Results 261 to 270 of about 674,070 (352)

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

Nature Biotechnology, 2013
J. Denny, L. Bastarache, M. Ritchie, R. Carroll, Raquel M. Zink, J. Mosley, Julie Field, J. Pulley, A. Ramirez, E. Bowton, Melissa A. Basford, D. Carrell, P. Peissig, A. Kho, J. Pacheco, L. Rasmussen, D. Crosslin, P. Crane, Jyotishman Pathak, S. Bielinski, S. Pendergrass, Hua Xu, L. Hindorff, Rongling Li, T. Manolio, C. Chute, R. Chisholm, E. Larson, G. Jarvik, M. Brilliant, C. McCarty, I. Kullo, J. Haines, D. Crawford, D. Masys, D. Roden   +35 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Genome-Wide Association Study of Immune Indices in Yaks. [PDF]

Animals (Basel)
Yu D, Ma X, Huang C, Wang T, Zhang M, Feng F, Wu X, La Y, Guo X, Yan P, Zhang D, Liang C.   +11 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Genome-wide association study of pulpal and apical diseases. [PDF]

Nat Commun
Salminen A, Hyvärinen K, Ritari J, Leppilahti JM, Palotie U, Vuollo V, Kambur O, FinnGen, Estonian Biobank Research Team, Reis K, Reigo A, Palta P, Perola M, Sinisalo J, Havulinna AS, Mäntylä P, Gürsoy UK, Suominen AL, Rice DP, Anttonen V, Nieminen P, Pussinen PJ.   +21 more
europepmc   +1 more source

Additional file 7: Tables S5a-b. of Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

, 2016
Yasmmyn Salinas, Leyao Wang, Andrew T. DeWan   +2 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Genome-wide association study of chlamydia reinfection in African American women. [PDF]

Front Immunol
Tiwari HK, Patki A, Srinivasasainagendra V, Vejandla SC, Sadeesh A, Gupta K, Appah M, Geisler WM.   +7 more
europepmc   +1 more source

Genome-Wide Association Studies and Diet

Journal of Nutrigenetics and Nutrigenomics, 2010
openaire   +3 more sources

A Comprehensive Overview of the Clinical, Electrophysiological, and Neuroimaging Features of BPAN: Insights From a New Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun, Ozgu Kizek, Sibel Aylin Ugur Iseri, Ibrahim Kamaci, Ayse Deniz Elmali, Pinar Iscen, Berfin Gulkaya Guzel, Gul Yalcin Cakmakli, Bulent Elibol, Berril Donmez, Raif Cakmur, Pinar Topaloglu, Turkish NBIA Study Group, Abdullah Acar, Ahmet Acarer, Arzu Karabay, Asuman Ali, Ayla Barlas, Aysegul Gunduz, Banu Ozen Barut, Baris Baslo, Bilge Kocer, Bilgehan Mus, Birsen Karaman, Burcu Gokce Cokal, Cem Ismail Kucukali, Cenk Akbostanci, Ceyhun Sayman, Cagla Turan, Dilek Ince Gunal, Ebru Bilge Dirik, Ebru Erzurumluoglu, Elif Kocasoy Orhan, Enes Demiryurek, Emrah Yucesan, Ercan Kose, Erdem Tuzun, Esen Saka Topcuoglu, Esra Okuyucu, Fatma Betul Ozdilek, Feriha Ozer, Gencer Genc, Gozde Unal, Gulay Kenangil, Gullu Tarhan, Gunes Kiziltan, Halil Onder, Hamit Genc, Hasmet Hanagasi, Hatice Yuksel, Hulya Apaydin, Koray Kirimtay, Mehmet Guney Senol, Melisa Kilic, Meltem Demirkiran, Mert Karaca, Miray Erdem, Muhammet Bilgehan Mus, Murat Gultekin, Nalan Capan, Nazan Karagoz Sakalli, Nazli Basak, Nihan Hande Akcakaya, Ozan Ezer, Ozge Uygun, Ozge Yilmaz Kuspeci, Ozgur Oztop Cakmak, Pervin Iseri, Petek Ballar Kirmizibayrak, Pinar Elkoca, Recep Alp, Remzi Yigiter, Rezzak Yilmaz, Sadika Ozdemir, Selda Keskin, Selen Ilhan Alp, Selen Soylu, Serdar Ceylaner, Serhat Ozkan, Sevda Erer Ozbek, Sevgin Gundogan, Sevil Yasufli, Sezin Alpaydin Baslo, Sibel Ertan, Sultan Cagirici, Seyma Aykac, Vuslat Yilmaz, Yaprak Secil, Yasar Kutukcu, Yeliz Ciftci, Yesim Sucullu Karadag, Yildiz Değirmenci, Zeliha Matur, Nerses Bebek, Murat Emre, Zuhal Yapici   +95 more
wiley   +1 more source