Results 151 to 160 of about 893,715 (267)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mitochondrial Genome Comparison and Phylogenetic Analysis of Four Species of Dung Beetles (Coleoptera: Scarabaeidae: Scarabaeinae). [PDF]

Ecol Evol
Zhang H, He Q, Zhao Z, Zhang B, Zhou J, Wang C, Yi C, Zhao M.   +7 more
europepmc   +1 more source

Whole genome comparison of Pakistani Corona virus with Chinese and US Strains along with its predictive severity of COVID-19. [PDF]

Gene Rep, 2021
Saif R, Mahmood T, Ejaz A, Zia S, Qureshi AR.   +4 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Algorithms for genome comparison applied to bacterial genomes

, 2010
Avec plus de 1000 génomes complets disponibles (la grande majorité venant de bactéries), les analyses comparatives de génomes deviennent indispensables pour leur annotation fonctionnelle, ainsi que pour la compréhension de leur structure et leur évolution, et s’appliquent par exemple en phylogénomique ou au design des vaccins.
openaire   +1 more source

Advances and challenges in understanding evolution through genome comparison: meeting report of the European Molecular Biology Organization (EMBO) lecture course "Evolutionary and Comparative Genomics". [PDF]

Bioinform Adv
Gavriilidou A, Stamatakis A, Kupczok A, Bista I, Jiggins CD, Fernández R, Skourtanioti E, Amoutzias G, Delneri D, Kyrpides N, Nikolaou C, Pittis AA, Manousaki T, Vakirlis N.   +13 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Chloroplast genome comparison and taxonomic reassessment of Polygonatum sensu Lato (Asparagaceae): implications for molecular marker development in traditional medicinal plants. [PDF]

BMC Genomics
Hu Y, Wang S, Xu Z, Yan S, Ali M, Li Z, Shao J.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mitochondrial Genome Comparison and Phylogenetic Variety of Four Morphologically Similar Bamboo Pests. [PDF]

Ecol Evol
Ying Y, Wang W, Li Y, Li Z, Zhao X, Zhang S, Shu J, Shen Z, Zhang W.   +8 more
europepmc   +1 more source