Results 241 to 250 of about 434,983 (266)

Study Designs for Genome‐Wide Association Studies

2008
Advances in high-throughput genotyping and a flood of data on human genetic variation from the Human Genome and HapMap projects have made genome-wide association studies technically feasible. However, researchers designing such studies face a number of challenges, including how to avoid subtle systematic biases and how to achieve sufficient statistical
Peter, Kraft, David G, Cox
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The road to genome-wide association studies

Nature Reviews Genetics, 2008
The recent crop of results from genome-wide association studies might seem like a sudden development. However, this blooming follows a long germination period during which the necessary concepts, resources and techniques were developed and assembled.
openaire   +2 more sources

Genome-Wide Association Studies

JAMA, 2019
Xiuqing, Guo, Jerome I, Rotter
openaire   +3 more sources

Quality Control for Genome-Wide Association Studies

2013
This chapter overviews the quality control (QC) issues for SNP-based genotyping methods used in genome-wide association studies. The main metrics for evaluating the quality of the genotypes are discussed followed by a worked out example of QC pipeline starting with raw data and finishing with a fully filtered dataset ready for downstream analysis.
Gondro, Cedric, Lee, Seung Hwan, Lee, Hak Kyo, Porto-Neto, Laercio R.   +3 more
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Genome-wide association study for osteoarthritis

The Lancet, 2013
Hao, Pang, Fei, Luo, Fei, Dai, Xue-Hui, Wu, Jian-Zhong, Xu   +4 more
openaire   +2 more sources

[Genome-wide association studies].

Ugeskrift for laeger, 2008
Within the last year, genome-wide association (GWA) studies have identified a large number of robust associations between genetic variants and common diseases. Two key premises underlie this burst of discovery. First, the HapMap project has provided a catalogue of human genetic variation.
Bjarke, Feenstra, Heather Allison, Boyd, Mads, Melbye   +2 more
openaire   +1 more source

Advancing the use of genome-wide association studies for drug repurposing

Nature Reviews Genetics, 2021
William R Reay, Murray J Cairns
exaly  

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Nature Genetics, 2022
Aysu Okbay, Julia Sidorenko, Hyeokmoon Kweon   +2 more
exaly  

Genome-wide association studies

Nature Reviews Methods Primers, 2021
Emil Uffelmann, Qin Qin Huang, Nchangwi Syntia Munung   +2 more
exaly  

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

Nature Reviews Drug Discovery, 2016
Kathleen M Giacomini, Sook Wah Yee, Richard M Weinshilboum   +2 more
exaly