Results 171 to 180 of about 2,754,601 (316)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Development and deployment of a public mid-density genotyping panel for crimson clover (Trifolium incarnatum L.) based on whole-genome re-sequencing of diverse germplasm. [PDF]

Plant Genome
Castillo MP, Oyebode OG, Talag J, Bunting V, Kaur N, Doran P, Barry K, Competti D, Schmutz J, Schlautman B, Humphries A, Ghamkhar K, Moore V, Rios E, Harkess A, Wolfe M.   +15 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Tetraploid Wheat Germplasm Diversity Scan based on the Durum Wheat Genome Assembly

, 2018
The genome of modern durum wheat (DW) cultivar Svevo has been assembled based on a combination of whole genome shotgun sequencing (270X), NRGene deNovoMagic assembler, high-resolution genetic mapping obtained from the cross between Svevo DW and Zavitan ...
Raj K Pasam, Silvio Salvi, Hakan Ozkan, Matt Hayden, Simona Corneti, Elisabetta Mazzucotelli, Steven Xu, Curtis Pozniak, The International Durum Wheat Genome Sequencing Consortium, Roberto Tuberosa, Benjamin Kilian, Shiaoman Chao, Elisabetta Frascaroli, Marco Maccaferri, Anna Maria Mastrangelo, Nicola Pecchioni, Luigi Cattivelli, Neils Harris, Reem Joukhadar   +18 more
core  

Comparative genome assemblies reveal distinct allelic and structural variation at blast resistance loci in rice CT21375-F4-4 and Moroberekan. [PDF]

Plant Genome
Martin F, Duitama J, Narvaez M, Perez-Quintero AL, Quintero C, Neupane K, Bonilla DS, Rebolledo Cid C, Alvarez MF, Mosquera GM, Leach JE.   +10 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Genome-wide prediction of cloned disease resistance homologues across the Oryza genus. [PDF]

Plant Genome
Morrison S, Batley J, Navea IP, Schepler-Luu V, Henry RJ.   +4 more
europepmc   +1 more source

Genome Evolution [PDF]

Advances in Bioinformatics, 2010
Izabela Makalowska, Igor B. Rogozin, Wojciech Makalowski   +2 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Coniochaeta ligniaria strain:NRRL 32068 Genome sequencing

, 2014
Genome sequence of the inhibitor-tolerant Ascomycete Coniochaeta ligniaria ...
DOE Joint Genome Institute (17854997)
core