Results 191 to 200 of about 850,713 (297)

Genome-wide association study reveals candidate genes for body size and reproductive traits in Hu sheep [PDF]

Mao Li, Xin Xiang, Wei Gao, Lan Zhao, Zhengguang Wang, Kui Li   +5 more
openalex   +1 more source

An imputation-based genome-wide association study for growth and fatness traits in Sujiang pigs

, 2022
Pan Xu, Desen Li, Zhongping Wu, Ligang Ni, Jiaxing Liu, Ying Tang, Tongshun Yu, Jun Ren, Xuting Zhao, Min Huang   +9 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genome-Wide Association Study of Varenicline-Aided Smoking Cessation. [PDF]

Nicotine Tob Res
Coley K, Wang Q, Packer R, John C, Abner E, Reis K, Estonian Biobank Research Team, Bedair KF, Srinivasan S, Paciga S, Hyde C, Free RC, Reeve NF, Shepherd DJ, Esko T, Palmer C, Pearson E, Malarstig A, Tobin MD, Batini C.   +19 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The brief resilience scale: a genome-wide association study in the UK Biobank. [PDF]

BMC Med
Cornelis MC, Caldwell JA, Vu THT, Hennigar SR, Berryman CE, Lieberman HR.   +5 more
europepmc   +1 more source

Supplementary Table S8 from Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma

Karen Alpen, Robert J. MacInnis, Claire M. Vajdic, John Lai, James G. Dowty, Eng‐Siew Koh, Elizabeth Hovey, Rosemary Harrup, Tuong L. Nguyen, Shuai Li, David Joseph, Geza Benke, Pierre‐Antoine Dugué, Melissa C. Southey, Graham G. Giles, Anna K. Nowak, Katharine J. Drummond, Daniel F. Schmidt, John L. Hopper, Miroslaw K. Kapuscinski, Enes Makalic   +20 more
openalex   +1 more source

Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population [PDF]

, 2019
Ikuo Otsuka, Masato Akiyama, Osamu Shirakawa, Kenji Okazaki, Yukihide Momozawa, Yoichiro Kamatani, Takeshi Izumi, Shusuke Numata, Motonori Takahashi, Shuken Boku, Ichiro Sora, Ken Yamamoto, Yasuhiro Ueno, Tatsushi Toda, Michiaki Kubo, Akitoyo Hishimoto   +15 more
openalex   +1 more source

Genome-wide association study reveals novel QTLs and candidate genes for seed vigor in rice

, 2022
Liping Dai, Xueli Lu, Lan Shen, Longbiao Guo, Guangheng Zhang, Zhenyu Gao, Li Zhu, Jiang Hu, Guojun Dong, Deyong Ren, Qiang Zhang, Dali Zeng, Qian Qian, Qing Li   +13 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source