Results 331 to 340 of about 571,422 (359)
Some of the next articles are maybe not open access.
2019
Programmable nucleases like CRISPR/Cas9 enable to edit the mouse genome directly in the zygote. Several methods have been successfully used for this. Here we describe injection into one of the pronuclei of the zygote and electroporation of zygotes. Alternative methods will be mentioned.
Lisbeth Ahm Hansen +1 more
openaire +2 more sources
Programmable nucleases like CRISPR/Cas9 enable to edit the mouse genome directly in the zygote. Several methods have been successfully used for this. Here we describe injection into one of the pronuclei of the zygote and electroporation of zygotes. Alternative methods will be mentioned.
Lisbeth Ahm Hansen +1 more
openaire +2 more sources
2022
The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic components in pathogenesis of diabetes and its complications. There are several established genes such as ABCC8, TCF7L2, SLC2A2, and CAPN10 which are known to influence blood insulin and glucose levels.
openaire +2 more sources
The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic components in pathogenesis of diabetes and its complications. There are several established genes such as ABCC8, TCF7L2, SLC2A2, and CAPN10 which are known to influence blood insulin and glucose levels.
openaire +2 more sources
2021
Although barley is of great importance for the brewing and animal feed industries and is regarded as a model for small grain cereals, only a few results on targeted gene modification using CRISPR/Cas endonuclease technology have been published to date.
Martin Becker, Goetz Hensel
openaire +1 more source
Although barley is of great importance for the brewing and animal feed industries and is regarded as a model for small grain cereals, only a few results on targeted gene modification using CRISPR/Cas endonuclease technology have been published to date.
Martin Becker, Goetz Hensel
openaire +1 more source
Regulate genome-edited products, not genome editing itself
Nature Biotechnology, 2016Dana Carroll +4 more
openaire +2 more sources
In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
Nature, 2021Luke W Koblan +2 more
exaly
2017
Caenorhabditis elegans, a 1 mm long free-living nematode, is a traditional model animal for genetic investigations of various biological processes. Characteristic features that make C. elegans a powerful model of choice for eukaryotic genetic studies include its rapid life cycle, well-annotated genome, simple morphology, and transparency.
openaire +4 more sources
Caenorhabditis elegans, a 1 mm long free-living nematode, is a traditional model animal for genetic investigations of various biological processes. Characteristic features that make C. elegans a powerful model of choice for eukaryotic genetic studies include its rapid life cycle, well-annotated genome, simple morphology, and transparency.
openaire +4 more sources
Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
exaly