Results 131 to 140 of about 1,479,681 (326)

ColorHOR—novel graphical algorithm for fast scan of alpha satellite higher-order repeats and HOR annotation for GenBank sequence of human genome [PDF]

, 2004
V. Paar, Nenad Pavin, Marija Rosandić, Matko Glunčić, I. Basar, Robert Pezer, Sonja Durajlija Žinić   +6 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genome cartography through domain annotation.

Genome biology, 2002
The evolutionary history of eukaryotic proteins involves rapid sequence divergence, addition and deletion of domains, and fusion and fission of genes. Although the protein repertoires of distantly related species differ greatly, their domain repertoires do not.
Ponting, C, Dickens, N
openaire   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Improved hybrid de novo genome assembly and annotation of African wild rice, Oryza longistaminata , from Illumina and PacBio sequencing reads

, 2020
Wei Li, Kui Li, Qun‐Jie Zhang, Ting Zhu, Yun Zhang, Cong Shi, Yunlong Liu, Enhua Xia, Jianjun Jiang, Chao Shi, Liping Zhang, Hui Huang, Yan Tong, Yuan Liu, Dan Zhang, Yuan Zhao, Wenkai Jiang, Youjie Zhao, Shu‐Yan Mao, Jun-Ying Jiao, Ping‐zhen Xu, Lili Yang, Guoying Yin, Lizhi Gao   +23 more
openalex   +1 more source

Gene trap as a tool for genome annotation and analysis of X chromosome inactivation in human embryonic stem cells [PDF]

, 2004
S. K. Dhara
openalex   +1 more source

BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs

Bioinform., 2015
Felipe A. Simão, Robert M. Waterhouse, P. Ioannidis, E. Kriventseva, E. Zdobnov   +4 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

IMA Genome – F19

IMA Fungus
The pace at which Next Generation Sequence data is being produced continues to accelerate as technology improves. As a result, such data are increasingly becoming accessible to biologists outside of the field of bioinformatics.
Janneke Aylward, Andi M. Wilson, Cobus M. Visagie, Joseph Spraker, Irene Barnes, Carla Buitendag, Callin Ceriani, Lina Del Mar Angel, Deanné du Plessis, Taygen Fuchs, Katharina Gasser, Daniella Krämer, WenWen Li, Kiara Munsamy, Anja Piso, Jenna-Lee Price, Byron Sonnekus, Chanel Thomas, Ariska van der Nest, Alida van Dijk, Alishia van Heerden, Nicole van Vuuren, Neriman Yilmaz, Tuan A. Duong, Nicolaas A. van der Merwe, Michael J. Wingfield, Brenda D. Wingfield   +26 more
doaj   +1 more source