Results 161 to 170 of about 874,950 (354)

Comparative genome analysis and genome evolution

, 2002
This thesis described a collection of bioinformatic analyses on complete genome sequence data. We have studied the evolution of gene content and find that vertical inheritance dominates over horizontal gene trasnfer, even to the extent that we can use the gene content to make genome phylogenies.
openaire   +2 more sources

Additional file 21: of Long-read based assembly and synteny analysis of a reference Drosophila subobscura genome reveals signatures of structural evolution driven by inversions recombination-suppression effects

, 2019
Charikleia Karageorgiou, Víctor Gámez-Visairas, Rosa Tarrı́o, Francisco Rodrı́guez-Trelles   +3 more
openalex   +1 more source

Detecting Adaptation with Genome-Scale Molecular Evolutionary Analysis: An Educational Primer for Use with “RNA Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates” [PDF]

, 2018
Brian P. Lazzaro
openalex   +1 more source

A chromosome‐levelAmaranthus cruentusgenome assembly highlights gene family evolution and biosynthetic gene clusters that may underpin the nutritional value of this traditional crop [PDF]

, 2021
Xiao Ma, Fabián E. Vaistij, Yi Li, W.S. Jansen van Rensburg, Sarah Harvey, Michael W. Bairu, S.L. Venter, Sydney Mavengahama, Zemin Ning, Ian A. Graham, Allen Van Deynze, Yves Van de Peer, Katherine Denby   +12 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Genome evolution in allotetraploid Nicotiana [PDF]

, 2004
Kar Yoong Lim, Roman Matyášek, Aleš Kovařı́k, Andrew R. Leitch   +3 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evolution of the core and pan-genome of Streptococcus: positive selection, recombination, and genome composition [PDF]

, 2007
Tristan Lefébure, Michael J. Stanhope
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Distribution, diversity, evolution, and survival of Helitrons in the maize genome [PDF]

, 2009
Lixing Yang, Jeffrey L. Bennetzen
openalex   +1 more source