Results 221 to 230 of about 850,713 (297)

Genome-wide association study and genome prediction of tallness trait in spinach phenotyping. [PDF]

Front Plant Sci
Alatawi I, Xiong H, Alkabkabi H, Chiwina K, Mou B, Luo Q, Qu Y, Du R, Riaz A, Harrison DJ, Shi A.   +10 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

TidyGWAS: a scalable approach for standardized cleaning of genome-wide association study summary statistics. [PDF]

Bioinform Adv
Harder A, Guintivano J, Pasman JA, Sullivan PF, Lu Y.   +4 more
europepmc   +1 more source

A Genome‐Wide Association Study of Apple Quality and Scab Resistance

, 2018
Kendra A. McClure, Kyle M. Gardner, Gavin M. Douglas, Jun Song, Charles F. Forney, John M. DeLong, Lihua Fan, Lina Du, P.M.A. Toivonen, Daryl J. Somers, Istvan Rajcan, Sean Myles   +11 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Noncoding Genome‐Wide Association Studies Variant for Obesity: Inroads Into MechanismAn Overview From the AHA's Council on Functional Genomics and Translational Biology

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Connie Wu, Pankaj Arora
doaj   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Genome-wide association study of adolescent-onset depression

Grimes PZ, Mitchell BL, Thompson KN, Deng Q, Shen X, Wolfe JC, Thomas JT, Wootton RE, Adkins DE, Arirangan S, Assary E, Chatzinakos C, Dennison CA, Gangaraju SH, Jangmo A, Jeong Y, Kurvits S, Li QS, Motazedi E, Naamanka J, Nguyen T, Nolte IM, Ota VK, Pasman JA, Shahisavandi M, Shakeshaft A, Shorter JR, Slaney C, Tesli M, Wang CA, Zubizarreta-Arruti U, PGC MDD Working Group, GLAD+, NIHR BioResource, Alemany S, Andreassen OA, Ask H, Belangero SI, Bosch R, Breen G, Bressan RA, Buil A, Byrne EM, Casas M, Copeland WE, Eley TC, Hannigan LJ, Hartman CA, Havdahl A, Hickie IB, Khandaker GM, Lehto K, Maes H, Martin NG, Neumann A, Oldehinkel AJ, Pan PM, Pan H, Pennell CE, Peterson RE, Rodriguez A, Salum GA, Vrijkotte TG, Wedow R, Whitehouse AJ, Thapar A, Larsson H, Middeldorp CM, McIntosh A, Adams MJ, Lu Y, Whalley HC, Kwong AS.   +72 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Loci and natural alleles for leaf length and width revealed by a genome wide association study in adzuki bean. [PDF]

BMC Plant Biol
Wu X, Wen Y, Wu K, Li R, Li X, Zhang X, Chu L, Li Y, Yang K, Wan P, Yu J, Zhao B.   +11 more
europepmc   +1 more source