Results 181 to 190 of about 1,963,187 (422)

Pseudomonas Genome Editing

, 2023
Our Pseudomonas genome editing services are based on CRISPR/Cas9 technology and homologous recombination technique. The state-of-art Pseudomonas editing system helps you successfully achieve gene knockout, gene insertion and point mutation for either research or industrial purposes.
openaire   +2 more sources

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3

Cell Communication and Signaling
Sestrin1 and Sestrin2 (SESN1&2) are evolutionarily conserved, stress-responsive proteins that regulate cell growth and viability. The primary target of Sestrins is the mTORC1 protein kinase, an activator of anabolic processes and an autophagy inhibitor ...
Alexander Haidurov, Andrei O. Zheltukhin, Anastasiya V. Snezhkina, George S. Krasnov, Anna V. Kudryavtseva, Andrei V. Budanov   +5 more
doaj   +1 more source

PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair

STAR Protocols, 2022
Summary: The repair products of double-stranded DNA breaks (DSBs) are crucial for investigating the mechanism underlying DNA damage repair as well as evaluating the safety and efficiency of gene-editing; however, a comprehensively quantitative assay ...
Yang Liu, Jianhang Yin, Tingting Gan, Mengzhu Liu, Changchang Xin, Weiwei Zhang, Jiazhi Hu   +6 more
doaj  

The Mitochondrial Genome of Cathaya argyrophylla Reaches 18.99 Mb: Analysis of Super-Large Mitochondrial Genomes in Pinaceae [PDF]

arXiv
Mitochondrial genomes in the Pinaceae family are notable for their large size and structural complexity. In this study, we sequenced and analyzed the mitochondrial genome of Cathaya argyrophylla, an endangered and endemic Pinaceae species, uncovering a genome size of 18.99 Mb, meaning the largest mitochondrial genome reported to date.
arxiv  

Regional Physical Mapping: Genome Analysis, vol. 5. Edited by K. E. Davies, and S. M. Tilghman. Cold Spring Harbor Laboratory Press. 1993. 140 pages. Cloth. $49.00. ISBN 0 87969 413 0. [PDF]

, 1994
Wendy A. Bickmore
openalex   +1 more source

Prime editing for precise and highly versatile genome manipulation

Nature reviews genetics, 2022
Peter J. Chen, David R. Liu
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Heterozygous deletion of 10q24.31-q24.33– a new syndrome associated with multiple congenital anomalies: case report and literature review

Neurological Research and Practice
Background Congenital anomalies and neurodevelopmental disorders are complex conditions often requiring comprehensive diagnostic approaches. Next-generation sequencing (NGS), particularly whole-exome sequencing (WES), has greatly improved the detection ...
Anastasiia A. Buianova, Yulia S. Lashkova, Tatiana V. Kulichenko, Ivan S. Kuznetsov, Artem A. Ivanov, Olga P. Parshina, Oleg N. Suchalko, Svetlana S. Vakhlyarskaya, Dmitriy O. Korostin   +8 more
doaj   +1 more source

Agptools: a utility suite for editing genome assemblies [PDF]

arXiv
The AGP format is a tab-separated table format describing how components of a genome assembly fit together. A standard submission format for genome assemblies is a fasta file giving the sequence of contigs along with an AGP file showing how these components are assembled into larger pieces like scaffolds or chromosomes.
arxiv