Results 171 to 180 of about 3,706,718 (308)

Genome Evolution in Plant Pathogenic Bacteria. [PDF]

Genome Biol Evol
Weis KS, Kaur A, Ghosh P, Potnis N.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Genomes and evolution

Current Opinion in Genetics & Development, 1992
openaire   +2 more sources

Orchid genome evolution and trait innovation. [PDF]

J Integr Plant Biol
Zeng MY, Zhou CY, Wang L, Gao J, Yin W, Peng DH, Lan S, Yang FX, Liu ZJ.   +8 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Genome evolution and long-term demographic history in true crocodiles. [PDF]

G3 (Bethesda)
Saldarriaga-Gómez AM, Luzuriaga-Neira A, Vargas-Ramírez M, Amato G, Hekkala E.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Centromeric satellite expansion drives genome evolution in the snowy owl. [PDF]

Genome Biol
Baalsrud HT, Garmann-Aarhus B, Enevoldsen ELG, Krabberød AK, Fischer D, Tooming-Klunderud A, Skage M, Skage M, Árnyasi M, Sandve SR, Sandve SR, Jakobsen KS, Nielsen R, Boessenkool S, Tørresen OK.   +14 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The heterogeneous selection landscape of genome evolution in prokaryotes. [PDF]

Proc Natl Acad Sci U S A
Kogay R, Karamycheva S, Rochman ND, Wolf YI, Koonin EV.   +4 more
europepmc   +1 more source