Results 191 to 200 of about 1,111,517 (383)

MultiGWAS: An integrative tool for Genome Wide Association Studies (GWAS) in tetraploid organisms [PDF]

, 2020
Luis Garreta, Ivania Cerón‐Souza, Manfred Ricardo Palacio, Paula H. Reyes‐Herrera   +3 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genome-Wide Association Study for Age-Related Hearing Loss (AHL) in the Mouse: A Meta-Analysis [PDF]

, 2014
Jeffrey D. Ohmen, Eun Yong Kang, Xin Li, Jong Wha J. Joo, Farhad Hormozdiari, Qing Yin Zheng, Richard C. Davis, Aldons J. Lusis, Eleazar Eskin, Rick A. Friedman   +9 more
openalex   +1 more source

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Nature Genetics, 2007
J. Rioux, J. Rioux, R. Xavier, K. Taylor, M. Silverberg, P. Goyette, A. Huett, Todd Green, Petric Kuballa, M. Barmada, L. Datta, Y. Shugart, A. Griffiths, S. Targan, A. Ippoliti, E. Bernard, L. Mei, Dan L. Nicolae, M. Regueiro, L. P. Schumm, A. Steinhart, J. Rotter, R. Duerr, Judy H. Cho, M. J. Daly, M. J. Daly, S. Brant   +26 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Genome-wide association study of aromatase inhibitor discontinuation due to musculoskeletal symptoms

, 2022
Daniel L. Hertz, Julie A. Douglas, Robert M. Miller, Kelley M. Kidwell, Christina L. Gersch, Zeruesenay Desta, Anna Maria Storniolo, Vered Stearns, Todd C. Skaar, Daniel F. Hayes, N. Lynn Henry, James M. Rae   +11 more
openalex   +2 more sources

Identification of Quantitative Trait Loci for Leaf Rust and Stem Rust Seedling Resistance in Bread Wheat Using a Genome-Wide Association Study [PDF]

, 2021
Алибек Затыбеков, Yuliya Genievskaya, Aralbek Rsaliyev, Akerke Maulenbay, Gulbahar Yskakova, Timur Savin, Yerlan Turuspekov, Сауле Абугалиева   +7 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy [PDF]

, 2011
Eric Villard, Claire Perret, Françoise Gary, Carole Proust, Gilles Dilanian, Christian Hengstenberg, Volker Ruppert, Eloisa Arbustini, Thomas Wichter, Marine Germain, Olivier Dubourg, Luigi Tavazzi, Marie-Claude Aumont, Pascal de Groote, Laurent Fauchier, Jean‐Noël Trochu, Pierre Gibelin, Jean‐François Aupetit, Klaus Stark, Jeanette Erdmann, Roland Hetzer, Angharad M. Roberts, Paul J.R. Barton, Vera Regitz‐Zagrosek, Uzma Aslam, Laëtitia Duboscq-Bidot, Matthias Meyborg, Bernhard Maisch, Hugo Madeira, Anders Waldenström, Enrique Galve, John G.F. Cleland, Richard Dorent, Gérard Roizès, Tanja Zeller, Stefan Blankenberg, Alison H. Goodall, Stuart A. Cook, David‐Alexandre Trégouët, Laurence Tiret, Richard Isnard, Michel Komajda, Philippe Charron, François Cambien   +43 more
openalex   +1 more source