +3 more
doaj   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris, Kumari, Meena, Hardy, R, Berry, Diane J, Cooper, Jackie, Ulf de Faire, Angelakopoulou, A, Jutta Palmen, de Faire, Ulf, Tzoulaki, I, Fowkes, F. Gerry R., Marmot, Michael, Samani, Nilesh, Price, Jackie; id_orcid, Andrew Wong, Wong, A, Munroe, Patricia B, Kumari, M, Shah, T, Jefferis, BJ, Deanfield, John, Simpson, Iain A., Simpson, Iain A, Shah, S, Juan P. Casas, Thomson, Andy, Jefferis, Barbara J., Samani, N, Whittaker, John C, Bruna Gigante, Philippa J. Talmud, Lathrop, Mark, Munroe, Patricia B., John C. Whittaker, Drenos, F, Motterle, Anna, John Deanfield, F. Gerry R. Fowkes, Helen Ireland, Shu Ye, Price, J, Whincup, PH, Steve E. Humphries, Verzilli, C, Kivimaki, Mika, Power, C, Leander, Karin, Sofat, R, Jackie Price, Hypponen, Elina, Caulfield, Mark, Humphries, Steve E, Tina Shah, Anna Motterle, Kuh, Diana, Jefferis, Barbara J, Gigante, B, Maniatis, Nikolas, Whincup, Peter H, Casas, Juan P, Palmen, J, Diana Kuh, Shah, Sonia, Liam Smeeth, Gigante, Bruna, Ireland, Helen, Price, Jackie, Thomson, A, Elina Hypponen, Verzilli, Claudio, Nikolas Maniatis, Smeeth, Liam, Casas, JP, Angelakopoulou, Aspasia, Marmot, M, Ross C. Laxton, Munroe, PB, Barbara J. Jefferis, Cooper, J, Wallace, C, Simpson, IA, Caulfield, M, Talmud, PJ, Andy Thomson, Laxton, Ross C., Drenos, Fotios, Morris, Richard W, Iain A. Simpson, Chris Wallace, Mika Kivimaki, Lathrop, M, Humphries, SE, Motterle, A, Hingorani, AD, de Faire, U, Whittaker, JC, Meena Kumari, Jackie Cooper, Laxton, Ross C, Ioanna Tzoulaki, Claudio Verzilli, Ye, S, Wallace, Chris, Sonia Shah, Hardy, Rebecca, Shah, Tina, Aspasia Angelakopoulou, Berry, DJ, Hingorani, Aroon D, Laxton, RC, Nilesh Samani, Hypponen, E, Fowkes, F Gerry R, Morris, RW, Diane J. Berry, Rebecca Hardy, Maniatis, N, Mark Lathrop, Fowkes, FG, Reecha Sofat, Tzoulaki, Ioanna, Chris Power, Michael Marmot, Leander, K, Power, Chris, Smeeth, L, Mark Caulfield, Ye, Shu, Sofat, Reecha, Ireland, H, Fotios Drenos, Talmud, Philippa J, Kuh, D, Deanfield, J, Kivimaki, M, Wong, Andrew, Peter H. Whincup, Patricia B. Munroe, Berry, Diane J., Karin Leander, Palmen, Jutta, Aroon D. Hingorani, Hingorani, A.D., Angelakopoulou, A., Hypponen, E., Sofat, R., Shah, S., Shah, T.   +147 more
core   +1 more source

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes

Human Genomics, 2019
Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate causal genes at these regions and
Molly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper, Brian A. Walker, Walter M. Gregory, Per Hoffmann, Graham H. Jackson, Markus M. Nöthen, Miguel Inacio da Silva Filho, Hauke Thomsen, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Markus Hansson, Martin Kaiser, Pieter Sonneveld, Hartmut Goldschmidt, Kari Stefansson, Kari Hemminki, Björn Nilsson, Gareth J. Morgan, Richard S. Houlston   +28 more
doaj   +1 more source

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits [PDF]

, 2011
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ...
