Results 191 to 200 of about 674,070 (352)
PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi +13 morewiley +1 more sourceGenome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Nature Genetics, 2019 Hunna J. Watson, Z. Yilmaz, L. Thornton, Christopher Hübel, J. Coleman, Héléna A. Gaspar, J. Bryois, A. Hinney, V. Leppä, M. Mattheisen, S. Medland, S. Ripke, Shuyang Yao, P. Giusti-Rodríguez, K. Hanscombe, K. Purves, R. Adan, L. Alfredsson, T. Ando, O. Andreassen, J. Baker, W. Berrettini, Ilka Boehm, C. Boni, V. B. Perica, Katharina Buehren, R. Burghardt, M. Cassina, S. Cichon, M. Clementi, R. Cone, P. Courtet, S. Crow, J. Crowley, U. Danner, O. Davis, M. Zwaan, G. Dedoussis, D. Degortes, J. DeSocio, D. Dick, D. Dikeos, C. Dina, M. Dmitrzak-Węglarz, E. Docampo, L. Duncan, K. Egberts, S. Ehrlich, G. Escaramís, T. Esko, X. Estivill, A. Farmer, A. Favaro, F. Fernández-Aranda, M. Fichter, K. Fischer, M. Föcker, L. Foretova, A. Forstner, M. Forzan, C. Franklin, S. Gallinger, I. Giegling, J. Giuranna, F. Gonidakis, P. Gorwood, Monica Gratacos Mayora, S. Guillaume, Yiran Guo, H. Hakonarson, K. Hatzikotoulas, J. Hauser, J. Hebebrand, S. Helder, S. Herms, B. Herpertz-Dahlmann, W. Herzog, L. Huckins, J. Hudson, H. Imgart, H. Inoko, V. Janout, S. Jiménez-Murcia, A. Julià, G. Kalsi, D. Kaminská, J. Kaprio, L. Karhunen, A. Karwautz, M. Kas, J. Kennedy, A. Keski-Rahkonen, K. Kiezebrink, Youl-Ri Kim, L. Klareskog, K. Klump, G. Knudsen, M. C. Via, S. Hellard, R. Levitan, Dong Li, L. Lilenfeld, Bochao D. Lin, J. Lissowska, J. Luykx, P. Magistretti, M. Maj, Katrin Mannik, S. Marsal, C. Marshall, M. Mattingsdal, S. McDevitt, P. McGuffin, A. Metspalu, I. Meulenbelt, N. Micali, K. Mitchell, A. Monteleone, P. Monteleone, Melissa A. Munn-Chernoff, B. Nacmias, M. Navratilova, I. Ntalla, J. O'toole, R. Ophoff, L. Padyukov, A. Palotie, J. Pantel, H. Papežová, D. Pinto, R. Rabionet, Anu Raevuori, N. Ramoz, T. Reichborn-Kjennerud, V. Ricca, S. Ripatti, Franziska Ritschel, Marion E. Roberts, A. Rotondo, D. Rujescu, F. Rybakowski, P. Santonastaso, A. Scherag, S. Scherer, U. Schmidt, N. Schork, A. Schosser, J. Seitz, L. Šlachtová, P. Slagboom, M. S. '. Slof-Op 't Landt, A. Słopień, S. Sorbi, B. Świątkowska, J. Szatkiewicz, I. Tachmazidou, E. Tenconi, A. Tortorella, F. Tozzi, J. Treasure, A. Tsitsika, M. Tyszkiewicz-Nwafor, K. Tziouvas, A. Elburg, E. F. Furth, G. Wagner, E. Walton, E. Widén, E. Zeggini, S. Zerwas, S. Zipfel, A. Bergen, J. Boden, H. Brandt, Steven Crawford, K. Halmi, L. Horwood, Craig Johnson, A. Kaplan, W. Kaye, James E Mitchell, C. Olsen, J. Pearson, N. Pedersen, M. Strober, T. Werge, D. Whiteman, D. Woodside, G. Stuber, S. Gordon, J. Grove, A. Henders, A. Juréus, K. Kirk, J. Larsen, Richard Parker, L. Petersen, J. Jordan, M. Kennedy, G. Montgomery, T. Wade, A. Birgegård, P. Lichtenstein, C. Norring, M. Landén, N. Martin, P. Mortensen, P. Sullivan, G. Breen, C. Bulik, Anorexia Nervosa Genetics Initiative, Eating Disorder Working Group of the Psychiatric Genomics Consortium +211 moresemanticscholar +1 more sourcePlecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor +10 morewiley +1 more sourceGenome-Wide Association Study on Grain Length and Grain Width of Rice. [PDF]
Biology (Basel)Li X, Wang S, Ma S, Liu S, Yin W, Xu L, Wang C, Yang X, Gu X, Xiang X, Hu Y. +10 moreeuropepmc +1 more sourceCrucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel +10 morewiley +1 more sourcePhenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer +9 morewiley +1 more sourceGenome-wide association study and polygenic risk prediction of hypothyroidism. [PDF]
Nat GenetRand SA, Ahlberg G, Tragante V, Monfort LM, Zheng C, Feldt-Rasmussen U, Klose MC, Teder-Laving M, Metspalu A, Poulsen HE, Ellervik C, Nygaard B, Erikstrup C, Bruun MT, A Jensen B, Ullum H, Brunak S, DBDS Genomic Consortium, Estonian Biobank Research Team, 23andMe Research Team, Schwinn M, Ostrowski SR, Pedersen OB, Sørensen E, Jonsdottir I, Gudbjartsson DF, Thorleifsson G, Holm H, Saevarsdottir S, Stefansson K, Salling Olesen M, Bundgaard H, Ghouse J. +32 moreeuropepmc +1 more sourceGenome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Nature Genetics, 2010 E. Stahl, S. Raychaudhuri, E. Remmers, G. Xie, S. Eyre, Brian Thomson, Yonghong Li, F. Kurreeman, A. Zhernakova, A. Hinks, C. Guiducci, Robert Chen, L. Alfredsson, C. Amos, K. Ardlie, A. Barton, J. Bowes, E. Brouwer, N. Burtt, J. Catanese, J. Coblyn, M. Coenen, K. Costenbader, L. Criswell, J. Crusius, J. Cui, P. D. Bakker, P. D. Jager, B. Ding, P. Emery, E. Flynn, Pille Harrison, L. Hocking, T. Huizinga, D. Kastner, X. Ke, Annette Lee, Xiangdong Liu, Paul Martin, A. Morgan, L. Padyukov, M. Posthumus, T. Radstake, D. Reid, Mark Seielstad, M. Seldin, N. Shadick, S. Steer, P. Tak, W. Thomson, A. Mil, I. Horst-Bruinsma, C. E. Schoot, P. Riel, M. Weinblatt, A. Wilson, G. Wolbink, Bryan Paul Wordsworth, C. Wijmenga, E. Karlson, R. Toes, N. Vries, A. Begovich, Jane Worthington, K. Siminovitch, P. Gregersen, L. Klareskog, R. Plenge +67 moresemanticscholar +1 more sourceRedox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter +2 morewiley +1 more source
