Results 151 to 160 of about 571,422 (359)

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Zinc finger nuclease (ZFN)-mediated genome editing to generate isogenic, pluripotent cell lines [PDF]

, 2011

openalex   +1 more source

Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis

FEBS Open Bio, EarlyView.
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir, Lotte W. Nijman, Robert S. Jansen, Laura van Niftrik, Wouter Versantvoort   +4 more
wiley   +1 more source

Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors

Biomedicines
Background: Organoids are a valuable model for studying hereditary diseases such as cystic fibrosis (CF). Recombinant adenoviral (rAdV) and adeno-associated viral (rAAV) vectors are promising tools for CF gene therapy and genome editing.
Lyubava Belova, Anna Demchenko, Anastasia Erofeeva, Konstantin Kochergin-Nikitsky, Olga Zubkova, Olga Popova, Tatiana Ozharovskaia, Diana Salikhova, Anna Efremova, Alexander Lavrov, Svetlana Smirnikhina   +10 more
doaj   +1 more source

Bacteria herald a new era of gene editing. [PDF]

, 2013
The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome ...
Segal, David J
core  

Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases [PDF]

, 2012
Fayza Daboussi, Mikhail Zaslavskiy, Laurent Poirot, Mariana Loperfido, Agnès Gouble, Valérie Guyot, Sophie Leduc, Román Galetto, Sylvestre Grizot, Danusia Oficjalska, Christophe Perez, Fabien Delacôte, Aurélie Dupuy, Isabelle Chion-Sotinel, Diane Le Clerre, Céline Lebuhotel, Olivier Danos, Frédéric Lemaire, Kahina Oussedik, Frédéric Cédrone, Jean-Charles Epinat, Julianne Smith, Rafael J. Yáñez‐Muñoz, George Dickson, Linda Popplewell, Taeyoung Koo, Thierry VandenDriessche, Marinee Chuah, Aymeric Duclert, Philippe Duchâteau, Frédéric Pâques   +30 more
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

CRISPR/Cas9-mediated mutagenesis of CAROTENOID CLEAVAGE DIOXYGENASE 8 in tomato provides resistance against the parasitic weed Phelipanche aegyptiaca. [PDF]

, 2019
Broomrapes (Phelipanche aegyptiaca and Orobanche spp.) are obligate plant parasites that cause extreme damage to crop plants. The parasite seeds have strict requirements for germination, involving preconditioning and exposure to specific chemicals ...
Aly, Radi, Bari, Vinay Kumar, Britt, Anne, Gal-On, Amit, Kheredin, Sally Marzouk, Nassar, Jackline Abu, Ron, Mily, Steele, Daniel, Yoder, John   +8 more
core  

Genome Editing with CompoZr Custom Zinc Finger Nucleases (ZFNs) [PDF]

, 2012
Keith Hansen, Matthew J. Coussens, Jack Sago, Shilpi Subramanian, Monika Gjoka, Dave Briner   +5 more
openalex   +1 more source

Genome editing in hymenoptera

Insect Biochemistry and Molecular Biology
The application of genome editing tools in Hymenoptera has transformative potential for functional genetics and understanding their unique biology. Hymenoptera comprise one of the most diverse Orders of animals, and the development of methods for efficiently creating precise genome modifications could have applications in conservation, pest management ...
Hamish A. Salvesen, Peter K. Dearden
openaire   +2 more sources