Palmer Cameron D., Schwartz, SM, Benjamin F Voight, Fox, Caroline S., Hwang, Shih-Jen, GIANT Consortium, Launer, Lenore, Hernaez, R, Melissa E. Garcia, Hwang, SJ, Pietiläinen, Kirsi Hannele, Harris, Tamara B, Mitchell, Braxton D., CRISPONI, LAURA, Butler, Johannah L, Massaro, J.M., Gudnason, V., Feitosa, MF, Jeanne M. Clark, Massaro, J., Jørgensen, Torben, O'Donnell Christopher J., Stephen M. Schwartz, Schwartz SM, Palmer, C., Eiriksdottir, Gudny, Joel N Hirschhorn, Kao W. H. Linda, Laura M. Yerges-Armstrong, Stephen M Schwartz, Jeanne M Clark, Borecki Ingrid B., Mitchell, Braxton, Smith, AV, null null, Palmer, C.D., Kao, W.H.L., Johannah L. Butler, Butler, Johannah L., Borecki, IB, Palmer CD, Salomaa, V., Hirschhorn, Joel, Borecki, Ingrid B., Johannah L Butler, Speliotes, Elizabeth K, Fox Caroline S., Shuldiner, Alan R., Fox CS, Hoffmann, Udo, Palmer, CD, Nalls, Michael, Garcia, Melissa E, Hwang SJ, Wu, Jun, Mary F Feitosa, Massaro, Joseph M., Eiriksdottir G, Schadt, EE, Voight, Benjamin F, Nalls, Michael A., Clark, Jeanne M., Eiriksdottir, G, Smith AV, O'Donnell, CJ, Sahani DV, NASH CRN, Schwartz Stephen M., Lauren J Kim, CJ, Butler Johannah L., Speliotes, Elizabeth K., Tamara B Harris, Speliotes, E.K., Feitosa, Mary F., Joseph M. Massaro, Caroline S. Fox, Smith, Albert V, Launer, Lenore J, Shuldiner Alan R., GOLD Consortium, Hoffmann, U, Harris, Tamara, Tamara B. Harris, Garcia Melissa E., Kao, W. H Linda, Albert V. Smith, Mitchell BD, Smith, A.V., Voight, BF, Voight, Benjamin F., Mary F. Feitosa, Alan R Shuldiner, Kim, L.J., Kao, W H Linda, Speliotes EK, Siscovick, DS, Schadt, Eric E., Fox, C.S., Vilmundur Gudnason, Sahani, Dushyant V, Ruben Hernaez, Raychaudhuri, Soumya, Cameron D Palmer, Dushyant V Sahani, Salomaa, Veikko, O'Donnell, Christopher J., Feitosa, Mary, Shuldiner AR, Carr, J Jeffrey, Harris, T.B., Speliotes Elizabeth K., Salomaa, V, Posthuma, D., Tomas, Marta, Palmer, Cameron D, Tomas, M, Wu Jun, Siscovick David S., Launer Lenore J., Palmer, Cameron, et al., de Geus, E.J.C.; id_orcid, Butler, J.L., Clark Jeanne M., Hernaez, R., Mitchell, Braxton D, Borecki, Ingrid B, Shuldiner, A.R., Voight Benjamin F., Benjamin F. Voight, Kao, WH Linda, Lenore J. Launer, Feitosa MF, Siscovick, David, Nalls, M.A., Carr, J. Jeffrey, Clark, JM, Garcia, Melissa E., Lenore J Launer, Hirschhorn Joel N., Hwang, S.J., Eiriksdottir, G., Launer, L.J., Laura M Yerges-Armstrong, Melissa E Garcia, Hwang, S., Christopher J O'Donnell, Yerges-Armstrong, Laura M., Clark, J., Kim Lauren J., Launer, Lenore J., Hirschhorn JN, Harris, Tamara B., Michael A. Nalls, Launer LJ, Boomsma, D.I.; id_orcid, J Jeffrey Carr, Massaro, JM, Braxton D. Mitchell, Posthuma, D.; id_orcid, Heijer, M. den, Shih-Jen Hwang, Siscovick, David S., Mitchell, BD, Siscovick DS, Gudnason V, Yerges-Armstrong, L.M., Launer, LJ (Lenore), Gudnason, Vilmundur, Veikko