Results 151 to 160 of about 931,274 (267)

Retrospective whole-genome comparison of Salmonella enterica serovar Enteritidis from foodborne outbreaks in Southern Brazil. [PDF]

Braz J Microbiol, 2021
Mascitti AK, Kipper D, Dos Reis RO, da Silva JS, Fonseca ASK, Ikuta N, Tondo EC, Lunge VR.   +7 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Algorithms for genome comparison applied to bacterial genomes

, 2010
Avec plus de 1000 génomes complets disponibles (la grande majorité venant de bactéries), les analyses comparatives de génomes deviennent indispensables pour leur annotation fonctionnelle, ainsi que pour la compréhension de leur structure et leur évolution, et s’appliquent par exemple en phylogénomique ou au design des vaccins.
openaire   +1 more source

The Complete Chloroplast Genome Sequences of <i>Salvia reflexa</i> and Genome Comparison: Implications for Phylogeny and Plant Invasion. [PDF]

Ecol Evol
Ding L, Yang T, Wang S, Zhou H, Xin R, Miao Q, Guan P, Qu B.   +7 more
europepmc   +1 more source

A Large-Scale Multiple Genome Comparison of Acidophilic Archaea (pH ≤ 5.0) Extends Our Understanding of Oxidative Stress Responses in Polyextreme Environments. [PDF]

Antioxidants (Basel), 2021
Neira G, Vergara E, Cortez D, Holmes DS.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Chloroplast genome comparison of Valeriana species with sequence variation, selective pressure, and divergence analysis. [PDF]

PLoS One
Jeong S, Kim YG, Kim Y, Nam BM, Park YJ, Jin BJ, Park I.   +6 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Phylogeny and Underground Adaptation of Eulipotyphla Revealed by Whole Genome Comparison Phylogeny and Adaptation of Eulipotyphla. [PDF]

Genes (Basel)
Zhang H, Liu X, Lin Z, Li L, Gao M, Sun J, Li R, Lu H, Li K.   +8 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source