Results 271 to 280 of about 368,532 (309)

Genome Sequencing and Annotation

2003
The availability of complete microbial genome sequences enormously facilitates experimental molecular investigations of the respective organisms by providing complete lists of genes, their genetic contexts, and their predicted functions. This can be used in a number of ways to focus studies on bacterial pathogenesis and also vaccine development (1,2 ...
A C, Jeffries, N J, Saunders, D W, Hood
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Bacterial Genome Annotation

2012
Annotation of prokaryotic sequences can be separated into structural and functional annotation. Structural annotation is dependent on algorithmic interrogation of experimental evidence to discover the physical characteristics of a gene. This is done in an effort to construct accurate gene models, so understanding function or evolution of genes among ...
Nicholas, Beckloff, Shawn, Starkenburg, Tracey, Freitas, Patrick, Chain   +3 more
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Genome annotation

Plant Physiology and Biochemistry, 2001
85 ref.
Aubourg, Sebastien, Rouzé, Pierre
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Comparative Genome Annotation

Newly sequenced genomes are being added to the tree of life at an unprecedented fast pace. A large proportion of such new genomes are phylogenetically close to previously sequenced and annotated genomes. In other cases, whole clades of closely related species or strains ought to be annotated simultaneously.
Stefanie, Nachtweide, Lars, Romoth, Mario, Stanke   +2 more
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Genome Annotation

The hallmark of genome sequencing projects is to provide genetic information on a species with functional annotations of genes and proteins. This process heavily relies on genome annotation based on homology detections from previously known genomic data.
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Using the transcriptome to annotate the genome

Nature Biotechnology, 2002
A remaining challenge for the human genome project involves the identification and annotation of expressed genes. The public and private sequencing efforts have identified approximately 15,000 sequences that meet stringent criteria for genes, such as correspondence with known genes from humans or other species, and have made another approximately 10 ...
Saurabh, Saha, Andrew B, Sparks, Carlo, Rago, Viatcheslav, Akmaev, Clarence J, Wang, Bert, Vogelstein, Kenneth W, Kinzler, Victor E, Velculescu   +7 more
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Annotating the genome of Medicago truncatula

Current Opinion in Plant Biology, 2006
Medicago truncatula will be among the first plant species to benefit from the completion of a whole-genome sequencing project. For each of these species, Arabidopsis, rice and now poplar and Medicago, annotation, the process of identifying gene structures and defining their functions, is essential for the research community to benefit from the sequence
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Genome annotation and protein structure

Proceedings. IEEE Computer Society Bioinformatics Conference, 2003
Summary form only given. Structural genomics aims to provide a good experimental structure or computational model of every tractable protein in a complete genome. Underlying this goal is the immense value of protein structure, especially in permitting recognition of distant evolutionary relationships for proteins whose sequence analysis has failed to ...
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Plant Genome Annotation Methods

2009
Annotation of plant genomic sequences can be separated into structural and functional annotation. Structural annotation is the foundation of all genomics as without accurate gene models understanding gene function or evolution of genes across taxa can be impeded.
Shu, Ouyang, Françoise, Thibaud-Nissen, Kevin L, Childs, Wei, Zhu, C Robin, Buell   +4 more
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Tutorial: annotation of animal genomes

Nature Protocols
As DNA sequencing technologies improve, it is becoming easier to sequence and assemble new genomes from non-model organisms. However, before a newly assembled genome sequence can be used as a reference, it must be annotated with genes and other features. This can be conducted by individual laboratories using publicly available software.
Zoe A. Clarke, Dustin J. Sokolowski, Ciaran K. Byles-Ho, Ruth Isserlin, Michael D. Wilson, Jared T. Simpson, Gary D. Bader   +6 more
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