Salomaa, de Geus, E.J.C., O' DONNELL, Willemsen, G.; id_orcid, Mitchell, B., Shuldiner, Alan, Kim, Lauren J, Sahani Dushyant V., Smith Albert V., David S Siscovick, Schadt, Eric, Kao WH, Fox, CS, David S. Siscovick, Carr JJ, Butler, Johannah, Massaro, Joseph, Hoffmann U, Garcia, Melissa, Tomas Marta, Mitchell Braxton D., Christopher J. O'Donnell, Lokki, Marja-Liisa, Gudnason Vilmundur, Fox, Caroline, DIAGRAM Consortium, Schadt, E.E., Tomas M, Hirschhorn, J.N., Jun Wu, Nalls, M., Ingrid B Borecki, Launer, L., Harris TB, Palmer, Cameron D., O'Donnell, C.J., Nalls MA, Voight BF, Borecki IB, Salomaa V, Massaro, Joseph M, Voight, B.F., Nalls, MA, O'Donnell, Christopher J, Garcia, M., Harris Tamara B., Kao, W., Kao, WH, Elizabeth K Speliotes, Gudnason, V, Siscovick, D.S., Yerges-Armstrong, Laura, Siscovick, David S, Cameron D. Palmer, Smith, Albert, Garcia ME, Marta Tomas, Clark, Jeanne M, Eric E. Schadt, Hottenga, J.J., Wu, J, Caroline S Fox, Joel N. Hirschhorn, Wu, J., Hoffmann Udo, Schadt EE, Albert V Smith, Carr J. Jeffrey, Sahani, D.V., J. Jeffrey Carr, Michael A Nalls, Feitosa, Mary F, Kao, W.H., O'Donnell, Christopher, Kim LJ, Nalls Michael A., Feitosa Mary F., Schwartz, S.M., Smith, Albert V., Shuldiner, Alan R, Voight, Benjamin, Wu J, Alan R. Shuldiner, Borecki, Ingrid, Massaro Joseph M., Lauren J. Kim, Schwartz, Stephen M, SCUTERI, ANGELO, Kao, WHL, Speliotes, Elizabeth, Kim, LJ, Clark, Jeanne, Carr, J.J., Nalls, Michael A, Feitosa, M.F., Harris, TB, Willemsen, G., Hirschhorn, Joel N., Clark JM, Yerges-Armstrong, L., Ingrid B. Borecki, Eric E Schadt, Butler, J., Butler JL, Schwartz, Stephen, Yerges-Armstrong LM, Garcia, M.E., Hernaez Ruben, Shuldiner, AR, GIANT, Boomsma, D.I., Kim, L., Elizabeth K. Speliotes, O’Donnell, C., Clark, J.M., Yerges-Armstrong, Laura M, Kim, Lauren J., Garcia, ME, Joseph M Massaro, Mitchell, B.D., Massaro JM, Speliotes, EK, Kim, Lauren, Udo Hoffmann, Jansson, John-Olov,, W H Linda Kao, MAGIC Investigators, Launer, LJ, Shuldiner, A., Hirschhorn, Joel N, Salomaa Veikko, Dushyant V. Sahani, Hwang Shih-Jen, Tomas, M., Hernaez R, Geus, E.J.C. de, Borecki, I.B., Kao, W. H. Linda, Hwang, Shih Jen, Butler, JL, Sahani, Dushyant, Hirschhorn, JN, Sahani, Dushyant V., Speliotes, E., YERGES ARMSTRONG LM, Yerges-Armstrong Laura M., Hernaez, Ruben, Eiriksdottir Gudny, Sahani, DV, Gudny Eiriksdottir, Braxton D Mitchell, Schadt Eric E., Schadt, Eric E, Hoffmann, U., PAOLISSO, Giuseppe, Schwartz, Stephen M., W. H. Linda Kao, Carr, JJ, Yerges-Armstrong, LM, Fox, Caroline S, Kaplan, Robert C., Chalasani, Naga, Welch, Ryan, Assimes, Themistocles L., Sanna, Serena, Teslovich, Tanya M., Hengstenberg, Christian, Zgaga, Lina, Dasarathy, Srinivasan, Peters, Annette, Gyurkey, Grace, Kaprio, Jaakko, Ketkar, Shamika, Navarro, Pau, Qi, Lu, Monda, Keri L., Gejman, Pablo V., Lawrence, Robert W., Abecasis, Gonçalo R., Diehl, Anna