Results 1 to 10 of about 42,522 (251)
Retrotransposon-induced mosaicism in the neural genome [PDF]
Open Biology, 2018 Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain ...
Gabriela O Bodea, Geoffrey J Faulkner
exaly +4 more sources
Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells. [PDF]
PLoS Computational Biology, 2012 Retrotransposons are highly prevalent in mammalian genomes due to their ability to amplify in pluripotent cells or developing germ cells. Host mechanisms that silence retrotransposons in germ cells and pluripotent cells are important for limiting the ...
Judith Reichmann +7 more
doaj +2 more sources
Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells. [PDF]
PLoS Genetics, 2013 Retrotransposon sequences are positioned throughout the genome of almost every eukaryote that has been sequenced. As mobilization of these elements can have detrimental effects on the transcriptional regulation and stability of an organism's genome, most
Andrew T Schuster +3 more
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Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.
PLoS ONE, 2014 In the human placenta, DNA hypomethylation permits the expression of retrotransposon-derived genes that are normally silenced by methylation in somatic tissues.
Erin C Macaulay +5 more
doaj +2 more sources
Retrotransposons and Telomeres
Biochemistry (Moscow), 2023 Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle.
Alla I, Kalmykova, Olesya A, Sokolova
openaire +2 more sources
Exogenous Coronavirus Interacts With Endogenous Retrotransposon in Human Cells
Frontiers in Cellular and Infection Microbiology, 2021 There is an increased global outbreak of diseases caused by coronaviruses affecting respiratory tracts of birds and mammals. Recent dangerous coronaviruses are MERS-CoV, SARS-CoV, and SARS-CoV-2, causing respiratory illness and even failure of several ...
Ying Yin +10 more
doaj +1 more source
Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. [PDF]
PLoS Genetics, 2017 Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity.
Kota Inoue +4 more
doaj +1 more source
Biomedicines, 2021 Small extracellular vesicles (SEVs) such as exosomes are released by multiple cell types. Originally believed to be a mechanism for selectively removing unwanted cellular components, SEVs have received increased attention in recent years for their ...
Marilou H. Barrios +5 more
doaj +1 more source
Pathogens, 2021 While hybridization probe-based real-time PCR assays targeting highly repetitive multi-copy genome sequences for the diagnosis of S. mansoni complex or S.
Hagen Frickmann +13 more
doaj +1 more source
Frontiers in Genetics, 2021 In eukaryotic genomes, cycles of repeat expansion and removal lead to large-scale genomic changes and propel organisms forward in evolution. However, in conifers, active repeat removal is thought to be limited, leading to expansions of their genomes ...
Tony Heitkam +12 more
doaj +1 more source