Results 261 to 270 of about 526,413 (332)

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

One-step genome engineering in bee gut bacterial symbionts. [PDF]

mBio
Lariviere PJ, Ashraf AHMZ, Navarro-Escalante L, Leonard SP, Miller LG, Moran NA, Barrick JE.   +6 more
europepmc   +1 more source

Figure S7. from High-Specificity CRISPR-Mediated Genome Engineering in Anti-BCMA Allogeneic CAR T Cells Suppresses Allograft Rejection in Preclinical Models [PDF]

Émilie Degagné, Paul D. Donohoue, Suparna Roy, Jessica Scherer, Tristan W. Fowler, Ryan T. Davis, Gustavo Reyes, George Kwong, Morena Stanaway, Vanina Larroca Vicena, Devin Mutha, Raymond Guo, Leslie Edwards, Benjamin Schilling, McKay Shaw, Stephen C. Smith, Bryan Kohrs, Heinrich J. Kufeldt, Glen Churchward, Finey Ruan, David B. Nyer, Kyle McSweeney, Matthew J. Irby, Christopher K. Fuller, Lynda Banh, Mckenzi S. Toh, Matthew R. Thompson, Arthur L.G. Owen, Zili An, Scott Gradia, Justin Skoble, Mara Bryan, Elizabeth Garner, Steven B. Kanner   +33 more
openalex   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

A Consecutive Genome Engineering Method Reveals a New Phenotype and Regulation of Glucose and Glycerol Utilization in Clostridium Pasteurianum. [PDF]

Eng Life Sci
Nguyen T, Meleski LWG, Belavatta MP, Gurumoorthi S, Zhang C, Heins AL, Zeng AP.   +6 more
europepmc   +1 more source

Origins of Programmable Nucleases for Genome Engineering

, 2015
Srinivasan Chandrasegaran, Dana Carroll
openalex   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Author Correction: ReaL-MGE is a tool for enhanced multiplex genome engineering and application to malonyl-CoA anabolism. [PDF]

Nat Commun
Zheng W, Wang Y, Cui J, Guo G, Li Y, Hou J, Tu Q, Yin Y, Stewart AF, Zhang Y, Bian X, Wang X.   +11 more
europepmc   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Exploring the m⁵C epitranscriptome of mRNAs in breast cancer cells through genome engineering and long-read sequencing approaches. [PDF]

Funct Integr Genomics
Athanasopoulou K, Adamopoulos PG, Tsiakanikas P, Scorilas A.   +3 more
europepmc   +1 more source