Mae, White, Melanie, Valle, Timo T., Facheris, Maurizio F., Frayling, Timothy M., Jarvelin, Marjo-Riitta, Liu, Jianjun, Piercy, Dawn, Ludwig, Barbara, Wang, Chia, Killenberg, Paul, Kilpeläinen, Tuomas O., Almgren, Peter, Balmforth, Anthony J., Huikuri, Heikki V., Gräβler, Jürgen, Strachan, David P., Waeber, Gérard, Bergman, Richard N., König, Inke R., Ingelsson, Erik, Workalemahu, Tsegaselassie, Lajunen, Taina, Kwan, Samantha, Nelson, James, Gloyn, Anna L., Clark, Lisa, Lehtimäki, Terho, Vitart, Veronique, Iribarren, Carlos, Stringham, Heather M., Chasman, Daniel I., Weedon, Michael N., Selph, Kimberly, Mc, Steven A., Contos, Melissa J., Farooqi, I. Sadaf, Erdmann, Jeanette, O'Rahilly, Stephen, Loos, Ruth J. F., Roberts, Sarah, Hall, Per, Rafelt, Suzanne, Hicks, Andrew A., Munroe, Patricia B., Dupuis, Josée, Mägi, Reedik, Quertermous, Thomas, Gaget, Stefan, Gyllensten, Ulf, Dehghan, Abbas, Manunta, Paolo, Perola, Markus, Wallaschofski, Henri, Heard-Costa, Nancy L., Ruokonen, Aimo, Sargeant, Carol, Molleston, Jean, King, Debra, Polasek, Ozren, Koskinen, Seppo, Ziegler, Andreas, Dixon, Anna L., van Duijn, Cornelia M., Bass, Nathan M., Smith, Melissa, Klipsch, Ann, Raitakari, Olli, Randall, Joshua, Zhang, Qunyuan, Wilson, James F., Wiegand, Susanna, Bhimalli, Prajakta, Robertson, Neil R., Schlessinger, David, Illig, Thomas, Hoesel, Volker, Rogers, Nicholette, Ruth Sargent, P. A. -C., Myers, Richard H., Laakso, Markku, Hayes, Richard B., Knowles, Joshua W., Buchanan, Thomas A., Visscher, Peter M., Lamina, Claudia, Chen, Chih-Mei, Ngwa, Julius S., Wheeler, Eleanor, Lanzani, Chiara, Duan, Jubao, Purcell, Shaun, Luan, Jian'an, Edwards, Kevin, Elosua, Roberto, Caulfield, Mark J., Kleiner, David, Jeffrey Carr, J., Ebrahim, Shah, Greenawalt, Danielle M., Sandhu, Manjinder S., Guiducci, Candace, Yeh, Matthew, Smit, Jan H., Bragi Walters, G., MAGIC Investigators, ,, Hall, Alistair S., Berndt, Sonja I., Kvaløy, Kirsti, Campbell, Harry, Narisu, Narisu, Folsom, Aaron R., Rayner, Nigel W., Schwimmer, Jeffrey B., Watanabe, Richard M., Allen, Hana Lango, Graham, Martin, Day, Ian N. M., Hu, Frank B., Atwood, Larry D., Mooney, Jody, Mulic, Rosanda, Groop, Leif C., Tammesoo, Mari-Liis, Brancati, Fred, Chanock, Stephen J., Franklin, Christopher S, Jacobs, Kevin B., Colvin, Ryan, Grönberg, Henrik, Peltonen, Leena, Widen, Elisabeth, Boehnke, Michael, Thomson, Brian, Brunt, Elizabeth, Johansson, Åsa, Green, Mika, Preuss, Michael, Witte, Daniel R., Steinthorsdottir, Valgerdur, Pichler, Irene, Silander, Kaisa, Xu, Jianfeng, Zitting, Paavo, Spector, Timothy D., Egan, Josephine M, Wilson, Laura, Khaw, Kay-Tee, Lecoeur, Cecile, Platou, Carl G. P., Stefansson, Kari, Cappuccio, Francesco P., Boomsma, Dorret