Results 311 to 320 of about 1,963,187 (422)

Efficiency of genome editing using modified single-stranded oligodeoxyribonucleotides in human cells. [PDF]

Sci Rep
Kim S, Matsushita Y, Katagiri T, Maseda H.   +3 more
europepmc   +1 more source

Faculty Opinions recommendation of CRISPR-Cas9 knockin mice for genome editing and cancer modeling.

, 2014
Vijay Tiwari, Angela Garding
openalex   +2 more sources

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

Cell, 2013
F. Ran, P. Hsu, C. Lin, J. Gootenberg, Silvana, Konermann, Alexandro E. Trevino, David A. Scott, Azusa Inoue, Shogo Matoba, Yi, Zhang, Feng Zhang   +12 more
semanticscholar   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source

Advancements in genome editing tools for genetic studies and crop improvement. [PDF]

Front Plant Sci
Ahmadikhah A, Zarabizadeh H, Nayeri S, Abbasi MS.   +3 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Perspectives of Genome Editing Mediated Haploid Inducer Systems in Legumes. [PDF]

Int J Mol Sci
Liu Y, Elshan M, Li G, Han X, Chen X, Feng X.   +5 more
europepmc   +1 more source

Transcriptional Slippage and RNA Editing Increase the Diversity of Transcripts in Chloroplasts: Insight from Deep Sequencing of Vigna radiata Genome and Transcriptome

, 2015
Ching-Ping Lin, Chia-Yun Ko, Ching-I Kuo, Mao-Sen Liu, Roland Schafleitner, Long-Fang Oliver Chen   +5 more
openalex   +2 more sources

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Automated plasmid design for marker-free genome editing in budding yeast. [PDF]

G3 (Bethesda)
Stojković L, Gligorovski V, Geramimanesh M, Labagnara M, Rahi SJ.   +4 more
europepmc   +1 more source