Results 231 to 240 of about 1,111,517 (383)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genome-Wide Association Study on Grain Length and Grain Width of Rice. [PDF]

Biology (Basel)
Li X, Wang S, Ma S, Liu S, Yin W, Xu L, Wang C, Yang X, Gu X, Xiang X, Hu Y.   +10 more
europepmc   +1 more source

Determining the Genetic Architecture and Breeding Potential of Quality Traits in Alfalfa (Medicago sativa L.) Through Genome-Wide Association Study and Genomic Prediction [PDF]

Ming Xu, Kai Zhu, Xueqian Jiang, Fan Zhang, Bilig Sod, Huijie Leng, Tian Zhang, Yanchao Xu, Tianhui Yang, Mingna Li, Xue Wang, Qingchuan Yang, Junmei Kang, Zhang Tie-jun, Lin Chen, Ruicai Long, Fei He   +16 more
openalex   +1 more source

Cross-Trait Prediction Accuracy of Summary Statistics in Genome-Wide Association Studies

, 2022
Bingxin Zhao, Fei Zou, Hongtu Zhu
openalex   +2 more sources

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Nature Genetics, 2010
E. Stahl, S. Raychaudhuri, E. Remmers, G. Xie, S. Eyre, Brian Thomson, Yonghong Li, F. Kurreeman, A. Zhernakova, A. Hinks, C. Guiducci, Robert Chen, L. Alfredsson, C. Amos, K. Ardlie, A. Barton, J. Bowes, E. Brouwer, N. Burtt, J. Catanese, J. Coblyn, M. Coenen, K. Costenbader, L. Criswell, J. Crusius, J. Cui, P. D. Bakker, P. D. Jager, B. Ding, P. Emery, E. Flynn, Pille Harrison, L. Hocking, T. Huizinga, D. Kastner, X. Ke, Annette Lee, Xiangdong Liu, Paul Martin, A. Morgan, L. Padyukov, M. Posthumus, T. Radstake, D. Reid, Mark Seielstad, M. Seldin, N. Shadick, S. Steer, P. Tak, W. Thomson, A. Mil, I. Horst-Bruinsma, C. E. Schoot, P. Riel, M. Weinblatt, A. Wilson, G. Wolbink, Bryan Paul Wordsworth, C. Wijmenga, E. Karlson, R. Toes, N. Vries, A. Begovich, Jane Worthington, K. Siminovitch, P. Gregersen, L. Klareskog, R. Plenge   +67 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Genome-wide association study and polygenic risk scores of eosinophilia in Taiwan. [PDF]

Clin Transl Immunology
Lu HF, Boon-Yong S, Yang CY, Wang JY, Chang YT, Tsai FJ.   +5 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Genome-wide association study and polygenic risk prediction of hypothyroidism. [PDF]

Nat Genet
Rand SA, Ahlberg G, Tragante V, Monfort LM, Zheng C, Feldt-Rasmussen U, Klose MC, Teder-Laving M, Metspalu A, Poulsen HE, Ellervik C, Nygaard B, Erikstrup C, Bruun MT, A Jensen B, Ullum H, Brunak S, DBDS Genomic Consortium, Estonian Biobank Research Team, 23andMe Research Team, Schwinn M, Ostrowski SR, Pedersen OB, Sørensen E, Jonsdottir I, Gudbjartsson DF, Thorleifsson G, Holm H, Saevarsdottir S, Stefansson K, Salling Olesen M, Bundgaard H, Ghouse J.   +32 more
europepmc   +1 more source

A genome‐wide association study for reading and language abilities in two population cohorts [PDF]

, 2013
Michelle Luciano, David M. Evans, Narelle K. Hansell, Sarah E. Medland, Grant W. Montgomery, Nicholas G. Martin, Margaret J. Wright, Timothy C. Bates   +7 more
openalex   +1 more source