Results 321 to 330 of about 1,963,187 (422)

Multiplexed CRISPR/Cas9 genome editing increases the efficacy of homologous-dependent repair of donor sequences in mammalian cells

, 2015
Ezio T. Fok, Clement Penny, Musa M. Mhlanga, Marc S. Weinberg   +3 more
openalex   +2 more sources

Cryo‐EM Analysis of a Tri‐Heme Cytochrome‐Associated RC‐LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae

Advanced Science, EarlyView.
Cryo‐EM reveals a closed 17‐subunit LH ring encircling the RC‐LH1 complex in Dinoroseobacter shibae, featuring a novel helix‐turn‐helix subunit bridging RC and LH. Mg2⁺/Ca2⁺ stabilizes the complex, while periplasmic Cyt c₂ mediates electron transfer via a tri‐heme Cyt to the special pair of bacteriochlorophylls. Insights into energy/electron efficiency
Weiwei Wang, Yanting Liu, Jiayi Gu, Shaoya An, Cheng Ma, Haichun Gao, Nianzhi Jiao, Jian‐Ren Shen, John Thomas Beatty, Michal Koblížek, Xing Zhang, Qiang Zheng, Jing‐Hua Chen   +12 more
wiley   +1 more source

Genome editing in spinocerebellar ataxia type 3 cells improves Golgi apparatus structure. [PDF]

Sci Rep
Wang Y, Cheng Y, Sun H, Wang Z, Chen N, Shi C, Liu H, Yang J, Xu Y.   +8 more
europepmc   +1 more source

A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation

, 2015
Levi G. Lowder, Dengwei Zhang, Nicholas J. Baltes, Joseph W. Paul, Xu Tang, Xuelian Zheng, Daniel F. Voytas, Tzung‐Fu Hsieh, Yong Zhang, Yiping Qi   +9 more
openalex   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source

Computationally derived RNA polymerase III promoters enable maize genome editing. [PDF]

Front Plant Sci
Nagy ED, Davis IW, Song S, No V, Wu C, Kanizay L, Turner-Hissong S, Li H, Ye X, Berry JC, Chiapelli B, To JPC, Marengo MS.   +12 more
europepmc   +1 more source

Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools

, 2015
Adrian Kee Keong Teo, Manoj K. Gupta, Alessandro Doria, Rohit Kulkarni   +3 more
openalex   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Africa and zero hunger agenda: genome editing policy landscape, challenges and opportunities. [PDF]

Front Bioeng Biotechnol
Akinbo O, Nkhabindze B, Amedu J, Ebegba R, Asagbra A, Ratemo BO, Angira Dada S, Muia A, Mugiira R, Chimphepo L, Wristberg LO, Rouamba MW, Some K, Nuaila VNA, Atanásio A, Shittu OB, Adetunji CO, Hamidi L, Monga E, Obukosia S, Adegbaju MS, Acheampong S, Fotabong E.   +22 more
europepmc   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source