I., Marek, Diana, Kovacs, Peter, Tönjes, Anke, Chatterjee, Nilanjan, Jones, Amy, Rissanen, Aila, Kraft, Peter, Stager, Margaret, Soranzo, Nicole, Hayward, Caroline, Schwarz, Peter, Igl, Wilmar, Filipowski, Danuta, Gustafsson, Stefan, Gieger, Christian, Viikari, Jorma, Hinney, Anke, NASH CRN, ,, Van Natta, Mark, Barlow, Sarah, Tyrer, Jonathan P., Hottenga, Jouke Jan, Kuusisto, Johanna, Thorleifsson, Gudmar, Neville, Matt J., Watkins, Hugh, Arnold, Alice M., Paré, Guillaume, Scott, Laura J., Oostra, Ben, Pellikka, Niina, Aspelund, Thor, van Meurs, Joyce B. J., Gottfried, Marcia, Boes, Tanja, Song, Kijoung, Petcharaporn, Lita, Schunkert, Heribert, Kathiresan, Sekar, Jula, Antti, Froguel, Philippe, Belt, Patricia, Wild, Sarah H., Lavine, Joel E., Uitterlinden, André G., Jansson, John-Olov, Sanyal, Arun J., Ripatti, Samuli, Connell, John, Yates, Katherine, Ridker, Paul M., Tuomilehto, Jaakko, Ouwehand, Willem H., Jewell, Elizabeth, Lantieri, Olivier, McKnight, Barbara, Pedersen, Oluf, Goddard, Michael E., Amin, Najaf, Linda Kao, W. H., Kettunen, Johannes, Rosenthal, Philip, Jackson, Anne U., Elliott, Paul, Vogel, Carla I. G., Isaacson, Milana, den Heijer, Martin, Hoofnagle, Jay H., Lanzani C, Boerwinkle, Eric, Wabitsch, Martin, Heinrich, Joachim, Vedantam, Sailaja, Perry, John R. B., Fischer-Posovszky, Pamela, Stewart, Susan, Rzehak, Peter, Wood, Andrew R., Lettre, Guillaume, Friedrich, Nele, Hartikainen, Anna-Liisa, Lee, Lydia, Surakka, Ida, Goel, Anuj, Erdos, Michael R., Shi, Jianxin, Behling, Cynthia, Havulinna, Aki S., Freimer, Nelson B., Hebebrand, Johannes, ?, ?, Zhao, Jing Hua, Yang, Jian, Winkler, Thomas W., Kaplan, Lee M., Kiemeney, Lambertus A., Kajantie, Eero, Donithan, Michele, Uda, Manuela, Isomaa, Bo, Prokopenko, Inga, Parker, Alex N., Bergmann, Sven, Groves, Christopher J., Lawlor, Debbie A., Cavalcanti-Proença, Christine, Steel, Tessa, Sparsø, Thomas, Bringman, Diane, Henneman, Peter, Visvikis-Siest, Sophie, Liu, Yao-Chang, Thompson, John R., Savolainen, Markku J., Ridderstråle, Martin, McArdle, Wendy L., Scherag, Susann, McCullough, Arthur, Pan, Yi-Ping, Grarup, Niels, Aben, Katja K., Adrienne Cupples, L., Chen, Yii-Der Ida, Ferreira, Teresa, Busonero, Fabio, Miriel, Laura, Park, Ju-Hyun, Stead, Alice, Haritunians, Talin, Bryan, Daphne, Penninx, Brenda W., Wright, Alan F., Thiering, Elisabeth, Tardif, Jean-Claude, Morris, Andrew P., Coin, Lachlan J. M., Ong, Ken K., Fuchs, Michael, Sinisalo, Juha, Homuth, Georg, Deloukas, Panos, Jarick, Ivonne, Wiklund, Fredrik, Wareham, Nicholas J., Laitinen, Jaana, Hawkins, Carol, Brown, Morris J., Stumvoll, Michael, Karpe, Fredrik, Timpson, Nicholas J., Pietiläinen, Kirsi H., Hofman, Albert, Durelle, Janis, Glazer, Nicole L., Meitinger, Thomas, Li, Shengxu, Neuschwander-Tetri, Brent A., Luben, Robert N., Bornstein, Stefan R., Moffatt, Miriam F., Vuppalanchi, Raj, Krude, Heiko, Robuck, Patricia R., McCarthy, Anne, Sandhu, Bimalijit, Wichmann, H. -Erich, Sternberg, Alice, Stein, Tanya, Guy, Cynthia, Hassanein, Tarek, Bambha, Kiran, Doney, Alex, Hveem, Kristian, Mohlke, Karen