Results 171 to 180 of about 1,632,775 (273)

A framework for cost-constrained genome rearrangement under Double Cut and Join [PDF]

arXiv, 2018
The study of genome rearrangement has many flavours, but they all are somehow tied to edit distances on variations of a multi-graph called the breakpoint graph. We study a weighted 2-break distance on Eulerian 2-edge-colored multi-graphs, which generalizes weighted versions of several Double Cut and Join problems, including those on genomes with ...
arxiv  

Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors

Biomedicines
Background: Organoids are a valuable model for studying hereditary diseases such as cystic fibrosis (CF). Recombinant adenoviral (rAdV) and adeno-associated viral (rAAV) vectors are promising tools for CF gene therapy and genome editing.
Lyubava Belova, Anna Demchenko, Anastasia Erofeeva, Konstantin Kochergin-Nikitsky, Olga Zubkova, Olga Popova, Tatiana Ozharovskaia, Diana Salikhova, Anna Efremova, Alexander Lavrov, Svetlana Smirnikhina   +10 more
doaj   +1 more source

Zinc finger nuclease (ZFN)-mediated genome editing to generate isogenic, pluripotent cell lines [PDF]

, 2011

openalex   +1 more source

Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases [PDF]

, 2012
Fayza Daboussi, Mikhail Zaslavskiy, Laurent Poirot, Mariana Loperfido, Agnès Gouble, Valérie Guyot, Sophie Leduc, Román Galetto, Sylvestre Grizot, Danusia Oficjalska, Christophe Perez, Fabien Delacôte, Aurélie Dupuy, Isabelle Chion-Sotinel, Diane Le Clerre, Céline Lebuhotel, Olivier Danos, Frédéric Lemaire, Kahina Oussedik, Frédéric Cédrone, Jean-Charles Epinat, Julianne Smith, Rafael J. Yáñez‐Muñoz, George Dickson, Linda Popplewell, Taeyoung Koo, Thierry VandenDriessche, Marinee Chuah, Aymeric Duclert, Philippe Duchâteau, Frédéric Pâques   +30 more
openalex   +1 more source

Targeted mutagenesis of FaTM6 in the Octoploid Strawberry (Fragaria x ananassa) using the CRISPR/Cas9 System [PDF]

, 2018
The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family.
Duarte-Conde, José Antonio, Martín-Pizarro, Carmen, Posé, David   +2 more
core  

Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells With Zinc Finger Nucleases for Cellular Imaging [PDF]

, 2012
Yongming Wang, Wendy Y. Zhang, Shijun Hu, Feng Lan, Andrew S. Lee, Bruno Hüber, Leszek Lisowski, Ping Liang, Mei Huang, Patricia E. de Almeida, Jong Hak Won, Ning Sun, Robert C. Robbins, Mark A. Kay, Fyodor D. Urnov, Joseph C. Wu   +15 more
openalex   +1 more source

Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks

Nature Communications
Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery.
Jinchun Wu, Yang Liu, Liqiong Ou, Tingting Gan, Zhengrong Zhangding, Shaopeng Yuan, Xinyi Liu, Mengzhu Liu, Jiasheng Li, Jianhang Yin, Changchang Xin, Ye Tian, Jiazhi Hu   +12 more
doaj   +1 more source

Genome Editing with CompoZr Custom Zinc Finger Nucleases (ZFNs) [PDF]

, 2012
Keith Hansen, Matthew J. Coussens, Jack Sago, Shilpi Subramanian, Monika Gjoka, Dave Briner   +5 more
openalex   +1 more source

The genome-editing decade

Molecular Therapy, 2021
Paula M. Cannon, Hans-Peter Kiem
openaire   +3 more sources

Simple and precise targeted editing of the human genome using rAAV-mediated homologous recombination [PDF]

, 2012
C Torrance
openalex   +1 more source