Results 251 to 260 of about 4,524,973 (357)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Draft genome sequence of Talaromyces trachyspermus, a biocontrol fungus isolated from broomrape. [PDF]

G3 (Bethesda)
Hemmati R, Dolatabadian A, Saeedi S, Batley J.   +3 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Chromosome-Level Reference Genome of an Endemic, Endangered Long-Armed Scarab (<i>Cheirotonus formosanus</i>): Discovery of a Putative Y-Linked Scaffold and Demographic History. [PDF]

Ecol Evol
Chien S, Huang JP, Blackmon H.
europepmc   +1 more source

Comparative genomics and genome evolution.

Current genomics, 2012
Das, Sabyasachi, Hirano, Masayuki
openaire   +2 more sources

Genome engineering using the CRISPR-Cas9 system

Nature Protocols, 2013
F. Ran, P. Hsu, Jason B Wright, Vineeta Agarwala, Vineeta Agarwala, David A. Scott, Feng Zhang   +6 more
semanticscholar   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

De Novo Chromosome-Level Genome Assembly of 'Qing Zhou Mi' Landrace Peach and Analysis of Late Maturity and Fruit Weight Traits in Peach. [PDF]

Plants (Basel)
Li M, Gong Q, Li G, Gao J, Zhang A.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Chloroplast genome assembly, annotation, comparative genomics, and genetic diversity analysis of a vulnerable endemic species Lavandula maroccana Murb. [PDF]

PLoS One
Kumar Biswas M, Legeay J, Errafii K, Abbad I, Heslop-Harrison P, Hijri M, Ahmed B.   +6 more
europepmc   +1 more source