L., Midthjell, Kristian, Heid, Iris M., Lindgren, Cecilia M., Kutalik, Zoltán, Hattersley, Andrew T., Abdelmalek, Manal, Sirlin, Claude, Kaakinen, Marika, Martin, Nicholas G., Samani, Nilesh J., Bouatia-Naji, Nabila, Alavere, Helene, Langenberg, Claudia, Barroso, Inês, Siegner, Joan, Eriksson, Johan G., Doo, Edward, Carola Zillikens, M., Geus, Eco J. C., North, Kari E., Biebermann, Heike, Teder-Laving, Maris, Ragozzino, Linda, Swift, Amy, Pouta, Anneli, Lorentzon, Mattias, Sanders, Alan R., Schreiber, Stefan, Rivadeneira, Fernando, Derdoy, Jose, Grallert, Harald, Willemsen, Gonneke, Saramies, Jouko, Vatin, Vincent, Fu, Mao, Clarke, Robert, Rosenthal, Monique, Luketic, Velimir A. C., Mangino, Massimo, Tonascia, James, Barlassina, Christina, Ünalp, Aynur, Thorsteinsdottir, Unnur, Willer, Cristen J., Macciardi, Fabio, Hassanali, Neelam, Cummings, Oscar W., Stephens, Jonathan, Chines, Peter, John, Ulrich, Meyre, David, McCarthy, Mark I., Saxena, Richa, Hunter, David J., Marre, Michel, Merriman, Raphael, Navarro, Pau; id_orcid, Boeing, Heiner, O'DONNELL CJ, Jousilahti, Pekka, Kowdley, Kris V., Fisher, Eva, Rudan, Igor, Felix, Stephan B., Sandholt, Camilla, Reinehr, Thomas, Beckmann, Jacques S., Smith, George Davey, Morken, Mario A., van Ommen, Gert-Jan, Nelis, Mari, Ben-Shlomo, Yoav, White, Charles C., Alibrandi, Maria T. S., Everhart, Jay, Esko, Tõnu, Cooper, Matthew N., Absher, Devin M., Estrada, Karol, Johnson, Toby, Rief, Winfried, Gjesing, Anette P., GIANT Consortium, ,, MANUNTA P, Saunders, Cheryl, Scherag, Andre, Bennett, Amanda J., Hoffmann, Joyce, Nemesh, James, Kim, Wana, Heath, Andrew C., van Wingerden, Sophie, Blakemore, Alexandra I. F., Hui, Jennie, Pabst, Mark, Gold Consortium, ,, Montgomery, Grant W., Goyette, Philippe, Ferrell, Linda D., Levinson, Douglas F., Thompson, Judy, Bonnycastle, Lori L., Balkau, Beverley, Melander, Olle, Liang, Liming, Kolcic, Ivana, Segrè, Ayellet V., Seeff, Leonard, Kinnunen, Leena, Rybin, Denis, Nieminen, Markku S., Hansen, Torben, Sovio, Ulla, Witteman, Jacqueline C., Waite, Lindsay L., Nyholt, Dale R., Beilby, John P., Schipf, Sabine, Peters, Marjolein J., James, Alan L., O'Connell, Jeffrey R., Weyant, Robert J., Boyett, Sherry, Pramstaller, Peter P., Ohlsson, Claes, Kähönen, Mika, Tuomi, Tiinamaija, Metspalu, Andres   +803 more
core   +5 more sources

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Selecting Closely-Linked SNPs Based on Local Epistatic Effects for Haplotype Construction Improves Power of Association Mapping

G3: Genes, Genomes, Genetics, 2019
Genome-wide association studies (GWAS) have gained central importance for the identification of candidate loci underlying complex traits. Single nucleotide polymorphism (SNP) markers are mostly used as genetic variants for the analysis of genotype ...
