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An Introduction to Genome Annotation
Current Protocols in Bioinformatics, 2015AbstractGenome projects have evolved from large international undertakings to tractable endeavors for a single lab. Accurate genome annotation is critical for successful genomic, genetic, and molecular biology experiments. These annotations can be generated using a number of approaches and available software tools.
Mark Yandell, Michael S. Campbell
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Annotation of Parasite Genomes
2004Genome annotation is the application of useful biological descriptions to sequence data. Different levels of time and effort can be invested to produce correspondingly different depths of annotation depending on what methods are employed. Researchers using genome data should, therefore, understand how annotations are generated to assess their validity ...
Matthew Berriman, Midori A. Harris
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Annotating the Regulatory Genome
2010Determining the timing and molecular repertoire responsible for gene expression is fundamental to understanding a gene's function. Heritable differences in this character are increasingly regarded as explanatory for complex and common traits. For many known trait-predisposing genes, studies have sought to elucidate the associated logic behind gene ...
Obi L. Griffith +3 more
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International Rice Research Notes, 2007
A high-quality finished sequence of the rice genome was completed in 2005. However, to maximally use the sequences, quality annotation of the genes and genome features is necessary. The process of annotation is iterative in nature and requires the application and refinement of computational tools coupled with manual curation and evalutation.
Yuandan Lee +11 more
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A high-quality finished sequence of the rice genome was completed in 2005. However, to maximally use the sequences, quality annotation of the genes and genome features is necessary. The process of annotation is iterative in nature and requires the application and refinement of computational tools coupled with manual curation and evalutation.
Yuandan Lee +11 more
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2017
Newly sequenced genomes are being added to the tree of life at an unprecedented fast pace. Increasingly, such new genomes are phylogenetically close to previously sequenced and annotated genomes. In other cases, whole clades of closely related species or strains ought to be annotated simultaneously.
Lars Romoth +2 more
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Newly sequenced genomes are being added to the tree of life at an unprecedented fast pace. Increasingly, such new genomes are phylogenetically close to previously sequenced and annotated genomes. In other cases, whole clades of closely related species or strains ought to be annotated simultaneously.
Lars Romoth +2 more
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2018
The term "genome annotation" includes identification of protein-coding and noncoding sequences (e.g., repeats, rDNA, and ncRNA) in genome assemblies and attaching functional information (metadata) to these annotated features. Here, we describe the basic outline of fungal nuclear and mitochondrial genome annotation as performed at the US Department of ...
Igor V. Grigoriev +2 more
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The term "genome annotation" includes identification of protein-coding and noncoding sequences (e.g., repeats, rDNA, and ncRNA) in genome assemblies and attaching functional information (metadata) to these annotated features. Here, we describe the basic outline of fungal nuclear and mitochondrial genome annotation as performed at the US Department of ...
Igor V. Grigoriev +2 more
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Genome Sequencing and Annotation
2003The availability of complete microbial genome sequences enormously facilitates experimental molecular investigations of the respective organisms by providing complete lists of genes, their genetic contexts, and their predicted functions. This can be used in a number of ways to focus studies on bacterial pathogenesis and also vaccine development (1,2 ...
Alex C. Jeffries +2 more
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2012
Annotation of prokaryotic sequences can be separated into structural and functional annotation. Structural annotation is dependent on algorithmic interrogation of experimental evidence to discover the physical characteristics of a gene. This is done in an effort to construct accurate gene models, so understanding function or evolution of genes among ...
Tracey Allen K. Freitas +3 more
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Annotation of prokaryotic sequences can be separated into structural and functional annotation. Structural annotation is dependent on algorithmic interrogation of experimental evidence to discover the physical characteristics of a gene. This is done in an effort to construct accurate gene models, so understanding function or evolution of genes among ...
Tracey Allen K. Freitas +3 more
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Towards multidimensional genome annotation [PDF]
Nature Reviews Genetics, 2006 Our information about the gene content of organisms continues to grow as more genomes are sequenced and gene products are characterized. Sequence-based annotation efforts have led to a list of cellular components, which can be thought of as a one-dimensional annotation.
Iman Famili +3 more
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Genome Sequencing and Annotation
2004Many microbial genome sequences have been determined, and more new genome projects are ongoing. Shotgun sequencing of randomly cloned short pieces of genomic DNA can provide a simple way of determining whole genome sequences. This process requires sequencing of many fragments, compilation of the separate sequences into one contiguous sequence, and ...
Makoto Kuroda, Keiichi Hiramatsu
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