Fang Liu, Renate H. Schmidt, Jochen C. Reif, Yong Jiang   +3 more
doaj   +1 more source

Genome-wide Association Studies

, 2013
Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 2000 loci for common human diseases have been identified by GWAS.
Duncan, Emma, Brown, Matthew
openaire   +5 more sources

A genome-wide association search for type 2 diabetes genes in African Americans. [PDF]

, 2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Kumari, Meena, Seedorf, Udo, Sladek, Rob, Wu, Guanming, Rocheleau, Ghislain, McCarroll, Steve A, Bostrom, Meredith A, Pedersen, Oluf, Sanna, Serena, Marmot, Michael, McCarthy, Mark I, Amin, Najaf, van Dijk, Ko Willems, Divers, Jasmin, Hicks, Andrew A, Yarnell, John W G, Pearson, Daniel, Langefeld, Carl D, Dedoussis, George V, Elliott, Paul, Kao, Wen H L, Owen, Katharine R, Kaprio, Jaakko, Cavalcanti-Proença, Christine, Cooper, Matthew N, van Haeften, Timon W, Navarro, Pau, Strassburger, Klaus, Hammond, Naomi, Qi, Lu, McCulloch, Laura J, Uitterlinden, André G, Groves, Christopher J, Tönjes, Anke, Barroso, Inês, Palmer, Nicholette D, Kyvik, Kirsten Ohm, Waeber, Gérard, Boehm, Bernhard O, Loos, Ruth J F, Sijbrands, Eric, Bochud, Murielle, Boerwinkle, Eric, Bowden, Donald W, Lind, Lars, Le Bacquer, Olivier, Kong, Augustine, Mooser, Vincent, Timpson, Nicholas J, Pakyz, Ruth, Meisinger, Christa, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Wichmann, H-Erich, Ardlie, Kristin, Klopp, Norman, Goel, Anuj, Wright, Alan F, Franzosi, Maria Grazia, de Geus, Eco J C, Hallmans, Göran, Pramstaller, Peter Paul, Raychaudhuri, Soumya, Syvänen, Ann-Christine, Cauchi, Stephane, Salomaa, Veikko, Han, Xijing, Zethelius, Björn, Collins, Francis S, Blagieva, Roza, Hillman, David R, Ingelsson, Erik, Singleton, Andrew, Williams, Gordon H, Fischer-Rosinsky, Antje, Zhao, Jing Hua, Sethupathy, Praveen, Pattou, François, Lajunen, Taina, Serrano-Ríos, Manuel, Walker, Mark, Zillikens, M Carola, Borecki, Ingrid B, Rotimi, Charles N, Doney, Alex S F, Shields, Beverley, Melzer, David, Vitart, Veronique, Elliott, Katherine S, Uda, Manuela, McAteer, Jarred B, Scuteri, Angelo, Isomaa, Bo, Prokopenko, Inga, Rice, Kenneth, Bergmann, Sven, Hofmann, Oliver M, Lu, Lingyi, Dupuis, Josée, Pfeiffer, Andreas F H, Hunter, David J, Sparsø, Thomas, Mukherjee, Sutapa, Sladek, Robert, Uitterlinden, Andre, Martínez-Larrad, María Teresa, Morris, Andrew P, Crisponi, Laura, Chines, Peter S, Morris, Andrew D, 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Developing Novel Therapeutic Strategies Against Ring Finger Protein 213 Vasculopathy: Is It an Achievable Goal?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
See Article Choi et ...
Minghua Liu, Jose Gutierrez
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Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

Rice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei, Ryokei Tanaka, Taiji Kawakatsu, Shota Teramoto, Nobuhiro Tanaka, Matthew Shenton, Yusaku Uga, Shiori Yabe   +7 more
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